tRNA Synthetase Research

Maggie (Na) Wei, Ph.D.

Education:
B.S., Biological Technology, Huazhong University of Science and Technology, 2005
Ph.D., Molecular and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 2010

Research:
My research is focused on elucidating the pathomechanism of mutation on tyrosyl tRNA-synthetases (TyrRS) in neurodegenerative disease.

Publications:
Blocquel D, Li S, Wei N, Daub H, Sajish M, Erfurth ML, Kooi G, Zhou J, Bai G, Schimmel P, Jordanova A, Yang XL. Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy. Nucleic Acids Res. 2017 May 22. Doi: 10.1093/nar/gkx455.

Sleigh JN, Dawes JM, West SJ, Wei N, Spaulding EL, Gómez-Martín A, Zhang Q, Burgess RW, Cader MZ, Talbot K, Yang XL, Bennett DL, Schiavo G. Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations. Proceeding of the National Academy of Sciences of the United States of America. 2017 Apr 18; 114 (16): E3324-E3333.

Shi Y, Wei N, Yang XL. Studying nuclear functions of aminoacyl tRNA synthetases. Methods. 2017 Jan 15; 113: 105-110.

He W, Bai G, Zhou H, Wei N, White NM, Lauer J, Liu H, Shi Y, Dumitru CD, Lettieri K, Shubavev V, Jordanova A, Guergueltcheva V, Griffin PR, Burgess RW, Pfaff SL, Yang XL. CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature. 2015 Oct 29; 526 (7575): 710-4.

Wei N, Shi Y, Truong LN, Fisch KM, Xu T, Gardiner E, Fu G, Hsu YS, Kishi S, Su AI, Wu X, Yang XL. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Molecular Cell. 2014 Oct 23; 56 (2): 323-32.

Fu G, Xu T, Shi Y, Wei N, Yang XL. tRNA-controlled Nuclear Import of a Human tRNA Synthetase. Journal of Biological Chemistry. 287 (2012) 9330-9334

Zhang KJ, Zhang J, Wu YM, Qian J, Liu XJ, Yan LC, Zhou XM, Xiao RJ, Wang YG, Cao X, Wei N, Liu XR, Chen K, Liu XY. Complete eradication of hepatomas using an oncolytic adenovirus containing AFP promoter controlling E1A and E1B deletion to drive IL-24 expression. Cancer Gene Ther. 2012 Sep; 19(9):619-29

Xu HN, Huang WD, Cai Y, Ding M, Gu JF, Wei N, Sun LY, Cao X, Li HG, Zhang KJ, Liu XR, Liu XY. HCCS1-armed, quadruple-regulated oncolytic adenovirus specific for liver cancer as a cancer targeting gene-viro-therapy strategy. Molecular Cancer. (2011)10:133

Cao X, Yang M, Wei RC, Zeng Y, Gu JF, Huang WD, Yang DQ, Li HL, Ding M, Wei N, Zhang KJ, Xu B, Liu XR, Qian QJ, Liu XY. Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene. Gene Ther. 2011 Aug; 18(8): 765-77.

Wei N, Fan JK, Gu JF, He LF, Tang WH, Cao X, Liu XY. A double-regulated oncolytic adenovirus with improved safety for adenocarcinoma therapy. Biochemical and Biophysical Research Communications. 388 (2009) 234-239

Fan JK, Wei N*, Ding M, Gu JF, Liu XR, Li BH, Qi R, Huang WD, Li YH, Xiong XQ, Wang J, Li RS, Liu XY. Targeting Gene-ViroTherapy for Prostate Cancer by DD3-driven Oncolytic Virus Harboring IL-24 Gene. International Journal of Cancer. 127 (2010) 707-717. (*co-first author)

Wei N, Fan JK, Gu JF, Liu XY. Double-regulated oncolytic adenovirus-mediated IL-24 overexpression exhibits potent antitumor activity on gastric adenocarcinoma.Human Gene Therapy. 21 (2010) 855-864

Fan JK, Xiao T, Gu JF, Wei N, He LF, Ding M, Liu XY. Increased suppression of oncolytic adenovirus carrying mutant k5 on colorectal tumor. Biochemical and Biophysical Research Communications. 374 (2008) 198-203

He LF, Gu JF, Tang WH, Fan JK, Wei N, Zou WG, Zhang YH, Zhao LL, Liu XY. Significant antitumor activity of oncolytic adenovirus expressing human interferon-β for hepatocellular carcinoma. Journal of Gene Medicine. 2008 Sep; 10 (9): 983-92.

Awards:
The Charcot-Marie-Tooth Association travel fellowship (the 5th International CMT Consortium 2013).

_____

Lab Home
_

About SLTSR
_

Principal Investigators
_

Lab Members
_

Alumni
_

Collaborators
_

Publications
_

News
_

Photos
_

Protocols
_

Members Only
_

Joining SLTSR
_

Contact Us
_____