Publications 2009 - Present
Bianco, N., Kim, S.-H., Ruffner, M. and Robbins, P. D. (2009) Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum. 60:380-9. PMC3491653. PubMed Link
Evans, C. H., Ghivizzani, S. C. and Robbins, P. D. (2009) Gene Therapy of the Rheumatic Diseases 1998-2008. Arthr. Rheum. & Ther. 11:209, PMC2688220. PubMed Link
Evans, C. H., Ghivizzani, S. C., and Robbins, P. D. (2009) Orthopaedic gene therapy in 2008. Mol. Ther. 17:231-44. PMC2835052. PubMed Link
Evans, C. H., Ghivizzani, S. C., and Robbins, P. D. (2009) Progress and prospects: genetic treatments for disorders of bones and joints. Gene Ther. 16:944-52. PubMed Link
Jeong, M., Kwon, Y.-S., Park, S.-H., Kim, C.-Y., Jeun, S.-S., Song, K.-W., Ko, Y., Robbins, P. D., Billiar, T. and Kim, B.-M. (2009) Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. PLoS ONE 4:4545. PMC2641005. PubMed Link
Kay, J. D., Gouze, E., Oligino, T. J., Gouze, J. N., Watson, R. S., Levings, P. P., Bush, M. L., Dacanay, A., Nickerson, D. M., Robbins P. D., Evans, C. H., and Ghivizzani, S. C. (2009) Intra-articular gene delivery and expression of IL-1Ra mediated by self complementary adeno-associated virus. J. Gene Med. 11:605-14. PMC2876984. PubMed Link
Lefèvre, S., Knedla, A., Tennie. C., Kampmann, A., Wunrau, C., Dinser, R., Korb, A., Schnäker, E. M., Tarner, I. H., Robbins, P. D., Evans, C. H., Stürz, H., Steinmeyer, J., Gay, S., Schölmerich, J., Pap, T., Müller-Ladner, U.,and Neumann, E. (2009) Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat. Med. 15:1414-1420. NIHMS406794. PubMed Link
Reay, J., Kim, S.-H., Lockhart, E., Kolls, J. K., and Robbins, P. D. (2009) Adenoviral mediated, intra-tumoral gene transfer of interleukin 23 induces a systemic therapeutic response. Cancer Gene Ther. 16:776-8. PMC2745505. PubMed Link
Ruffner, M. A., Kim, S. H., Bianco, N. R., Francisco, L. M., Sharpe, A. H. and P. D. Robbins. (2009) B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. E. Jour. Immunol. 39:3084-3090. PMC3075967. PubMed Link
Wehling, P., Reinecke, J., Baltzer, A. W. A., Granrath, M., Schulitz, K. P., Schulz, C., Krauspe, R., Whiteside, T. W., Elder, E., Ghivizzani, S. C., Robbins, P. D. and Evans, C. H. (2009) Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis. Human Gene Ther. 20:97-101. PMC2855248. PubMed Link
Bernardini, C., Saulnier, N., Parrilla, C., Pola, E., Gambotto, A., Michetti, F., Robbins, P. D., and Lattanzi, W. (2010) Early transcriptional events during osteogenic differentiation of human bone marrow stromal cells induced by Lim Mineralization Protein 3. Gene Expr. 15:27-42. PMID21061915. PubMed Link
Chernajovsky, Y. and Robbins, P. D (2010) Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapy, in Gene Therapy for Autoimmune and Inflammatory Diseases, Chernajovsky and Robbins, Eds.
Gaddy, D. F., Riedel, M. J., Pejawar-Gaddy, S., Kieffer, T. J, and P. D. Robbins. (2010) In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ß-cell proliferation and improves pathology in the db/db mouse model of diabetes. Diabetes 59:3108-3016. PMC2992772. PubMed Link
Gaddy, D. F., Ruffner, M. A. and Robbins, P. D. (2010) Gene therapy for autoimmunedisorders. In A Guide to Human Gene Therapy, R. Herzog and S. Zolotukhin, eds.
Ghosh, H. S., McBurney, M. and Robbins, P. D. (2010) Sirt1 negatively regulates the mammalian target of rapamycin. PLoS ONE 5:e9199. PMC2821410. PubMed Link
Rehman, K. K. and Robbins, P. D. (2010) Comparison of Functional Protein Transduction Domain Delivery using the Nemo Binding Domain Peptide. Pharmaceuticals 3:110-124.
Riedel, M., Gaddy, D. F., Asadi, A., Robbins, P. D. and T. Kieffer. (2010) dsAAV8-Mediated Expression of Glucagon-like Peptide-1 in Pancreatic Beta Cells Ameliorates Streptozotocin-Induced Diabetes. Gene Ther. 17:171-80. PMID19865180. PubMed Link
Ruffner, M. A. and Robbins, P. D. (2010) Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PLoS ONE 5:e1184. PMC2912295. PubMed Link
Tang, Y., Reay, D. P., Salay, M. N., Mi, M. Y., Clemens, P. R., Guttridge, D. C., Robbins, P. D., Huard, J., and Wang, B. (2010) Inhibition of the IKK/NF-kB Pathway by AAV Gene Transfer Improves Muscle Regeneration in Older mdx Mice. Gene Ther. 17:1476-83. PMC3471137. PubMed Link
Vo, N., Seo, H.-Y., Robinson, A. R., Sowa, G., Studer, R., Bentley, D., Taylor, L., Usas, A., Alber, S., Huard, J., Watkins, S. C., Lee, J., Coehlo, P., Wang, D., Loppini, M., Robbins, P. D., Niedernhofer, L. J., and J. Kang (2010) Accelerated aging of intervertebral discs in a mouse model of progeria. J. Ortho. Res. 28:1600-7. PMC3477798. PubMed Link
Zahid, M., Lu, X., Mi, Z. and Robbins, P. D. (2010) Cationic and tissue-specific protein transduction domains identification, characterization, and therapeutic application. Adv Genet. 69:83-95. PubMed Link
Zahid, M., Phillips, B. E., Albers. S. M, Giannoukakis, N., Watkins, S. C. and Robbins, P.D. (2010) Identification of a Cardiac Specific Protein Transduction Domain by in vivo Biopanning using a M13 Phage Peptide Display Library. PLoS One 5:e12252. PMC2923200. PubMed Link
Evans, C. H., Ghivizzani, S. C. and Robbins, P. D. (2011) Getting arthritis gene therapy into the clinic. Nat. Rev. Rheum. 7:244-9. PMC3460537. PubMed Link
Gaddy, D. F., Riedel, M. J., Bertera, S., Kieffer, T. J, and P. D. Robbins. (2011) DsAAV8-mediated gene transfer and ß-cell expression of IL-4 and β-cell growth factors is capable of reversing early-onset diabetes in NOD mice. Gene Ther. 19:791-9. PMID22089495. PubMed Link
Gatson, N. N., Williams, J. L., Powell, N. D., McClain, M. A., Hennon, T. R., Robbins, P. D. and Whitacre, C.C. (2011) Induction of pregnancy during established EAE halts progression of CNS autoimmune injury via pregnancy-specific serum factors. J Neuroimmunol. 230:105-13. PMC3021646. PubMed Link
Ghosh, H., Reizis, B., and Robbins, P. D. (2011) SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Sci Rep. 1:150. PMC3252071. PubMed Link
Goss, J. R., Beer-Stolz, D., Robinson, A. R., Zhang, M., Arbujas, N., Robbins, P. D., Glorioso, J. C. and L. J. Niedernhofer. (2011) Premature Aging-related Peripheral Neuropathy in a Mouse Model of Progeria. Mech Ageing Dev. 132:437-42. PMC3179831. PubMed Link
Kim, C. Y., Park, S. H., Jeong, M., Kwon, O. S., Doh, H., Kang, S. H., Robbins, P. D., Kim, B. M., Seol, D. W. and Kim, B. G. (2011) Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy. Exp Mol Med. 43:580-6. PMC3222819. PubMed Link
Niedernhofer, L. J., Glorioso, J. C., and Robbins, P. D. (2011) Dedifferentiation rescuessenescence of progeria cells but only while pluripotent. Stem Cell Research & Therapy 2:28. PMC3152996. PubMed Link
Peterson, J. M., Kline, W., Canan B., Ricca, D., Kaspar, B., Delfin, D. A., DiRienzo, K., Clemens, P. Robbins, P. D., Baldwin, A. S., Lood, P., Frietas, M., Kornegay, J., Mednell, J. R., Rafael-Fortney, J. A., Guttridge, D. C., and Janssen, P. M. L. (2011) Peptide based inhibition of NF-ΚB rescues diaphragm muscle dysfunction in the mdx murine model of muscular dystrophy. Mol. Med. 17:508-15. PMC3105127. PubMed Link
Pola, E., Nasto, L. A., Tampieri, A., Lattanzi, W., Di Giacomo, G., Colangelo, D., Ciriello, V., Pagano, E., Spinelli, S., Robbins, P. D., Logroscino, G. (2011) Bioplasty for vertebral fractures: preliminary results of a pre-clinical study on goats using autologous modified skin fibroblasts. Int J Immunopathol Pharmacol 24(1 Suppl 2): 139-142. PMC3512194. PubMed Link
Reay, D. P., Yang, M., Watchko, J. F., Daood, M., Rehman, K. K., O’Day, T. L., Guttridge, D. C., Robbins, P. D. and Clemens, P. R. (2011) Systemic delivery of NEMO binding domain/IKKgamma inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology. Neurobiol Dis. 43:598-608. PMC3145633. PubMed Link
Tilstra, J. S., Clauson, C. L., Niedernhofer, L. J. and Robbins, P. D. (2011) NF-ΚB in aging and disease. Aging and Disease 2:449-465 PMC3295063. PubMed Link
Yang, C., Kim, S.-H, Bianco, N. R. and Robbins, P. D. (2011) Tumor-Derived Exosomes Confer Antigen-Specific Immunosuppression in a Murine Delayed-Type Hypersensitivity Model. PLoS ONE 6:e22517. PMC3149056. PubMed Link
Yang, C., and Robbins, P. D. (2011) The roles of tumor-derived exosomes in cancerpathogenesis. Clin. Dev. Immunol. 2011:842849 PMC3235485. PubMed Link
Zahid, M. and Robbins, P. D. (2011) Identification and characterization of tissue-specific protein transduction domains using Peptide phage display. Methods Mol Biol. 683:277-89. PubMed Link
Barba, M., Pirozzi, F., Saulnier, N., Vitali, T., Natale, M. T., Logroscino, G., Robbins, P. D., Gambotto, A., Neri, G., Michetti, F., Pola, E., and Lattanzi, W. (2012) Lim Mineralization Protein 3 induces the osteogenic differentiation of Human Amniotic Fluid Stromal Cells through Kruppel-like Factor-4 down-regulation and further bone-specific gene expression. J. Biomed. Biotech., 2012:813894. Doi: 10.1155-2012-813894. PMC3471036. PubMed Link
Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J. and Ouyang, H. (2012) DNA damage drives accelerated bone aging via an NF-kB dependent mechanism. J. Bone Min. Res. 2012 Dec 21, doi: 10.1002/jbmr.1851 [Epub ahead of print], PMID: 23281008, PMC Journal – In Process. PubMed Link
Evans, C. H., Ghivizzani, S. C. and Robbins, P. D. (2012) Orthopaedic Gene Therapy - Lost in Translation. J Cell Physiol. 227:416-20. PMC3264489. PubMed Link
Lavasani, M., Robinson, A. R., Lu, A., Song, M., Feduska, J. M., Ahani, B., Tilstra, J. S., Feldman, C. H., Robbins, P. D., Niedernhofer, L. J., and Huard, J. (2012) Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat. Commun. 3:608. doi: 10.1038/ncomms1611. PMC3272577. PubMed Link
Lin. Z., Rios, H. F., Park, C.-H., Taut, A., Jin, Q., Sugai, J. V., Robbins, P. D. and W. V. Giannobile. (2012) Lim domain protein-3 cooperates with BMP-7 to promote tissue regeneration by ligament progenitor cells. Gene Ther. doi: 10.1038/gt.2011.203. PMC3330200. PubMed Link
Lu, A., Proto, J., Guo, L., Tang, Y., Lavasani, M., Tilstra, J. S., Wang, B., Guttridge, D. C., Niedernhofer, L. J., Robbins, P. D. and J. Huard. (2012) NF-ΚB negatively impacts the myogenic potential of muscle-derived stem cells. Mol. Ther. 20:661-8. PMC3293604 PubMed Link
Nasto, L. A., Seo, H.-Y., Robinson, A. R., Tilstra, J. S., Clauson, C. L., Sowa, G. A., Ngo, K., Dong, Q., Pola, E., Lee, J. Y., Niedernhofer, L. J., Kang, J. D., Robbins, P. D. and N.V. Vo (2012) Inhibition of NF-ΚB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging. Spine, 37:1819-25. PMC3395770 *awarded as the best biology manuscript by the International Society for the Study of the Lumbar Spine (ISSLS) PubMed Link
Reay, J., Gambotto, A. and Robbins, P. D. (2012) The Anti-tumor Effects of Adenoviral-Mediated, Intra-tumoral delivery of Interleukin 23 require Endogenous IL-12. Can. Gene Therapy, 19:135-43. PMC3508719. PubMed Link
Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S., Clauson, C. L., Reay, D., Nasto, L. A., St. Croix, C., Vo, N., Usas, A., Huard, J., Clemens, P. A., Stoltz, D., Guttridge, D. C., Watkins, S. C., Garinis, G. A., Wang, Y., Niedernhofer, L. J., and P. D. Robbins. (2012) NF-kB inhibition delays DNA damage-inducedsenescence and aging in mice. J. Clin. Invest. 122:2601-12. PMC3386805. PubMed Link
Wang, J., Clauson, C. L.., Robbins, P. D., Niedernhofer, L. J., Wang, Y. (2012). The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell 11(4): 714-716. PMC3399950. PubMed Link
Xun, Z., Rivera-Sanchez, S., Ayala-Pena, S., Lim, J., Budworth, H., Skoda, E. M., Robbins, P. D., Niedernhofer, L. J., Wipf, P., McMurray, C. (2012) Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington’s disease. Cell Rep., 2:1137-42, PMC3513647. PubMed Link
Yang, C., Chalasani, G., Ng, W.-H, Konda, H. C. and Robbins, P. D. (2012) Exosomes released from mycoplasma infected tumor cells activate inhibitory B cells. PLoS ONE 7:e36138. PMC3338602. PubMed Link
Yang, C. and Robbins, P. D. (2012) Immunosuppressive exosomes: a new approach fortreating arthritis. Int J Rheumatol. 2012:573528, PMC3324137. PubMed Link
Yang, C., Ruffner, M. A., Kim, S.-H., and Robbins, P. D. (2012) Plasma-derived MHCII+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses. Eur. J. Immunol. 42(7):1778-84. PMC3471134. PubMed Link
Zahid, M. and Robbins, P. D. (2012) Protein Transduction Domains: Applications for Molecular Medicine. Current Gene Ther.12:374-80, PMID: 22920684. PubMed Link
Gaddy, D. F. and Robbins, P. D. (2012) Gene transfer to muscle. In Regenerative therapy for the musculoskeletal system using recombinant adeno-associated viral vectors. M.Cucchiarini, ed., in press.
Lavasani, M., Lu, A., Thompson, S.D., Robbins, P.D., Huard, J., and L.J. Niedernhofer (2013) “Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces” in Methods in Molecular Biology ed. K. Turksen, Springer., in press.
Nasto, L. A., Wang, D., Robinson, A. R., Clauson, C. L., Ngo, K., Dong, Q., Roughley, P., Epperly, M., Huq, S. M., Pola, E., Sowa, G., Robbins, P. D., Kang, J., Niedernhofer, L. J., Vo, N. (2013) Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs. Mech Ageing Dev., 134:35-42. PMC3558562 PubMed Link
Vo, N., Niedernhofer, L. J., Nasto, L. A., Jacobs, L., Robbins, P. D., Kang, J. and C. H. Evans (2013) Investigating the underlying cause of age-related degenerative disorders of the spine and synovial joints. J Orthop Res., in press.
Wipf, P., Frantz, M-C., Skoda, E., Davoren, J., Wang, Z., Epperly, M., Stripay, J., Tyurin, V., Fink, B., Beyir, H., Robbins, P. D., Niedernhofer, L. J., and V. Kagan (2013) Synthesis and biochemical analysis of mitochondria-targeted nitroxide conjugates based on gramicidin S. J. Am. Chem. Soc., in press.
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