 |
|
K. Barry Sharpless Publications
|
| 355 |
R. Vanacore, A.-J. L. Ham, M. Voehler, C. R. Sanders, T. P. Conrads, T. D. Veenstra, K. B. Sharpless, P. E. Dawson and B. G. Hudson,
A Sulfilimine Bond Identified in Collagen IV,
Science, 325(5945), 1230 (2009). |
| 354 |
C. A. Valdez, J. C. Tripp, Y. Miyamoto, J. Kalisiak, P. Hruz, Y. S. Andersen, S. E. Brown, K. Kangas, L. V. Arzu, B. J. Davids, F. D. Gillin, J. A. Upcroft, P. Upcroft, V. V. Fokin, D. K. Smith, K. B. Sharpless and L. Eckmann,
Synthesis and Electrochemistry of 2-Ethenyl and 2-Ethanyl Derivatives of 5-Nitroimidazole and Antimicrobial Activity against Giardia lamblia,
J. Med. Chem., 52(13), 4038 (2009). |
| 353 |
D. Minond, S. A. Saldanha, P. Subramaniam, M. Spaargaren, T. Spicer, J. R. Fotsing, T. Weide, V. V. Fokin, K. B. Sharpless, M. Galleni, C. Bebrone, P. Lassaux and P. Hodder,
Inhibitors of VIM-2 by Screening Pharmacologically Active and Click-Chemistry Compound Libraries,
Bioorg. Med. Chem., 17(14), 5027 (2009). |
| 352 |
J. Kalisiak, S. A. Trauger, E. Kalisiak, H. Morita, V. V. Fokin, M. W. W. Adams, K. B. Sharpless and G. Siuzdak,
Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach,
J. Am. Chem. Soc., 131(1), 378 (2009). |
| 351 |
T. Hirose, T. Sunazuka, A. Sugawara, A. Endo, K. Iguchi, T. Yamamoto, H. Ui, K. Shiomi, T. Watanabe, K. B. Sharpless and S. Omura,
Chitinase Inhibitors: Extraction of the Active Framework from Natural Argifin and Use of In Situ Click Chemistry,
J. Antibiot., 62(5), 277 (2009). |
| 350 |
J. E. Hein, J. C. Tripp, L. B. Krasnova, K. B. Sharpless and V. V. Fokin,
Copper(I)-Catalyzed Cycloaddition of Organic Azides and 1-Iodoalkynes,
Angew. Chem., Int. Ed., 48(43), 8018 (2009). |
| 349 |
H. D. Agnew, R. D. Rohde, S. W. Millward, A. Nag, W.-S. Yeo, J. E. Hein, S. M. Pitram, A. A. Tariq, V. M. Burns, R. J. Krom, V. V. Fokin, K. B. Sharpless and J. R. Heath,
Iterative In Situ Click Chemistry Creates Antibody-like Protein-Capture Agents,
Angew. Chem., Int. Ed., 48(27), 4944 (2009). |
| 348 |
V. Fokin, V. A. Rostovtsev, L. Green, F. Himo and K. B. Sharpless,
Copper-Catalysed Ligation of Azides and Acetylenes,
U.S. Patent Number 7,375,234, issued May 20, 2008.
|
| 347 |
E. J. Yoo, M. Ahlquist, I. Bae, K. B. Sharpless, V. V. Fokin and S. Chang,
Mechanistic Studies on the Cu-Catalyzed Three-Component Reactions of Sulfonyl Azides, 1-Alkynes and Amines, Alcohols, or Water: Dichotomy via a Common Pathway,
J. Org. Chem., 73(14), 5520 (2008). |
| 346 |
Z. Radic, R. Manetsch, D. Fournier, K. B. Sharpless and P. Taylor,
Probing Gorge Dimensions of Cholinesterases by Freeze-Frame Click Chemistry,
Chem.-Biol. Interact., 175(1-3), 161 (2008). |
| 345 |
S. W. Kwok, J. E. Hein, V. V. Fokin and K. B. Sharpless,
Regioselective Synthesis of either 1H- or 2H-1,2,3-Triazoles via Michael Addition to Alpha, Beta-Unsaturated Ketones,
Heterocycles, 76(2), 1141 (2008). |
| 344 |
J. Kalisiak, K. B. Sharpless and V. V. Fokin,
Efficient Synthesis of 2-Substituted-1,2,3-triazoles,
Org. Lett., 10(15), 3171 (2008). |
| 343 |
E. Van der Eycken and K. B. Sharpless,
Click Chemistry,
QSAR Comb. Sci., 26(11-12), 1115 (2007). |
| 342 |
A. Sugawara, T. Sunazuka, T. Hirose, K. Nagai, Y. Yamaguchi, H. Hanaki, K. B. Sharpless and S. Omura,
Design and Synthesis via Click Chemistry of 8,9-Anhydroerythromycin A 6,9-Hemiketal Analogues with anti-MRSA and -VRE Activity,
Bioorg. Med. Chem. Lett., 17(22), 6340 (2007). |
| 341 |
M. G. Finn, H. C. Kolb, V. V. Fokin and K. B. Sharpless,
Concept and Applications of Click Chemistry. From the Standpoint of Advocates,
Kagaku to Kogyo (Tokyo, Jpn.), 60(10), 976 (2007). |
| 340 |
R. Vestberg, M. Malkock, M. Kade, P. Wu, V. V. Fokin, K. B. Sharpless, E. Drokenmuller and C. J. Hawker,
Role of Architecture and Molecular Weight in the Formation of Tailor-made Ultrathin Multilayers Using Dendritic Macromolecules and Click Chemistry,
J. Polymer Sci., Part A., 45(14), 2835 (2007). |
| 339 |
Y. Liu, D. D. Diaz, A. A. Accurso, K. B. Sharpless, V. V. Fokin and M. G. Finn,
Metal-Adhesive Polymers from Cu(I)-Catalyzed Azide-Alkyne Cycloaddition,
J. Polymer Sci., Part A., 45, 5182 (2007). |
| 338 |
C. J. Hawker, V. V. Fokin, M. G. Finn and K. B. Sharpless,
Bringing Efficiency to Materials Synthesis: The Philosophy of Click Chemistry,
Aust. J. Chem., 60(6), 381 (2007). |
| 337 |
E. J. Yoo, M. Ahlquist, S. H. Kim, I. Bae, V. V. Fokin, K. B. Sharpless and S. Chang,
Synthesis of N-Sulfonyl-1,2,3-triazoles: Controlling Selectivity,
Angew. Chem. Int. Ed., 46(10), 1730 (2007). |
| 336 |
S. Narayan, V. V. Fokin and K. B. Sharpless
Organic Synthesis in Aqueous Suspension: Chemistry 'On Water' in "Organic Synthesis in Water",
U. Lindstrom, ed., Blackwell Scientific (2007).
|
| 335 |
T. Hirose, T. Sunazuka, Y. Noguchi, Y. Yamaguchi, H. Hanaki, K. B. Sharpless and S. Omura,
Rapid 'SAR' via Click Chemistry: An Alkyne-Bearing Spiramycin is Fused with Diverse Azides to Yield New Triazole-Antibacterial Candidates,
Heterocycles, 69, 55 (2006). |
| 334 |
K. B. Sharpless and R. Manetsch,
In Situ Click Chemistry: A Powerful Means for Lead Discovery,
Expert Opinion in Drug Discovery, 1(6), 525 (2006). |
| 333 |
M. Whiting, J. Tripp, Y.-C. Lin, W. Lindstrom, A. J. Olson, J. H. Elder, K. B. Sharpless and V. V. Fokin,
Rapid Discovery and Structure-Activity Profiling of Novel Inhibitors of HIV-1 Protease Enabled by the Copper(I)-Catalyzed Synthesis of 1,2,3-Triazoles and Their Further Functionalization,
J. Med. Chem., 49, 7697 (2006). |
| 332 |
D. D. Diaz, A. Converso, K. B. Sharpless and M. G. Finn,
2,6-Dichloro-9-thiabiycyclo[3.3.1]nonane: Multigram Display of Azide and Cyanide Components on a Versatile Scaffold,
Molecules, 11(4), 212 (2006). |
| 331 |
M. Whiting, J. Muldoon, Y.-C. Lin, S. M. Silverman, W. Lindstrom, A. Olson, H. C. Kolb, M. G. Finn, K. B. Sharpless, J. H. Elder and V. V. Fokin,
Inhibitors of HIV-1 Protease By Using In Situ Click Chemistry,
Angew. Chem. Int. Ed., 45(9), 1435 (2006). |
| 330 |
Z. Radić, R. Manetsch, A. Krasiński, J. Raushel, J. Yamauchi, C. Garcia, H. Kolb, K. B. Sharpless and P. Taylor,
Molecular Basis of Interactions of Cholinesterases with Tight Binding Inhibitors,
Chem.-Biol. Interact., 157-158, 133 (2005). |
| 329 |
Y. Bourne, Z. Radić, H. C. Kolb, K. B. Sharpless, P. Taylor and P. Marchot,
Structural Insights into Conformational Flexibility at the Peripheral Site and Within the Active Center Gorge of AChE,
Chem.-Biol. Interact., 157-158, 159 (2005). |
| 328 |
P. Wu, M. Malkoch, J. Hunt, R. Vestburg, E. Kaltgrad, M. G. Finn, V. V. Fokin, K. B. Sharpless and C. J. Hawker,
Multivalent, Bifunctional Dendrimers Prepared by Click Chemistry,
Chem. Commun., 46, 5775 (2005). |
| 327 |
L. Zhang, X. Chen, P. Xue, H. H. Y. Sun, I. D. Williams, K. B. Sharpless, V. V. Fokin and G. Jia,
Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides,
J. Am. Chem. Soc., 127 (46), 15998 (2005). |
| 326 |
J. C. Loren, A. Krasiński, V. V. Fokin and K. B. Sharpless,
NH-1,2,3-Triazoles from Azidomethyl Pivalate and Carbamates: Tunable Base Labile Protecting Groups,
Synlett, 18, 2847 (2005). |
| 325 |
S. M. Johnson, H.M. Petrassi, S. K. Palaninathan, N. N. Mohamedmohaideen, H. E. Purkey, C. Nichols, K. P. Chiang, T. Walkup, J. C. Sacchettini,
K. B. Sharpless and J. W. Kelly, Bisaryloxime Ethers as Potent Inhibitors of Transthyretin Amyloid Fibril Formation,
J. Med. Chem., 48, 1576 (2005). |
| 324 |
J. C. Loren and K. B. Sharpless,
The Banert Cascade: A Synthetic Sequence to Polyfunctional NH-1,2,3-Triazoles,
Synthesis, 9, 1514 (2005). |
| 323 |
A. K. Feldman, B. Colasson, K. B. Sharpless and V. V. Fokin,
The Allylic Azide Rearrangement: Achieving Selectivity,
J. Am. Chem. Soc, 127, 13444 (2005). |
| 322 |
K. B. Sharpless, M. Andersson, R. Epple and V. V. Fokin,
Second Cycle Asymmetric Dihydroxylation Reaction, U.S. Patent Number 6,852,874 B2, issued February 8, 2005.
|
| 321 |
A. Krasiński, Z. Radik, R. Manetsch, J. Raushel, P. Taylor, K. B. Sharpless and H. C. Kolb,
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors,
J. Am. Chem. Soc., 127, 6686 (2005). |
| 320 |
S. Narayan, M. G. Finn, V. V. Fokin, H. C. Kolb and K. B. Sharpless,
"On Water": Unique Reactivity Effects of Organic Compounds in Aqueous Suspensions,
Angew. Chem. Int. Ed., 44, 3275 (2005). |
| 319 |
V. P. Mocharla, B. Colasson, L. V. Lee, S. Roeper, K. B. Sharpless, C.-H. Wong and H. C. Kolb,
In Situ Click Chemistry: Enzyme-Generated Inhibitors of Carbonic Anhydrase II,
Angew. Chem. Int. Ed., 44, 116 (2005). |
| 318 |
F. Himo, T. Lovell, R. Hilgraf, V. V. Rostovtsev, L. Noodleman,
K. B. Sharpless and V. V. Fokin, Copper(I)-Catalyzed Synthesis
of Azoles. DFT Study Predicts Unprecedented Reactivity and
Intermediates, J. Am. Chem. Soc., 127, 210 (2005). |
| 317 |
T. R. Chan, R. Hilgraf, K. B. Sharpless and V. V. Fokin,
Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis,
Org. Lett., 6, 2853 (2004). |
| 316 |
R. Manetsch, A. Krasiński, Z. Radić, J. Raushel, P. Taylor,
K. B. Sharpless and H. C. Kolb, In Situ Click Chemistry:
Enzyme Inhibitors Made to Their Own Specifications, J. Am.
Chem. Soc., 126, 12809 (2004). |
| 315 |
A. Converso, P.-L. Saaidi, M. G. Finn and K. B. Sharpless,
Nucleophilic Substitution by Grignard Reagents on Sulfur
Mustards, J. Org. Chem., 69, 7336 (2004). |
| 314 |
D. D. Diaz, S. Punna, P. Holzer, A. K. McPherson, K. B. Sharpless,
V. V. Fokin, and M. G. Finn, Click Chemistry in Materials Synthesis.
1. Adhesive Polymers from Copper-Catalyzed Azide-Alkyne Cycloaddition,
J. Polym. Sci. Part A: Polym. Chem., 42, 4392 (2004). |
| 313 |
P. Wu, A. K. Feldman, A. K. Nugent, C. J. Hawker, A. Scheel,
B. Voit, J. Pyun, J. M. J. Fréchet, K. B. Sharpless and V. V.
Fokin, Efficiency and Fidelity in a Click Chemistry Route to
Triazole Dendrimers via the Cu(I)-Catalyzed Ligation of Azides
and Alkynes, Angew. Chem. Int. Ed., 43, 3928 (2004). |
| 312 |
A. Krasiński, V. V. Fokin and K. B. Sharpless, The Direct Synthesis
of 1,5-Disubstituted-4-magnesio-1,2,3-triazoles, Revisited,
Org. Lett., 6(8), 1237 (2004). |
| 311 |
Y. Bourne, H. C. Kolb, Z. Radić, K. B. Sharpless, P. Taylor
and P. Marchot, Freeze-frame Inhibitor Captures Acetylcholinesterase
in a Unique Conformation, Proc. Nat. Acad. Sci., 101(6), 1449 (2004). |
| 310 |
Kitayama, T. Yokoi, Y. Kawai, R. K. Hill, M. Morita, T. Okamoto, Y. Yamamoto,
V. V. Fokin, K. B. Sharpless and S. Sawada, The Chemistry of Zerumbone.
Part 5: Structural Transformation of the Dimethylamine Derivatives, Tetrahedron,
59, 4857 (2003). |
| 309 |
H. C. Kolb and K. B. Sharpless, The Growing Impact of Click
Chemistry on Drug Discovery, Drug Discovery Today, 8, 1128
(2003). |
| 308 |
A. Brik, J. Muldoon, Y.-C. Lin, J. Elder, D. Goodsell, A.
Olson, V. V. Fokin, K. B. Sharpless and C.-H. Wong, Rapid
Diversity-Oriented Synthesis in Microtiter Plates for In Situ
Screening of HIV Protease Inhibitors, ChemBioChem, 4, 1246 (2003). |
| 307 |
L. V. Lee, M. L. Mitchell, S.-J. Huang, V. V. Fokin, K. B.
Sharpless and C.-H. Wong, A Potent and Highly Sensitive
Inhibitor of Human α–1,3–Fucosyltransferase Via Click
Chemistry, J. Am. Chem. Soc., 125, 9588 (2003). |
| 306 |
A. E. Rubin and K. B. Sharpless, Synthesis of α,β–Substituted
Amino Amides, Esters, and Acids, U.S. Patent Number 6,573,387,
issued June 3, 2003. |
| 305 |
F. Himo, Z. P. Demko, L. Noodleman and K. B. Sharpless,
Why is Tetrazole Formation by Addition of Azide to Organic
Nitriles Catalyzed by Zinc (II) Salts?, J. Am. Chem. Soc.,
125, 9983 (2003). |
| 304 |
A. S. Ripka, D. D. Diaz, K. B. Sharpless and M. G. Finn,
The First Practical Synthesis of Formamidine Ureas and Derivatives,
Org. Lett., 5, 1531 (2003). |
| 303 |
G. Li and K. B. Sharpless, Two Step Synthesis of D–and
L–α–Amino Acids and D– and L–α–Amino
Aldehydes, U.S. Patent Number 6,509,506, issued January 21,
2003. |
| 302 |
Q. Wang, T. R. Chan, R. Hilgraf, V. V. Fokin, K. B. Sharpless
and M. G. Finn, Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne
[3+2] Cycloaddition, J. Am. Chem. Soc., 125, 3192 (2003). |
| 301 |
F. Himo, Z. P. Demko, L. Noodleman and K. B. Sharpless, Mechanisms
of Tetrazole Formation by Addition of Azide to Nitriles,
J. Am. Chem. Soc., 124, 12210 (2002). |
| 300 |
V. V. Rostovtsev, L. G. Green, V. V. Fokin and K. B. Sharpless,
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed
Regioselective "Ligation" of Azides and Terminal Alkynes, Angew.
Chem. Int. Ed., 41, 2596 (2002). |
| 299 |
Z. P. Demko and K. B. Sharpless, An Expedient Route to the
Tetrazole Analogs of α–Amino Acids, Org. Lett., 4, 2525 (2002). |
| 298 |
K. B. Sharpless, Searching for New Reactivity, Angew. Chem.
Int. Ed., 41, 2024 (2002). |
| 297 |
V. Fokin and K. B. Sharpless, Aminohydroxylation of Olefins,
U.S. Patent Number 6,350,905, issued February 26, 2002. |
| 296 |
Z. Demko and K. B. Sharpless, A Click Chemistry Approach
to Tetrazoles by Huisgen 1,3-Dipolar Cycloaddition: Synthesis
of 5-Acyltetrazoles from Azides and Acyl Cyanides, Angew. Chem.
Int. Ed., 41, 2113 (2002). |
| 295 |
Z. Demko and K. B. Sharpless, A Click Chemistry Approach to
Tetrazoles by Huisgen 1,3-Dipolar Cycloaddition: Synthesis
of 5-Sulfonyl Tetrazoles from Azides and Sulfonyl Cyanides,
Angew. Chem. Int. Ed., 41, 2110 (2002). |
| 294 |
W. G. Lewis, L. G. Green, F. Grynszpan, Z. Radic, P. R. Carlier,
P. Taylor, M. G. Finn and K. B. Sharpless, Click Chemistry
in Situ: Aceytlcholinesterase as a Molecular-Scale Reaction
Vessel for the Selective Assembly of a Femtomolar Inhibitor
from an Array of Building Blocks, Angew. Chem. Int. Ed., 41, 1053 (2002). |
| 293 |
P. Dupau, R. Epple, A. A. Thomas, V. V. Fokin and K. B. Sharpless,
Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media:
Old Process, New Tricks, Adv. Synth. Catal., 344, 421 (2002). |
| 292 |
M. A. Andersson, R. Epple, V. V. Fokin and K. B. Sharpless,
A New Approach to Osmium-Catalyzed Asymmetric Dihydroxylation
and Aminohydroxylation of Olefins, Angew. Chem. Int. Ed., 41,
472 (2002). |
| 291 |
Z. P. Demko and K. B. Sharpless, An Intramolecular [2+3]
Cycloaddition Route to Fused 5-Heterosubstituted Tetrazoles,
Org. Lett., 3, 4091 (2001). |
| 290 |
Z. P. Demko and K. B. Sharpless, Preparation of 5-Substituted-
1H-Tetrazoles from Nitriles in Water, J. Org. Chem., 66, 7945 (2001). |
| 289 |
A.
K. Yudin and K. B. Sharpless, Epoxidation of Olefins, U.S. Patent
number 6,271,400, issued August 7, 2001. |
| 288 |
A.
Converso, K. Burow, A. Marzinzik, K. B. Sharpless and M.G. Finn,
2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: a Privileged, Bivalent
Scaffold for the Display of Nucelophilic Components, J. Org. Chem.,
66, 4386 (2001). |
| 287 |
V.
V. Fokin and K. B. Sharpless, A Practical and Highly Efficient
Aminohydroxylation of Unsaturated Carboxylic Acids, Angew. Chem.
Int. Ed., 40, 3455 (2001). |
| 286 |
H.
Becker and K. B. Sharpless, Asymmetric Dihydroxylation, in "Asymmetric
Oxidation Reactions: A Practical Approach in Chemistry",
T. Katsuki, ed., Oxford University Press (2001). |
| 285 |
H.
M. Petrassi, K. B. Sharpless and J. W. Kelly, The Copper Mediated
Cross-Coupling of Phenylboronic Acids and N-Hydroxyphthalimide
at Room Temperature: Synthesis of Aryloxyamines, Org. Lett.,
3, 139 (2001). |
| 284 |
H.
C. Kolb, M. G. Finn and K. B. Sharpless, Click Chemistry: Diverse
Chemical Function From a Few Good Reactions, Angew. Chem., 40,
2004 (2001). |
| 283 |
T.-H.
Chuang and K. B. Sharpless, Applications of Aziridinium Ions.
Selective Syntheses of α,β-Diamino Esters, α-Sulfanyl-β-amino
Esters, Ψ-Lactams and 1,5-Benzodiazepin-2-one, Org. Lett.,
2, 3555 (2000). |
| 282 |
A.
L. Marzinzik and K. B. Sharpless, A Simple Method for the Preparation
of N-Sulfonylsulfilimines from Sulfides, J. Org. Chem., 66, 594
(2001). |
| 281 |
T.-H.
Chuang and K. B. Sharpless, Applications of Aziridinium Ions:
Selective Syntheses of Pyrazolidin-3-ones and Pyrazolo[1,2-a]pyrazoles,
Helv. Chim. Acta, 83, 1734 (2000). |
| 280 |
B.
Tao, G. Schlingloff and K. B. Sharpless, Synthesis of Aryl Serines,
U.S. Patent number 6,057,473, issued May 2, 2000. |
| 279 |
Z.
Demko, M. Bartsch and K. B. Sharpless, Primary Amides. A General
Nitrogen Source for Catalytic Asymmetric Aminohydroxylation of
Olefins, Org. Lett., 2, 2221 (2000). |
| 278 |
A.
Gontcharov, H. Liu and K. B. Sharpless, Aminohydroxylation of
Olefins with Tert-Alkyl Sulfonamides, U. S. Patent number 6,008,376,
issued December 28, 1999. |
| 277 |
G.
Li and K. B. Sharpless, Two Step Synthesis of D- and L- α-Amino
Acids and D- and L- α-Amino-Aldehydes, U.S. Patent number 5,994,583,
issued November 30, 1999. |
| 276 |
J.
Rudolph and K. B. Sharpless, Accelerated Catalysis of Olefinic
Epoxidations, U.S. Patent number 5,939,568, issued August 17,
1999. |
| 275 |
J.
U. Jeong and K. B. Sharpless, Aziridination of Olefins, U.S. Patent
number 5,929,252, issued July 27, 1999. |
| 274 |
T.-H.
Chuang and K. B. Sharpless, Applications of Aziridinium Ions.
Selective Syntheses of β-Aryl-α,β-diamino Esters, Org. Lett.,
1, 1435 (1999). |
| 273 |
G.
Li, H.-T. Chang and K. B. Sharpless, Catalytic Asymmetric Aminohydroxylation
of Olefins with Sulfonamides, U.S. Patent number 5,859,281, issued
January 12, 1999. |
| 272 |
A.
A. Thomas and K. B. Sharpless, The Catalytic Asymmetric Aminohydroxylation
(AA) of Unsaturated Phosphonates, J. Org. Chem., 64, 8379 (1999). |
| 271 |
A.
V. Gontcharov, H. Liu and K. B. Sharpless, tert-Butylsulfonamide.
A New Nitrogen Source for Catalytic Aminohydroxylation and Aziridination
of Olefins, Org. Lett., 1, 783 (1999). |
| 270 |
W.
Pringle and K. B. Sharpless, The Osmium-Catalyzed Aminohydroxylation
of Baylis-Hillman Olefins, Tetrahedron Lett., 40, 5151 (1999). |
| 269 |
H.
Adolfsson, A. Converso and K. B. Sharpless, Comparison of Amine
Additives Most Effective in the New Methyltrioxorhenium-Catalyzed
Epoxidation Process, Tetrahedron Lett., 40, 3991 (1999). |
| 268 |
L.
J. Goossen, H. Liu, K. R. Dress and K. B. Sharpless, Catalytic
Asymmetric Aminohydroxylation with Amino-Substituted Heterocycles
as Nitrogen Sources, Angew. Chem., 38, 1089 (1999). |
| 267 |
G.
Li and K. B. Sharpless, Catalytic Asymmetric Aminohydroxylation
of Olefins with Carbamates, U.S. Patent number 5,767,304, issued
June 16, 1998. |
| 266 |
A.
Gypser, D. Michel, D. S. Nirschl and K. B. Sharpless, Dihydroxylation
of Polyenes using Narasaka's Modification of the Upjohn Procedure,
J. Org. Chem., 63, 7322 (1998). |
| 265 |
K.
R. Dress, L. J. Goossen, H. Liu, D. M. Jerina and K. B. Sharpless,
Catalytic Aminohydroxylation Using Adenine-Derivatives as the
Nitrogen Source, Tetrahedron Lett., 39, 7669 (1998). |
| 264 |
J.
U. Jeong, B. Tao, I. Sagasser, H. Henniges and K. B. Sharpless,
Bromine-Catalyzed Aziridination of Olefins. A Rare Example of
Atom-Transfer Redox Catalysis by a Main Group Element, J. Am.
Chem. Soc., 120, 6844 (1998). |
| 263 |
K.
L. Reddy, K. R. Dress and K. B. Sharpless, N-Chloro-N-Sodio-2-Trimethylsilyl
Ethyl Carbamate: A New Nitrogen Source for the Catalytic Asymmetric
Aminohydroxylation, Tetrahedron Lett., 39, 3667 (1998). |
| 262 |
B.
Tao, G. Schlingloff and K. B. Sharpless, Reversal of Regioselection
in the Asymmetric Aminohydroxylation of Cinnamates, Tetrahedron
Lett., 39, 2507 (1998). |
| 261 |
C.
Copéret, H. Adolfsson, T.-A. V. Khuong, A. K. Yudin and
K. B. Sharpless, A Simple and Efficient Method for the Preparation
of Pyridine-N-oxides, J. Org. Chem., 63, 1740 (1998). |
| 260 |
H.
C. Kolb and K. B. Sharpless, Asymmetric Dihydroxylation, in "Transition
Metals for Organic Synthesis: Building Blocks and Fine Chemicals",
M. Beller and C. Bolm, eds., Wiley-VCH (1998). |
| 259 |
H.
C. Kolb and K. B. Sharpless, Asymmetric Aminohydroxylation, in
"Transition Metals for Organic Synthesis: Building Blocks
and Fine Chemicals", M. Beller and C. Bolm, eds., Wiley-VCH
(1998). |
| 258 |
G.
Schlingloff and K. B. Sharpless, Asymmetric Aminohydroxylation,
in "Asymmetric Oxidation Reactions: A Practical Approach
in Chemistry", T. Katsuki, ed., Oxford University Press (2001). |
| 257 |
C.
Copéret, H. Adolfsson, J. P. Chiang, A. K. Yudin and K.
B. Sharpless, A Simple and Efficient Method for the Preparation
of Pyridine-N-oxides II, Tetrahedron Lett., 39, 761 (1998). |
| 256 |
K.
L. Reddy and K. B. Sharpless, From Styrenes to Enantiopure α-Arylglycines
in Two Steps, J. Am. Chem. Soc., 120, 1207 (1998). |
| 255 |
A.
J. DelMonte, J. Haller, K. N. Houk, K. B. Sharpless, D. A. Singleton,
T. Strassner and A. A. Thomas, Experimental and Theoretical Kinetic
Isotope Effects for Asymmetric Dihyroxylation. Evidence Supporting
a Rate-Limiting "(3 + 2)" Cycloaddition, J. Am. Chem. Soc., 119, 9907 (1997). |
| 254 |
A.
K. Yudin and K. B. Sharpless, Bis(trimethylsilyl) Peroxide Extends
the Range of Oxorhenium Catalysts for Olefin Expoxidation, J.
Am. Chem. Soc., 119, 11536 (1997). |
| 253 |
A.
Erik Rubin and K. B. Sharpless, A Highly Efficient Aminohydroxylation
Process, Angew. Chem., 36, 2637 (1997). |
| 252 |
C.
Copéret, H. Adolfsson and K. B. Sharpless, A Simple and
Efficient Method for Epoxidation of Terminal Alkenes, Chem. Comm.,
16, 1565 (1997). |
| 251 |
J.
Rudolph, K.L. Reddy, J. P. Chiang and K. B. Sharpless, Highly
Efficient Epoxidation of Olefins using Aqueous H2O2 and Catalytic
Methyltrioxorhenium/Pyridine: Pyridine-mediated Ligand Acceleration,
J. Am. Chem. Soc., 119, 6189 (1997). |
| 250 |
M.
Bruncko, G. Schlingloff and K. B. Sharpless, N-Bromoacetamide
- A New Nitrogen Source for the Catalytic Asymmetric Aminohydroxylation,
Angew. Chem., 36, 1483 (1997). |
| 249 |
D.W.
Nelson, A. Gypser, P.T. Ho, H.C. Kolb, T. Kondo, H.-L. Kwong,
D.V. McGrath, A.E. Rubin, P.-O. Norrby, K.P. Gable and K.B. Sharpless,
Toward an Understanding of the High Enantioselectivity in the
Osmium-Catalyzed Asymmetric Dihydroxylation. 4. Electronic Effects in Amine-Accelerated Osmylations,
J. Am. Chem. Soc., 119, 1840 (1997). |
| 248 |
K.P.M.
Vanhessche and K.B. Sharpless, Catalytic Asymmetric Synthesis
of New Halogenated Chiral Synthons, Chemistry - A European Journal,
3, 517 (1997). |
| 247 |
G.
Li, H.H. Angert and K.B. Sharpless, N-Halocarbamate Salts Provide
a More Useful Catalytic-Asymmetric-Aminohydroxylation Process,
Angew. Chem., 35, 2813 (1996). |
| 246 |
J.
Rudolph, P.C. Sennhenn, C.P. Vlaar and K.B. Sharpless, Smaller
Substituents on Nitrogen Facilitate the Osmium Catalyzed Asymmetric
Aminohydroxylation Process, Angew. Chem., 35, 2810 (1996). |
| 245 |
K.P.M.
Vanhessche and K.B. Sharpless, Ligand-Dependent Reversal of Facial
Selectivity in the Asymmetric Dihydroxylation, J. Org. Chem.,
61, 7978 (1996). |
| 244 |
H.-T.
Chang and K.B. Sharpless, Molar Scale Synthesis of Enantiopure
Stilbene Oxide, J. Org. Chem., 61, 6456 (1996). |
| 243 |
M.
Beller and K.B. Sharpless, Syntheses of Diols by Catalytic Dihydroxylation
Reactions, "Applied Homogeneous Catalysis by Organometallic
Complexes", Boy Cornils and Wolfgang A. Herrmann. Eds.; VCH
Publishers, 1996. |
| 242 |
K.B.Sharpless,
M. Beller, B. Blackburn, Y. Kawanami, H.-L. Kwong, Y. Ogino, T.
Shibata, T. Ukita and L. Wang, Method For Catalytic Asymmetric
Dihydroxylation of Olefins Using Heterocyclic Chiral Ligands,
U.S. Patent 5,516,929, 1996 assigned to Massachusetts Institute of Technology. |
| 241 |
I.E.
Marko and K. B. Sharpless, Ligand-Accelerated Catalytic Asymmetric
Dihydroxylation, European Patent 0395729, 1996, assigned to Massachusetts
Institute of Technology. |
| 240 |
H.-T.
Chang and K.B. Sharpless, A Practical Route to Enantiopure 1,2-Aminoalcohols,
Tetrahedron Lett., 37, 3219 (1996). |
| 239 |
G.
Li and K.B. Sharpless, Catalytic Asymmetric Aminohydroxylation
Provides a Short Taxol Side-chain Synthesis, Acta Chem. Scand.,
50, 649 (1996). |
| 238 |
M.
Bruncko, T.-A.V. Khuong. and K.B. Sharpless, Allylic Amination
and 1,2-Diamination via a Modified Diimido Selenium Reagent, Angew.
Chem., 35, 454 (1996). |
| 237 |
G.
Li, H.-T. Chang, and K.B. Sharpless, Catalytic Asymmetric Aminohydroxylation
of Olefins, Angew. Chem., 35, 451 (1996). |
| 236 |
H.
Becker and K.B. Sharpless, A New Ligand Class for the Asymmetric
Dihydroyxlation of Olefins, Angew. Chem., 35, 448 (1996). |
| 235 |
P.F.
Richardson, L.T.J. Nelson, and K.B. Sharpless, Synthesis of Vicinal
Diamines from Cyclic Sulfates, Tetrahedron Lett., 36, 9241 (1995). |
| 234 |
P.-O.
Norrby, H. Becker, and K.B. Sharpless, Towards an Understanding
of the High Enantioselectivity in the Osmium Catalyzed Asymmetric
Dihydroyxlation (AD). Part 3. New Insights into Isomeric Forms
of the Putative Osmaoxetane Intermediate, J. Am. Chem. Soc, 118, 35 (1996). |
| 233 |
H.-T.
Chang, C.-T. Chen, T. Kondo, G. Siuzdak, and K.B. Sharpless, Asymmetric
Dihydroxylation Enables Rapid Construction of Chiral Dendrimers,
Angew. Chem., 35, 182 (1996). |
| 232 |
U.
Hugger and K.B. Sharpless, Asymmetric Dihyroxylation Affords Enantiomerically
Pure C12 Building Blocks from trans, trans, cis-1,5,9-Cyclododecatriene,
Tetrahedron Lett., 36, 6603 (1995). |
| 231 |
H.
Becker, S.B. King, M. Taniguchi, K.P.M. Vanhessche, and K.B. Sharpless,
New Ligands and Improved Enantioselectivities for the Asymmetric
Dihydroxylation of Olefins, J. Org. Chem., 60, 3940 (1995). |
| 230 |
K.B.
Sharpless and J.M. Klunder, Optically Active Derivatives of Glycidol,
U.S. Patent 5,344,947, 1994 assigned to Massachusetts Institute
of Technology. |
| 229 |
D.J.
Berrisford, C. Bolm, and K.B. Sharpless, Ligand Accelerated Catalysis,
Angew. Chem., Int. Ed. Engl., 34, 1059 (1995). |
| 228 |
H.
Becker, M.A. Soler, and K.B. Sharpless, Selective Asymmetric Dihydroxylation
of Polyenes, Tetrahedron, 51, 1345 (1995). |
| 227 |
Z.-M.
Wang and K.B. Sharpless, A Solid-to-Solid Asymmetric Dihydroxylation
Procedure for Kilo-Scale Preparation of Enantiopure Hydrobenzoin,
J. Org. Chem., 59, 8302 (1994). |
| 226 |
Z.-M.
Wang, K. Kakiuchi, and K.B. Sharpless, Osmium-Catalyzed Asymmetric
Dihydroxylation of Cyclic cis-Disubstituted Olefins, J. Org. Chem.,
59, 6895 (1994). |
| 225 |
H.C.
Kolb, M.S. VanNieuwenhze, and K.B. Sharpless, Catalytic Asymmetric
Dihydroxylation, Chem. Rev., 94, 2483 (1994). |
| 224 |
H.
Becker, P.T. Ho, H.C. Kolb, S. Loren, P.-O. Norrby, and K.B. Sharpless,
Comparing Two Models for the Selectivity in the Asymmetric Dihydroxylation
Reaction (AD), Tetrahedron Lett., 35, 7315 (1994). |
| 223 |
P.-O.
Norrby, H.C. Kolb, and K.B. Sharpless, Towards an Understanding
of the High Enantioselectivity in the Osmium Catalyzed Asymmetric
Dihydroxylation (AD). Part 2. A Qualitative Molecular Mechanics
Approach., J. Am. Chem. Soc., 116, 8470 (1994). |
| 222 |
Y.L.
Bennani, K.P.M. Vanhessche, and K.B. Sharpless, A Short Route
to a Mosher's Acid Precursor Via Catalytic Asymmetric Dihydroxylation
(AD), Tetrahedron: Asymmetry, 5, 1473 (1994). |
| 221 |
K.B.
Sharpless and Y. Gao, Ruthenium-Catalyzed Production of Cyclic
Sulfates, U.S. Patent 5,321,143, 1994 assigned to Massachusetts
Institute of Technology. |
| 220 |
S.B.
King and K.B. Sharpless, An Efficient Synthesis of Enantiomerically
Pure trans-2-Phenylcyclohexanol, Tetrahedron Lett., 35, 5611 (1994). |
| 219 |
Z.-M.
Wang, H.C. Kolb, and K.B. Sharpless, A Large-Scale and Highly
Enantioselective Synthesis of the Taxol C-13 Side Chain Through
Asymmetric Dihydroxylation (AD), J. Org. Chem., 59, 5104 (1994). |
| 218 |
P.J.
Walsh, P.T. Ho, S.B. King, and K.B. Sharpless, Asymmetric Dihydroxylation
of Olefins Containing Sulfur: Chemoselective Oxidation of C-C
Double Bonds in the Presence of Sulfides, 1,3-Dithianes, and Disulfides,
Tetrahedron Lett., 35, 5129 (1994). |
| 217 |
D.
Xu and K.B. Sharpless, Synthesis and Stereochemical Assignments
for Goniobutenolides A and B, Tetrahedron Lett., 35, 4685 (1994). |
| 216 |
K.
P. M. Vanhessche, Z.-M. Wang, and K. B. Sharpless, Asymmetric
Dihydroxylation of Primary Alloylic Halides and a Concise Synthesis
of (-)-Diepoxybutane, Tetrahedron Lett., 35, 3469 (1994) |
| 215 |
D.
Xu, C.Y. Park, and K.B. Sharpless, Study of the Regio- and Enantioselectivity
of the Reactions of Osmium Tetroxide with Allylic Alcohols and
Allylic Sulfonamides, Tetrahedron Lett., 35, 2495 (1994). |
| 214 |
K.B.
Sharpless, Coelacanths and Catalysis, Tetrahedron, 50, 4235 (1994). |
| 213 |
H.C.
Kolb, P.G. Andersson, and K.B. Sharpless, Towards an Understanding
of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric
Dihydroxylation (AD). Part 1: Kinetics, J. Am. Chem. Soc., 116,
1278 (1994). |
| 212 |
M.S.
VanNieuwenhze and K.B. Sharpless, The Asymmetric Dihydroxylation
of cis-Allylic and Homoallylic Alcohols, Tetrahedron Lett., 35,
843 (1994). |
| 211 |
I.
Henderson, K.B. Sharpless, and C.-H. Wong, Synthesis of Carbohydrates
via Tandem Use of the Osmium-Catalyzed Asymmetric Dihydroxylation
and Enzyme-Catalyzed Aldol Addition Reactions, J. Am. Chem. Soc.,
116, 558 (1994). |
| 210 |
H.C.
Kolb, P.G. Andersson, Y.L. Bennani, G.A. Crispino, K.-S. Jeong,
H.-L. Kwong, and K.B. Sharpless, On "The Origin of High Enantioselectivity
in the Dihydroxylation of Olefins Using Osmium Tetroxide and Cinchona
Alkaloid Catalysts," J. Am. Chem. Soc., 115, 12226 (1993). |
| 209 |
G.
Crispino, A. Makita, Z.-M. Wang, and K.B. Sharpless, A Comparison
of Ligands Proposed for the Asymmetric Dihydroxylation, Tetrahedron
Lett., 35, 543 (1994). |
| 208 |
P.-O.
Norrby, H. Kolb, and K.B. Sharpless, Calculations on the Reaction
of Ruthenium Tetroxide with Olefins Using Density Functional Theory
(DFT). Implications for the Possibility of Intermediates in the
Osmium-catalyzed Asymmetric Dihydroxylation (AD), Organometallics, 13, 344 (1994). |
| 207 |
Z.-M.
Wang and K.B. Sharpless, Asymmetric Dihydroxylation of Tertiary
Allylic Alcohols, Tetrahedron Lett., 34, 8225 (1993). |
| 206 |
R.
Oi and K.B. Sharpless, 3-(1S,2-Dihydroxyethyl)-1,5-Dihydro-3H-2,4-Benzodioxepine,
Org. Synth., 73, 1 (1995). |
| 205 |
M.
Arrington, Y.L. Bennani, T. Göbel, P. Walsh, S.-H. Zhao,
and K.B. Sharpless, Modified Cinchona Alkaloid Ligands: Improved
Selectivities in the Osmium Tetroxide Catalyzed Asymmetric Dihydroxylation
(AD) of Terminal Olefins, Tetrahedron Lett., 34, 7375 ( |
| 204 |
K.
Morikawa and K.B. Sharpless, Double Diastereoselection in Asymmetric
Dihydroxylation, Tetrahedron Lett., 34, 5575 (1993). |
| 203 |
K.
Morikawa, J. Park, P.G. Andersson, T. Hashiyama, and K.B. Sharpless,
Catalytic Asymmetric Dihydroxylation of Tetrasubstituted Olefins,
J. Am. Chem. Soc., 115, 8463 (1993). |
| 202 |
P.J.
Walsh, Y.L. Bennani, and K.B. Sharpless, Asymmetric Dihydroxylation
(AD)/Cyclization of N-DiBoc Allylic and Homoallylic Amines: Selective
Differentiation of the Hydroxyl Groups, Tetrahedron Lett., 34,
5545 (1993). |
| 201 |
D.V.
McGrath, G.D. Brabson, K.B. Sharpless, and L. Andrews, Reinvestigation
of the Infrared Spectra of Oxoosmium (VI) Esters by Isotopic Labeling,
Inorg. Chem., 32, 4164 (1993). |
| 200 |
G.A.
Crispino and K.B. Sharpless, Enantioselective Synthesis of Juvenile
Hormone III in Three Steps from Methyl Farnesoate, Synthesis,
8, 777 (1993). |
| 199 |
P.J.
Walsh and K.B. Sharpless, Asymmetric Dihydroxylation (AD) of a,b-Unsaturated
Ketones, Synlett, 8, 605 (1993). |
| 198 |
Z.-M.
Wang and K.B. Sharpless, Asymmetric Dihydroxylation of a-Substituted
Styrene Derivatives, Synlett, 8, 603 (1993). |
| 197 |
M.S.
VanNieuwenhze and K.B. Sharpless, Kinetic Resolution of Racemic
Olefins via Asymmetric Dihydroxylation, J. Am. Chem. Soc., 115,
7864 (1993). |
| 196 |
P.G.
Andersson and K.B. Sharpless, A Dramatic Ligand Effect on the
Relative Reactivities of Substituted Alkenes with Osmium Tetroxide,
J. Am. Chem. Soc., 115, 7047 (1993). |
| 195 |
T.
Göbel and K.B. Sharpless, Temperature Effects in Asymmetric
Dihydroxylation: Evidence for a Stepwise Mechanism, Angew. Chem.,
Int. Ed. Engl., 32, 1329 (1993). |
| 194 |
G.
Crispino, K.-S. Jeong, H. Kolb, Z.-M. Wang, D. Xu, and K.B. Sharpless,
Improved Enantioselectivity in Asymmetric Dihydroxylations of
Terminal Olefins Using Pyrimidine Ligands, J. Org. Chem., 58,
3785 (1993). |
| 193 |
S.
Okamoto, K. Tani, F. Sato, K.B. Sharpless, and D. Zargarian, Synthesis
of Optically Active Secondary Allylic Alcohols from Allylsilanes
via Successive Asymmetric Dihydroxylation (AD) and Peterson Olefination
Reactions, Tetrahedron Lett., 34, 2509 (1993 |
| 192 |
Z.-M.
Wang, X.L. Zhang, and K.B. Sharpless, Asymmetric Dihydroxylation
of Aryl Allyl Ethers, Tetrahedron Lett., 34, 2267 (1993). |
| 191 |
Y.L.
Bennani and K.B. Sharpless, Asymmetric Synthesis of g-Hydroxy
a,b-Unsaturated Amides via an AD-Elimination Process; Synthesis
of (+)-Coriolic Acid, Tetrahedron Lett., 34, 2083 (1993). |
| 190 |
Y.L.
Bennani and K.B. Sharpless, Asymmetric Dihydroxylation (AD) of
N,N-Dialkyl and N-Methoxy-N-methyl α,β-and β, γ-unsaturated amides,
Tetrahedron Lett., 34, 2079 (1993). |
| 189 |
D.
Xu and K.B. Sharpless, A Simple Route to Enantiomerically Enriched
Oxazolidin-2-ones, Tetrahedron Lett., 34, 951 (1993). |
| 188 |
H.C.
Kolb, Y.L. Bennani, and K.B. Sharpless, Short and Practical Syntheses
of (R)-(–)-Carnitine and (R)-(–)-g-Amino-b-hydroxybutyric
Acid (GABOB), Tetrahedron: Asymmetry, 4, 133 (1993). |
| 187 |
G.A.
Crispino and K.B. Sharpless, Enantioselective Synthesis of Both
Enantiomers of 7,7-Dimethyl-6,8-dioxabicyclo-[3.2.1]octane via
Regioselective Asymmetric Dihydroxylation, Synlett, 1, 47 (1993)
. |
| 186 |
G.A.
Crispino, P.T. Ho, and K.B. Sharpless, Selective Perhydroxylation
of Squalene: Taming the Arithmetic Demon, Science, 259, 64 (1993). |
| 185 |
H.C.
Kolb and K.B. Sharpless, A Simplified Procedure for the Stereospecific
Transformation of 1,2-Diols into Epoxides, Tetrahedron, 48, 10515
(1992). |
| 184 |
E.
Keinan, S.C. Sinha, A. Sinha-Bagchi, Z.-M. Wang, X.L. Zhang, and
K.B. Sharpless, Synthesis of All Four Isomers of Disparlure Using
Osmium-Catalyzed Asymmetric Dihydroxylation, Tetrahedron Lett.,
33, 6411 (1992). |
| 183 |
Z.-M.
Wang, X.L. Zhang, K.B. Sharpless, S.C. Sinha, A. Sinha-Bagchi,
and E. Keinan, A General Approach to g-Lactones via Osmium-Catalyzed
Asymmetric Dihydroxylation. Synthesis of (–)- and (+)-Muricatacin,
Tetrahedron Lett., 33, 6407 (1992). |
| 182 |
R.A.
Johnson and K.B. Sharpless, Catalytic Asymmetric Dihydroxylation,
"Catalytic Asymmetric Synthesis," Iwao Ojima, Ed.; VCH
Publishers (1993). |
| 181 |
R.A.
Johnson and K.B. Sharpless, Catalytic Asymmetric Epoxidation of
Allylic Alcohols, "Catalytic Asymmetric Synthesis,"
Iwao Ojima, Ed.; VCH Publishers (1993). |
| 180 |
W.
Amberg, Y.L. Bennani, R.J. Chadha, G.A. Crispino, W.D. Davis,
J. Hartung, K.-S. Jeong, Y. Ogino, T. Shibata, and K.B. Sharpless,
Syntheses and Crystal Structures of the Cinchona Alkaloid Derivatives
used as Ligands in the Osmium-Catalyzed Asymmetric Dihydroxylation of Olefins,
J. Org. Chem., 58, 844 (1993). |
| 179 |
T.
Hashiyama, K. Morikawa, and K.B. Sharpless, a-Hydroxy Ketones
in High Enantiomeric Purity from Asymmetric Dihydroxylation of
Enol Ethers, J. Org. Chem., 57, 5067 (1992). |
| 178 |
D.
Xu, G. A. Crispino, and K.B. Sharpless, Selective Asymmetric Dihydroxylation
(AD) of Dienes, J. Am. Chem. Soc., 114, 7570 (1992). |
| 177 |
L.
Wang and K.B. Sharpless, Catalytic Asymmetric Dihydroxylation
of Cis-Disubstituted Olefins, J. Am. Chem. Soc., 114, 7568 (1992). |
| 176 |
T.
Kalantar and K.B. Sharpless, Transformations of Hydroxy Cyclic
Sulfates: Stereospecific Conversion to 2,3,5-Trisubstituted Tetrahydrofurans,
Acta Chemica Scandinavica, 47, 307 (1993). |
| 175 |
G.
Crispino and K.B. Sharpless, Asymmetric Dihydroxylation of Squalene,
Tetrahedron Lett., 33, 4273 (1992). |
| 174 |
K.-S.
Jeong, P. Sjö, and K.B. Sharpless, Asymmetric Dihydroxylation
of Enynes, Tetrahedron Lett., 33, 3833 (1992). |
| 173 |
K.B.
Sharpless, W. Amberg, Y. Bennani, G. Crispino, J. Hartung, K.
Jeong, H. Kwong, K. Morikawa, Z.M. Wang, D. Xu, and X.L. Zhang,
The Osmium-Catalyzed Asymmetric Dihydroxylation (AD): A New Ligand
Class and a Process Improvement, J. Org. Chem., 57, 2768 |
| 172 |
R.
Oi and K.B. Sharpless, Asymmetric Dihydroxylation of Acrolein
Acetals: Synthesis of Stable Equivalents of Enantiopure Glyceraldehyde
and Glycidaldehyde, Tetrahedron Lett., 33, 2095 (1992). |
| 171 |
B.
McKee, T. Kalantar, and K.B. Sharpless, Subtle Effects in the
Asymmetric Epoxidation: Dependence of Kinetic Resolution Efficiency
on the Monodentate Alkoxide Ligands of the Bystander Titanium
Center, J. Org. Chem., 56, 6966 (1991). |
| 170 |
Y.
Ogino, H. Chen, E. Manoury, T. Shibata, M. Beller, D. Lübben,
and K.B. Sharpless, A Ligand Structure-Enantioselectivity Relationship
for the Osmium-Catalyzed Asymmetric Dihydroxylation of Olefins,
Tetrahedron Lett., 32, 5761, (1991). |
| 169 |
R.
Oi and K.B. Sharpless, Facile Synthesis of Enantiopure trans-2,3-Diphenyl-1,4-Diazabicyclo[2.2.2.]Octane,
Tetrahedron Lett., 32, 4853, (1991). |
| 168 |
K.
B. Sharpless, W. Amberg, M. Beller, H. Chen, J. Hartung, Y. Kawanami,
D. Lübben, E. Manoury, Y. Ogino, T. Shibata, and T. Ukita,
New Ligands Double the Scope of the Catalytic Asymmetric Dihydroxylation
of Olefins., J. Org. Chem., 56, 4585, (1991). |
| 167 |
Y.
Ogino, H. Chen, H.L. Kwong, and K.B. Sharpless, On the Timing
of Hydrolysis/Reoxidation in the Osmium-Catalyzed Asymmetric Dihydroxylation
of Olefins Using Potassium Ferricyanide as the Reoxidant., Tetrahedron
Lett., 32, 3965, (1991). |
| 166 |
K.B.
Sharpless, J.M. Klunder, and T.H. Onami, Optically Active Derivatives
of Glycidol, U. S. Patent 4,946,974, 1990 assigned to Massachusetts
Institute of Technology. |
| 165 |
K.B.
Sharpless and I.E. Markó, Ligand-Accelerated Catalytic
Asymmetric Dihydroxylation, U.S. Patent 4,965,364, 1990 assigned
to Massachusetts Institute of Technology. |
| 164 |
B.
McKee, D. Gilheany, and K.B. Sharpless, R,R-1,2-Diphenyl-1,2-ethanediol
(stilbene diol)., Org. Synth., 70, 47, (1991). |
| 163 |
C.
Park, B.M. Kim, and K.B. Sharpless, Catalytic Osmylation of Conjugated
Dienes: A One-Pot Stereoselective Synthesis of Polyols., Tetrahedron
Lett., 32, 1003, (1991). |
| 162 |
R.
Oi and K.B. Sharpless, Stereospecific Conversion of Chiral 1,2-Cyclic
Sulfates to Chiral Imidazolines., Tetrahedron Lett., 32, 999,
(1991). |
| 161 |
P.R.
Fleming and K.B. Sharpless, Selective Transformation of threo-2,3-Dihydroxy
Esters., J. Org. Chem., 56, 2869, (1991). |
| 160 |
M.G.
Finn and K.B. Sharpless, Mechanism of Asymmetric Epoxidation.
2. Catalyst Structure, J. Am. Chem. Soc., 113, 113, (1991). |
| 159 |
S.S.
Woodard, M.G. Finn, and K. Barry Sharpless, The Mechanism of Asymmetric
Epoxidation. 1. Kinetics, J. Am. Chem. Soc., 113, 106, (1991). |
| 158 |
R.A.
Johnson and K.B. Sharpless, Addition Reactions with Formation
of Carbon-Oxygen Bonds: (ii) Asymmetric Methods of Epoxidation,
"Comprehensive Organic Synthesis," Vol. 7, Barry M.
Trost, Ed.; Pergamon Press, (1991), pp. 389-436. |
| 157 |
B.M.
Kim and K.B. Sharpless, A Short Route to ß-Lactams: Use
of Cyclic Sulfites From Syn-2,3-Dihydroxy Esters, Tetrahedron
Lett., 31, 4317, (1990). |
| 156 |
T.
Shibata, D.G. Gilheany, B.K. Blackburn, and K.B. Sharpless, Ligand-Based
Improvement of Enantioselectivity in the Catalytic Asymmetric
Dihydroxylation of Dialkyl Substituted Olefins, Tetrahedron Lett.,
31, 3817, (1990). |
| 155 |
K.B.
Sharpless, R. Hanson, and S.Y. Ko, Catalytic Asymmetric Epoxidation,
U.S. Patent 4,900,847, 1990 assigned to the Massachusetts Institute
of Technology. |
| 154 |
B.M.
Kim and K.B. Sharpless, Heterogeneous Catalytic Asymmetric Dihydroxylation:
Use of a Polymer-Bound Alkaloid, Tetrahedron Lett., 31, 3003,
(1990). |
| 153 |
H.
Kwong, C. Sorato, Y. Ogino, H. Chen, and K.B. Sharpless, Preclusion
of the "Second Cycle" in the Osmium-Catalyzed Asymmetric
Dihydroxylation of Olefins Leads to a Superior Process, Tetrahedron
Lett., 31, 2999, (1990). |
| 152 |
R.M.
Pearlstein, B.K. Blackburn, W.M. Davis, and K.B. Sharpless, Structural
Characterization of the Pseudoenantiomeric Cis-Dioxo Osmium(VI)
Esters of Chiral Diols with Cinchona Alkaloid Ligands, Angew.
Chem., Int. Ed. Engl., 29, 639, (1990). |
| 151 |
M.
Hayashi, F. Okamura. T. Toba, N. Oguni, and K.B. Sharpless, Kinetic
Resolution of Racemic β-Hydroxy Amines by Enantioselective N-Oxide
Formation, Chem. Lett., 547 (1990). |
| 150 |
K.B.
Sharpless and I.E. Markó, Ligand-Accelerated Catalytic
Asymmetric Dihydroxylation using Dihydroquinidine and Dihydroquinidine
Esters as Ligands, U.S Patent 4,871,855, 1989 assigned to the
Massachusetts Institute of Technology. |
| 149 |
G.D.H.
Dijkstra, R.M. Kellogg, and H. Wynberg; J.S. Svendsen, I. Markó,
and K.B. Sharpless, Conformational Study of Cinchona Alkaloids.
A Combined NMR, Molecular Mechanics and X-Ray Approach, J. Am.
Chem. Soc., 111, 8069 (1989). |
| 148 |
P.R.
Carlier and K.B. Sharpless, Studies on the Mechanism of the Asymmetric
Epoxidation: A Ligand Variation Approach, J. Org. Chem., 54, 4016
(1989). |
| 147 |
C.J.
Burns, C.A. Martin, and K.B. Sharpless, Tartrate-Like Ligands
in the Asymmetric Epoxidation, J. Org. Chem., 54, 2826 (1989). |
| 146 |
B.M.
Kim and K.B. Sharpless, Cyclic Sulfates Containing Acid-Sensitive
Groups and Chemoselective Hydrolysis of Sulfate Esters, Tetrahedron
Lett., 30, 655, (l989). |
| 145 |
B.B.
Lohray, T.H. Kalantar, B.M. Kim, C.Y. Park, T. Shibita, J.S.M.
Wai, and K.B. Sharpless, Documenting the Scope of the Catalytic
Asymmetric Dihydroxylation, Tetrahedron Lett., 30, 2041 (1989). |
| 144 |
J.S.
Svendsen, I. Markó, E.N. Jacobsen, Ch.P. Rao, S. Bott,
and K.B. Sharpless, On the Structure of Osmium Tetroxide-Cinchona
Alkaloid Complexes, J. Org. Chem., 54, 2263 (1989). |
| 143 |
B.B.
Lohray, Y. Gao, and K.B. Sharpless, One Pot Synthesis of Homochiral
Aziridines and Aminoalcohols from Homochiral 1,2-Cyclic Sulfates,
Tetrahedron Lett., 30, 2623 (1989). |
| 142 |
W.
Bartmann and K.B. Sharpless, eds., "Stereochemistry of Organic
and Bioorganic Transformations," VCH Verlagsgesellschaft,
Weinheim, 1987. |
| 141 |
S.Y. Ko, A.W.M. Lee, S.A. Masamune, L.A. Reed, III, K.B. Sharpless,
and F.J. Walker, Total Synthesis of the L-Hexoses, Tetrahedron,
46, 245 (1990). |
| 140 |
J.S.M.
Wai, I. Markó, J.S. Svendsen, M.G. Finn, E.N. Jacobsen,
and K.B. Sharpless, A Mechanistic Insight Leads to a Greatly Improved
Osmium-Catalyzed Asymmetric Dihydroxylation Process, J. Am. Chem.
Soc., 111, 1123 (1989). |
| 139 |
E.N.
Jacobsen, I. Markó, M.B. France, J.S. Svendsen, and K.B.
Sharpless, Kinetic Role of the Alkaloid Ligands in Asymmetric
Catalytic Dihydroxylation, J. Am. Chem. Soc., 111, 737 (1989). |
| 138 |
J.M.
Klunder, T. Onami, and K.B. Sharpless, Arenesulfonate Derivatives
of Homochiral Glycidol: Versatile Chiral Building Blocks for Organic
Synthesis, J. Org. Chem., 54, 1295 (1989). |
| 137 |
Y.
Gao and K.B. Sharpless, Vicinal Diol Cyclic Sulfates: Like Epoxides
Only More Reactive, J. Am. Chem. Soc., 110, 7538 (1988). |
| 136 |
C.
Bolm and K.B. Sharpless, Synthesis of a C3-Symmetric Phospha[2.2.2]
Cyclophane, Tetrahedron Lett., 29, 5101 (1988). |
| 135 |
M.
Caron, P.R. Carlier, and K.B. Sharpless, Regioselective Azide
Opening of 2,3-Epoxy Alcohols by [Ti(Oi-Pr)2(N3)2]: Synthesis
of a-Amino Acids, J. Org. Chem., 53, 5185 (1988). |
| 134 |
Y.
Gao and K.B. Sharpless, Asymmetric Synthesis of Both Enantiomers
of Tomoxetine and Fluoxetine. Selective Reduction of 2,3-Epoxycinnamyl
Alcohol with Red-Al, J. Org. Chem., 53, 4081 (1988). |
| 133 |
Y.
Gao and K.B. Sharpless, Ti(O-i-Pr)4-Mediated Formation of 2,3-Epithio
Alcohols from 2,3-Epoxy Alcohols, J. Org. Chem., 53, 4114 (1988). |
| 132 |
C.
Bolm, W.M. Davis, R.L. Halterman, and K.B. Sharpless, Synthesis
and Crystal Structure of a Chiral C3-Symmetric Monophosphine,
Angew. Chem., Int. Ed. Engl., 27, 835 (1988). |
| 131 |
P.
Carlier, W.S. Mungall, G. Schröder, and K.B. Sharpless, Enhanced
Kinetic Resolution and Enzyme-Like Shape Selectivity, J. Am. Chem.
Soc., 110, 2978 (1988). |
| 130 |
K.B.
Sharpless, Catalytic Asymmetric Epoxidation, Janssen Chimica Acta,
6, 3 (1988). |
| 129 |
E.N.
Jacobsen, I. Markó, W.S. Mungall, G. Schröder, and
K.B. Sharpless, Asymmetric Dihydroxylation via Ligand-Accelerated
Catalysis, J. Am. Chem. Soc., 110, 1968 (1988). |
| 128 |
J.M.
Hawkins and K.B. Sharpless, Asymmetric Epoxidation Models: An
Alkyl Hydroperoxide Dependent Change in Mechanism, Tetrahedron
Lett., 28, 2825 (1987). |
| 127 |
J.M.
Klunder and K.B. Sharpless, A Convenient Synthesis of Sulfinate
Esters from Sulfonyl Chlorides, J. Org. Chem., 52, 2598 (1987). |
| 126 |
S.F.
Pedersen, J.C. Dewan, R.R. Eckman, and K.B. Sharpless, Unexpected
Diversity in the Coordination Chemistry of Tartrate Esters with
Titanium(IV), J. Am. Chem. Soc., 109, 1279 (1987). |
| 125 |
A.D.
Elbein, T. Szumilo, B.A. Sanford, K.B. Sharpless, and C.E. Adams,
Effect of Isomers of Swainsonine on Glycosidase Activity and Glycoprotein
Processing, Biochemistry, 26, 2502 (1987). |
| 124 |
S.Y.
Ko, H. Masamune, and K.B. Sharpless, p-Nitrobenzoate Esters of
Epoxy Alcohols: Convenient Synthons for Water-Soluble Epoxy Alcohols,
J. Org. Chem., 52 , 667 (1987). |
| 123 |
K.B.
Sharpless, Architecturally Interesting Metal Complexes with Thermodynamically
Dictated Structures, Chemica Scripta (Sweden), 27, 521 (1987). |
| 122 |
S.Y.
Ko and K.B. Sharpless, In Situ Opening of Epoxy Alcohols: A Convenient
Alternative to the Isolation of Unstable Epoxy Alcohols, J. Org.
Chem., 51, 5413 (1986). |
| 121 |
Y.
Gao, R.M. Hanson, J.M. Klunder, S.Y. Ko, H. Masamune, and K.B.
Sharpless, Catalytic Asymmetric Epoxidation and Kinetic Resolution:
Modified Procedures Including In Situ Derivatization, J. Am. Chem.
Soc., 109, 5765 (1987). |
| 120 |
K.S.
Kirshenbaum and K.B. Sharpless, Regioselective Nucleophilic Opening
of erythro- and threo-2, 3 Epoxy Alcohols, Chem. Lett., 11 (1987). |
| 119 |
J.M.
Klunder, S.Y. Ko, and K.B. Sharpless, Asymmetric Epoxidation of
Allyl Alcohol: Efficient Routes to Homochiral b-Adrenergic Blocking
Agents, J. Org. Chem., 51, 3710 (1986). |
| 118 |
K.B.
Sharpless and R.A. Johnson, Metal-Mediated Halohydrin Formation,
U. S. Patent 4,560,811, 1985, assigned to the Massachusetts Institute
of Technology. |
| 117 |
R.M.
Hanson and K.B. Sharpless, Procedure for the Catalytic Asymmetric
Epoxidation of Allylic Alcohols in the Presence of Molecular Sieves,
J. Org. Chem., 51, 1922 (1986). |
| 116 |
K.B.
Sharpless, The Discovery of the Asymmetric Epoxidation, Chem.
Brit., 22, 1 (1986). |
| 115 |
J.M.
Hawkins, J.C. Dewan, and K.B. Sharpless, Dioxomolybdenum(VI)-Substituted
2,6-Pyridinedimethanol Complexes: New Five-Coordinate Species,
Inorg. Chem., 25, 1501 (1986). |
| 114 |
K.B.
Sharpless, The Discovery of Titanium-Catalyzed Asymmetric Epoxidation,
CHEMTECH, 692 (1985). |
| 113 |
T.
Katsuki and K.B. Sharpless, Method for Asymmetric Epoxidation,
U.S. Patent 4,471,130, 1984, assigned to Stanford University. |
| 112 |
C.H.
Behrens and K.B. Sharpless, Selective Transformations of 2,3-Epoxy
Alcohols and Related Derivatives. Strategies for Nucleophilic
Attack at Carbon-3 or Carbon-2, J. Org. Chem., 50, 5696 (1985). |
| 111 |
C.H.
Behrens, S.Y. Ko, F.J. Walker, and K.B. Sharpless, Selective Transformation
of 2,3-Epoxy Alcohols and Related Derivatives. Strategies for
Nucleophilic Attack at Carbon-1, J. Org. Chem., 50, 5687 (1985). |
| 110 |
J.M.
Chong and K.B. Sharpless, Regioselective Openings of 2,3-Epoxy
Acids with Organocuprates, Tetrahedron Lett., 4683 (1985). |
| 109 |
S.
Miyano, L.D.-L. Lu, S.M. Viti and K.B. Sharpless, Kinetic Resolution
of Racemic b-Hydroxyamines by Enantioselective N-Oxide Formation,
J. Org. Chem., 50, 4350 (1985). |
| 108 |
J.M.
Chong and K.B. Sharpless, Nucleophilic Opening of 2,3-Epoxy Acids
and Amides Mediated by Ti(OiPr)4 . Reliable C-3 Selectivity, J.
Org. Chem., 50, 1560 (1985). |
| 107 |
M.
Caron and K.B. Sharpless, Ti(OiPr)4-Mediated Nucleophilic Openings
of 2,3-Epoxy Alcohols. A Mild Procedure for Regioselective Ring-Opening,
J. Org. Chem., 50, 1557 (1985). |
| 106 |
M.J.
Schweiter and K.B. Sharpless, The Asymmetric Epoxidation of tert-Butyl
Substituted Allylic Alcohols, Tetrahedron Lett., 2543 (1985). |
| 105 |
K.S.
Kirshenbaum and K.B. Sharpless, Improved Procedure for the Tungstate-catalyzed
Epoxidation of a,b-Unsaturated Acids, J. Org. Chem., 50, 1979
(1985). |
| 104 |
J.M.
Klunder, M. Caron, M. Uchiyama, and K.B. Sharpless, Chlorohydroxylation
of Olefins with Peroxides and Titanium Tetrachloride, J. Org.
Chem., 50, 912 (1985). |
| 103 |
M.G.
Finn and K.B. Sharpless, On the Mechanism of Asymmetric Epoxidation
with Titanium-Tartrate Catalysts, "Asymmetric Synthesis,"
Vol. 5, James D. Morrison, Ed.; Academic Press, Inc., New York,
(1985), Chapter 8, pp. 247-308. |
| 102 |
K.B.
Sharpless, A New Strategy For Full Control of Relative Stereochemistry
Expands the Role of Asymmetric Synthesis, Chemica Scripta (Sweden),
25, 71 (1985). |
| 101 |
C.E.
Adams, F.J. Walker, and K.B. Sharpless, Enantioselective Synthesis
of Swainsonine, A Trihydroxylated Indolizidine Alkaloid, J. Org.
Chem., 50, 420 (1985). |
| 100 |
J.G.
Hill, K.B. Sharpless, C.M. Exon, and R. Regenye, Enantioselective
Epoxidation of Allylic Alcohols: (2S,3S)-3-Propyloxiranemethanol,
Org. Synth., 63, 66 (1984). |
| 99 |
I.D.
Williams, S.F. Pedersen, K.B. Sharpless, and S.J. Lippard, Crystal
Structures of Two Titanium Tartrate Asymmetric Epoxidation Catalysts,
J. Am. Chem. Soc., 106, 6430 (1984). |
| 98 |
J.M.
Hawkins and K.B. Sharpless, threo-N,N’-Bis (a-methylbenzyl)
sulfamide: A Readily Available Chiral Ligand for Asymmetric Lithium
Aluminum Hydride Reductions. J. Org. Chem., 49, 3861, (1984). |
| 97 |
B.E.
Rossiter and K.B. Sharpless, Asymmetric Epoxidation of Homoallylic
Alcohols. Synthesis of (–)-g-Amino-b-(R)-Hydroxybutyric Acid
(GABOB). J. Org. Chem., 49, 3707 (1984). |
| 96 |
K.B.
Sharpless, Discovery of the Titanium-Catalyzed Asymmetric Epoxidation—A
Personal Account., Proceedings of the Robert A. Welch Foundation
Conferences on Chemical Research XXVII Stereospecificity in Chemistry
and Biochemistry, November 7–9, 1983, Houston, TX. |
| 95 |
L.D.-L.
Lu, R.A. Johnson, M.G. Finn, and K.B. Sharpless, Two New Asymmetric
Epoxidation Catalysts. Unusual Stoichiometry and Inverse Enantiofacial
Selection, J. Org. Chem., 49, 728 (1984). |
| 94 |
C.H.
Behrens and K.B. Sharpless, New Transformations of 2,3-Epoxy Alcohols
and Related Derivatives. Easy Routes to Homochiral Substances,
Aldrichimica Acta, 16, 4 (1983). |
| 93 |
K.B.
Sharpless, S.S. Woodard and M.G. Finn, On the Mechanism of Titanium-Tartrate
Catalyzed Asymmetric Epoxidation, Pure and Appl. Chem., 55, 1823
(1983). |
| 92 |
S.
Miyano, L.D.-L. Lu, S.M. Viti, and K.B. Sharpless, Kinetic Resolution
of Racemic b-Hydroxyamines by Enantioselective N-Oxide Formation.,
J. Org. Chem., 48, 3608 (1983). |
| 91 |
J.G.
Hill, B.E. Rossiter, and K.B. Sharpless, Anhydrous tert-Butyl
Hydroperoxide in Toluene. The Preferred Reagent for Applications
Requiring Dry TBHP., J. Org. Chem., 48, 3607 (1983). |
| 90 |
S.Y.
Ko, A.W.M. Lee, S. Masamune, L.A. Reed, K.B. Sharpless, and F.J.
Walker, Total Synthesis of the L-Hexoses, Science, 220, 949 (1983). |
| 89 |
L.A.
Reed, Y. Ito, S. Masamune, and K.B. Sharpless, Synthesis of Saccharides
and Related Polyhydroxylated Natural Products. 4. a-D-and b-D-C-Glycopyranosides
(2,6-Dialkyl-Substituted Tetrahydropyrans), J. Am. Chem. Soc.,
104, 6468 (1982). |
| 88 |
K.B.
Sharpless, C.H. Behrens, T. Katsuki, A.W.M. Lee, V.S. Martin,
M. Takatani, S.M. Viti, F.J. Walker, and S.S. Woodard, Stereo-
and Regioselective Openings of Chiral 2,3-Epoxy Alcohols. Versatile
Routes to Optically Pure Natural Products and Drugs. Unususal Kinetic Resolutions,
, 55, 589 (1983). |
| 87 |
N.C.
Gonnella, K. Nakanishi, V.S. Martin, and K.B. Sharpless, General
Method for Determining Absolute Configurations of Acyclic Allylic
Alcohols, J. Am. Chem. Soc., 104, 3775 (1982). |
| 86 |
M.A.
Warpehoski, B. Chabaud, and K.B. Sharpless, Selenium Dioxide Oxidation
of Endocyclic Olefins. Evidence for a Dissociation-Recombination
Pathway, J. Org. Chem., 47, 2897 (1982). |
| 85 |
A.W.M.
Lee, V.S. Martin, S. Masamune, K.B. Sharpless, and F.J. Walker,
Synthesis of Saccharides and Related Polyhydroxylated Natural
Products 3: Efficient Conversion of 2,3-erythro-Aldoses to 2,3-threo-Aldoses,
J. Am. Chem. Soc., 104, 3515 (1982). |
| 84 |
P.
Ma, V.S. Martin, S. Masamune, K.B. Sharpless, and S.M. Viti, Synthesis
of Saccharides and Related Polyhydroxylated Natural Products 2:
Simple Deoxyalditols, J. Org. Chem., 47, 1378 (1982). |
| 83 |
T.
Katsuki, A.W.M. Lee, P. Ma, V.S. Martin, S. Masamune, K.B. Sharpless,
D. Tuddenham, and F.J. Walker, Synthesis of Saccharides and Related
Polyhydroxylated Natural Products 1: Simple Alditols, J. Org.
Chem., 47, 1373 (1982). |
| 82 |
V.S.
Martin, S.S. Woodard, T. Katsuki, Y. Yamada, M. Ikeda, and K.B.
Sharpless, Kinetic Resolution of Racemic Allylic Alcohols by Enantioselective
Epoxidation. A Route to Substances of Absolute Enantiomeric Purity?,
J. Am. Chem. Soc., 103, 6237 (1981). |
| 81 |
P.H.J.
Carlsen, T. Katsuki, V.S. Martin, and K.B. Sharpless, A Greatly
Improved Procedure for Ruthenium Tetroxide-Catalyzed Oxidations
of Organic Compounds, J. Org. Chem., 46, 3936 (1981). |
| 80 |
E.
Herranz and K.B. Sharpless, Osmium Catalyzed Vicinal Oxyamination
of Olefins by N-Chloro-N-Argento-Carbamates: threo-N-(1-Hydroxy-1,2-Diphenyl-2-yl)
Ethyl Carbamate, Org. Synth., 61, 93 (1981). |
| 79 |
D.J.
Morgans, K.B. Sharpless, and S.G. Traynor, Epoxy Alcohol Rearrangements:
Hydroxyl Mediated Delivery of Lewis Acid Promoters, J. Am. Chem.
Soc., 103, 462 (1981). |
| 78 |
B.E.
Rossiter, T. Katsuki, and K.B. Sharpless, Asymmetric Epoxidation
Provides Shortest Routes to Four Chiral Epoxy Alcohols which are
Key Intermediates in Syntheses of Methymycin, Erythromycin, Leukotriene
C-1 and Disparlure, J. Am. Chem. Soc., 103, 464 |
| 77 |
E.
Herranz and K.B. Sharpless, Osmium Catalyzed Vicinal Oxyamination
of Olefins by Chloramine-T: cis-2-(p-Toluenesulfonamido)-cyclohexanol
and 2-Methyl-3-(p-toluenesulfonamido)-2-pentanol, Org. Synth.,
61, 85 (1983). |
| 76 |
T.
Katsuki and K.B. Sharpless, The First Practical Method for Asymmetric
Epoxidation, J. Am. Chem. Soc., 102, 5974 (1980). |
| 75 |
S.G.
Hentges and K.B. Sharpless, Improved Procedure for the Oxyamination
of Olefins with Trioxo(tert-butylimido)osmium(VIII), J. Org. Chem.,
45, 2257 (1980). |
| 74 |
S.G.
Hentges and K.B. Sharpless, Asymmetric Induction in the Reaction
of Osmium Tetroxide with Olefins, J. Am. Chem. Soc., 102, 4263
(1980). |
| 73 |
E.
Herranz and K.B. Sharpless, Osmium-Catalyzed Vicinal Oxyamination
of Olefins by N-Chloro-N-Metallocarbamates, J. Org. Chem., 45,
2710 (1980). |
| 72 |
M.A.
Umbreit and K.B. Sharpless, Deoxygenation of Epoxides with Lower
Valent Tungsten Halides: trans-Cyclododecene, Org. Synth., 60,
29 (1981). |
| 71 |
K.B.
Sharpless and T.R. Verhoeven, Metal-Catalyzed, Highly Selective
Oxygenations of Olefins and Acetylenes with tert-Butyl Hydroperoxide.
Practical Considerations and Mechanisms, Aldrichimica Acta, 12,
63 (1979). |
| 70 |
B.E.
Rossiter, T.R. Verhoeven, and K.B. Sharpless, Stereoselective
Epoxidation of Acyclic Allylic Alcohols. A Correction of Our Previous
Work, Tetrahedron Lett., 4733 (1979). |
| 69 |
B.
Chabaud and K.B. Sharpless, Oxidation of Acetylenes with tert-Butyl
Hydroperoxide Catalyzed by Selenium Dioxide. a,a’-Dioxygenation
of Internal Alkynes, J. Org. Chem., 44, 4202 (1979). |
| 68 |
T.
Hori and K.B. Sharpless, Selenium Catalyzed Non-Radical Chlorination
of Olefins with N-Chlorosuccinimide, J. Org. Chem., 44, 4204 (1979). |
| 67 |
T.
Hori and K.B. Sharpless, Conversion of Allylic Phenylselenides
to the Rearranged Allylic Chlorides by N-Chlorosuccinimide. Mechanism
of Selenium Catalyzed Allylic Chlorination of &$946;-Pinene, J. Org.
Chem., 44, 4208 (1979). |
| 66 |
J.-E.
Bäckvall, K. Oshima, R.E. Palermo, and K.B. Sharpless, Some
Reactions of N-(2-hydroxyalkyl)-p-toluenesulfonamides and N-allyl-p-toluenesulfonamides,
J. Org. Chem., 44, 1953 (1979). |
| 65 |
S.
Current and K.B. Sharpless, Carbonyl Participation in the Addition
of p-Chlorophenylselenenyl Bromide to (E)-4-Hexenal: A New Route
to 2,6-Dideoxyglycosides, Tetrahedron Lett., 5075 (1978). |
| 64 |
L.S.
Liebeskind, K.B. Sharpless, R.D. Wilson, and J.A. Ibers, The First
d0 Metallooxaziridines. Amination of Olefins, J. Am. Chem. Soc.,
100, 7061 (1978).63. |
| 63 |
E.
Herranz, S.A. Biller, and K.B. Sharpless, Osmium-Catalyzed Vicinal
Oxyamination of Olefins by N-Chloro-N-Argentocarbamates, J. Am.
Chem. Soc., 100, 3596 (1978). |
| 62 |
E.
Herranz and K.B. Sharpless, Improvements in the Osmium Catalyzed
Oxyamination of Olefins by Chloramine-T, J. Org. Chem., 43, 2544
(1978). |
| 61 |
T.
Frejd and K.B. Sharpless, A New Rearrangement of N-Arylhydroxamic
Acids Catalyzed by Seleninic Acids and Phenylselenenyl Chloride,
Tetrahedron Lett., 2239 (1978). |
| 60 |
D.W.
Patrick, L.K. Truesdale, S.A. Biller, and K.B. Sharpless, Stereospecific
Vicinal Oxyamination of Olefins by Alkyl Imido Osmium Compounds,
J. Org. Chem., 43, 2628 (1978). |
| 59 |
K.
Akashi, R.E. Palermo, and K.B. Sharpless, A Major Improvement
in the Osmium Catalyzed Vicinal Hydroxylation of Olefins by tert-Butyl
Hydroperoxide, J. Org. Chem., 43, 2063 (1978). |
| 58 |
T.
Hori and K.B. Sharpless, Synthetic Applications of Arylselenenic
and of Arylseleninic Acids. Conversion of Olefins to Allylic Alcohols
and to Epoxides, J. Org. Chem., 43, 1689 (1978). |
| 57 |
S.P.
Singer and K.B. Sharpless, Synthesis of d,l-Gabaculine Utilizing
Direct Allylic Amination as the Key Step, J. Org. Chem., 43, 1448
(1978). |
| 56 |
T.
Hori, S.P. Singer, and K.B. Sharpless, Allylic Deuteration and
Tritiation of Olefins with N-Sulfinylsulfonamides, J. Org. Chem.,
43, 1456 (1978). |
| 55 |
J.-E.
Bäckvall, M.W. Young, and K.B. Sharpless, Vicinal Acetoxychlorination
of Olefins by Chromyl Chloride in Acetyl Chloride, Tetrahedron
Lett., 3523 (1977). |
| 54 |
M.A.
Umbreit and K.B. Sharpless, Allylic Oxidation of Olefins by Catalytic
and Stoichiometric Selenium Dioxide with tert-Butyl Hydroperoxide,
J. Am. Chem. Soc., 99, 5526 (1977). |
| 53 |
A.O.
Chong, K. Oshima, and K.B. Sharpless, Synthesis of Dioxo(tert-alkylimido)Osmium(VIII)
and Oxotris(tert-alkylimido)Osmium(VIII) Complexes. Stereospecific
Vicinal Diamination of Olefins, J. Am. Chem. Soc., 99, 3420 (1977). |
| 52 |
K.B.
Sharpless, A.Y. Teranishi, and J.-E. Bäckvall, Chromyl Chloride
Oxidations of Olefins. Possible Role of Organometallic Intermediates
in the Oxidations of Olefins by Oxotransition Metal Species, J.
Am. Chem. Soc., 99, 3120 (1977). |
| 51 |
A.O.
Chong and K.B. Sharpless, On the Mechanism of the Molybdenum and
Vanadium Catalyzed Epoxidation of Olefins by Alkyl Hydroperoxides,
J. Org. Chem., 42, 1587 (1977). |
| 50 |
R.C.
Michaelson, R.E. Palermo, and K.B. Sharpless, Chiral Hydroxamic
Acids as Ligands in the Vanadium Catalyzed Asymmetric Epoxidation
of Allylic Alcohols by tert-Butyl Hydroperoxide, J. Am. Chem.
Soc., 99, 1990 (1977). |
| 49 |
K.B.
Sharpless and S.P. Singer, 1,2-Diamination of 1,3-Dienes by Imido
Selenium Compounds, J. Org. Chem., 41, 2504 (1976). |
| 48 |
K.B.
Sharpless, K. Akashi, and K. Oshima, Ruthenium Catalyzed Oxidation
of Alcohols to Aldehydes and Ketones by Amine-N-Oxides, Tetrahedron
Lett., 22503 (1976). |
| 47 |
K.B.
Sharpless and K. Akashi, Osmium Catalyzed Vicinal Hydroxylation
of Olefins by tert-Butyl Hydroperoxide Under Alkaline Conditions,
J. Am. Chem. Soc., 98, 1986 (1976). |
| 46 |
K.B.
Sharpless, A.O. Chong, and K. Oshima, Osmium Catalyzed Oxyamination
of Olefins by Chloramine-T, J. Org. Chem., 41, 177 (1976). |
| 45 |
K.B.
Sharpless and T. Hori, Allylic Amination of Olefins and Acetylenes
by Imido Sulfur Compounds, J. Org. Chem., 41, 176 (1976). |
| 44 |
K.B.
Sharpless and K.M. Gordon, Selenium Dioxide Oxidation of Ketones
and Aldehydes. Evidence for the Intermediacy of b-Ketoseleninic
Acids, J. Am. Chem. Soc., 98, 300 (1976). |
| 43 |
K.B.
Sharpless, T. Hori, L.K. Truesdale, and C.O. Dietrich, Allylic
Amination of Olefins and Acetylenes by Imido Selenium Compounds,
J. Am. Chem. Soc., 98, 269 (1976). |
| 42 |
K.B.
Sharpless and K. Akashi, Oxidation of Alcohols to Aldehydes by
Reagents Derived from Chromyl Chloride, J. Am. Chem. Soc., 97,
5927 (1975). |
| 41 |
K.B.
Sharpless, K.M. Gordon, R.F. Lauer, D.W. Patrick, S.P. Singer,
and M.W. Young, The Utility of Selenium Reagents in Organic Synthesis,
Chemica Scripta (Sweden), Vol. 8A, 9 (1975). |
| 40 |
J.A.
Nelson, S. Kahn, T.A. Spencer, K.B. Sharpless, and R.B. Clayton,
Some Aspects of Substrate Specificity in Biological Demethylation
at C4 of Steroids, Bioorgan. Chem., 4, 363 (1975). |
| 39 |
K.B.
Sharpless and D.R. Williams, The Reactions of Olefins with Permanganate,
Ruthenium Tetroxide, and Osmium Tetroxide; Dependence of Rate
on Degree of Substitution, Tetrahedron Lett., 3045 (1975). |
| 38 |
K.B.
Sharpless, A.O. Chong, and J.A. Scott, Rapid Separation of Organic
Mixtures by Formation of Metal Complexes, J. Org. Chem., 40, 1252
(1975). |
| 37 |
K.B.
Sharpless, D.W. Patrick, L.K. Truesdale, and S.A. Biller, A New
Reaction. Stereospecific Vicinal Oxyamination of Olefins by Alkyl
Imido Osmium Compounds, J. Am. Chem. Soc., 97, 2305 (1975). |
| 36 |
K.B.
Sharpless and M.W. Young, Olefin Synthesis. Rate Enhancement of
the Elimination of Alkyl Aryl Selenoxides by Electron-Withdrawing
Substituents, J. Org. Chem., 40, 947 (1975). |
| 35 |
H.P.
Jensen and K.B. Sharpless, Selenium Dioxide Oxidation of d-Limonene—a
Reinvestigation, J. Org. Chem., 40, 264 (1975). |
| 34 |
H.P.
Jensen and K.B. Sharpless, An Improved Procedure for the Direct
Oxidation of Olefins to a-Diketones by Potassium Permanganate
in Acetic Anhydride, J. Org. Chem., 39, 2314 (1974). |
| 33 |
K.B.
Sharpless and H.P. Jensen, Synthesis of a Novel Pentacoordinate
Glyoxime Based Ligand and Preparation of its Chlorocobalt(III)
Complex, Inorg. Chem., 13, 2617 (1974) |
| 32 |
S.
Tanaka, H. Yamamoto, H. Nozaki, K.B. Sharpless, R.C. Michaelson,
and J.D. Cutting, Stereoselective Epoxidations of Acyclic Allylic
Alcohols by Transition Metal-Hydroperoxide Reagents. Synthesis
of d,l-C18 Cecropia Juvenile Hormone from Farnesol, J. Am. Chem. Soc., 96, 5254 (1974). |
| 31 |
K.B.
Sharpless and R.F. Lauer, Electrophilic Organoselenium Reagents.
A New Route to Allylic Acetates and Ethers, J. Org. Chem., 39,
429 (1974). |
| 30 |
D.
Arigoni, A. Vasella, K.B. Sharpless, and H.P. Jensen, Selenium
Dioxide Oxidations of Olefins. Trapping of the Allylic Seleninic
Acid Intermediate as a Seleninolactone, J. Am. Chem. Soc., 95,
7917 (1973). |
| 29 |
K.B.
Sharpless, R.F. Lauer, and A.Y. Teranishi, Electrophilic and Nucleophilic
Organoselenium Reagents. New Routes to a,b-Unsaturated Carbonyl
Compounds, J. Am. Chem. Soc., 95, 6137 (1973). |
| 28 |
K.B.
Sharpless and R.C. Michaelson, High Stereo- and Regioselectivities
in the Transition Metal Catalyzed Epoxidations of Olefinic Alcohols
by t-Butyl Hydroperoxide, J. Am. Chem. Soc., 95, 6136 (1973). |
| 27 |
K.B.
Sharpless, M.W. Young, and R.F. Lauer, Reactions of Selenoxides.
Thermal syn-Elimination and H218O Exchange, Tetrahedron Lett.,
1979 (1973). |
| 26 |
K.B.
Sharpless and R.F. Lauer, A Mild Procedure for the Conversion
of Epoxides to Allylic Alcohols. The First Organoselenium Reagent,
J. Am. Chem. Soc., 95, 2697 (1973). |
| 25 |
K.B.
Sharpless and A.Y. Teranishi, Chromyl Chloride in Acetone. a-Chloro
Ketones or Ketones Directly from Olefins, J. Org. Chem., 38, 185
(1973). |
| 24 |
K.B.
Sharpless and R.F. Lauer, Facile Thermal Rearrangements of Allyl
Selenides and Diselenides. [1,3] and [2,3] Shifts, J. Org. Chem.,
37, 3973 (1972). |
| 23 |
K.B.
Sharpless and R.F. Lauer, Selenium Dioxide Oxidation of Olefins,
Evidence for the Intermediacy of Allyl Seleninic Acids, J. Am.
Chem. Soc., 94, 7154 (1972). |
| 22 |
J.M.
Townsend and K.B. Sharpless, Mechanism of Decomposition of Sulfonium
Betaines to Epoxides, Tetrahedron Lett., 3313 (1972). |
| 21 |
K.B.
Sharpless, M.A. Umbreit, M.T. Nieh, and T.C. Flood, Lower Valent
Tungsten Halides. A New Class of Reagents for Deoxygenation of
Organic Molecules, J. Am. Chem. Soc., 94, 6538 (1972). |
| 20 |
K.B.
Sharpless and T.C. Flood, Direct Deoxygenation of Vicinal Diols
with Tungsten (IV). A New Olefin Synthesis, J. Chem. Soc., Chem.
Commun., 370, (1972). |
| 19 |
K.B.
Sharpless, J.M. Townsend, and D.R. Williams, On the Mechanism
of Epoxidation of Olefins by Covalent Peroxides of Molybdenum(VI),
J. Am. Chem. Soc., 94, 295 (1972). |
| 18 |
K.B.
Sharpless and R.F. Lauer, O. Repic, A.Y. Teranishi, and D.R. Williams,
Permanganate in Acetic Anhydride. a-Diketones Directly from Olefins,
J. Am. Chem. Soc., 93, 3303 (1971). |
| 17 |
K.B.
Sharpless and T.C. Flood, Oxotransition Metal Oxidants as Mimics
for the Action of Mixed-Function Oxygenases. "NIH Shift"
with Chromyl Reagents, J. Am. Chem. Soc., 93, 2316 (1971). |
| 16 |
K.B.
Sharpless, d,l-Malabaricane Diol. The First Cyclic Natural Product
Derived from Squalene in a Nonenzymic Process, J. Am. Chem. Soc.,
92, 6999 (1970). |
| 15 |
K.B.
Sharpless, Synthesis of erythro-18,19-Dihydroxysqualene 2,3-Oxide
and Other Internally Oxidized Squalene Derivatives, J. Chem. Soc.,
Chem. Commun., 1450 (1970). |
| 14 |
R.
Rahman, K.B. Sharpless, T.A. Spencer, and R.B. Clayton, Removal
of the 4,4-Dimethyl Carbons in the Enzymic Conversion of Lanosterol
to Cholesterol: Initial Loss of the 4a-Methyl Group, J. Biol.
Chem., 245, 2667 (1970). |
| 13 |
K.B.
Sharpless, T.E. Snyder, T.A. Spencer, K.K. Maheshwari, J.A. Nelson,
and R.B. Clayton, Biological Demethylation of 4,4-Dimethyl Sterols.
Evidence for Enzymic Epimerization of the 4b-Methyl Group Prior
to Its Oxidative Removal, J. Am. Chem. Soc., 91, 3 |
| 12 |
R.
J. Anderson, R.P. Hanzlik, K.B. Sharpless, and E.E. van Tamelen,
Enzymic Transformation of an Acyclic Sesterterpene Terminal Epoxide
to a Lanosterol Analog, J. Chem. Soc., Chem. Commun., 53 (1969). |
| 11 |
E.E.
van Tamelen, B. Åkermark, and K.B. Sharpless, Mechanism
of the Titanium-Promoted Deoxygenative Coupling of Allyl and Benzyl
Alcohols to Hydrocarbons, J. Am. Chem. Soc., 91, 1552 (1969). |
| 10 |
K.B.
Sharpless and E.E. van Tamelen, Terpene Terminal Epoxides. Skeletal
Rearrangement Accompanying Bicyclization of Squalene 2,3-Oxide,
J. Am. Chem. Soc., 91, 1848 (1969). |
| 9 |
K.B.
Sharpless, T.E. Snyder, T.A. Spencer, K.K. Maheshwari, G. Guhn,
and R.B. Clayton, Biological Demethylation of 4,4-Dimethyl Sterols.
Initial Removal of the 4a-Methyl Group, J. Am. Chem. Soc., 90,
6874 (1968). |
| 8 |
K.B.
Sharpless, Studies of the Mechanism of Action of 2,3-Oxidosqualene-Lanosterol
Cyclase: Featuring Enzymic Cyclization of Modified Squalene Oxides,
Ph.D. Dissertation, Stanford University (1968). |
| 7 |
E.E.
van Tamelen, R.P. Hanzlik, K.B. Sharpless, R.B. Clayton, W.J.
Richter, and A.L. Burlingame, Enzymic Cyclization of 15-Norsqualene
2,3-Oxide, J. Am. Chem. Soc., 90, 3284 (1968) |
| 6 |
E.E.
van Tamelen, K.B. Sharpless, R.P. Hanzlik, R.B. Clayton, A.L.
Burlingame, and, P.C. Wszolek, Enzymic Cyclization of trans, trans,
trans-18,19-Dihydrosqualene 2,3-Oxide, J. Am. Chem. Soc., 89,
7150 (1967). |
| 5 |
K.B.
Sharpless, R.P. Hanzlik, and E.E. van Tamelen, A One-Step Synthesis
of 1,5-Dienes Involving Reductive Coupling of Allyl Alcohols,
J. Am. Chem. Soc., 90, 209 (1968). |
| 4 |
E.E.
van Tamelen, K.B. Sharpless, J.D. Willett, R.B. Clayton, and A.L.
Burlingame, Biological Activities of Some Terminally Modified
Squalene and Squalene 2,3-Oxide Analogs, J. Am. Chem. Soc., 89,
3920 (1967). |
| 3 |
J.D.
Willett, K.B. Sharpless, K.E. Lord, E.E. van Tamelen, and R.B.
Clayton, Squalene-2,3-Oxide, an Intermediate in the Enzymatic
Conversion of Squalene to Lanosterol and Cholesterol, J. Biol.
Chem., 242, 4182 (1967). |
| 2 |
E.E.
van Tamelen and K.B. Sharpless, Positional Selectivity During
Controlled Oxidation of Polyolefins, Tetrahedron Lett., 28, 2655
(1967). |
| 1 |
T.A.
Spencer, M.A. Schwartz, and K.B. Sharpless, Synthesis of Resin
Acid Intermediates. 8a,10b-Dimethyl-8-carbomethoxy-D19-octalone-2,
J. Org. Chem., 29, 782 (1964). |
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