The Sauer Lab
Research
- Research - Home
- 1. Functional Genomics
- 2. Inositol-Polyphosphate Signaling in Thymocytes
- 2.1. A Brief Overview of T Cell Development
- 2.2. A Novel Function for Soluble IP4
- 2.3. Untangling a Second Messenger Conundrum
- 3. Multidisciplinary Kinase Analyses
2. Inositol-Polyphosphate Signaling in Lymphocyte Development and Function
A major project in the lab is centered around our recent discovery that the soluble small molecule Inositol(1,3,4,5)tetrakisphosphate (IP4) is required for T cell development through essential functions in TCR signaling1,2. The elucidation of the precise molecular mechanism(s) by which IP4 mediates TCR signaling and governs T cell development is an exciting and highly stimulating focus of current research in our group.
- 2.1. A brief overview of T cell development.
- 2.2. A novel function for soluble IP4 in positively regulating PH domain recruitment to membrane phospholipids in vivo.
- 2.3. Untangling a second messenger conundrum: IP4 establishes a feedback loop of Diacylglycerol production that is essential for positive selection.
Further Reading
- Wen, B.G. et al. Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Proc Natl Acad Sci U S A 101, 5604-5609 (2004).
- Huang, Y.H. et al. Positive Regulation of Itk PH Domain Function by Soluble IP4. Science 316, 886-889 (2007).
- VISIT
- CA Campus:
- • Maps & Directions
- • Parking
- FL Campus:
- • Maps & Directions
- • Parking
- RESEARCH
- LEARN
- WORK
- CHALLENGE
California: 10550 North Torrey Pines Road, La Jolla, CA 92037 - (858) 784-1000
Florida: 130 Scripps Way, Jupiter, FL 33458 - (561) 228-2000
Copyright © 2013, The Scripps Research Institute. All Rights Reserved.