Our research centers around themes of total synthesis, reaction development and medicinal chemistry. Over 25 structurally complex, biologically active natural products have been synthesized in the Roush lab. These serve both as testing grounds for new methods and as inspiration for potential therapeutics.

Our total synthesis projects are often attempted in parallel with reaction design. Synthetic applications of intramolecular Diels-Alder reactions and acyclic diastereoselective syntheses involving allylmetal compounds are of especial interest.

Total synthesis and methods development interact synergistically toward the development of medicinally relevant compounds. Current targets of interest include chemotherapeutics built upon the exploitation of tumor cell metabolism, cystein protease inhibitors for treatment of parasitic diseases and diagnostic probes for the Scripps Molecular Screening Center.

Total Synthesis
Total Synthesis
Medicinal Chemistry
Medicinal Chemistry

Methodology Development
Methodology