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Scripps Laboratories for tRNA Synthetase Research

Youngzee Song

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I graduated from Seoul National University College of Pharmacy. I started research at professor Sung Hoon Kim's lab and first started working on amino-acyl tRNA synthetases. Now I am a graduate student in the Scripps Research Institute in professor Paul Schimmel's lab, and I am working on editing deficient amino-acyl tRNA synthetases. Editing deficiency has proven to be related with disease, such as neurodegeneration, and has been shown to cause cell death. Also it was shown to induce DNA mutations in bacteria. My project goal is to extend this observation and show that mistranslation caused by an editing deficient amino-acyl tRNA synthease, could cause DNA mutations, either from defects in DNA repair, or through error prone DNA polymerases, in the mammalian system. If this is the case, it will be a good hint for understanding why cancer patients have so many gene mutations.

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