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Scripps Laboratories for tRNA Synthetase Research

Eric (Yi) Shi, Ph.D

Photo of Eric (Yi) Shi, Ph.D.

Education

B.S Biochemistry - Nanjing University, Nanjing, China. July 1997

Ph.D. Molecular Biology - Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. May 2007

Current Research Focus

Aminoacyl-tRNA synthetases (ARSs) catalyze aminoacylations of their cognate tRNAs that are indispensable for protein synthesis. In addition to their aminoacylation activities (canonical activity), several ARSs are known to possess diverse biological functions (noncanonical activity), such as inflammation, angiogenesis, transcription regulation, and apoptosis. It was found recently that mutation in seryl-tRNA synthetase (SARS) could cause defective in vascular patterning in zebrafish. This means that SARS also has noncanonical activity in  angiogenesis like tyrosyl-tRNA synthetase and tryptophanyl-tRNA synthetase. My work is focused on the cell mechanism and molecular mechanism of the role of SARS in angiogenesis.

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