415 |
Li H, Chang BS, Kim H, Xie Z, Laine A, Ma L, Xu T, Yang C, Kwon J, Shelton SW, Klivansky LM, Altoe V, Gao B, Schwartzberg AM, Peng Z, Ritchie RO, Xu T, Salmeron M, Ruiz R, Sharpless KB, Wu P, Liu Y.,
High-performing polysulfate dielectrics for electrostatic energy storage under harsh conditions.
Joule., 7(1):95-111, (2023).
|
414 |
Cheng Y, Li G, Smedley CJ, Giel M-C, Kitamura S, Woehl JL, Bianco G, Forli S, Homer JA, Cappiello JR, Wolan DW, Moses JE, Sharpless KB.,
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors.
Proc Natl Acad Sci USA., 119(37):e2208540119, (2022).
|
413 |
Kim H, Zhao J, Bae J, Klivansky LM, Dailing EA, Liu Y, Cappiello JR, Sharpless KB, Wu P.,
Chain-Growth Sulfur(VI) Fluoride Exchange Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates.
ACS Cent Sci., 7(11):1919-28, (2021).
|
412 |
Li S, Li G, Gao B, Pujari SP, Chen X, Kim H, Zhou F, Klivansky LM, Liu Y, Driss H, Liang DD, Lu J, Wu P, Zuilhof H, Moses J, Sharpless KB.,
SuFExable polymers with helical structures derived from thionyl tetrafluoride.
Nat Chem., 13(9):858-867, (2021).
|
411 |
Sun S, Gao B, Chen J, Sharpless KB, Dong J.,
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines.
Angew Chem Int Ed Engl., 60(39):21195-21199, (2021).
|
410 |
Zhang J, Zhao X, Cappiello JR, Yang Y, Cheng Y, Liu G, Fang W, Luo Y, Zhang Y, Dong J, Zhang L, Sharpless KB.,
Identification of simple arylfluorosulfates as potent agents against resistant bacteria.
Proc Natl Acad Sci USA., 118(28):e2103513118, (2021).
|
409 |
Shyong YJ, Sepulveda Y, Garcia A, Samskey NM, Radic Z, Sit R, Sharpless KB, Momper JD, Taylor PW.,
Enhancing target tissue levels and diminishing plasma clearance of ionizing zwitterionic antidotes in organophosphate exposures.
J Pharmacol Exp Ther., 378(3):315-321, (2021).
|
408 |
Garnar-Wortzel L, Bishop TR, Kitamura S, Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, Cravatt BF, Wolan DW, Erb MA.,
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia.
ACS Cent Sci., 7(5):815-30, (2021).
|
407 |
Taylor P, Shyong YI, Samskey N, Ho KY, Radic Z, Fenical W, Sharpless KB, Kovarik Z, Camacho-Hernandez GA.,
Ligand design for human acetylcholinesterase and nicotine acetylcholine receptors, extending beyond the conventional and canonical.
J Neurochem., 158(6):1217-1222, (2021).
|
406 |
Zheng Q, Xu H, Wang H, Du WH, Wang N, Xiong H, Gu Y, Noodleman L, Sharpless KB, Yang G, Wu P.,
Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis.
J Am Chem Soc., 143(10):3753-63, (2020).
|
405 |
Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, Morisseau C, Wang H, Hammock BD, Sharpless KB, Kelly JW.,
Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery.
Nat Chem., 12(10):906-13, (2020).
|
404 |
Kitamura S, Zheng Q, Woehl JL, Solania A, Chen E, Dillon N, Hull MV, Kotaniguchi M, Cappiello JR, Kitamura S, Nizet V, Sharpless KB, Wolan DW.,
Sulfur(VI) fluoride exchange (SuFEx)-enabled high-throughput medicinal chemistry.
J Am Chem., 142(25):10899-904, (2020).
|
403 |
Lauwaet T, Miyamoto Y, Ihara S, Le C, Kalisiak J, Korthals KA, Ghassemian M, Smith DK, Sharpless KB, Fokin VV, Eckmann L.,
Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis.
PLoS Negl Trop Dis., 14(4):e0008224, (2020).
|
402 |
Smedley CJ, Li G, Barrow AS, Gialelis TL, Giel MC, Ottonello A, Cheng Y, Kitamura S, Wolan DW, Sharpless KB, Moses JE.,
Diversity oriented clicking (DOC): Divergent synthesis of SuFExable pharmacophores from 2-substituted-alkynyl-1-sulfonyl fluoride (SASF) hubs.
Angew Chem Intl Ed Engl., 59(30):12460-9, (2020).
|
401 |
Macek Hrvat N, Kalisiak J, Sinko G, Radic Z, Sharpless KB, Taylor P, Kovarik Z.,
Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases.
Toxicol Lett., 321:83-9, (2020).
|
400 |
Meng G, Guo T, Ma T, Zhang J, Shen Y, Sharpless KB, Dong J.,
Modular click chemistry libraries for functional screens using a diazotizing reagent.
Nature., 574(7776):86, (2019).
|
399 |
Zheng Q, Woehl JL, Kitamura S, Santos-Martins D, Smedley CJ, Li G, Forli S, Moses JE, Wolan DW, Sharpless KB.,
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
Proc Natl Acad Sci USA., 116(38):18808, (2019).
|
398 |
Hong S, Shi Y, Wu NC, Grande G, Douthit L, Wang H, Zhou W, Sharpless KB, Wilson IA, Xie J, Wu P.,
Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification.
Nat Commun., 10(1):1799, (2019).
|
397 |
Kovarik Z, Kalisiak J, Hrvat NM, Katalinic M, Zorbaz T, Zunec S, Green C, Radic Z, Fokin VV, Sharpless KB, Taylor P.,
Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.
Chemistry, 25(16):4100-4114, (2019).
|
396 |
Kovarik Z, Macek Hrvat N, Kalisiak J, Katalinic M, Sit RK, Zorbaz T, Radic Z, Fokin VV, Sharpless KB, Taylor P.,
Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.
Toxicol Appl Pharmacol., 372:40-46, (2019).
|
395 |
Liu F, Wang H, Li S, Bare GAL, Chen X, Wang C, Moses JE, Wu P, Sharpless KB.,
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4 )-Derived Connective Hubs for Bioconjugation to DNA and Proteins.
Angew Chem Int Ed Engl., 58(24):8029-8033, (2019).
|
394 |
Taylor P, Yan-Jye S, Momper J, Hou W, Camacho-Hernandez GA, Radic Z, Rosenberg Y, Kovarik Z, Sit R, Sharpless KB.,
Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure.
Chem Biol Interact., 308:194-197, (2019).
|
393 |
Smedley CJ, Zheng Q, Gao B, Li S, Molino A, Duivenvoorden HM, Parker BS, Wilson DJD, Sharpless KB, Moses JE.,
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides.
Angew Chem Int Ed Engl., 58(14):4552-4556, (2019).
|
392 |
Sit RK, Kovarik Z, Macek Hrvat N, Zunec S, Green C, Fokin VV, Sharpless KB, Radic Z, Taylor P.,
Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.
J Pharmacol Exp Ther., 367(2):363-372, (2018).
|
391 |
Gahtory D, Sen R, Pujari S, Li S, Zheng Q, Moses JE, Sharpless KB, Zuilhof H.,
Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms.
Chemistry., 24 (41), 10550-10556, (2018).
|
390 |
Guo T, Meng G, Zhan X, Yang Q, Ma T, Xu L, Sharpless KB, Dong J.,
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an "F-SO2 +" Donor of Unprecedented Reactivity, Selectivity, and Scope.
Angew Chem Int Ed Engl., 57 (10), 2605-2610, (2018).
|
389 |
Liu Z, Li J, Li S, Li G, Sharpless KB, Wu P.,
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization.
J Am Chem Soc., 140 (8), 2919-2925, (2018).
|
388 |
Gao B, Li S, Wu P, Moses JE, Sharpless KB.,
"Inverse Drug Discovery" SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates.
Angew Chem Int Ed Engl., 57 (7), 1939-1943, (2018).
|
387 |
Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW.,
"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.
J Am Chem Soc., 140 (1), 200-210, (2018).
|
386 |
Gao B, Zhang L, Zheng Q, Zhou F, Klivansky LM, Lu J, Liu Y, Dong J, Wu P, Sharpless KB.,
Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates.
Nat Chem., 9 (11), 1083-1088, (2017).
|
385 |
Wang H, Zhou F, Ren G, Zheng Q, Chen H, Gao B, Klivansky L, Liu Y, Wu B, Xu Q, Lu J, Sharpless KB, Wu P.,
SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts.
Angew Chem Int Ed Engl., 56 (37), 11203-11208, (2017).
|
384 |
Kim WJ, Korthals KA, Li S, Le C, Kalisiak J, Sharpless KB, Fokin VV, Miyamoto Y, Eckmann L.,
Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia.
Antimicrob Agents Chemother. , 61 (6), pii: e02397-16, (2017).
|
383 |
Zha GF, Zheng Q, Leng J, Wu P, Qin HL, Sharpless KB.,
Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides.
Angew Chem Int Ed Engl. , 56 (17), 4849-4852 (2017).
|
382 |
Li S, Wu P, Moses JE, Sharpless KB.,
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub..
Angew Chem Int Ed Engl. , 56 (11), 2903-2908 (2017).
|
381 |
Silverman SM, Moses JE, Sharpless KB.,
Reengineering Antibiotics to Combat Bacterial Resistance: Click Chemistry [1,2,3]-Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE.
Chemistry, 23 (1), 79-83 (2017).
|
380 |
Zheng Q, Dong J, Sharpless KB.,
Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation.
J Org Chem, 81 (22), 11360-1136 (2016).
|
379 |
Qin HL, Zheng Q, Bare GA, Wu P, Sharpless KB.,
A Heck-Matsuda Process for the Synthesis of -Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry.
Angew Chem Int Ed Engl, 55 (45), 14155-14158 (2016).
|
378 |
Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly JW.,
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.
J Am Chem Soc,138 (23), 7353-64 (2016).
|
377 |
Zhang E, Tang J, Li S, Wu P, Moses JE, Sharpless KB.,
Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates.
Chemistry, 22 (16), 5692-7 (2016).
|
376 |
Bourne Y, Sharpless KB, Taylor P, Marchot P.,
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase.
J Am Chem Soc,138 (5), 1611-21 (2016).
|
375 |
Toguchi S, Hirose T, Yorita K, Fukui K, Sharpless KB, Omura S, Sunazuka T.,
In situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor.
Chem Pharm Bull (Tokyo), 64 (7), 695-703 (2016).
|
374 |
Chen W, Dong J, Li S, Liu Y, Wang Y, Yoon L, Wu P, Sharpless KB, Kelly JW.,
Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy.
Angew Chem Int Ed Engl., 55 (5), 1835-8 (2016).
|
373 |
Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW.,
A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans,
J Am Chem Soc,137 (23), 7404-14 (2015).
|
372 |
Liang Q, Xing P, Huang Z, Dong J, Sharpless KB, Li X, Jiang B.,
Palladium-catalyzed, ligand-free Suzuki reaction in water using aryl fluorosulfates.,
Org Lett, 17 (8), 1942-5 (2015).
|
371 |
Sharpless KB, Finn MG, Martin VS.,
Tsutomu Katsuki (1946-2014),
Angew Chem Int Ed Engl, 54 (16), 4708 (2015).
|
370 |
Dong J, Krasnova L, Finn MG, Sharpless KB.,
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry,
Angew Chem Int Ed Engl, 53 (36), 9430-48 (2014).
|
369 |
Dong J, Sharpless KB, Kwisnek L, Oakdale JS, Fokin VV.,
SuFEx-Based Synthesis of Polysulfates,
Angew Chem Int Ed Engl, 53 (36), 9466-70 (2014).
|
368 |
Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radic Z,
Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification,
J Med Chem, 57 (4), 1378-1389 (2014).
|
367 |
Morris GM, Green LG, Radi Z, Taylor P, Sharpless KB, Olson AJ, Grynszpan F.,
Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase,
J Chem Inf Model, 53 (4), 898-906 (2013).
|
366 |
Miyamoto Y, Kalisiak J, Korthals K, Lauwaet T, Cheung DY, Lozano R, Cobo ER, Upcroft P, Upcroft JA, Berg DE, Gillin FD, Fokin VV, Sharpless KB, Eckmann L.,
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity,
Proc Natl Acad Sci U S A, 110 (43), 17564-17569 (2013).
|
365 |
Hirose T, Maita N, Gouda H, Koseki J, Yamamoto T, Sugawara A, Nakano H, Hirono S, Shiomi K, Watanabe T, Taniguchi H, Sharpless KB, Omura S, Sunazuka T.,
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor,
Proc Natl Acad Sci U S A, 110 (40), 15892-15897 (2013).
|
364 |
Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW.,
Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate,
J Am Chem Soc, 135 (15), 5656-5668 (2013).
|
363 |
Yamauchi JG, Gomez K, Grimster N, Dufouil M, Nemecz A, Fotsing JR, Ho KY, Talley TT, Sharpless KB, Fokin VV, Taylor P.,
Synthesis of selective agonists for the alpha7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates,
Mol Pharmacol, 82 (4), 687-699 (2012).
|
362 |
Radic Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Fokin VV, Sharpless KB, Taylor P.,
Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases,
J Biol Chem, 287 (15), 11798-11809 (2012).
|
361 |
Grimster NP, Stump B, Fotsing JR, Weide T, Talley TT, Yamauchi JG, Nemecz A, Kim C, Ho KY, Sharpless KB, Taylor P, Fokin VV.,
Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template,
J Am Chem Soc, 134 (15), 6732-6740 (2012).
|
360 |
Sit RK, Radic Z, Gerardi V, Zhang L, Garcia E, Katalinic M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.,
New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases,
J Biol Chem, 286 (22), 19422-19430 (2011).
|
359 |
Millward SW, Henning RK, Kwong GA, Pitram S, Agnew HD, Deyle KM, Nag A, Hein J, Lee SS, Lim J, Pfeilsticker JA, Sharpless KB, Heath JR.,
Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1,
J Am Chem Soc, 133 (45), 18280-18288 (2011).
|
358 |
Gastaminza P, Pitram SM, Dreux M, Krasnova LB, Whitten-Bauer C, Dong J, Chung J, Fokin VV, Sharpless KB, Chisari FV.,
Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection,
J Virol, 85 (11), 5513-5523 (2011).
|
357 |
Cochran R, Kalisiak J, Kucukkilinc T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.,
Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging,
J Biol Chem, 286 (34), 29718-29724 (2011).
|
356 |
Weide T, Saldanha SA, Minond D, Spicer TP, Fotsing JR, Spaargaren M, Frere JM, Bebrone C, Sharpless KB, Hodder PS, Fokin VV.,
NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-beta-Lactamase: Synthesis and Structure-Activity Studies,
ACS Med Chem Lett, 1 (4), 150-154 (2010).
|
355 |
Radic Z, Kalisiak J, Fokin VV, Sharpless KB, Taylor P.,
Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase,
Chem Biol Interact, 187 (1-3), 163-166 (2010).
|
354 |
Vanacore R, Ham AJ, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG.,
A Sulfilimine Bond Identified in Collagen IV,
Science, 325(5945), 1230 (2009).
|
353 |
Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L.,
Synthesis and Electrochemistry of 2-Ethenyl and 2-Ethanyl Derivatives of 5-Nitroimidazole and Antimicrobial Activity against Giardia lamblia,
J. Med. Chem., 52(13), 4038 (2009). |
352 |
Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P.,
Inhibitors of VIM-2 by Screening Pharmacologically Active and Click-Chemistry Compound Libraries,
Bioorg. Med. Chem., 17(14), 5027 (2009). |
351 |
Kalisiak J, Trauger SA, Kalisiak E, Morita H, Fokin VV, Adams MW, Sharpless KB, Siuzdak G.,
Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach,
J. Am. Chem. Soc., 131(1), 378 (2009). |
350 |
Hirose T, Sunazuka T, Sugawara A, Endo A, Iguchi K, Yamamoto T, Ui H, Shiomi K, Watanabe T, Sharpless KB, Omura S.,
Chitinase Inhibitors: Extraction of the Active Framework from Natural Argifin and Use of In Situ Click Chemistry,
J. Antibiot., 62(5), 277 (2009). |
349 |
Hein JE, Tripp JC, Krasnova LB, Sharpless KB, Fokin VV.,
Copper(I)-Catalyzed Cycloaddition of Organic Azides and 1-Iodoalkynes,
Angew. Chem., Int. Ed., 48(43), 8018 (2009). |
348 |
Agnew HD, Rohde RD, Millward SW, Nag A, Yeo WS, Hein JE, Pitram SM, Tariq AA, Burns VM, Krom RJ, Fokin VV, Sharpless KB, Heath JR.,
Iterative In Situ Click Chemistry Creates Antibody-like Protein-Capture Agents,
Angew. Chem., Int. Ed., 48(27), 4944 (2009). |
347 |
Fokin V, Rostovtsev VA, Green L, Himo F, Sharpless KB,
Copper-Catalysed Ligation of Azides and Acetylenes,
U.S. Patent Number 7,375,234, issued May 20, 2008.
|
346 |
Yoo EJ, Ahlquist M, Bae I, Sharpless KB, Fokin VV, Chang S.,
Mechanistic Studies on the Cu-Catalyzed Three-Component Reactions of Sulfonyl Azides, 1-Alkynes and Amines, Alcohols, or Water: Dichotomy via a Common Pathway,
J. Org. Chem., 73(14), 5520 (2008). |
345 |
Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P.,
Probing Gorge Dimensions of Cholinesterases by Freeze-Frame Click Chemistry,
Chem.-Biol. Interact., 175(1-3), 161 (2008). |
344 |
Kwok SW, Hein JE, Fokin VV, Sharpless KB.,
Regioselective Synthesis of either 1H- or 2H-1,2,3-Triazoles via Michael Addition to Alpha, Beta-Unsaturated Ketones,
Heterocycles, 76(2), 1141 (2008). |
343 |
Kalisiak J, Sharpless KB, Fokin VV.,
Efficient Synthesis of 2-Substituted-1,2,3-triazoles,
Org. Lett., 10(15), 3171 (2008). |
342 |
Van der Eycken E, Sharpless KB.,
Click Chemistry,
QSAR Comb. Sci., 26(11-12), 1115 (2007). |
341 |
Sugawara A, Sunazuka T, Hirose T, Nagai K, Yamaguchi Y, Hanaki H, Sharpless KB, Omura S.,
Design and Synthesis via Click Chemistry of 8,9-Anhydroerythromycin A 6,9-Hemiketal Analogues with anti-MRSA and -VRE Activity,
Bioorg. Med. Chem. Lett., 17(22), 6340 (2007). |
340 |
M. G. Finn, H. C. Kolb, V. V. Fokin and K. B. Sharpless,
Concept and Applications of Click Chemistry. From the Standpoint of Advocates,
Kagaku to Kogyo (Tokyo, Jpn.), 60(10), 976 (2007). |
339 |
R. Vestberg, M. Malkock, M. Kade, P. Wu, V. V. Fokin, K. B. Sharpless, E. Drokenmuller and C. J. Hawker,
Role of Architecture and Molecular Weight in the Formation of Tailor-made Ultrathin Multilayers Using Dendritic Macromolecules and Click Chemistry,
J. Polymer Sci., Part A., 45(14), 2835 (2007). |
338 |
Y. Liu, D. D. Diaz, A. A. Accurso, K. B. Sharpless, V. V. Fokin and M. G. Finn,
Metal-Adhesive Polymers from Cu(I)-Catalyzed Azide-Alkyne Cycloaddition,
J. Polymer Sci., Part A., 45, 5182 (2007). |
337 |
C. J. Hawker, V. V. Fokin, M. G. Finn and K. B. Sharpless,
Bringing Efficiency to Materials Synthesis: The Philosophy of Click Chemistry,
Aust. J. Chem., 60(6), 381 (2007). |
336 |
Yoo EJ, Ahlquist M, Kim SH, Bae I, Fokin VV, Sharpless KB, Chang S.,
Copper-catalyzed synthesis of N-sulfonyl-1,2,3-triazoles: controlling selectivity,
Angew. Chem. Int. Ed., 46(10), 1730 (2007). |
335 |
S. Narayan, V. V. Fokin and K. B. Sharpless
Organic Synthesis in Aqueous Suspension: Chemistry 'On Water' in "Organic Synthesis in Water",
U. Lindstrom, ed., Blackwell Scientific (2007).
|
334 |
T. Hirose, T. Sunazuka, Y. Noguchi, Y. Yamaguchi, H. Hanaki, K. B. Sharpless and S. Omura,
Rapid 'SAR' via Click Chemistry: An Alkyne-Bearing Spiramycin is Fused with Diverse Azides to Yield New Triazole-Antibacterial Candidates,
Heterocycles, 69, 55 (2006). |
333 |
Sharpless KB, Manetsch R.,
In Situ Click Chemistry: A Powerful Means for Lead Discovery,
Expert Opinion in Drug Discovery, 1(6), 525 (2006). |
332 |
Whiting M, Tripp JC, Lin YC, Lindstrom W, Olson AJ, Elder JH, Sharpless KB, Fokin VV.,
Rapid Discovery and Structure-Activity Profiling of Novel Inhibitors of HIV-1 Protease Enabled by the Copper(I)-Catalyzed Synthesis of 1,2,3-Triazoles and Their Further Functionalization,
J. Med. Chem., 49, 7697 (2006). |
331 |
Diaz DD, Converso A, Sharpless KB, Finn MG.,
2,6-Dichloro-9-thiabiycyclo[3.3.1]nonane: Multigram Display of Azide and Cyanide Components on a Versatile Scaffold,
Molecules, 11(4), 212 (2006). |
330 |
Whiting M, Muldoon J, Lin YC, Silverman SM, Lindstrom W, Olson AJ, Kolb HC, Finn MG, Sharpless KB, Elder JH, Fokin VV.,
Inhibitors of HIV-1 Protease By Using In Situ Click Chemistry,
Angew. Chem. Int. Ed., 45(9), 1435 (2006). |
329 |
Radic Z, Manetsch R, Krasinski A, Raushel J, Yamauchi J, Garcia C, Kolb H, Sharpless KB, Taylor P.,
Molecular Basis of Interactions of Cholinesterases with Tight Binding Inhibitors,
Chem.-Biol. Interact., 157-158, 133 (2005). |
328 |
Bourne Y, Radic Z, Kolb HC, Sharpless KB, Taylor P, Marchot P.,
Structural Insights into Conformational Flexibility at the Peripheral Site and Within the Active Center Gorge of AChE,
Chem.-Biol. Interact., 157-158, 159 (2005). |
327 |
Wu P, Malkoch M, Hunt JN, Vestberg R, Kaltgrad E, Finn MG, Fokin VV, Sharpless KB, Hawker CJ.,
Multivalent, Bifunctional Dendrimers Prepared by Click Chemistry,
Chem. Commun., 46, 5775 (2005). |
326 |
Zhang L, Chen X, Xue P, Sun HH, Williams ID, Sharpless KB, Fokin VV, Jia G.,
Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides,
J. Am. Chem. Soc., 127 (46), 15998 (2005). |
325 |
J. C. Loren, A. Krasiński, V. V. Fokin and K. B. Sharpless,
NH-1,2,3-Triazoles from Azidomethyl Pivalate and Carbamates: Tunable Base Labile Protecting Groups,
Synlett, 18, 2847 (2005). |
324 |
Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW.,
Bisaryloxime Ethers as Potent Inhibitors of Transthyretin Amyloid Fibril Formation,
J. Med. Chem., 48, 1576 (2005). |
323 |
J. C. Loren and K. B. Sharpless,
The Banert Cascade: A Synthetic Sequence to Polyfunctional NH-1,2,3-Triazoles,
Synthesis, 9, 1514 (2005). |
322 |
Feldman AK, Colasson B, Sharpless KB, Fokin VV.,
The Allylic Azide Rearrangement: Achieving Selectivity,
J. Am. Chem. Soc, 127, 13444 (2005). |
321 |
K. B. Sharpless, M. Andersson, R. Epple and V. V. Fokin,
Second Cycle Asymmetric Dihydroxylation Reaction, U.S. Patent Number 6,852,874 B2, issued February 8, 2005.
|
320 |
Krasinski A, Radic Z, Manetsch R, Raushel J, Taylor P, Sharpless KB, Kolb HC.,
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors,
J. Am. Chem. Soc., 127, 6686 (2005). |
319 |
Narayan S, Muldoon J, Finn MG, Fokin VV, Kolb HC, Sharpless KB.,
"On Water": Unique Reactivity Effects of Organic Compounds in Aqueous Suspensions,
Angew. Chem. Int. Ed., 44, 3275 (2005). |
318 |
Mocharla VP, Colasson B, Lee LV, Roper S, Sharpless KB, Wong CH, Kolb HC.,
In Situ Click Chemistry: Enzyme-Generated Inhibitors of Carbonic Anhydrase II,
Angew. Chem. Int. Ed., 44(1):116-20 (2004). |
317 |
Himo F, Lovell T, Hilgraf R, Rostovtsev VV, Noodleman L, Sharpless KB, Fokin VV.,
Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates,
J. Am. Chem. Soc., 127, 210 (2005). |
316 |
Chan TR, Hilgraf R, Sharpless KB, Fokin VV.,
Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis,
Org. Lett., 6(17):2853-5, (2004). |
315 |
Manetsch R, Krasinski A, Radic Z, Raushel J, Taylor P, Sharpless KB, Kolb HC.,
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications,
J. Am. Chem. Soc., 126(40):12809-18, (2004). |
314 |
Converso A, Saaidi PL, Sharpless KB, Finn MG.,
Nucleophilic Substitution by Grignard Reagents on Sulfur
Mustards, J. Org. Chem., 69(21):7336-9, (2004). |
313 |
D. D. Diaz, S. Punna, P. Holzer, A. K. McPherson, K. B. Sharpless,
V. V. Fokin, and M. G. Finn, Click Chemistry in Materials Synthesis.
1. Adhesive Polymers from Copper-Catalyzed Azide-Alkyne Cycloaddition,
J. Polym. Sci. Part A: Polym. Chem., 42, 4392 (2004). |
312 |
Wu P, Feldman AK, Nugent AK, Hawker CJ, Scheel A, Voit B, Pyun J, Frechet JM, Sharpless KB, Fokin VV.,
Efficiency and Fidelity in a Click Chemistry Route to
Triazole Dendrimers via the Cu(I)-Catalyzed Ligation of Azides
and Alkynes, Angew. Chem. Int. Ed., 43(30):3928-32, (2004). |
311 |
Krasinski A, Fokin VV, Sharpless KB.,
Direct Synthesis of 1,5-Disubstituted-4-magnesio-1,2,3-triazoles, Revisited,
Org. Lett., 6(8):1237-40, (2004). |
310 |
Bourne Y, Kolb HC, Radi Z, Sharpless KB, Taylor P, Marchot P.,
Freeze-frame Inhibitor Captures Acetylcholinesterase in a Unique Conformation,
Proc. Nat. Acad. Sci., 101(6):1449-54, (2004). |
309 |
Kitayama, T. Yokoi, Y. Kawai, R. K. Hill, M. Morita, T. Okamoto, Y. Yamamoto,
V. V. Fokin, K. B. Sharpless and S. Sawada, The Chemistry of Zerumbone.
Part 5: Structural Transformation of the Dimethylamine Derivatives, Tetrahedron,
59, 4857 (2003). |
308 |
Kolb HC, Sharpless KB.,
The Growing Impact of Click Chemistry on Drug Discovery,
Drug Discovery Today, 8(24):1128-37, (2003). |
307 |
Brik A, Muldoon J, Lin YC, Elder JH, Goodsell DS, Olson AJ, Fokin VV, Sharpless KB, Wong CH.,
Rapid Diversity-Oriented Synthesis in Microtiter Plates for In Situ Screening of HIV Protease Inhibitors,
ChemBioChem, 4(11):1246-8, (2003). |
306 |
Lee LV, Mitchell ML, Huang SJ, Fokin VV, Sharpless KB, Wong CH.,
A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry,
J. Am. Chem. Soc., 125(32):9588-9, (2003). |
305 |
A. E. Rubin and K. B. Sharpless, Synthesis of α,βSubstituted
Amino Amides, Esters, and Acids, U.S. Patent Number 6,573,387,
issued June 3, 2003. |
304 |
F. Himo, Z. P. Demko, L. Noodleman and K. B. Sharpless,
Why is Tetrazole Formation by Addition of Azide to Organic
Nitriles Catalyzed by Zinc (II) Salts?, J. Am. Chem. Soc.,
125, 9983 (2003). |
303 |
Ripka AS, Diaz DD, Sharpless KB, Finn MG.,
The First Practical Synthesis of Formamidine Ureas and Derivatives,
Org. Lett., 5(9):1531-3, (2003). |
302 |
G. Li and K. B. Sharpless, Two Step Synthesis of Dand
LαAmino Acids and D and LαAmino
Aldehydes, U.S. Patent Number 6,509,506, issued January 21,
2003. |
301 |
Wang Q, Chan TR, Hilgraf R, Fokin VV, Sharpless KB, Finn MG.,
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3+2] Cycloaddition,
J. Am. Chem. Soc., 125(11):3192-3, (2003). |
300 |
Himo F, Demko ZP, Noodleman L, Sharpless KB.,
Mechanisms of Tetrazole Formation by Addition of Azide to Nitriles,
J. Am. Chem. Soc., 124(41):12210-6, (2002). |
299 |
Rostovtsev VV, Green LG, Fokin VV, Sharpless KB.,
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective "Ligation" of Azides and Terminal Alkynes,
Angew. Chem. Int. Ed., 41(14):2596-9, (2002). |
298 |
Demko ZP, Sharpless KB.,
An expedient route to the tetrazole analogues of alpha-amino acids,
Org. Lett., 4(15):2525-7, (2002). |
297 |
Sharpless KB.,
Searching for New Reactivity,
Angew. Chem. Int. Ed., 41(12):2024-32, (2002). |
296 |
Fokin K, Sharpless KB., Aminohydroxylation of Olefins,
U.S. Patent Number 6,350,905, issued February 26, 2002. |
295 |
Demko ZP, Sharpless KB.,
A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-acyltetrazoles from azides and acyl cyanides.,
Angew. Chem. Int. Ed., 41(12):2113-6, (2002). |
294 |
Demko ZP, Sharpless KB., A Click Chemistry Approach to
A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-sulfonyl tetrazoles from azides and sulfonyl cyanides,
Angew. Chem. Int. Ed., 41(12):2110-3, (2002). |
293 |
Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG, Sharpless KB.,
Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks,
Angew. Chem. Int. Ed., 41(6):1053-7, (2002). |
292 |
Dupau P, Epple R, Thomas AA, Fokin VV, Sharpless KB.,
Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks,
Adv. Synth. Catal.
, 344, 421 (2002). |
291 |
Andersson MA, Epple R, Fokin VV, Sharpless KB.,
A New Approach to Osmium-Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins, Angew. Chem. Int. Ed.
, 41(3):472-5, (2002). |
290 |
Demko ZP, Sharpless KB.,
An intramolecular [2 + 3] cycloaddition route to fused 5-heterosubstituted tetrazoles,
Org. Lett., 3(25):4091-4, (2001). |
289 |
Demko ZP, Sharpless KB.,
Preparation of 5-substituted 1H-tetrazoles from nitriles in water,
J. Org. Chem., 66(24):7945-50, (2001). |
288 |
K. Yudin and K. B. Sharpless, Epoxidation of Olefins, U.S. Patent
number 6,271,400, issued August 7, 2001. |
287 |
Converso A, Burow K, Marzinzik A, Sharpless KB, Finn MG.,
2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: a Privileged, Bivalent Scaffold for the Display of Nucelophilic Components,
J. Org. Chem., 66(12):4386-92, (2001). |
286 |
Fokin VV, Sharpless KB.,
A Practical and Highly Efficient Aminohydroxylation of Unsaturated Carboxylic Acids,
Angew. Chem. Int. Ed., 40(18):3455-3457, (2001). |
285 |
Becker and K. B. Sharpless, Asymmetric Dihydroxylation, in "Asymmetric
Oxidation Reactions: A Practical Approach in Chemistry",
T. Katsuki, ed., Oxford University Press (2001). |
284 |
Petrassi HM, Sharpless KB, Kelly JW.,
The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: synthesis of aryloxyamines,
Org. Lett., 3(1):139-42, (2001). |
283 |
Kolb HC, Finn MG, Sharpless KB.,
Click Chemistry: Diverse Chemical Function from a Few Good Reactions,
Angew. Chem., 40(11), (2001). |
282 |
Chuang TH, Sharpless KB., Applications of aziridinium ions. Selective syntheses of alpha, beta-diamino esters, alpha-sulfanyl-beta-amino esters, beta-lactams, and 1,5-benzodiazepin-2-one,
Org. Lett., 2(23):3555-7, (2000). |
281 |
Marzinzik AL, Sharpless KB.,
A simple method for the preparation of N-sulfonylsulfilimines from sulfides.,
J. Org. Chem.,66(2):594-6, (2001). |
280 |
T.-H.
Chuang and K. B. Sharpless,
Applications of Aziridinium Ions:
Selective Syntheses of Pyrazolidin-3-ones and Pyrazolo[1,2-a]pyrazoles,
Helv. Chim. Acta, 83, 1734 (2000). |
279 |
Tao, G. Schlingloff and K. B. Sharpless, Synthesis of Aryl Serines,
U.S. Patent number 6,057,473, issued May 2, 2000. |
278 |
Demko ZP, Bartsch M, Sharpless KB.,
Primary amides. A general nitrogen source for catalytic asymmetric aminohydroxylation of olefins,
Org. Lett., 2(15):2221-3, (2000). |
277 |
Gontcharov, H. Liu and K. B. Sharpless, Aminohydroxylation of
Olefins with Tert-Alkyl Sulfonamides, U. S. Patent number 6,008,376,
issued December 28, 1999. |
276 |
G.
Li and K. B. Sharpless, Two Step Synthesis of D- and L- α-Amino
Acids and D- and L- α-Amino-Aldehydes, U.S. Patent number 5,994,583,
issued November 30, 1999. |
275 |
J.
Rudolph and K. B. Sharpless, Accelerated Catalysis of Olefinic
Epoxidations, U.S. Patent number 5,939,568, issued August 17,
1999. |
274 |
J.
U. Jeong and K. B. Sharpless, Aziridination of Olefins, U.S. Patent
number 5,929,252, issued July 27, 1999. |
273 |
Chuang TH, Sharpless KB.,
Applications of aziridinium ions. Selective syntheses of beta-aryl-alpha,beta-diamino esters,
Org. Lett., 1(9):1435-7, (1999). |
272 |
G.
Li, H.-T. Chang and K. B. Sharpless, Catalytic Asymmetric Aminohydroxylation
of Olefins with Sulfonamides, U.S. Patent number 5,859,281, issued
January 12, 1999. |
271 |
Thomas AA, Sharpless KB.,
The Catalytic Asymmetric Aminohydroxylation of Unsaturated Phosphonates,
J. Org. Chem., 64(22):8379-8385, (1999). |
270 |
Gontcharov AV, Liu H, Sharpless KB.,
Tert-butylsulfonamide. A new nitrogen source for catalytic aminohydroxylation and aziridination of olefins,
Org. Lett., 1(5):783-6, (1999). |
269 |
W.
Pringle and K. B. Sharpless, The Osmium-Catalyzed Aminohydroxylation
of Baylis-Hillman Olefins, Tetrahedron Lett., 40, 5151 (1999). |
268 |
H.
Adolfsson, A. Converso and K. B. Sharpless, Comparison of Amine
Additives Most Effective in the New Methyltrioxorhenium-Catalyzed
Epoxidation Process, Tetrahedron Lett., 40, 3991 (1999). |
267 |
Goossen LJ, Liu H, Dress KR, Sharpless KB.,
Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles as nitrogen sources,
Angew. Chem., 38(8):1080-3, (1999). |
266 |
G.
Li and K. B. Sharpless, Catalytic Asymmetric Aminohydroxylation
of Olefins with Carbamates, U.S. Patent number 5,767,304, issued
June 16, 1998. |
265 |
Gypser A, Michel D, Nirschl DS, Sharpless KB.,
Dihydroxylation of Polyenes Using Narasaka's Modification of the Upjohn Procedure.,
J. Org. Chem., 63(21):7322-7327, (1998). |
264 |
K.
R. Dress, L. J. Goossen, H. Liu, D. M. Jerina and K. B. Sharpless,
Catalytic Aminohydroxylation Using Adenine-Derivatives as the
Nitrogen Source, Tetrahedron Lett., 39, 7669 (1998). |
263 |
J.
U. Jeong, B. Tao, I. Sagasser, H. Henniges and K. B. Sharpless,
Bromine-Catalyzed Aziridination of Olefins. A Rare Example of
Atom-Transfer Redox Catalysis by a Main Group Element, J. Am.
Chem. Soc., 120, 6844 (1998). |
262 |
K.
L. Reddy, K. R. Dress and K. B. Sharpless, N-Chloro-N-Sodio-2-Trimethylsilyl
Ethyl Carbamate: A New Nitrogen Source for the Catalytic Asymmetric
Aminohydroxylation, Tetrahedron Lett., 39, 3667 (1998). |
261 |
B.
Tao, G. Schlingloff and K. B. Sharpless, Reversal of Regioselection
in the Asymmetric Aminohydroxylation of Cinnamates, Tetrahedron
Lett., 39, 2507 (1998). |
260 |
C.
Copéret, H. Adolfsson, T.-A. V. Khuong, A. K. Yudin and
K. B. Sharpless, A Simple and Efficient Method for the Preparation
of Pyridine-N-oxides, J. Org. Chem., 63, 1740 (1998). |
259 |
H.
C. Kolb and K. B. Sharpless, Asymmetric Aminohydroxylation, in
"Transition Metals for Organic Synthesis: Building Blocks
and Fine Chemicals", M. Beller and C. Bolm, eds., Wiley-VCH
(1998). |
258 |
G.
Schlingloff and K. B. Sharpless, Asymmetric Aminohydroxylation,
in "Asymmetric Oxidation Reactions: A Practical Approach
in Chemistry", T. Katsuki, ed., Oxford University Press (2001). |
257 |
C.
Copéret, H. Adolfsson, J. P. Chiang, A. K. Yudin and K.
B. Sharpless, A Simple and Efficient Method for the Preparation
of Pyridine-N-oxides II, Tetrahedron Lett., 39, 761 (1998). |
256 |
K.
L. Reddy and K. B. Sharpless, From Styrenes to Enantiopure α-Arylglycines
in Two Steps, J. Am. Chem. Soc., 120, 1207 (1998). |
255 |
A.
J. DelMonte, J. Haller, K. N. Houk, K. B. Sharpless, D. A. Singleton,
T. Strassner and A. A. Thomas, Experimental and Theoretical Kinetic
Isotope Effects for Asymmetric Dihyroxylation. Evidence Supporting
a Rate-Limiting "(3 + 2)" Cycloaddition, J. Am. Chem. Soc., 119, 9907 (1997). |
254 |
A.
K. Yudin and K. B. Sharpless, Bis(trimethylsilyl) Peroxide Extends
the Range of Oxorhenium Catalysts for Olefin Expoxidation, J.
Am. Chem. Soc., 119, 11536 (1997). |
253 |
A.
Erik Rubin and K. B. Sharpless, A Highly Efficient Aminohydroxylation
Process, Angew. Chem., 36, 2637 (1997). |
252 |
C.
Copéret, H. Adolfsson and K. B. Sharpless, A Simple and
Efficient Method for Epoxidation of Terminal Alkenes, Chem. Comm.,
16, 1565 (1997). |
251 |
J.
Rudolph, K.L. Reddy, J. P. Chiang and K. B. Sharpless, Highly
Efficient Epoxidation of Olefins using Aqueous H2O2 and Catalytic
Methyltrioxorhenium/Pyridine: Pyridine-mediated Ligand Acceleration,
J. Am. Chem. Soc., 119, 6189 (1997). |
250 |
M.
Bruncko, G. Schlingloff and K. B. Sharpless, N-Bromoacetamide
- A New Nitrogen Source for the Catalytic Asymmetric Aminohydroxylation,
Angew. Chem., 36, 1483 (1997). |
249 |
D.W.
Nelson, A. Gypser, P.T. Ho, H.C. Kolb, T. Kondo, H.-L. Kwong,
D.V. McGrath, A.E. Rubin, P.-O. Norrby, K.P. Gable and K.B. Sharpless,
Toward an Understanding of the High Enantioselectivity in the
Osmium-Catalyzed Asymmetric Dihydroxylation. 4. Electronic Effects in Amine-Accelerated Osmylations,
J. Am. Chem. Soc., 119, 1840 (1997). |
248 |
K.P.M.
Vanhessche and K.B. Sharpless, Catalytic Asymmetric Synthesis
of New Halogenated Chiral Synthons, Chemistry - A European Journal,
3, 517 (1997). |
247 |
G.
Li, H.H. Angert and K.B. Sharpless, N-Halocarbamate Salts Provide
a More Useful Catalytic-Asymmetric-Aminohydroxylation Process,
Angew. Chem., 35, 2813 (1996). |
246 |
J.
Rudolph, P.C. Sennhenn, C.P. Vlaar and K.B. Sharpless, Smaller
Substituents on Nitrogen Facilitate the Osmium Catalyzed Asymmetric
Aminohydroxylation Process, Angew. Chem., 35, 2810 (1996). |
245 |
Vanhessche KP, Sharpless KB.,
Ligand-Dependent Reversal of Facial Selectivity in the Asymmetric Dihydroxylation,
J. Org. Chem., 61(23):7978-7979, (1996). |
244 |
Chang HT, Sharpless KB.,
Molar Scale Synthesis of Enantiopure Stilbene Oxide,
J. Org. Chem., 61(18):6456-6457, (1996). |
243 |
M.
Beller and K.B. Sharpless, Syntheses of Diols by Catalytic Dihydroxylation
Reactions, "Applied Homogeneous Catalysis by Organometallic
Complexes", Boy Cornils and Wolfgang A. Herrmann. Eds.; VCH
Publishers, 1996. |
242 |
K.B.Sharpless,
M. Beller, B. Blackburn, Y. Kawanami, H.-L. Kwong, Y. Ogino, T.
Shibata, T. Ukita and L. Wang, Method For Catalytic Asymmetric
Dihydroxylation of Olefins Using Heterocyclic Chiral Ligands,
U.S. Patent 5,516,929, 1996 assigned to Massachusetts Institute of Technology. |
241 |
I.E.
Marko and K. B. Sharpless, Ligand-Accelerated Catalytic Asymmetric
Dihydroxylation, European Patent 0395729, 1996, assigned to Massachusetts
Institute of Technology. |
240 |
H.-T.
Chang and K.B. Sharpless, A Practical Route to Enantiopure 1,2-Aminoalcohols,
Tetrahedron Lett., 37, 3219 (1996). |
239 |
Li G, Sharpless KB.,
Catalytic Asymmetric Aminohydroxylation Provides a Short Taxol Side-chain Synthesis,
Acta Chem. Scand., 50(8):649-51, (1996). |
238 |
M.
Bruncko, T.-A.V. Khuong. and K.B. Sharpless, Allylic Amination
and 1,2-Diamination via a Modified Diimido Selenium Reagent, Angew.
Chem., 35, 454 (1996). |
237 |
G.
Li, H.-T. Chang, and K.B. Sharpless, Catalytic Asymmetric Aminohydroxylation
of Olefins, Angew. Chem., 35, 451 (1996). |
236 |
H.
Becker and K.B. Sharpless, A New Ligand Class for the Asymmetric
Dihydroyxlation of Olefins, Angew. Chem., 35, 448 (1996). |
235 |
P.F.
Richardson, L.T.J. Nelson, and K.B. Sharpless, Synthesis of Vicinal
Diamines from Cyclic Sulfates, Tetrahedron Lett., 36, 9241 (1995). |
234 |
P.-O.
Norrby, H. Becker, and K.B. Sharpless, Towards an Understanding
of the High Enantioselectivity in the Osmium Catalyzed Asymmetric
Dihydroyxlation (AD). Part 3. New Insights into Isomeric Forms
of the Putative Osmaoxetane Intermediate, J. Am. Chem. Soc, 118, 35 (1996). |
233 |
H.-T.
Chang, C.-T. Chen, T. Kondo, G. Siuzdak, and K.B. Sharpless, Asymmetric
Dihydroxylation Enables Rapid Construction of Chiral Dendrimers,
Angew. Chem., 35, 182 (1996). |
232 |
U.
Hugger and K.B. Sharpless, Asymmetric Dihyroxylation Affords Enantiomerically
Pure C12 Building Blocks from trans, trans, cis-1,5,9-Cyclododecatriene,
Tetrahedron Lett., 36, 6603 (1995). |
231 |
H.
Becker, S.B. King, M. Taniguchi, K.P.M. Vanhessche, and K.B. Sharpless,
New Ligands and Improved Enantioselectivities for the Asymmetric
Dihydroxylation of Olefins, J. Org. Chem., 60, 3940 (1995). |
230 |
K.B.
Sharpless and J.M. Klunder, Optically Active Derivatives of Glycidol,
U.S. Patent 5,344,947, 1994 assigned to Massachusetts Institute
of Technology. |
229 |
D.J.
Berrisford, C. Bolm, and K.B. Sharpless, Ligand Accelerated Catalysis,
Angew. Chem., Int. Ed. Engl., 34, 1059 (1995). |
228 |
H.
Becker, M.A. Soler, and K.B. Sharpless, Selective Asymmetric Dihydroxylation
of Polyenes, Tetrahedron, 51, 1345 (1995). |
227 |
Z.-M.
Wang and K.B. Sharpless, A Solid-to-Solid Asymmetric Dihydroxylation
Procedure for Kilo-Scale Preparation of Enantiopure Hydrobenzoin,
J. Org. Chem., 59, 8302 (1994). |
226 |
Z.-M.
Wang, K. Kakiuchi, and K.B. Sharpless, Osmium-Catalyzed Asymmetric
Dihydroxylation of Cyclic cis-Disubstituted Olefins, J. Org. Chem.,
59, 6895 (1994). |
225 |
H.C.
Kolb, M.S. VanNieuwenhze, and K.B. Sharpless, Catalytic Asymmetric
Dihydroxylation, Chem. Rev., 94, 2483 (1994). |
224 |
H.
Becker, P.T. Ho, H.C. Kolb, S. Loren, P.-O. Norrby, and K.B. Sharpless,
Comparing Two Models for the Selectivity in the Asymmetric Dihydroxylation
Reaction (AD), Tetrahedron Lett., 35, 7315 (1994). |
223 |
P.-O.
Norrby, H.C. Kolb, and K.B. Sharpless, Towards an Understanding
of the High Enantioselectivity in the Osmium Catalyzed Asymmetric
Dihydroxylation (AD). Part 2. A Qualitative Molecular Mechanics
Approach., J. Am. Chem. Soc., 116, 8470 (1994). |
222 |
Y.L.
Bennani, K.P.M. Vanhessche, and K.B. Sharpless, A Short Route
to a Mosher's Acid Precursor Via Catalytic Asymmetric Dihydroxylation
(AD), Tetrahedron: Asymmetry, 5, 1473 (1994). |
221 |
K.B.
Sharpless and Y. Gao, Ruthenium-Catalyzed Production of Cyclic
Sulfates, U.S. Patent 5,321,143, 1994 assigned to Massachusetts
Institute of Technology. |
220 |
S.B.
King and K.B. Sharpless, An Efficient Synthesis of Enantiomerically
Pure trans-2-Phenylcyclohexanol, Tetrahedron Lett., 35, 5611 (1994). |
219 |
Z.-M.
Wang, H.C. Kolb, and K.B. Sharpless, A Large-Scale and Highly
Enantioselective Synthesis of the Taxol C-13 Side Chain Through
Asymmetric Dihydroxylation (AD), J. Org. Chem., 59, 5104 (1994). |
218 |
P.J.
Walsh, P.T. Ho, S.B. King, and K.B. Sharpless, Asymmetric Dihydroxylation
of Olefins Containing Sulfur: Chemoselective Oxidation of C-C
Double Bonds in the Presence of Sulfides, 1,3-Dithianes, and Disulfides,
Tetrahedron Lett., 35, 5129 (1994). |
217 |
D.
Xu and K.B. Sharpless, Synthesis and Stereochemical Assignments
for Goniobutenolides A and B, Tetrahedron Lett., 35, 4685 (1994). |
216 |
K.
P. M. Vanhessche, Z.-M. Wang, and K. B. Sharpless, Asymmetric
Dihydroxylation of Primary Alloylic Halides and a Concise Synthesis
of (-)-Diepoxybutane, Tetrahedron Lett., 35, 3469 (1994) |
215 |
D.
Xu, C.Y. Park, and K.B. Sharpless, Study of the Regio- and Enantioselectivity
of the Reactions of Osmium Tetroxide with Allylic Alcohols and
Allylic Sulfonamides, Tetrahedron Lett., 35, 2495 (1994). |
214 |
K.B.
Sharpless, Coelacanths and Catalysis, Tetrahedron, 50, 4235 (1994). |
213 |
H.C.
Kolb, P.G. Andersson, and K.B. Sharpless, Towards an Understanding
of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric
Dihydroxylation (AD). Part 1: Kinetics, J. Am. Chem. Soc., 116,
1278 (1994). |
212 |
M.S.
VanNieuwenhze and K.B. Sharpless, The Asymmetric Dihydroxylation
of cis-Allylic and Homoallylic Alcohols, Tetrahedron Lett., 35,
843 (1994). |
211 |
I.
Henderson, K.B. Sharpless, and C.-H. Wong, Synthesis of Carbohydrates
via Tandem Use of the Osmium-Catalyzed Asymmetric Dihydroxylation
and Enzyme-Catalyzed Aldol Addition Reactions, J. Am. Chem. Soc.,
116, 558 (1994). |
210 |
H.C.
Kolb, P.G. Andersson, Y.L. Bennani, G.A. Crispino, K.-S. Jeong,
H.-L. Kwong, and K.B. Sharpless, On "The Origin of High Enantioselectivity
in the Dihydroxylation of Olefins Using Osmium Tetroxide and Cinchona
Alkaloid Catalysts," J. Am. Chem. Soc., 115, 12226 (1993). |
209 |
G.
Crispino, A. Makita, Z.-M. Wang, and K.B. Sharpless, A Comparison
of Ligands Proposed for the Asymmetric Dihydroxylation, Tetrahedron
Lett., 35, 543 (1994). |
208 |
P.-O.
Norrby, H. Kolb, and K.B. Sharpless, Calculations on the Reaction
of Ruthenium Tetroxide with Olefins Using Density Functional Theory
(DFT). Implications for the Possibility of Intermediates in the
Osmium-catalyzed Asymmetric Dihydroxylation (AD), Organometallics, 13, 344 (1994). |
207 |
Z.-M.
Wang and K.B. Sharpless, Asymmetric Dihydroxylation of Tertiary
Allylic Alcohols, Tetrahedron Lett., 34, 8225 (1993). |
206 |
R.
Oi and K.B. Sharpless, 3-(1S,2-Dihydroxyethyl)-1,5-Dihydro-3H-2,4-Benzodioxepine,
Org. Synth., 73, 1 (1995). |
205 |
M.
Arrington, Y.L. Bennani, T. Göbel, P. Walsh, S.-H. Zhao,
and K.B. Sharpless, Modified Cinchona Alkaloid Ligands: Improved
Selectivities in the Osmium Tetroxide Catalyzed Asymmetric Dihydroxylation
(AD) of Terminal Olefins, Tetrahedron Lett., 34, 7375 ( |
204 |
K.
Morikawa and K.B. Sharpless, Double Diastereoselection in Asymmetric
Dihydroxylation, Tetrahedron Lett., 34, 5575 (1993). |
203 |
K.
Morikawa, J. Park, P.G. Andersson, T. Hashiyama, and K.B. Sharpless,
Catalytic Asymmetric Dihydroxylation of Tetrasubstituted Olefins,
J. Am. Chem. Soc., 115, 8463 (1993). |
202 |
P.J.
Walsh, Y.L. Bennani, and K.B. Sharpless, Asymmetric Dihydroxylation
(AD)/Cyclization of N-DiBoc Allylic and Homoallylic Amines: Selective
Differentiation of the Hydroxyl Groups, Tetrahedron Lett., 34,
5545 (1993). |
201 |
D.V.
McGrath, G.D. Brabson, K.B. Sharpless, and L. Andrews, Reinvestigation
of the Infrared Spectra of Oxoosmium (VI) Esters by Isotopic Labeling,
Inorg. Chem., 32, 4164 (1993). |
200 |
G.A.
Crispino and K.B. Sharpless, Enantioselective Synthesis of Juvenile
Hormone III in Three Steps from Methyl Farnesoate, Synthesis,
8, 777 (1993). |
199 |
P.J.
Walsh and K.B. Sharpless, Asymmetric Dihydroxylation (AD) of a,b-Unsaturated
Ketones, Synlett, 8, 605 (1993). |
198 |
Z.-M.
Wang and K.B. Sharpless, Asymmetric Dihydroxylation of a-Substituted
Styrene Derivatives, Synlett, 8, 603 (1993). |
197 |
M.S.
VanNieuwenhze and K.B. Sharpless, Kinetic Resolution of Racemic
Olefins via Asymmetric Dihydroxylation, J. Am. Chem. Soc., 115,
7864 (1993). |
196 |
P.G.
Andersson and K.B. Sharpless, A Dramatic Ligand Effect on the
Relative Reactivities of Substituted Alkenes with Osmium Tetroxide,
J. Am. Chem. Soc., 115, 7047 (1993). |
195 |
T.
Göbel and K.B. Sharpless, Temperature Effects in Asymmetric
Dihydroxylation: Evidence for a Stepwise Mechanism, Angew. Chem.,
Int. Ed. Engl., 32, 1329 (1993). |
194 |
G.
Crispino, K.-S. Jeong, H. Kolb, Z.-M. Wang, D. Xu, and K.B. Sharpless,
Improved Enantioselectivity in Asymmetric Dihydroxylations of
Terminal Olefins Using Pyrimidine Ligands, J. Org. Chem., 58,
3785 (1993). |
193 |
S.
Okamoto, K. Tani, F. Sato, K.B. Sharpless, and D. Zargarian, Synthesis
of Optically Active Secondary Allylic Alcohols from Allylsilanes
via Successive Asymmetric Dihydroxylation (AD) and Peterson Olefination
Reactions, Tetrahedron Lett., 34, 2509 (1993 |
192 |
Z.-M.
Wang, X.L. Zhang, and K.B. Sharpless, Asymmetric Dihydroxylation
of Aryl Allyl Ethers, Tetrahedron Lett., 34, 2267 (1993). |
191 |
Y.L.
Bennani and K.B. Sharpless, Asymmetric Synthesis of g-Hydroxy
a,b-Unsaturated Amides via an AD-Elimination Process; Synthesis
of (+)-Coriolic Acid, Tetrahedron Lett., 34, 2083 (1993). |
190 |
Y.L.
Bennani and K.B. Sharpless, Asymmetric Dihydroxylation (AD) of
N,N-Dialkyl and N-Methoxy-N-methyl α,β-and β, γ-unsaturated amides,
Tetrahedron Lett., 34, 2079 (1993). |
189 |
D.
Xu and K.B. Sharpless, A Simple Route to Enantiomerically Enriched
Oxazolidin-2-ones, Tetrahedron Lett., 34, 951 (1993). |
188 |
H.C.
Kolb, Y.L. Bennani, and K.B. Sharpless, Short and Practical Syntheses
of (R)-()-Carnitine and (R)-()-g-Amino-b-hydroxybutyric
Acid (GABOB), Tetrahedron: Asymmetry, 4, 133 (1993). |
187 |
G.A.
Crispino and K.B. Sharpless, Enantioselective Synthesis of Both
Enantiomers of 7,7-Dimethyl-6,8-dioxabicyclo-[3.2.1]octane via
Regioselective Asymmetric Dihydroxylation, Synlett, 1, 47 (1993)
. |
186 |
Crispino GA, Ho PT, Sharpless KB.,
Selective perhydroxylation of squalene: taming the arithmetic demon,
Science, 259(5091):64-6, (1993). |
185 |
H.C.
Kolb and K.B. Sharpless, A Simplified Procedure for the Stereospecific
Transformation of 1,2-Diols into Epoxides, Tetrahedron, 48, 10515
(1992). |
184 |
E.
Keinan, S.C. Sinha, A. Sinha-Bagchi, Z.-M. Wang, X.L. Zhang, and
K.B. Sharpless, Synthesis of All Four Isomers of Disparlure Using
Osmium-Catalyzed Asymmetric Dihydroxylation, Tetrahedron Lett.,
33, 6411 (1992). |
183 |
Z.-M.
Wang, X.L. Zhang, K.B. Sharpless, S.C. Sinha, A. Sinha-Bagchi,
and E. Keinan, A General Approach to g-Lactones via Osmium-Catalyzed
Asymmetric Dihydroxylation. Synthesis of ()- and (+)-Muricatacin,
Tetrahedron Lett., 33, 6407 (1992). |
182 |
R.A.
Johnson and K.B. Sharpless, Catalytic Asymmetric Dihydroxylation,
"Catalytic Asymmetric Synthesis," Iwao Ojima, Ed.; VCH
Publishers (1993). |
181 |
R.A.
Johnson and K.B. Sharpless, Catalytic Asymmetric Epoxidation of
Allylic Alcohols, "Catalytic Asymmetric Synthesis,"
Iwao Ojima, Ed.; VCH Publishers (1993). |
180 |
W.
Amberg, Y.L. Bennani, R.J. Chadha, G.A. Crispino, W.D. Davis,
J. Hartung, K.-S. Jeong, Y. Ogino, T. Shibata, and K.B. Sharpless,
Syntheses and Crystal Structures of the Cinchona Alkaloid Derivatives
used as Ligands in the Osmium-Catalyzed Asymmetric Dihydroxylation of Olefins,
J. Org. Chem., 58, 844 (1993). |
179 |
T.
Hashiyama, K. Morikawa, and K.B. Sharpless, a-Hydroxy Ketones
in High Enantiomeric Purity from Asymmetric Dihydroxylation of
Enol Ethers, J. Org. Chem., 57, 5067 (1992). |
178 |
D.
Xu, G. A. Crispino, and K.B. Sharpless, Selective Asymmetric Dihydroxylation
(AD) of Dienes, J. Am. Chem. Soc., 114, 7570 (1992). |
177 |
L.
Wang and K.B. Sharpless, Catalytic Asymmetric Dihydroxylation
of Cis-Disubstituted Olefins, J. Am. Chem. Soc., 114, 7568 (1992). |
176 |
Kalantar TH, Sharpless KB.,
Transformations of hydroxy cyclic sulfates: stereospecific conversion into 2,3,5-trisubstituted tetrahydrofurans,
Acta Chemica Scandinavica, 47(3):307-13, (1993). |
175 |
G.
Crispino and K.B. Sharpless, Asymmetric Dihydroxylation of Squalene,
Tetrahedron Lett., 33, 4273 (1992). |
174 |
K.-S.
Jeong, P. Sjö, and K.B. Sharpless, Asymmetric Dihydroxylation
of Enynes, Tetrahedron Lett., 33, 3833 (1992). |
173 |
K.B.
Sharpless, W. Amberg, Y. Bennani, G. Crispino, J. Hartung, K.
Jeong, H. Kwong, K. Morikawa, Z.M. Wang, D. Xu, and X.L. Zhang,
The Osmium-Catalyzed Asymmetric Dihydroxylation (AD): A New Ligand
Class and a Process Improvement, J. Org. Chem., 57, 2768 |
172 |
R.
Oi and K.B. Sharpless, Asymmetric Dihydroxylation of Acrolein
Acetals: Synthesis of Stable Equivalents of Enantiopure Glyceraldehyde
and Glycidaldehyde, Tetrahedron Lett., 33, 2095 (1992). |
171 |
B.
McKee, T. Kalantar, and K.B. Sharpless, Subtle Effects in the
Asymmetric Epoxidation: Dependence of Kinetic Resolution Efficiency
on the Monodentate Alkoxide Ligands of the Bystander Titanium
Center, J. Org. Chem., 56, 6966 (1991). |
170 |
Y.
Ogino, H. Chen, E. Manoury, T. Shibata, M. Beller, D. Lübben,
and K.B. Sharpless, A Ligand Structure-Enantioselectivity Relationship
for the Osmium-Catalyzed Asymmetric Dihydroxylation of Olefins,
Tetrahedron Lett., 32, 5761, (1991). |
169 |
R.
Oi and K.B. Sharpless, Facile Synthesis of Enantiopure trans-2,3-Diphenyl-1,4-Diazabicyclo[2.2.2.]Octane,
Tetrahedron Lett., 32, 4853, (1991). |
168 |
K.
B. Sharpless, W. Amberg, M. Beller, H. Chen, J. Hartung, Y. Kawanami,
D. Lübben, E. Manoury, Y. Ogino, T. Shibata, and T. Ukita,
New Ligands Double the Scope of the Catalytic Asymmetric Dihydroxylation
of Olefins., J. Org. Chem., 56, 4585, (1991). |
167 |
Y.
Ogino, H. Chen, H.L. Kwong, and K.B. Sharpless, On the Timing
of Hydrolysis/Reoxidation in the Osmium-Catalyzed Asymmetric Dihydroxylation
of Olefins Using Potassium Ferricyanide as the Reoxidant., Tetrahedron
Lett., 32, 3965, (1991). |
166 |
K.B.
Sharpless, J.M. Klunder, and T.H. Onami, Optically Active Derivatives
of Glycidol, U. S. Patent 4,946,974, 1990 assigned to Massachusetts
Institute of Technology. |
165 |
K.B.
Sharpless and I.E. Markó, Ligand-Accelerated Catalytic
Asymmetric Dihydroxylation, U.S. Patent 4,965,364, 1990 assigned
to Massachusetts Institute of Technology. |
164 |
B.
McKee, D. Gilheany, and K.B. Sharpless, R,R-1,2-Diphenyl-1,2-ethanediol
(stilbene diol)., Org. Synth., 70, 47, (1991). |
163 |
C.
Park, B.M. Kim, and K.B. Sharpless, Catalytic Osmylation of Conjugated
Dienes: A One-Pot Stereoselective Synthesis of Polyols., Tetrahedron
Lett., 32, 1003, (1991). |
162 |
R.
Oi and K.B. Sharpless, Stereospecific Conversion of Chiral 1,2-Cyclic
Sulfates to Chiral Imidazolines., Tetrahedron Lett., 32, 999,
(1991). |
161 |
P.R.
Fleming and K.B. Sharpless, Selective Transformation of threo-2,3-Dihydroxy
Esters., J. Org. Chem., 56, 2869, (1991). |
160 |
M.G.
Finn and K.B. Sharpless, Mechanism of Asymmetric Epoxidation.
2. Catalyst Structure, J. Am. Chem. Soc., 113, 113, (1991). |
159 |
S.S.
Woodard, M.G. Finn, and K. Barry Sharpless, The Mechanism of Asymmetric
Epoxidation. 1. Kinetics, J. Am. Chem. Soc., 113, 106, (1991). |
158 |
R.A.
Johnson and K.B. Sharpless, Addition Reactions with Formation
of Carbon-Oxygen Bonds: (ii) Asymmetric Methods of Epoxidation,
"Comprehensive Organic Synthesis," Vol. 7, Barry M.
Trost, Ed.; Pergamon Press, (1991), pp. 389-436. |
157 |
B.M.
Kim and K.B. Sharpless, A Short Route to ß-Lactams: Use
of Cyclic Sulfites From Syn-2,3-Dihydroxy Esters, Tetrahedron
Lett., 31, 4317, (1990). |
156 |
T.
Shibata, D.G. Gilheany, B.K. Blackburn, and K.B. Sharpless, Ligand-Based
Improvement of Enantioselectivity in the Catalytic Asymmetric
Dihydroxylation of Dialkyl Substituted Olefins, Tetrahedron Lett.,
31, 3817, (1990). |
155 |
K.B.
Sharpless, R. Hanson, and S.Y. Ko, Catalytic Asymmetric Epoxidation,
U.S. Patent 4,900,847, 1990 assigned to the Massachusetts Institute
of Technology. |
154 |
B.M.
Kim and K.B. Sharpless, Heterogeneous Catalytic Asymmetric Dihydroxylation:
Use of a Polymer-Bound Alkaloid, Tetrahedron Lett., 31, 3003,
(1990). |
153 |
H.
Kwong, C. Sorato, Y. Ogino, H. Chen, and K.B. Sharpless, Preclusion
of the "Second Cycle" in the Osmium-Catalyzed Asymmetric
Dihydroxylation of Olefins Leads to a Superior Process, Tetrahedron
Lett., 31, 2999, (1990). |
152 |
R.M.
Pearlstein, B.K. Blackburn, W.M. Davis, and K.B. Sharpless, Structural
Characterization of the Pseudoenantiomeric Cis-Dioxo Osmium(VI)
Esters of Chiral Diols with Cinchona Alkaloid Ligands, Angew.
Chem., Int. Ed. Engl., 29, 639, (1990). |
151 |
M.
Hayashi, F. Okamura. T. Toba, N. Oguni, and K.B. Sharpless, Kinetic
Resolution of Racemic β-Hydroxy Amines by Enantioselective N-Oxide
Formation, Chem. Lett., 547 (1990). |
150 |
K.B.
Sharpless and I.E. Markó, Ligand-Accelerated Catalytic
Asymmetric Dihydroxylation using Dihydroquinidine and Dihydroquinidine
Esters as Ligands, U.S Patent 4,871,855, 1989 assigned to the
Massachusetts Institute of Technology. |
149 |
G.D.H.
Dijkstra, R.M. Kellogg, and H. Wynberg; J.S. Svendsen, I. Markó,
and K.B. Sharpless, Conformational Study of Cinchona Alkaloids.
A Combined NMR, Molecular Mechanics and X-Ray Approach, J. Am.
Chem. Soc., 111, 8069 (1989). |
148 |
P.R.
Carlier and K.B. Sharpless, Studies on the Mechanism of the Asymmetric
Epoxidation: A Ligand Variation Approach, J. Org. Chem., 54, 4016
(1989). |
147 |
C.J.
Burns, C.A. Martin, and K.B. Sharpless, Tartrate-Like Ligands
in the Asymmetric Epoxidation, J. Org. Chem., 54, 2826 (1989). |
146 |
B.M.
Kim and K.B. Sharpless, Cyclic Sulfates Containing Acid-Sensitive
Groups and Chemoselective Hydrolysis of Sulfate Esters, Tetrahedron
Lett., 30, 655, (l989). |
145 |
B.B.
Lohray, T.H. Kalantar, B.M. Kim, C.Y. Park, T. Shibita, J.S.M.
Wai, and K.B. Sharpless, Documenting the Scope of the Catalytic
Asymmetric Dihydroxylation, Tetrahedron Lett., 30, 2041 (1989). |
144 |
J.S.
Svendsen, I. Markó, E.N. Jacobsen, Ch.P. Rao, S. Bott,
and K.B. Sharpless, On the Structure of Osmium Tetroxide-Cinchona
Alkaloid Complexes, J. Org. Chem., 54, 2263 (1989). |
143 |
B.B.
Lohray, Y. Gao, and K.B. Sharpless, One Pot Synthesis of Homochiral
Aziridines and Aminoalcohols from Homochiral 1,2-Cyclic Sulfates,
Tetrahedron Lett., 30, 2623 (1989). |
142 |
W.
Bartmann and K.B. Sharpless, eds., "Stereochemistry of Organic
and Bioorganic Transformations," VCH Verlagsgesellschaft,
Weinheim, 1987. |
141 |
S.Y. Ko, A.W.M. Lee, S.A. Masamune, L.A. Reed, III, K.B. Sharpless,
and F.J. Walker, Total Synthesis of the L-Hexoses, Tetrahedron,
46, 245 (1990). |
140 |
J.S.M.
Wai, I. Markó, J.S. Svendsen, M.G. Finn, E.N. Jacobsen,
and K.B. Sharpless, A Mechanistic Insight Leads to a Greatly Improved
Osmium-Catalyzed Asymmetric Dihydroxylation Process, J. Am. Chem.
Soc., 111, 1123 (1989). |
139 |
E.N.
Jacobsen, I. Markó, M.B. France, J.S. Svendsen, and K.B.
Sharpless, Kinetic Role of the Alkaloid Ligands in Asymmetric
Catalytic Dihydroxylation, J. Am. Chem. Soc., 111, 737 (1989). |
138 |
J.M.
Klunder, T. Onami, and K.B. Sharpless, Arenesulfonate Derivatives
of Homochiral Glycidol: Versatile Chiral Building Blocks for Organic
Synthesis, J. Org. Chem., 54, 1295 (1989). |
137 |
Y.
Gao and K.B. Sharpless, Vicinal Diol Cyclic Sulfates: Like Epoxides
Only More Reactive, J. Am. Chem. Soc., 110, 7538 (1988). |
136 |
C.
Bolm and K.B. Sharpless, Synthesis of a C3-Symmetric Phospha[2.2.2]
Cyclophane, Tetrahedron Lett., 29, 5101 (1988). |
135 |
M.
Caron, P.R. Carlier, and K.B. Sharpless, Regioselective Azide
Opening of 2,3-Epoxy Alcohols by [Ti(Oi-Pr)2(N3)2]: Synthesis
of a-Amino Acids, J. Org. Chem., 53, 5185 (1988). |
134 |
Y.
Gao and K.B. Sharpless, Asymmetric Synthesis of Both Enantiomers
of Tomoxetine and Fluoxetine. Selective Reduction of 2,3-Epoxycinnamyl
Alcohol with Red-Al, J. Org. Chem., 53, 4081 (1988). |
133 |
Y.
Gao and K.B. Sharpless, Ti(O-i-Pr)4-Mediated Formation of 2,3-Epithio
Alcohols from 2,3-Epoxy Alcohols, J. Org. Chem., 53, 4114 (1988). |
132 |
C.
Bolm, W.M. Davis, R.L. Halterman, and K.B. Sharpless, Synthesis
and Crystal Structure of a Chiral C3-Symmetric Monophosphine,
Angew. Chem., Int. Ed. Engl., 27, 835 (1988). |
131 |
P.
Carlier, W.S. Mungall, G. Schröder, and K.B. Sharpless, Enhanced
Kinetic Resolution and Enzyme-Like Shape Selectivity, J. Am. Chem.
Soc., 110, 2978 (1988). |
130 |
K.B.
Sharpless, Catalytic Asymmetric Epoxidation, Janssen Chimica Acta,
6, 3 (1988). |
129 |
E.N.
Jacobsen, I. Markó, W.S. Mungall, G. Schröder, and
K.B. Sharpless, Asymmetric Dihydroxylation via Ligand-Accelerated
Catalysis, J. Am. Chem. Soc., 110, 1968 (1988). |
128 |
J.M.
Hawkins and K.B. Sharpless, Asymmetric Epoxidation Models: An
Alkyl Hydroperoxide Dependent Change in Mechanism, Tetrahedron
Lett., 28, 2825 (1987). |
127 |
J.M.
Klunder and K.B. Sharpless, A Convenient Synthesis of Sulfinate
Esters from Sulfonyl Chlorides, J. Org. Chem., 52, 2598 (1987). |
126 |
S.F.
Pedersen, J.C. Dewan, R.R. Eckman, and K.B. Sharpless, Unexpected
Diversity in the Coordination Chemistry of Tartrate Esters with
Titanium(IV), J. Am. Chem. Soc., 109, 1279 (1987). |
125 |
Elbein AD, Szumilo T, Sanford BA, Sharpless KB, Adams C.,
Effect of isomers of swainsonine on glycosidase activity and glycoprotein processing,
Biochemistry, 26(9):2502-10, (1987). |
124 |
S.Y.
Ko, H. Masamune, and K.B. Sharpless, p-Nitrobenzoate Esters of
Epoxy Alcohols: Convenient Synthons for Water-Soluble Epoxy Alcohols,
J. Org. Chem., 52 , 667 (1987). |
123 |
K.B.
Sharpless, Architecturally Interesting Metal Complexes with Thermodynamically
Dictated Structures, Chemica Scripta (Sweden), 27, 521 (1987). |
122 |
S.Y.
Ko and K.B. Sharpless, In Situ Opening of Epoxy Alcohols: A Convenient
Alternative to the Isolation of Unstable Epoxy Alcohols, J. Org.
Chem., 51, 5413 (1986). |
121 |
Y.
Gao, R.M. Hanson, J.M. Klunder, S.Y. Ko, H. Masamune, and K.B.
Sharpless, Catalytic Asymmetric Epoxidation and Kinetic Resolution:
Modified Procedures Including In Situ Derivatization, J. Am. Chem.
Soc., 109, 5765 (1987). |
120 |
K.S.
Kirshenbaum and K.B. Sharpless, Regioselective Nucleophilic Opening
of erythro- and threo-2, 3 Epoxy Alcohols, Chem. Lett., 11 (1987). |
119 |
J.M.
Klunder, S.Y. Ko, and K.B. Sharpless, Asymmetric Epoxidation of
Allyl Alcohol: Efficient Routes to Homochiral b-Adrenergic Blocking
Agents, J. Org. Chem., 51, 3710 (1986). |
118 |
K.B.
Sharpless and R.A. Johnson, Metal-Mediated Halohydrin Formation,
U. S. Patent 4,560,811, 1985, assigned to the Massachusetts Institute
of Technology. |
117 |
R.M.
Hanson and K.B. Sharpless, Procedure for the Catalytic Asymmetric
Epoxidation of Allylic Alcohols in the Presence of Molecular Sieves,
J. Org. Chem., 51, 1922 (1986). |
116 |
K.B.
Sharpless, The Discovery of the Asymmetric Epoxidation, Chem.
Brit., 22, 1 (1986). |
115 |
J.M.
Hawkins, J.C. Dewan, and K.B. Sharpless, Dioxomolybdenum(VI)-Substituted
2,6-Pyridinedimethanol Complexes: New Five-Coordinate Species,
Inorg. Chem., 25, 1501 (1986). |
114 |
K.B.
Sharpless, The Discovery of Titanium-Catalyzed Asymmetric Epoxidation,
CHEMTECH, 692 (1985). |
113 |
T.
Katsuki and K.B. Sharpless, Method for Asymmetric Epoxidation,
U.S. Patent 4,471,130, 1984, assigned to Stanford University. |
112 |
C.H.
Behrens and K.B. Sharpless, Selective Transformations of 2,3-Epoxy
Alcohols and Related Derivatives. Strategies for Nucleophilic
Attack at Carbon-3 or Carbon-2, J. Org. Chem., 50, 5696 (1985). |
111 |
C.H.
Behrens, S.Y. Ko, F.J. Walker, and K.B. Sharpless, Selective Transformation
of 2,3-Epoxy Alcohols and Related Derivatives. Strategies for
Nucleophilic Attack at Carbon-1, J. Org. Chem., 50, 5687 (1985). |
110 |
J.M.
Chong and K.B. Sharpless, Regioselective Openings of 2,3-Epoxy
Acids with Organocuprates, Tetrahedron Lett., 4683 (1985). |
109 |
S.
Miyano, L.D.-L. Lu, S.M. Viti and K.B. Sharpless, Kinetic Resolution
of Racemic b-Hydroxyamines by Enantioselective N-Oxide Formation,
J. Org. Chem., 50, 4350 (1985). |
108 |
J.M.
Chong and K.B. Sharpless, Nucleophilic Opening of 2,3-Epoxy Acids
and Amides Mediated by Ti(OiPr)4 . Reliable C-3 Selectivity, J.
Org. Chem., 50, 1560 (1985). |
107 |
M.
Caron and K.B. Sharpless, Ti(OiPr)4-Mediated Nucleophilic Openings
of 2,3-Epoxy Alcohols. A Mild Procedure for Regioselective Ring-Opening,
J. Org. Chem., 50, 1557 (1985). |
106 |
M.J.
Schweiter and K.B. Sharpless, The Asymmetric Epoxidation of tert-Butyl
Substituted Allylic Alcohols, Tetrahedron Lett., 2543 (1985). |
105 |
K.S.
Kirshenbaum and K.B. Sharpless, Improved Procedure for the Tungstate-catalyzed
Epoxidation of a,b-Unsaturated Acids, J. Org. Chem., 50, 1979
(1985). |
104 |
J.M.
Klunder, M. Caron, M. Uchiyama, and K.B. Sharpless, Chlorohydroxylation
of Olefins with Peroxides and Titanium Tetrachloride, J. Org.
Chem., 50, 912 (1985). |
103 |
M.G.
Finn and K.B. Sharpless, On the Mechanism of Asymmetric Epoxidation
with Titanium-Tartrate Catalysts, "Asymmetric Synthesis,"
Vol. 5, James D. Morrison, Ed.; Academic Press, Inc., New York,
(1985), Chapter 8, pp. 247-308. |
102 |
K.B.
Sharpless, A New Strategy For Full Control of Relative Stereochemistry
Expands the Role of Asymmetric Synthesis, Chemica Scripta (Sweden),
25, 71 (1985). |
101 |
C.E.
Adams, F.J. Walker, and K.B. Sharpless, Enantioselective Synthesis
of Swainsonine, A Trihydroxylated Indolizidine Alkaloid, J. Org.
Chem., 50, 420 (1985). |
100 |
J.G.
Hill, K.B. Sharpless, C.M. Exon, and R. Regenye, Enantioselective
Epoxidation of Allylic Alcohols: (2S,3S)-3-Propyloxiranemethanol,
Org. Synth., 63, 66 (1984). |
99 |
I.D.
Williams, S.F. Pedersen, K.B. Sharpless, and S.J. Lippard, Crystal
Structures of Two Titanium Tartrate Asymmetric Epoxidation Catalysts,
J. Am. Chem. Soc., 106, 6430 (1984). |
98 |
J.M.
Hawkins and K.B. Sharpless, threo-N,N-Bis (a-methylbenzyl)
sulfamide: A Readily Available Chiral Ligand for Asymmetric Lithium
Aluminum Hydride Reductions. J. Org. Chem., 49, 3861, (1984). |
97 |
B.E.
Rossiter and K.B. Sharpless, Asymmetric Epoxidation of Homoallylic
Alcohols. Synthesis of ()-g-Amino-b-(R)-Hydroxybutyric Acid
(GABOB). J. Org. Chem., 49, 3707 (1984). |
96 |
K.B.
Sharpless, Discovery of the Titanium-Catalyzed Asymmetric EpoxidationA
Personal Account., Proceedings of the Robert A. Welch Foundation
Conferences on Chemical Research XXVII Stereospecificity in Chemistry
and Biochemistry, November 79, 1983, Houston, TX. |
95 |
L.D.-L.
Lu, R.A. Johnson, M.G. Finn, and K.B. Sharpless, Two New Asymmetric
Epoxidation Catalysts. Unusual Stoichiometry and Inverse Enantiofacial
Selection, J. Org. Chem., 49, 728 (1984). |
94 |
C.H.
Behrens and K.B. Sharpless, New Transformations of 2,3-Epoxy Alcohols
and Related Derivatives. Easy Routes to Homochiral Substances,
Aldrichimica Acta, 16, 4 (1983). |
93 |
K.B.
Sharpless, S.S. Woodard and M.G. Finn, On the Mechanism of Titanium-Tartrate
Catalyzed Asymmetric Epoxidation, Pure and Appl. Chem., 55, 1823
(1983). |
92 |
S.
Miyano, L.D.-L. Lu, S.M. Viti, and K.B. Sharpless, Kinetic Resolution
of Racemic b-Hydroxyamines by Enantioselective N-Oxide Formation.,
J. Org. Chem., 48, 3608 (1983). |
91 |
J.G.
Hill, B.E. Rossiter, and K.B. Sharpless, Anhydrous tert-Butyl
Hydroperoxide in Toluene. The Preferred Reagent for Applications
Requiring Dry TBHP., J. Org. Chem., 48, 3607 (1983). |
90 |
Ko SY, Lee AW, Masamune S, Reed LA 3rd, Sharpless KB, Walker FJ.,
Total Synthesis of the L-Hexoses,
Science, 220(4600):949-51, (1983). |
89 |
L.A.
Reed, Y. Ito, S. Masamune, and K.B. Sharpless, Synthesis of Saccharides
and Related Polyhydroxylated Natural Products. 4. a-D-and b-D-C-Glycopyranosides
(2,6-Dialkyl-Substituted Tetrahydropyrans), J. Am. Chem. Soc.,
104, 6468 (1982). |
88 |
K.B.
Sharpless, C.H. Behrens, T. Katsuki, A.W.M. Lee, V.S. Martin,
M. Takatani, S.M. Viti, F.J. Walker, and S.S. Woodard, Stereo-
and Regioselective Openings of Chiral 2,3-Epoxy Alcohols. Versatile
Routes to Optically Pure Natural Products and Drugs. Unususal Kinetic Resolutions,
, 55, 589 (1983). |
87 |
N.C.
Gonnella, K. Nakanishi, V.S. Martin, and K.B. Sharpless, General
Method for Determining Absolute Configurations of Acyclic Allylic
Alcohols, J. Am. Chem. Soc., 104, 3775 (1982). |
86 |
M.A.
Warpehoski, B. Chabaud, and K.B. Sharpless, Selenium Dioxide Oxidation
of Endocyclic Olefins. Evidence for a Dissociation-Recombination
Pathway, J. Org. Chem., 47, 2897 (1982). |
85 |
A.W.M.
Lee, V.S. Martin, S. Masamune, K.B. Sharpless, and F.J. Walker,
Synthesis of Saccharides and Related Polyhydroxylated Natural
Products 3: Efficient Conversion of 2,3-erythro-Aldoses to 2,3-threo-Aldoses,
J. Am. Chem. Soc., 104, 3515 (1982). |
84 |
P.
Ma, V.S. Martin, S. Masamune, K.B. Sharpless, and S.M. Viti, Synthesis
of Saccharides and Related Polyhydroxylated Natural Products 2:
Simple Deoxyalditols, J. Org. Chem., 47, 1378 (1982). |
83 |
T.
Katsuki, A.W.M. Lee, P. Ma, V.S. Martin, S. Masamune, K.B. Sharpless,
D. Tuddenham, and F.J. Walker, Synthesis of Saccharides and Related
Polyhydroxylated Natural Products 1: Simple Alditols, J. Org.
Chem., 47, 1373 (1982). |
82 |
V.S.
Martin, S.S. Woodard, T. Katsuki, Y. Yamada, M. Ikeda, and K.B.
Sharpless, Kinetic Resolution of Racemic Allylic Alcohols by Enantioselective
Epoxidation. A Route to Substances of Absolute Enantiomeric Purity?,
J. Am. Chem. Soc., 103, 6237 (1981). |
81 |
P.H.J.
Carlsen, T. Katsuki, V.S. Martin, and K.B. Sharpless, A Greatly
Improved Procedure for Ruthenium Tetroxide-Catalyzed Oxidations
of Organic Compounds, J. Org. Chem., 46, 3936 (1981). |
80 |
E.
Herranz and K.B. Sharpless, Osmium Catalyzed Vicinal Oxyamination
of Olefins by N-Chloro-N-Argento-Carbamates: threo-N-(1-Hydroxy-1,2-Diphenyl-2-yl)
Ethyl Carbamate, Org. Synth., 61, 93 (1981). |
79 |
D.J.
Morgans, K.B. Sharpless, and S.G. Traynor, Epoxy Alcohol Rearrangements:
Hydroxyl Mediated Delivery of Lewis Acid Promoters, J. Am. Chem.
Soc., 103, 462 (1981). |
78 |
B.E.
Rossiter, T. Katsuki, and K.B. Sharpless, Asymmetric Epoxidation
Provides Shortest Routes to Four Chiral Epoxy Alcohols which are
Key Intermediates in Syntheses of Methymycin, Erythromycin, Leukotriene
C-1 and Disparlure, J. Am. Chem. Soc., 103, 464 |
77 |
E.
Herranz and K.B. Sharpless, Osmium Catalyzed Vicinal Oxyamination
of Olefins by Chloramine-T: cis-2-(p-Toluenesulfonamido)-cyclohexanol
and 2-Methyl-3-(p-toluenesulfonamido)-2-pentanol, Org. Synth.,
61, 85 (1983). |
76 |
T.
Katsuki and K.B. Sharpless, The First Practical Method for Asymmetric
Epoxidation, J. Am. Chem. Soc., 102, 5974 (1980). |
75 |
S.G.
Hentges and K.B. Sharpless, Improved Procedure for the Oxyamination
of Olefins with Trioxo(tert-butylimido)osmium(VIII), J. Org. Chem.,
45, 2257 (1980). |
74 |
S.G.
Hentges and K.B. Sharpless, Asymmetric Induction in the Reaction
of Osmium Tetroxide with Olefins, J. Am. Chem. Soc., 102, 4263
(1980). |
73 |
E.
Herranz and K.B. Sharpless, Osmium-Catalyzed Vicinal Oxyamination
of Olefins by N-Chloro-N-Metallocarbamates, J. Org. Chem., 45,
2710 (1980). |
72 |
M.A.
Umbreit and K.B. Sharpless, Deoxygenation of Epoxides with Lower
Valent Tungsten Halides: trans-Cyclododecene, Org. Synth., 60,
29 (1981). |
71 |
K.B.
Sharpless and T.R. Verhoeven, Metal-Catalyzed, Highly Selective
Oxygenations of Olefins and Acetylenes with tert-Butyl Hydroperoxide.
Practical Considerations and Mechanisms, Aldrichimica Acta, 12,
63 (1979). |
70 |
B.E.
Rossiter, T.R. Verhoeven, and K.B. Sharpless, Stereoselective
Epoxidation of Acyclic Allylic Alcohols. A Correction of Our Previous
Work, Tetrahedron Lett., 4733 (1979). |
69 |
B.
Chabaud and K.B. Sharpless, Oxidation of Acetylenes with tert-Butyl
Hydroperoxide Catalyzed by Selenium Dioxide. a,a-Dioxygenation
of Internal Alkynes, J. Org. Chem., 44, 4202 (1979). |
68 |
T.
Hori and K.B. Sharpless, Selenium Catalyzed Non-Radical Chlorination
of Olefins with N-Chlorosuccinimide, J. Org. Chem., 44, 4204 (1979). |
67 |
T.
Hori and K.B. Sharpless, Conversion of Allylic Phenylselenides
to the Rearranged Allylic Chlorides by N-Chlorosuccinimide. Mechanism
of Selenium Catalyzed Allylic Chlorination of &$946;-Pinene, J. Org.
Chem., 44, 4208 (1979). |
66 |
J.-E.
Bäckvall, K. Oshima, R.E. Palermo, and K.B. Sharpless, Some
Reactions of N-(2-hydroxyalkyl)-p-toluenesulfonamides and N-allyl-p-toluenesulfonamides,
J. Org. Chem., 44, 1953 (1979). |
65 |
S.
Current and K.B. Sharpless, Carbonyl Participation in the Addition
of p-Chlorophenylselenenyl Bromide to (E)-4-Hexenal: A New Route
to 2,6-Dideoxyglycosides, Tetrahedron Lett., 5075 (1978). |
64 |
L.S.
Liebeskind, K.B. Sharpless, R.D. Wilson, and J.A. Ibers, The First
d0 Metallooxaziridines. Amination of Olefins, J. Am. Chem. Soc.,
100, 7061 (1978).63. |
63 |
E.
Herranz, S.A. Biller, and K.B. Sharpless, Osmium-Catalyzed Vicinal
Oxyamination of Olefins by N-Chloro-N-Argentocarbamates, J. Am.
Chem. Soc., 100, 3596 (1978). |
62 |
E.
Herranz and K.B. Sharpless, Improvements in the Osmium Catalyzed
Oxyamination of Olefins by Chloramine-T, J. Org. Chem., 43, 2544
(1978). |
61 |
T.
Frejd and K.B. Sharpless, A New Rearrangement of N-Arylhydroxamic
Acids Catalyzed by Seleninic Acids and Phenylselenenyl Chloride,
Tetrahedron Lett., 2239 (1978). |
60 |
D.W.
Patrick, L.K. Truesdale, S.A. Biller, and K.B. Sharpless, Stereospecific
Vicinal Oxyamination of Olefins by Alkyl Imido Osmium Compounds,
J. Org. Chem., 43, 2628 (1978). |
59 |
K.
Akashi, R.E. Palermo, and K.B. Sharpless, A Major Improvement
in the Osmium Catalyzed Vicinal Hydroxylation of Olefins by tert-Butyl
Hydroperoxide, J. Org. Chem., 43, 2063 (1978). |
58 |
T.
Hori and K.B. Sharpless, Synthetic Applications of Arylselenenic
and of Arylseleninic Acids. Conversion of Olefins to Allylic Alcohols
and to Epoxides, J. Org. Chem., 43, 1689 (1978). |
57 |
S.P.
Singer and K.B. Sharpless, Synthesis of d,l-Gabaculine Utilizing
Direct Allylic Amination as the Key Step, J. Org. Chem., 43, 1448
(1978). |
56 |
T.
Hori, S.P. Singer, and K.B. Sharpless, Allylic Deuteration and
Tritiation of Olefins with N-Sulfinylsulfonamides, J. Org. Chem.,
43, 1456 (1978). |
55 |
J.-E.
Bäckvall, M.W. Young, and K.B. Sharpless, Vicinal Acetoxychlorination
of Olefins by Chromyl Chloride in Acetyl Chloride, Tetrahedron
Lett., 3523 (1977). |
54 |
M.A.
Umbreit and K.B. Sharpless, Allylic Oxidation of Olefins by Catalytic
and Stoichiometric Selenium Dioxide with tert-Butyl Hydroperoxide,
J. Am. Chem. Soc., 99, 5526 (1977). |
53 |
A.O.
Chong, K. Oshima, and K.B. Sharpless, Synthesis of Dioxo(tert-alkylimido)Osmium(VIII)
and Oxotris(tert-alkylimido)Osmium(VIII) Complexes. Stereospecific
Vicinal Diamination of Olefins, J. Am. Chem. Soc., 99, 3420 (1977). |
52 |
K.B.
Sharpless, A.Y. Teranishi, and J.-E. Bäckvall, Chromyl Chloride
Oxidations of Olefins. Possible Role of Organometallic Intermediates
in the Oxidations of Olefins by Oxotransition Metal Species, J.
Am. Chem. Soc., 99, 3120 (1977). |
51 |
A.O.
Chong and K.B. Sharpless, On the Mechanism of the Molybdenum and
Vanadium Catalyzed Epoxidation of Olefins by Alkyl Hydroperoxides,
J. Org. Chem., 42, 1587 (1977). |
50 |
R.C.
Michaelson, R.E. Palermo, and K.B. Sharpless, Chiral Hydroxamic
Acids as Ligands in the Vanadium Catalyzed Asymmetric Epoxidation
of Allylic Alcohols by tert-Butyl Hydroperoxide, J. Am. Chem.
Soc., 99, 1990 (1977). |
49 |
K.B.
Sharpless and S.P. Singer, 1,2-Diamination of 1,3-Dienes by Imido
Selenium Compounds, J. Org. Chem., 41, 2504 (1976). |
48 |
K.B.
Sharpless, K. Akashi, and K. Oshima, Ruthenium Catalyzed Oxidation
of Alcohols to Aldehydes and Ketones by Amine-N-Oxides, Tetrahedron
Lett., 22503 (1976). |
47 |
K.B.
Sharpless and K. Akashi, Osmium Catalyzed Vicinal Hydroxylation
of Olefins by tert-Butyl Hydroperoxide Under Alkaline Conditions,
J. Am. Chem. Soc., 98, 1986 (1976). |
46 |
K.B.
Sharpless, A.O. Chong, and K. Oshima, Osmium Catalyzed Oxyamination
of Olefins by Chloramine-T, J. Org. Chem., 41, 177 (1976). |
45 |
K.B.
Sharpless and T. Hori, Allylic Amination of Olefins and Acetylenes
by Imido Sulfur Compounds, J. Org. Chem., 41, 176 (1976). |
44 |
K.B.
Sharpless and K.M. Gordon, Selenium Dioxide Oxidation of Ketones
and Aldehydes. Evidence for the Intermediacy of b-Ketoseleninic
Acids, J. Am. Chem. Soc., 98, 300 (1976). |
43 |
K.B.
Sharpless, T. Hori, L.K. Truesdale, and C.O. Dietrich, Allylic
Amination of Olefins and Acetylenes by Imido Selenium Compounds,
J. Am. Chem. Soc., 98, 269 (1976). |
42 |
K.B.
Sharpless and K. Akashi, Oxidation of Alcohols to Aldehydes by
Reagents Derived from Chromyl Chloride, J. Am. Chem. Soc., 97,
5927 (1975). |
41 |
K.B.
Sharpless, K.M. Gordon, R.F. Lauer, D.W. Patrick, S.P. Singer,
and M.W. Young, The Utility of Selenium Reagents in Organic Synthesis,
Chemica Scripta (Sweden), Vol. 8A, 9 (1975). |
40 |
J.A.
Nelson, S. Kahn, T.A. Spencer, K.B. Sharpless, and R.B. Clayton,
Some Aspects of Substrate Specificity in Biological Demethylation
at C4 of Steroids, Bioorgan. Chem., 4, 363 (1975). |
39 |
K.B.
Sharpless and D.R. Williams, The Reactions of Olefins with Permanganate,
Ruthenium Tetroxide, and Osmium Tetroxide; Dependence of Rate
on Degree of Substitution, Tetrahedron Lett., 3045 (1975). |
38 |
K.B.
Sharpless, A.O. Chong, and J.A. Scott, Rapid Separation of Organic
Mixtures by Formation of Metal Complexes, J. Org. Chem., 40, 1252
(1975). |
37 |
K.B.
Sharpless, D.W. Patrick, L.K. Truesdale, and S.A. Biller, A New
Reaction. Stereospecific Vicinal Oxyamination of Olefins by Alkyl
Imido Osmium Compounds, J. Am. Chem. Soc., 97, 2305 (1975). |
36 |
K.B.
Sharpless and M.W. Young, Olefin Synthesis. Rate Enhancement of
the Elimination of Alkyl Aryl Selenoxides by Electron-Withdrawing
Substituents, J. Org. Chem., 40, 947 (1975). |
35 |
H.P.
Jensen and K.B. Sharpless, Selenium Dioxide Oxidation of d-Limonenea
Reinvestigation, J. Org. Chem., 40, 264 (1975). |
34 |
H.P.
Jensen and K.B. Sharpless, An Improved Procedure for the Direct
Oxidation of Olefins to a-Diketones by Potassium Permanganate
in Acetic Anhydride, J. Org. Chem., 39, 2314 (1974). |
33 |
K.B.
Sharpless and H.P. Jensen, Synthesis of a Novel Pentacoordinate
Glyoxime Based Ligand and Preparation of its Chlorocobalt(III)
Complex, Inorg. Chem., 13, 2617 (1974) |
32 |
Tanaka S, Yamamoto H, Nozaki H, Sharpless KB, Michaelson RC, Cutting JD.,
Stereoselective epoxidations of acyclic allylic alcohols by transition metal--hydroperoxide reagents. Synthesis of dl-C18 Cecropia juvenile hormone from farnesol,
J. Am. Chem. Soc., 96(16):5254-5, (1974). |
31 |
K.B.
Sharpless and R.F. Lauer, Electrophilic Organoselenium Reagents.
A New Route to Allylic Acetates and Ethers, J. Org. Chem., 39,
429 (1974). |
30 |
D.
Arigoni, A. Vasella, K.B. Sharpless, and H.P. Jensen, Selenium
Dioxide Oxidations of Olefins. Trapping of the Allylic Seleninic
Acid Intermediate as a Seleninolactone, J. Am. Chem. Soc., 95,
7917 (1973). |
29 |
K.B.
Sharpless, R.F. Lauer, and A.Y. Teranishi, Electrophilic and Nucleophilic
Organoselenium Reagents. New Routes to a,b-Unsaturated Carbonyl
Compounds, J. Am. Chem. Soc., 95, 6137 (1973). |
28 |
K.B.
Sharpless and R.C. Michaelson, High Stereo- and Regioselectivities
in the Transition Metal Catalyzed Epoxidations of Olefinic Alcohols
by t-Butyl Hydroperoxide, J. Am. Chem. Soc., 95, 6136 (1973). |
27 |
K.B.
Sharpless, M.W. Young, and R.F. Lauer, Reactions of Selenoxides.
Thermal syn-Elimination and H218O Exchange, Tetrahedron Lett.,
1979 (1973). |
26 |
K.B.
Sharpless and R.F. Lauer, A Mild Procedure for the Conversion
of Epoxides to Allylic Alcohols. The First Organoselenium Reagent,
J. Am. Chem. Soc., 95, 2697 (1973). |
25 |
K.B.
Sharpless and A.Y. Teranishi, Chromyl Chloride in Acetone. a-Chloro
Ketones or Ketones Directly from Olefins, J. Org. Chem., 38, 185
(1973). |
24 |
K.B.
Sharpless and R.F. Lauer, Facile Thermal Rearrangements of Allyl
Selenides and Diselenides. [1,3] and [2,3] Shifts, J. Org. Chem.,
37, 3973 (1972). |
23 |
K.B.
Sharpless and R.F. Lauer, Selenium Dioxide Oxidation of Olefins,
Evidence for the Intermediacy of Allyl Seleninic Acids, J. Am.
Chem. Soc., 94, 7154 (1972). |
22 |
J.M.
Townsend and K.B. Sharpless, Mechanism of Decomposition of Sulfonium
Betaines to Epoxides, Tetrahedron Lett., 3313 (1972). |
21 |
K.B.
Sharpless, M.A. Umbreit, M.T. Nieh, and T.C. Flood, Lower Valent
Tungsten Halides. A New Class of Reagents for Deoxygenation of
Organic Molecules, J. Am. Chem. Soc., 94, 6538 (1972). |
20 |
K.B.
Sharpless and T.C. Flood, Direct Deoxygenation of Vicinal Diols
with Tungsten (IV). A New Olefin Synthesis, J. Chem. Soc., Chem.
Commun., 370, (1972). |
19 |
K.B.
Sharpless, J.M. Townsend, and D.R. Williams, On the Mechanism
of Epoxidation of Olefins by Covalent Peroxides of Molybdenum(VI),
J. Am. Chem. Soc., 94, 295 (1972). |
18 |
K.B.
Sharpless and R.F. Lauer, O. Repic, A.Y. Teranishi, and D.R. Williams,
Permanganate in Acetic Anhydride. a-Diketones Directly from Olefins,
J. Am. Chem. Soc., 93, 3303 (1971). |
17 |
Sharpless KB, Flood TC.,
Oxotransition metal oxidants as mimics for the action of mixed-function oxygenases. "NIH shift" with chromyl reagents,
J. Am. Chem. Soc., 93(9):2316-8, (1971). |
16 |
K.B.
Sharpless, d,l-Malabaricane Diol. The First Cyclic Natural Product
Derived from Squalene in a Nonenzymic Process, J. Am. Chem. Soc.,
92, 6999 (1970). |
15 |
K.B.
Sharpless, Synthesis of erythro-18,19-Dihydroxysqualene 2,3-Oxide
and Other Internally Oxidized Squalene Derivatives, J. Chem. Soc.,
Chem. Commun., 1450 (1970). |
14 |
Rahman R, Sharpless KB, Spencer TA, Clayton RB.,
Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group,
J. Biol. Chem., 245(10):2667-71, (1970). |
13 |
Sharpless KB, Snyder TE, Spencer TA, Maheshwari KK, Nelson JA.,
Biological demethylation of 4,4-dimethyl sterols, Evidence for enzymic epimerization of the 4beta-methyl group prior to its oxidative removal,
J. Am. Chem. Soc.,91(12):3394-6, (1969). |
12 |
R.
J. Anderson, R.P. Hanzlik, K.B. Sharpless, and E.E. van Tamelen,
Enzymic Transformation of an Acyclic Sesterterpene Terminal Epoxide
to a Lanosterol Analog, J. Chem. Soc., Chem. Commun., 53 (1969). |
11 |
E.E.
van Tamelen, B. Åkermark, and K.B. Sharpless, Mechanism
of the Titanium-Promoted Deoxygenative Coupling of Allyl and Benzyl
Alcohols to Hydrocarbons, J. Am. Chem. Soc., 91, 1552 (1969). |
10 |
K.B.
Sharpless and E.E. van Tamelen, Terpene Terminal Epoxides. Skeletal
Rearrangement Accompanying Bicyclization of Squalene 2,3-Oxide,
J. Am. Chem. Soc., 91, 1848 (1969). |
9 |
K.B.
Sharpless, T.E. Snyder, T.A. Spencer, K.K. Maheshwari, G. Guhn,
and R.B. Clayton, Biological Demethylation of 4,4-Dimethyl Sterols.
Initial Removal of the 4a-Methyl Group, J. Am. Chem. Soc., 90,
6874 (1968). |
8 |
K.B.
Sharpless, Studies of the Mechanism of Action of 2,3-Oxidosqualene-Lanosterol
Cyclase: Featuring Enzymic Cyclization of Modified Squalene Oxides,
Ph.D. Dissertation, Stanford University (1968). |
7 |
E.E.
van Tamelen, R.P. Hanzlik, K.B. Sharpless, R.B. Clayton, W.J.
Richter, and A.L. Burlingame, Enzymic Cyclization of 15-Norsqualene
2,3-Oxide, J. Am. Chem. Soc., 90, 3284 (1968) |
6 |
van Tamelen EE, Sharpless KB, Hanzlik R, Clayton RB, Burlingame AL, Wszolek PC.,
Enzymic Cyclization of trans, trans, trans-18,19-Dihydrosqualene 2,3-Oxide,
J. Am. Chem. Soc., 89(26):7150-1, (1967). |
5 |
K.B.
Sharpless, R.P. Hanzlik, and E.E. van Tamelen, A One-Step Synthesis
of 1,5-Dienes Involving Reductive Coupling of Allyl Alcohols,
J. Am. Chem. Soc., 90, 209 (1968). |
4 |
E.E.
van Tamelen, K.B. Sharpless, J.D. Willett, R.B. Clayton, and A.L.
Burlingame, Biological Activities of Some Terminally Modified
Squalene and Squalene 2,3-Oxide Analogs,
J. Am. Chem. Soc., 89,
3920 (1967). |
3 |
Willett JD, Sharpless KB, Lord KE, van Tamelen EE, Clayton RB.,
Squalene-2,3-Oxide, an Intermediate in the Enzymatic Conversion of Squalene to Lanosterol and Cholesterol,
J. Biol. Chem., 242(18):4182-91, (1967). |
2 |
E.E.
van Tamelen EE, Sharpless KB,
Positional selectivity during controlled oxidation of polyolefins,
Tetrahedron Lett., 8(28):2655-59, (1967). |
1 |
Spencer TA, Schwartz MA, Sharpless KB,
Synthesis of Resin Acid Intermediates. 8a,10b-Dimethyl-8-carbomethoxy-D19-octalone-2,
J. Org. Chem., 29(4):782-6, (1964). |
|