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The Sauer Lab

Signaling Mechanisms Controlling the Hematopoietic System
and Blood Cancers

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Laboratory Address

The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, CA 92037, USA.

Email: ksauer [at] scripps.edu

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Publication Highlights

Westernberg, L., Conche, C., Huang, Y.H., Rigaud, S., Deng, Y., Siegemund, S., Mukherjee, S., Nosaka, L., Das, J. and Sauer, K. (2016) Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent. eLife 5:e10786. DOI: 10.7554/eLife.10786. abstract

Siegemund, S., Rigaud, S., Conche, C., Broaten, B., Schaffer, L., Westernberg, L., Head, S.R. and Sauer, K. (2015) IP3 3-Kinase B Controls Hematopoietic Stem Cell Homeostasis and Prevents Lethal Hematopoietic Failure in Mice. Blood 125, 2786-2797. abstract

Sauer, K.*, Park, E., Siegemund, S., French, A.R., Wahle, J.A., Sternberg, L., Rigaud, S., Jonsson, A.H., Yokoyama, W.M. and Huang, Y.H.* (2013) Inositol Tetrakisphosphate Limits NK Cell Effector Functions by Controlling PI3K Signaling. Blood 121, 286-297. *Co-corresponding authors. abstract

Sauer, K.*, and Cooke, M.P. Regulation of Immune Cell Development Through Soluble Inositol-1,3,4,5-tetrakisphosphate. (2010) Nature Reviews Immunology 10, 257-271. *Corresponding author. abstract

Barouch-Bentov, R., Che, J., Lee, C.C., Yang, Y., Herman, A., Jia, Y., Velentza, A., Watson, J., Sternberg, L., Kim, S., Ziaee, N., Miller, A., Jackson, C., Fujimoto, M., Young, M., Batalov, S., Liu, Y., Warmuth, M., Wiltshire, T., Cooke, M.P., and Sauer, K. (2009) A Conserved Salt Bridge in the G Loop of Multiple Protein Kinases Is Important for Catalysis and for in Vivo Lyn Function. Molecular Cell 33, 43-52. abstract

Huang, Y. H., Grasis, J., Miller, A. T., Xu, R., Soonthornvacharin, S., Andreotti, A. H., Tsoukas, C. D., Cooke, M. P., and Sauer, K. (2007) Positive Regulation of Itk PH Domain Function by Soluble IP4. Science 316, 886-889. abstract