We are pursuing several research programs in bioorganic chemistry, chemical biology and medicinal chemistry, including one focusing on the design and synthesis of inhibitors of cysteine proteases isolated from tropical parasites. This project is performed in collaboration with several groups of scientists at the University of California, San Francisco and the Unversity of California, San Diego. Additional projects in my laboratory at Scripps Florida include efforts to develop potent, selective inhibitors of several kinases and proteases, inhibitors of certain epigenetic targets, inhibitors (inverse agonists) or activators of nuclear receptors, and small molecule inhibotors of carboxylic acid transporters as potential therapeutic agents.