281. Y. Wang, N. Kumar, P. Nuhant, M. D. Cameron, M. A. Istrate, W. R. Roush, P. R. Griffin and T. P. Burris, “Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORa and RORg,” ACS Chem. Biol. 2010, 5, 1029-1034. 10.1021/cb100223d
280. S. M. Winbush and W. R. Roush, “Enantioselective Synthesis of (Z)-1,2-anti-2,5-anti-Triol Monosilyl Ethers Using a Cross-Metathesis Allylboration Sequence,” Org. Lett. 2010, 12, 4344. 10.1021/ol101789g
279. D. Gianni, N. Taulet, H. Zhang, C. DerMardirossian, J. Kister, L. Martinez, W. R. Roush, S. J. Brown, H. Rosen and G. M. Bokoch, “A novel selective and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells,” ACS Chem. Biol., 2010, 5, 981–993. 10.1021/cb100219n
278. F. Madoux, S. Simanski, P. Chase, J. K. Mishra, W. R. Roush, N. G. Ayad, and P. S. Hodder, “An Ultra-High Throughput Cell-Based Screen for Wee1 Degradation Inhibitors,” J. Biomol. Screen. 2010, 15, 907. 10.1177/1087057110375848
277. Y. T. Chen, L. S. Brinen, I. D. Kerr, E. Hansell, P. S. Doyle, J. H. McKerrow, and W. R. Roush, “In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi”, PLoS Neglected Tropical Diseases 2010, 4, e825. 10.1371/journal.pntd.0000825
276. M. Chen and W. R. Roush, “Highly (E)-Selective BF3•Et2O Promoted Allylboration of Chiral Nonracemic a-Substituted Allylboronates and Analysis of the Origin of Stereocontrol,” Org. Lett. 2010, 12, 2706. 10.1021/ol1007444
275. R. Barth and W. R. Roush, “Enantioselective Synthesis of a-Methylene-b-hydroxy Carboxylic Acid Derivatives via a Diastereoselective Aldol-b-Elimination Sequence: Application to the C(15)-C(21) Fragment of Tedanolide C,” Org. Lett. 2010, 12, 2342. 10.1021/ol1006955
274. M. Chen, D. H. Ess, and W. R. Roush, “Enantioselective Synthesis of (E)-d-Stannyl Homoallylic Alcohols Via Aldehyde Allylboration Using a-Stannylallylboranes Generated by Allene Hydroboration Followed By a Highly Diastereoselective 1,3-Boratropic Shift,” J. Am. Chem. Soc. 2010, 132, 7881. 10.1021/ja103041u
273. C. He, G. P. Nora, E. Schneider, I. D. Kerr, E. Hansell, K. Hirata, D. Gonzalez, M. Sajid, S. E. Boyd, P. Hruz, E. Cobo, C. Le, W. Liu, L. Eckmann, P. C. Dorrestein, E. R. Houpt, L. S. Brinen, C. Craik, W. R. Roush, J. McKerrow, S. L. Reed, “A Novel Entamoeba histolytica Cysteine Proteinase, EhCP4, is Key for Invasive Amebiasis and a Therapeutic Target,” J. Biol. Chem., 2010, 285, 18516. 10.1074/jbc.M109.086181
272. D. H. Ess, J. Kister, M. Chen and W R. Roush, “Origin of Thermodynamic versus Kinetic Control of Allene Hydroboration with 9-Borabicyclo[3.3.1]nonane and 10(R)-Trimethylsilyl-9-Borabicyclo[3.3.2]decane,” Org. Lett. 2009, 11, 5538. 10.1021/ol902364d
271. D. H. Ess, J. Kister, M. Chen and W R. Roush, “Quantum Mechanical Study of 10-R-9-Borabicyclo[3.3.2]decane Alkene Hydroboration,” J. Org. Chem. 2009, 74, 8626. 10.1021/jo901737d
270. J. Kister, A. C. DeBaillie, R. Lira and W. R. Roush, “Stereoselective Synthesis of g-Substituted (Z)-Allylic Boranes via Kinetically Controlled Hydroboration of Allenes with 10-TMS-9-borabicyclo[3.3.2]decane,” J. Am. Chem. Soc. 2009, 131, 14174. 10.1021/ja905494c
269. M. Chen, M. Handa and W. R. Roush, “Enantioselective Synthesis of 2-Methyl-1,2-syn- and 2-Methyl-1,2-anti-3-Butenediols Via Allene Hydroboration-Aldehyde Allylboration Reaction Sequences,” J. Am. Chem. Soc. 2009, 131, 14602. 10.1021/ja904599h
268. A. T. Dossey, M. Gottardo, J. Whitaker, W. R. Roush, and A. S. Edison, “Alkyldimethylpyrazines in the Defensive Spray of Phyllium westwoodi: A First for Order Phasmatodea,” J. Chem. Ecol. 2009, 35, 861. 10.1007/s10886-009-9666-9
267. F. Li and W. R. Roush, “Stereoselective Synthesis of Syn,Syn- and Syn,Anti-1,3,5-Triols via Intramolecular Hydrosilylation of Substituted Pent-3-en-1,5-diols,” Org. Lett. 2009, 11, 2932. 10.1021/ol9009877
266. G. T. Halvorsen and W. R. Roush, “Siloxacyclopentenes as Dienophile-Linked Directing Groups in Intramolecular Diels-Alder Reactions,” Org. Lett. 2008, 10, 5313. 10.1021/ol802266s
265. J. Dunetz, L. Julian, J. Newcom and W. R. Roush, “Total Syntheses of (+)-Tedanolide and (+)-13-Deoxytedanolide,” J. Am. Chem. Soc., 2008, 130, ASAP. 10.1021/ja8063205
264. M. Tortosa, N. A. Yakelis and W. R. Roush, “Total Synthesis of (+)-Superstolide A,” J. Org. Chem. 2008, 73, ASAP.10.1021/jo801794s
263. R. Pragani and W. R. Roush, “Studies on the Synthesis of Durhamycin A: Stereoselective Synthesis of a Model Aglycone,” Org. Lett. 2008, 10, 4613. 10.1021/ol8018727
262. R. H. Bates, J. B. Shotwell and W. R. Roush, “Stereoselective Syntheses of the C(1)-C(9) Fragment of Amphidinolide C,” Org. Lett.2008, 10, 4343. 10.1021/ol801852j
261. R. H. Bates, M. Chen, and W. R. Roush, “Applications of chiral allylmetallating agents toward the synthesis of oxygen heterocycles,” Current Opinion in Drug Discovery and Development, 2008, In Press.
260. C. W. Huh and W. R. Roush, “Highly Stereoselective and Modular Syntheses of 10-Hydroxytrilobacin and Three Diastereomers via Stereodivergent [3+2]-Annulation Reactions,” Org. Lett. 2008, 10, 3371. 10.1021/ol801242d
259. Y. T. Chen, R. Lira, E. Hansell, J. H. McKerrow and W. R. Roush, “Synthesis of macrocyclic inhibitors of trypanosomal cysteine proteases,” Bioorg. Med. Chem. Lett., 2008, 18, 5860. 10.1016/j.bmcl.2008.06.012
258. W. R. Roush, “Total Synthesis of Biologically Active Natural Products,” J. Am. Chem. Soc. 2008, 130, 6654. 10.1021/ja8028813
257. J. Dunetz and W. R. Roush, “Concerning the Synthesis of the Tedanolide C(13)-C(23) Fragment via an Anti-Aldol Reaction,” Org. Lett. 2008, 10, 2059. 10.1021/ol800546g
256. J. L. Methot and W. R. Roush, “Applications of Tricoordinated Phosphorus Compounds in Organic Catalysis,” Science of Synthesis 2008, 42, In press.
255. J. Roth, F. Madoux, P. Hodder and W. R. Roush, “Synthesis of Small Molecule Inhibitors of the Orphan Nuclear Receptor Steroidogenic Factor-1 (NR5A1) Based on Isoquinolinone Scaffolds,” Bioorg. Med. Chem. Lett. 2008, 18, 2628.10.1016/j.bmcl.2008.03.027
254. J. D. Hicks and W. R. Roush, “Synthesis of the C(26)-C(42) and C(43)-C(67) Pyran-Containing Fragments of Amphidinol 3 via a Common Pyran Intermediate,” Org. Lett., 2008, 10, 681. 10.1021/ol703042q
253. Winbush, S. M.; Mergott, D. J.; Roush, W. R., “Total Synthesis of (-)-Spinosyn A: Examination of Structural Features that Govern the Stereoselectivity of the Key Transannular Diels-Alder Reaction,” J. Org. Chem., 2008, 73, 1818. 10.1021/jo7024515
252. M. Tortosa, N. A. Yakelis, and W. R. Roush, “Total Synthesis of Superstolide A”, J. Am. Chem. Soc., 2008, 130, 2722.10.1021/ja710238h
251. M. Handa, W. J. Smith, III, and W. R. Roush, “Studies on the Synthesis of Apoptolidin A. 2. Synthesis of the Disaccharide Unit,” J. Org. Chem. 2008, 73, 1036. 10.1021/jo7022526
250. M. Handa, K. A. Scheidt, M. Bossart, N. Zheng, and W. R. Roush, “Studies on the Synthesis of Apoptolidin A. 1. Synthesis of the C(1)-C(11) Fragment,” J. Org. Chem. 2008, 73, 1031. 10.1021/jo702250z
249. J. D. Hicks, C. W. Huh, A. D. Legg, and W. R. Roush, “Concerning the Selective Protection of the Allylic Alcohol Unit of (Z)-1,4-syn-Endiols and (E)-1,5-anti-Enediols as Triethylsilyl Ethers,” Org. Lett., 2007, 9, 5621. 10.1021/ol702588h
248. R. Lira and W. R. Roush, “Enantio- and Diastereoselective Synthesis of syn-β-Hydroxyallylsilanes via a Chiral (Z)-γ-Silylallylboronate,” Org. Lett., 2007, 9, 4315. 10.1021/ol7018746
247. S. G. Meléndez-López, S. Herdman, K. Hirata, M.-H Choi, Y. Choe, C. Craik, C. Caffrey, C., E. Hansell, B. Chávez-Munguía, Y. T. Chen, W. R. Roush, J. McKerrow, l. Eckmann, J. Guo, S. L. Stanley, Jr., S. L. Reed, "EhCP1 is a Unique, Released Cysteine Proteinase of Invasive Entamoeba histolytica," Eucaryotic Cell 2007, 6, 1130. 10.1128/EC.00094-07
246. D. H. Goetz, T. Choe, E. Hansell, Y. T. Chen, W. R. Roush, J. McKerrow, and C. S. Craik, “Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus,” Biochemistry, 2007, 46, 8744.10.1021/bi0621415
245. G. T. Halvorsen and W. R. Roush, “Intramolecular Diels-Alder Reactions of Siloxacyclopentene Constrained Trienes,” Org. Lett.2007, 9, 2243. 10.1021/ol070858u
244. P. Va and W. R. Roush, “Total Synthesis of Amphidinolide E and Amphidinolide E Stereoisomers,” Tetrahedron, 2007, 63, 5768 (invited paper for 50th Anniversary Issue). 10.1016/j.tet.2007.02.058
243. R. Lira and W. R. Roush, “Stereoselective Synthesis of the C(1)-C(19) Fragment of Tetrafibracin,” Org. Lett., 2007, 9, 533.10.1021/ol062986
242. P. Va and W. R. Roush, “Synthesis of 2-epi-Amphidinolide E: An Unexpected and Highly Selective C(2) Inversion during an Esterification Reaction,” Org. Lett., 2007, 9, 307. 10.1021/ol0628098
241. P. Va and W. R. Roush, “Total Synthesis of Amphidinolide E,” J. Am. Chem. Soc., 2006, 128, 15960. 10.1021/ja066663j
240. T. K. Trullinger, J. Qi and W. R. Roush, “Studies on the Synthesis of Quartromicins A3 and D3: Synthesis of the Vertical and Horizontal Bis-Spirotetronate Fragments,” J. Org. Chem. 2006, 71, 6915. 10.1021/jo061059c
239. J. Qi and W. R. Roush, “Synthesis of Precursors of the Agalacto (Exo) Fragment of the Quartromicins via an Auxiliary-Controlled Exo-Selective Diels-Alder Reaction,” Org. Lett. 2006, 8, 2795. 10.1021/ol0609208
238. J. D. Hicks, E. M. Flamme and W. R. Roush, “Synthesis of the C(43)-C(67) Fragment of Amphidinol 3,” Org. Lett. 2005, 7, 5509.10.1021/ol052322j
237. W. T. Lambert and W. R. Roush, “Synthesis of the A-B Subunit of Angelmicin B,” Org. Lett. 2005, 7, 5501. 10.1021/ol052321r
236. L. C. Dias, A. M. Aguilar, A. G. Salles Jr., W. J. Steil and W. R. Roush, “Concerning the Application of the 1H NMR ABX Analysis for Assignment of Stereochemistry to Aldols Deriving from Aldehydes Lacking β-Branches.” J. Org. Chem. 2005, 70, 10461.10.1021/jo051773e
235. E. M. Flamme and W. R. Roush, “Synthesis of 2,6-Trans-Disubstituted 5,6-Dihydropyrans from (Z)-1,5-Syn-Endiols,” Beilstein J. Org. Chem. 2005, 1, 7. 10.1186/1860-5397-1-7
234. J. M. Tinsley, E. Mertz, P. Y. Chong, R.-A. F. Rarig and W. R. Roush, “Synthesis of (+)-Bullatacin via the Highly Diastereoselective [3+2] Annulation Reaction of a Racemic Aldehyde and a Non-Racemic Allylsilane,” Org. Lett. 2005, 7, 4245. 10.1021/ol051719k
233. R. M. Owen and W. R. Roush, “Stereoselective Synthesis of the C(1)-C(11) Fragment of Peloruside A,” Org. Lett. 2005, 7,3941.10.1021/ol0514303
232. R. K. Thalji and W. R. Roush, “Remarkable Phosphine-Effect on the Intramolecular Aldol Reactions of Unsaturated 1,5-Diketones: Highly Regioselective Synthesis of Cross-Conjugated Dienones,” J. Am. Chem. Soc. 2005, 127, 16778. 10.1021/ja054085l
231. E. Mertz, J. M. Tinsley, and W. R. Roush, “[3+2]-Annulation Reactions of Chiral Allylsilanes and Chiral Aldehydes. Studies on the Synthesis of Bis-Tetrahydrofuran Substructures of Annonaceous Acetogenins,” J. Org. Chem., 2005, 70, 8035. 10.1021/jo0511290
230. J. M. Tinsley and W. R. Roush, “Total Synthesis of Asimicin via Highly Stereoselective [3+2] Annulation Reactions of Substituted Allylsilanes,” J. Am. Chem. Soc. 2005, 127, 10818. 10.1021/ja051986l
229. C. L. Heitzman, W. T. Lambert, E. Mertz, J. Brad Shotwell, J. M. Tinsley, P. Va, and W. R. Roush , “Efficient Protiodesilylation of Unactivated C(sp3)-SiMe2Ph Bonds Using Tetrabutylammonium Fluoride”, Org. Lett. 2005, 7, 2405. 10.1021/ol0506821
228. L. D. Julian, J. S. Newcom, and W. R. Roush, “Total Synthesis of (+)-13-Deoxytedanolide,” J. Am. Chem. Soc. 2005, 127, 6186.10.1021/ja050729d
227. C. M. Liu, W. J. Smith, III, D. J. Gustin, and W. R. Roush, “Experimental Evidence for Chair-Like Transition States in Aldol Reactions of Methyl Ketone Lithium Enolates: Stereoselective Synthesis and Utilization of a Deuterium-Labeled Enolate as a Probe of Reaction Stereochemistry,” J. Am. Chem. Soc., 2005, 127, 5770. 10.1021/ja050730c
226. E. M. Flamme and W. R. Roush, “Synthesis of the C(1)–C(25) Fragment of Amphidinol 3: Application of the Double Allylboration Reaction for Synthesis of 1,5-Diols,” Org. Lett., 2005, 7, 1411. 10.1021/ol050250q
225. T. A. Dineen and W. R. Roush, “Stereoselective Synthesis of the Octahydronaphthalene Unit of Integramycin via an Intramolecular Diels-Alder Reaction,” Org. Lett. 2005, 7, 1355. 10.1021/ol050191g
224. B. P. Coppola and W. R. Roush, “Broadening the Existing Intergenerational Structure of Scholarly Development in Chemistry,”Peer Review 2004, 6, 19.
223. J. B. Shotwell and W. R. Roush, “Synthesis of the C11-C29 Fragment of Amphidinolide F”, Org. Lett. 2004, 6, 3865.10.1021/ol048381z
222. S. Narayan and W. R. Roush, “Studies Towards the Total Synthesis of Angelmicin B (Hibarimicin B): Synthesis of a Model CD-D’ Arylnaphthoquinone”, Org. Lett. 2004, 6, 3789. 10.1021/ol048436x
221. T. A. Dineen and W. R. Roush, “Total Synthesis of Cochleamycin A,” Org. Lett. 2004, 6, 2043. 10.1021/ol049331x
220. J. L. Methot and W. R. Roush, “Nucleophilic Phosphine Organocatalysis,” Adv. Synth. Catal., 2004, 346, 1035.10.1002/adsc.200404087
219. W. R. Roush and R. J. Neitz, “Studies on the Synthesis of Landomycin A. Synthesis of the Originally Assigned Structure of the Aglycone, Landomycinone, and Revision of Structure,” J. Org. Chem., 2004, 69, 4906. 10.1021/jo049426c
218. D. J. Mergott, S. A. Frank, and W. R. Roush, “Total Synthesis of (-)-Spinosyn A,” Proc. Natl. Acad. Sci. 2004, 101, 11955.10.1073/pnas.0401247101
217. T. B. Durham, B. M. Savall, N. Blanchard, N. A. Powell, and W. R. Roush, “Total Synthesis of Formamicin,” J. Am. Chem. Soc.,2004, 126, 9307. 10.1021/ja048493l
216. T. A. Dineen and W. R. Roush, “Probing the Lewis Acid Catalyzed Intramolecular Diels-Alder Cyclizations of Allylic Alkoxy-Substituted (Z)-1,3-Dienes,” Org. Lett. 2003, 5, 4725. 10.1021/ol035900+
215. J. L. Methot and W. R. Roush, “Synthetic Studies Toward FR182877. Remarkable Solvent Effects in the Vinylogous Morita-Baylis-Hillman Cyclization,” Org. Lett. 2003, 5, 4223. 10.1021/ol0357550
214. A. Boitano, F. Leonetii, C. Emal, T. A. Dineen, J. A. Ellman, W. R. Roush, A. W. Opipari, and G. D. Glick, “Structure Activity Studies of Novel Cytotoxic Benzodiazepine,” Bioorg. Med. Chem. Lett. 2003, 13, 3327. 10.1016/S0960-894X(03)00683-8
213. J. J. Reddick, J. Cheng, and W. R. Roush, "Relative Rates of Michael Reactions of 2’-(Phenethyl)thiol with Vinyl Sulfones, Vinyl Sulfonate Esters, and Vinyl Sulfonamides Relevant to Vinyl Sulfonyl Cysteine Protease Inhibitors," Org. Lett. 2003, 5, 1967.10.1021/ol034555l
212. T. B. Durham and W. R. Roush, “Stereoselective Synthesis of Functionalized Precursors of the CDEF and CDE 2,6-Dideoxy-Tetra- and Trisaccharide Units of Durhamycins A and B,” Org. Lett., 2003, 5, 1875. 10.1021/ol034395d
211. T. B. Durham and W. R. Roush, “Stereoselective Synthesis of 2-Deoxy-β-Galactosides via 2-Deoxy-2-bromo and 2-Deoxy-2-iodo-galactopyranosyl Donors,” Org. Lett., 2003, 5, 1871. 10.1021/ol034393t
210. J.-N. Heo, E. B. Holson, and W. R. Roush, “A Common-Intermediate Strategy for Synthesis of Conduritols and Inositols via β-Hydroxy Cyclohexenylsilanes, Org. Lett., 2003, 5, 1697. 10.1021/ol034349d
209. J.-N. Heo, G. C. Micalizio, and W. R. Roush, “Enantio- and Diastereoselective Synthesis of Cyclic β-Hydroxy Allylsilanes via Sequential Aldehyde γ-Silylallylboration and Ring Closing Metathesis, “ Org. Lett., 2003, 5, 1693. 10.1021/ol034347t
208. N. A. Yakelis and W. R. Roush, “Synthesis of the C(21)-C(26) Fragment of Superstolide A: Concerning the Stereochemistry of (E)-Crotylboration Reactions of Alaninal Derivatives,” J. Org. Chem. 2003, 68, 3838. 10.1021/jo0341012
207. B. M. Savall, N. Blanchard, and W. R. Roush, "Total Synthesis of the Formamicin Aglycon, Formamicinone," Org. Lett. 2003, 5, 377.10.1021/ol027569k
206. S. R. Chemler and W. R. Roush, "Stereochemistry of the Allylation and Crotylation Reactions of α-Methyl-β-Hydroxy Aldehydes with Allyl- and Crotyltrifluorosilanes. Synthesis of Anti, Anti-Dipropionate Stereotriads and Stereodivergent Pathways for the Reactions with 2,3-Anti and 2,3-Syn α-Methyl-β-Hydroxy Aldehydes," J. Org. Chem. 2003, 68, 1319. 10.1021/jo0267908
205. B. R. Shenai, B. J. Lee, A. Alvarez-Hernandez, P. Y. Chong, C. D. Emal, R. J. Neitz, W. R. Roush, and P. J. Rosenthal, “Structure activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones,”Antimicrob. Agents Chemother., 2003, 47, 154. 10.1128/AAC.47.1.154-160.2003
204. N. Blanchard and W. R. Roush, “2-Deoxy-2-Iodo-β-Glucopyranosyl Fluorides: Mild and Highly Stereoselective Glycosyl Donors for Synthesis of 2-Deoxy-β-Glycosides from β-Hydroxy Ketones,” Org. Lett. 2003, 5, 81 10.1021/ol027257h
203. W. R. Roush and J. Newcom, "Studies on the Synthesis of Tedanolide. 2. Stereoselective Synthesis of a Protected C(1)-C(12) Fragment," Org. Lett. 2002, 4, 4739. 10.1021/ol0272343
202. P. Y. Chong and W. R. Roush, “Concerning the Origin of the High β-Selectivity of Glycosidation Reactions of 2-Deoxy-2-iodo-glucopyranosyl Trichloroacetimidates,” Org. Lett. 2002, 4, 4523. 10.1021/ol027066e
201. E. Flamme and W. R. Roush, “Enantioselective Synthesis of 1,5-Anti and 1,5-Syn Diols Using a Highly Diastereoselective One-Pot Double Allylboration Reaction Sequence,” J. Am. Chem. Soc., 2002, 124, 13644. 10.1021/ja028055j
200. E. B. Holson and W. R. Roush, “Synthesis of the C(2)-C(13) A-B Spiroketal Unit of Spongistatin 1 (Altohyrtrin A): Use of a Common Intermediate for the Synthesis of the Two Spongistatin Spiroketal Units,” Org. Lett., 2002, 4, 3723. 10.1021/ol026688x
199. E. B. Holson and W. R. Roush, “A Highly Diastereoselective Synthesis of the C(17)-C(28) Fragment (C-D Spiroketal Unit) of Spongistatin 1 (Altohyrtrin A) via a Kinetically Controlled Iodo-Spiroketalization Reaction,” Org. Lett., 2002, 4, 3719. 10.1021/ol0266875
198. D. J. Mergott, S. A. Frank, and W. R. Roush, “Application of the Intramolecular Vinylogous Morita-Baylis-Hillman Reaction Toward the Synthesis of the Spinosyn A Tricyclic Nucleus,” Org. Lett., 2002, 4, 3157. 10.1021/ol026540d
197. W. R. Roush, D. A. Barda, C. Limberakis, and R. K. Kunz, “Studies on the Synthesis of the Quartromicins: Partial Stereochemical Assignment of Quartromicins A3 and D3 and Diastereoselective Synthesis of the Endo- and Exo-Spirotetronate Subunits,”Tetrahedron, 2002, 58, 6433 (invited paper, in honor of Prof. Y. Kishi). 10.1016/S0040-4020(02)00656-7
196. B. W. Gung, X. Xue, and W. R. Roush, “The Origin of Diastereofacial Control in Allylboration Reactions Using Tartrate Ester Derived Allylboronates: Attractive Interactions Between the Lewis Acid Coordinated Aldehyde Carbonyl Group and an Ester Carbonyl Oxygen,” J. Am. Chem. Soc., 2002, 124, 10692. 10.1021/ja026373c
195. A. Alvarez Hernandez and W. R. Roush, “Recent Advances in the Synthesis, Design and Selection of Cysteine Protease Inhibitors,”Current Opinion in Chemical Biology, 2002, 6, 459. 10.1016/S1367-5931(02)00345-9
194. W. R. Roush, H. Chen, and M. L. Reilly, “Studies on the Synthesis of Kijanolide: Synthesis of an Advanced Seco-Acid Intermediate,” Heterocycles, 2002, 58, 259 (invited manuscript, in honor of Prof. A. I. Meyers). Access Online
193. S. A. Frank and W. R. Roush, “Studies on the Synthesis of (-)-Spinosyn A: Application of the Steric Directing Group Strategy to Transannular Diels-Alder Reactions,” J. Org. Chem., 2002, 67, 4316. 10.1021/jo025580s
192. W. R. Roush, L. Hertel, M. J. Schnaderbeck, and N. A. Yakelis, “Synthesis of the C(18)-C(26) Segment of Superstolide A,”Tetrahedron Lett., 2002, 43, 4885. 10.1016/S0040-4039(02)00903-6
191. W. R. Roush, C. Limberakis, R. Kunz and D. A. Barda, “Diastereoselective Syntheses of the endo- and exo-Spirotetronate Subunits of the Quartromicins. The First Example of an Enantioselective Diels-Alder Reaction of an Acyclic (Z)-Diene,” Org. Lett., 2002,4, 1543. 10.1021/ol025772+
190. W. R. Roush and D. A. Barda, “Stereochemical Assignment of Quartromicins A3 and D3,” Org. Lett., 2002, 4, 1539.10.1021/ol025771h
189. W. R. Roush, T. D. Bannister, M. D. Wendt, M. S. VanNieuwenhze, D. J. Gustin, G. D. Dilley, G. C. Lane, K. A. Scheidt, and W. J. Smith, III, “An NMR Method for Assigning Stereochemistry to β-Hydroxy Ketones Deriving from Aldol Reactions of Methyl Ketones,” J. Org. Chem., 2002, 67, 4284. 10.1021/jo0164148
188. K. A. Scheidt, A. Tasaka, T. D. Bannister, M. D. Wendt, B. M. Savall, G. J. Fegley, and W. R. Roush, “Total Synthesis of (-)-Bafilomycin A1,” J. Am. Chem. Soc., 2002, 124, 6981. 10.1021/ja017885e
187. W. R. Roush, T. D. Bannister, M. D. Wendt, J. A. Jablonowski, and K. A. Scheidt, “Studies on the Synthesis of Bafilomycin A1: Stereochemical Aspects of the Fragment Assembly Aldol Reaction for Construction of the C(13)-C(25) Segment,” J. Org. Chem., 2002,67, 4275. 10.1021/jo016413f
186. W. R. Roush and R. A. James, "Towards the Synthesis of Aureolic Acid Analog Conjugates: Synthesis and Glycosidation Reactions of 4-Azido-2,4,6-Trideoxy-L-glucopyranose,” Aust. J. Chem., 2002, 55, 141 (invited paper). 10.1071/CH01199
185. W. R. Roush, N. A. Powell and R. A. James, "Synthesis of Aureolic Acid Aglycone-C-D-E Trisaccharide Analogs,” Aust. J. Chem.,2002, 55, 113 (invited paper). 10.1071/CH01198
184. S. A. Frank, D. J. Mergott and W. R. Roush, “The Vinylogous Intramolecular Morita-Baylis-Hillman Reaction: Synthesis of Functionalized Cyclopentenes and Cyclohexenes Using Trialkylphosphines as Nucleophilic Catalysts,” J. Am. Chem. Soc., 2002, 124, 2404. 10.1021/ja017123j
183. B. M. Savall, N. A. Powell and W. R. Roush, “Highly Diastereoselective Synthesis of Propargylic 1,2-anti-Diol Derivatives Using α-Alkoxypropargylstannanes”, Org. Lett., 2001, 3, 3057. 10.1021/ol016536m
182. W. R. Roush, C. E. Bennett, and S. E. Roberts, “Studies on the Synthesis of Landomycin A: Synthesis and Glycosidation Reactions of L-Rhodinosyl Acetate Derivatives”, J. Org. Chem., 2001, 66, 6389. 10.1021/jo015756a
181. G. C. Micalizio and W. R. Roush, “Studies on the Synthesis of Pectenotoxin II: Synthesis of a C(11)-C(26) Fragment Precursor via [3+2]-Annulation Reactions of Chiral Allylsilanes," Org. Lett, 2001, 3, 1949. 10.1021/ol0160250
180. N. A. Yakelis and W. R. Roush, “Lewis Acid Catalyzed Intramolecular Diels-Alder Reactions of Acyclic (Z)-Substituted 1,3-Dienes,”Org. Lett. 2001, 3, 957. 10.1021/ol015667k
179. W. R. Roush, D. J. Madar, and D. S. Coffey, “Synthesis of Highly Functionalized Naphthoate Precursors to Damavaricin D. Observation of Kinetically Stable Benzocyclohexadienones in the Bromination Reactions of Highly Functionalized β-Napththol Derivatives,” Can. J. Chem., 2001, 79, 1711 (invited paper for issue in honor of Prof. V. Snieckus). 10.1139/cjc-79-11-1711
178. W. R. Roush and G. J. Dilley, “Studies on the Synthesis of 2,6-Disubstituted Dihydropyrans: Intervention of Oxonia-Cope Rearrangements in the Lewis Acid Mediated Cyclodehydrative Reactions of Aldehydes and β-Hydroxyallylsilanes,” SynLett., 2001, 955 (invited paper for issue in honor of Prof. R. Noyori). 10.1055/s-2001-14632
177. W. R. Roush, J. Cheng, B. Knapp-Reed, A. Alvarez-Hernandez, J. H. McKerrow, E. Hansell and J. C. Engel, “Potent Second Generation Vinyl Sulfonamide Inhibitors of the Trypanosmal Cysteine Protease Cruzain,” Bioorg. Med. Chem. Lett., 2001, 11, 2759.10.1016/S0960-894X(01)00566-2
176. N. A. Powell and W. R. Roush, “Studies on the Total Synthesis of Formamicin: Synthesis of the C(1)-C(11) Fragment,” Org. Lett.,2001, 3, 453. 10.1021/ol0069610
175. C. R. Caffrey, E. Hansell, K. D. Lucas, L. S. Brinen, A. Alvarez-Hernandez, J. Cheng, S. L. Gwaltney II, W. R. Roush, Y.-D. Stierhof, M. Bogyo, D. Steverding and J. H. McKerrow, “Rhodesian: the major cysteine protease of Trypanosoma brucei rhodesiense. Recombinant expression, purification, localization and enzymatic characterization,” Mol. Biochem. Parasitol., 2001, 118, 61. 10.1016/S0166-6851(01)00368-1
174. R. Ménard, C. Therrien, P. Lachance, T. Sulea, H. Qi, A. Alvarez-Hernandez, and W. R. Roush, “Cathepsins X and B Display Distinctive Activity Profiles that can be Exploited for Inhibitor Design,” Biol. Chem. 2001, 682, 839. 10.1515/BC.2001.102
173. C. Therrien, P. Lachance, T. Sulea, E. O. Purisima, H. Qi, E. Ziomek, A. Alvarez-Hernandez, W. R. Roush and R. Ménard, “Cathepsins X and B Can Be Differentiated Through Their Respective Mono- and Dipeptidy Carboxypeptidase Activities”, Biochemistry,2001, 40, 2702. 10.1021/bi002460a
172. W. R. Roush, A. N. Pinchuk, and G. C. Micalizio, “[(E)-γ-(dimethylphenylsilyl)allyl]-diisopinocampheylborane: a highly enantioselective reagent for the synthesis of anti-β-hydroxyallylsilanes,” Tetrahedron Lett., 2000, 41, 9413 (invited paper for issue in honor of Prof. H. Wasserman). 10.1016/S0040-4039(00)01526-4
171. G. C. Micalizio, A. N. Pinchuk, and W. R. Roush, “Synthesis of the C(29)-C(45) Bis-pyran Subunit (E-F) of Spongistatin 1 (Altohyrtrin A),” J. Org. Chem., 2000, 65, 8730. 10.1021/jo001236o
170. L. S. Brinen, E. Hansell, J. Cheng, W. R. Roush, J. H. McKerrow and R. J. Fletterick, “A target within the target: probing cruzain’s P1’ site to define structural determinants for the Chagas’ disease protease,” Structure 2000, 8, 831. 10.1016/S0969-2126(00)00173-8
169. S. A. Frank, H. Chen, R. K. Kunz, M. J. Schnaderbeck, and W. R. Roush, “Use of Thallium(I) Ethoxide in Suzuki Cross Coupling Reactions,” Org. Lett., 2000, 2, 2691. 10.1021/ol0062446
168. W. R. Roush, A. Alvarez Hernandez, J. H. McKerrow, P. M. Selzer, E. Hansell and J. C. Engel, "Design, Synthesis and Evaluation of D-Homophenylalanyl Epoxysuccinate Inhibitors of the Trypanosomal Cysteine Protease Cruzain," Tetrahedron, 2000, 56, 9747 (invited paper for Symposium-in-Print). 10.1016/S0040-4020(00)00882-6
167. W. R. Roush and C. E. Bennett, "A Highly Stereoselective Synthesis of the Landomycin A Hexasaccharide Unit," J. Am. Chem. Soc., 2000, 122, 6124. 10.1021/ja000743k
166. W. R. Roush and L. A. Pfeifer, "Total Synthesis of Mycalamide A and 7-epi-Mycalamide A", Org. Lett., 2000, 2, 859.10.1021/ol005629l
165. S. R. Chemler and W. R. Roush, "Recent Applications of the Carbonyl Allylation Reaction to the Synthesis of Natural Products", in "Modern Carbonyl Chemistry," J. Otera, ed., Wiley-VCH, 2000, 403.
164. S. A. Frank, A. B. Works, and W. R. Roush, "Studies on the Synthesis of the Decahydro-as-Indacene Ring System of (-)-Spinosyn A via Transannular Diels-Alder Reactions of Substituted (E,E,E)-Cyclododeca-1,6,8-Trienes," Can. J. Chem., 2000, 78, 757 (invited paper for issue in honor of Prof. S. Hanessian). 10.1139/cjc-78-6-757
