|
|
Addiction, particularly to drugs of abuse, is a serious and growing problem for society.
New technologies are providing tools for investigating the genetic basis of conditions
such as drug addiction, and offer hope that successful interventions can be developed
to help alleviate the effects of drug addiction.
This project is designed to identify genes or gene products whose expression patterns
are regulated by repeated administration of a non-toxic dose regimen of methamphetamine,
similar to that experienced by a human addict. The results of these studies will
be published both here and through conventional means, and this information will
be accessible to both the research community as well as to the public.
Overall, this project is designed to:
1) Characterize patterns of gene expression upon initiation and expression of behavioral
sensitization to methamphetamine in the striatum and pre-frontal cortex (PFC) using
DNA "chip" technology.
2) Identify novel genes in the striatum and PFC with expression patterns associated
with behavioral sensitization to METH.
Members of S.M.A.R.T.:
Dr. Luis de Lecea, TSRI, llecea@scripps.edu
Dr. Steven J. Henriksen, TSRI, steven@scripps.edu
Dr. Jose R. Criado, TSRI, jcriado@scripps.edu
Dr. Veronique Fabre, TSRI, vfabre@scripps.edu
Dr. David Gauvin, USDEA |
