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The Sauer Lab

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Laboratory Address

The Scripps Research Institute
Mailstop IMM-24, Room R219
10550 North Torrey Pines Road
La Jolla, CA 92037, USA.

Lab phone : +1-858-784-7399
Fax: +1-858-784-7422
Email: ksauer@scripps.edu

News from our lab

The Leukemia and Lymphoma Society Scholar Award: web version/pdf.

Itk PH domain regulation by soluble IP4: web version/pdf.

Importance of the G-loop Salt Bridge for Kinase Function and Inhibition: web version/pdf.

Selected recent publications

Sauer, K.*, and Cooke, M.P. Regulation of Immune Cell Development Through Soluble Inositol-1,3,4,5-tetrakisphosphate. (2010) Nature Reviews Immunology 10, 257-271. *Corresponding author. abstract

Barouch-Bentov, R., Che, J., Lee, C.C., Yang, Y., Herman, A., Jia, Y., Velentza, A., Watson, J., Sternberg, L., Kim, S., Ziaee, N., Miller, A., Jackson, C., Fujimoto, M., Young, M., Batalov, S., Liu, Y., Warmuth, M., Wiltshire, T., Cooke, M.P., and Sauer, K. (2009) A Conserved Salt Bridge in the G Loop of Multiple Protein Kinases Is Important for Catalysis and for in Vivo Lyn Function. Molecular Cell 33, 43-52. abstract

Huang, Y. H., Grasis, J., Miller, A. T., Xu, R., Soonthornvacharin, S., Andreotti, A. H., Tsoukas, C. D., Cooke, M. P., and Sauer, K. (2007) Positive Regulation of Itk PH Domain Function by Soluble IP4. Science 316, 886-889. abstract (Free reprint under Publications)