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Department of Neuroscience


Cindy Ehlers, Ph.D.

Professor
Department of Neuroscience
California Campus
Laboratory Website
cindye@scripps.edu
(858) 784-7058

Scripps Research Joint Appointments

Professor, Department of Molecular and Experimental Medicine

Other Joint Appointments

Professor of Psychiatry (adjunct), University of California, San Diego, CA
Professor of Psychiatry (adjunct), University of Pittsburgh, Pittsburgh, PA

Research Focus

Understanding genetic risk and protective factors for alcoholism in Native, African and Hispanic Americans.

Our laboratory has been studying natural variation in the genes that encode the structure of the enzymes that metabolize alcohol between ethnic groups and conducting genome-wide scans for other genes that influence the development of alcoholism. The goal of our studies is to identify candidate genes that encode for the neurophysiological processes that underlie drug dependence. Genetic information is combined with data on clinical course and environmental risk factors with the aim of: describing the etiology of substance dependence; and developing prevention and intervention programs appropriate to the different ethnic groups.

A second thrust of our laboratory involves the investigation of the toxic effects of alcohol on the developing fetal and adolescent brain.

Education

Ph.D., Physiology, University of California, Davis, 1977
B.S., Physiology, University of California, Davis, 1973

Professional Experience

1977-1979 Post Doctoral Fellow, University of California, Los Angeles
1979-1983 Senior Research Associate, Arthur Vining David Center for Behavioral Neurobiology, The Salk Institute for Biological Studies
1983-1989 Assistant Professor, The Scripps Research Institute, Department of Neuropharmacology
1990-2008 Associate Professor, The Scripps Research Institute, Molecular and IntegrativeNeurosciences Department (formerly the Department of Neuropharmacology)
2008-present: Professor, The Scripps Research Institute, Molecular and Integrative Neurosciences Department and Molecular and Experimental Medicine, La Jolla, CA

Awards & Professional Activities

Awards
Citation for outstanding performance in Physiology, UC Davis
Giannini Foundation Fellow, UCLA
Klingenstein Foundation Fellow, The Salk Institute
Development Award, NIAAA
MacArthur Foundation Network on the Psychobiology of Depression
Thurman Award, UNC Bowles Center for Alcohol Studies
National Institutes of Health (NIH) Merit Award (2007)
Wendy & Stanley Marsh Lectureship in Pharmacology and Neurochemistry of Substance Abuse/Addiction Disorders (2011)

Other Professional Activities
Journal Associate Editorships: Reviewing Editor, Alcoholism, Clinical & Experimental Research, Associate Editor, Biological Psychiatry and Journal of Alcohol Studies
NIAAA National Advisory Council on Alcohol Abuse and Alcoholism, 2007-2010
Extramural Advisory Board Member NIAAA 2004-present.
Steering Committee member National Advisory Board on Underage Drinking 2004-present.
Scientific Advisory Board Alcohol Research Center Howard University 2004-present.
Scientific Advisory Board Alcohol Research Center UC Berkeley CA 2004-present.
Member, program committee ACNP 2000-2003
Chairman, Awards Committee RSA, 2000-present.
Member, Committee on Social Outcomes, San Diego Foundation 1998-2000.
Chair: Education & Training Committee, ACNP, 1998-1999
Consultant, Native American Graves protection and repatriation committee, culture and language retention committee, Luiseno nation-inter tribal coalition, 1998-present.
Scientific Advisory Board for the Alcohol Research Center University of North Carolina, Skipper Bowles Center 1997-present

Journal Associate/Review Editorships:
Alcoholism: Clinical Experimental Research
Biological Psychiatry
Critical Reviews in Neurobiology
Depression and Anxiety
Neuropsychopharmacology

Selected References

Wehrenberg W, Ehlers CL. The effects of growth hormone releasing factor on the brain. Science 232:1271-1272, 1986. PMID: 3085220

Ehlers CL, Frank E, Kupfer DJ.  Social zeitgebers and biological rhythms: a unified approach to understanding the etiology of depression. Arch Gen Psychiatry 45:948-952, 1988. PMID: 3048226

 

Kupfer DJ, Ehlers CL. Two roads to REM latency. Arch Gen Psychiat 46:945-948, 1989. PMID: 2679484

Ehlers CL, Schuckit MA Evaluation of EEG alpha activity in sons of alcoholics. Neuropsychopharmacol 4:199-205, 1991. PMID: 2064719

Ehlers CL, Havstad JW, Garfinkel A, Kupfer DJ. Non-linear analysis of EEG sleep states. Neuropsychopharmacol 5:167-176, 1991. PMID: 1755932

Ehlers CL. The new physics of chaos: can it help us to understand the effects of alcohol? Alcohol, Health and Research World 16:267-272, 1992.

Ehlers CL, Kupfer DJ, Frank E, Monk TH. Biological rhythms and depression: the role of zeitgebers and zeitstorers. Depression 1:285-293, 1993.

Ehlers CL. Chaos and complexity: Can it help us to understand mood and behavior? Arch Gen Psychiatry 52:960-964, 1995. PMID: 7487344

Ehlers CL, Havstad JW, Kupfer DJ. Estimation of the time course of slow-wave sleep over the night in depressed patients: effects of clomipramine and clinical response. Biol Psychiatry 39:171-181, 1996. PMID: 8837978

Garcia-Andrade C, Wall TL, Ehlers CL. The firewater myth and response to alcohol in Mission Indians. Am J Psychiatry 154:983-987, 1997. PMID: 9210750

Ehlers CL, Kupfer DJ, Buysse DJ, Cluss PA, Miewald JM, Bisson EF, Grochocinski VJ. The Pittsburgh study of Normal Sleep: Focus on the relationship between waking and sleeping EEG spectral patterns. Electroencephalograph Clin Neurophysiol 106:199-205, 1998. PMID: 9743277

Ehlers CL, Havstad JW, Prichard D, Theiler J. Low doses of ethanol reduce evidence for nonlinear structure in brain activity.  J Neurosci 18:7474-7486, 1998. PMID: 9736666

Ehlers CL, Gilder DA, Harris L, Carr L. Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults. Alcohol Clin Exp Res 12:1773-1777, 2001. PMID: 11781511

Ehlers CL, Gilder DA, Phillips E, Wall TL, Feiler H, Wilhelmsen K. Genomic screen for loci associated with alcohol dependence in Mission Indians. Am J Med Genetics 129B: 110-15. 2004. PMID:15274051

Ehlers CL, Wall TL, Betancourt M, Gilder D. Clinical course of alcoholism in 243 Mission Indians. Am J Psychiatry,1(7):1204-1210, 2004. PMID: 15229052

Ehlers CL, Wilhelmsen KC. Genomic scan for alcohol craving in Mission Indians. Psychiatric Genet 15:71-75, 2005. PMID: 15722961

Ehlers CL, Wilhelmsen KC. Genomic screen for loci associated with tobacco usage in Mission Indians. BMC Medical Genetics Feb 10; 7:9, 2006. PMID: 16472381, PMC:1386651

Ehlers CL, Slutske W, Gilder DA, Lau P, Wilhelmsen, KC. Age at first intoxication and alcohol use disorders in Southwest California Indians. Alcohol Clin Exp Res 30:1856-1865, 2006. PMID: 17067349

Ehlers CL, Wilhelmsen KC. Genomic screen for substance dependence and body mass index in Southwest California Indians. Genes, Brain Behavior 6(2):184-91, 2007. PMID: 16764678

Ehlers CL, Montane-Jaime K, Moore S, Shafe S, Joseph R, Carr L. Association of the ADH1B*3 allele with alcohol related phenotypes in Trinidad. Alcohol Clin Exp Res 31:216-220, 2007. PMID: 17250612

Ehlers CL, Slutske WS, Lind PA, Wilhelmsen KC. Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in Southwest California Indians. Twin Res. Hum Genet. 10(6): 805-11, 2007. PMID: 18179391

Ehlers CL, Lind PA, Wilhelmsen KC. Association between single nucleotide polymorphisms in the Mu Opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. BMC Med Genet 2008 Apr 23;9(1):35 PMID: 18433502; PMC: 2386778

Gilder DA, Lau P, Corey L, Ehlers CL. Factors associated with remission from alcohol dependence in an American Indian Community Group. Am J Psychiatr 165(9):1172-1178, 2008. PMID: 18519526; PMC: 2835695

Moore SM, Liang T, Graves TJ, McCall KM, Carr LG, Ehlers CL. Identification of a Novel Cytosolic Aldehyde Dehydrogenase Allele, ALDH1A1* Human Genomics, 3(4):304-307, 2009. PMID: 19706361; PMC  2885287

Ehlers CL, Criado JR. Adolescent ethanol exposure: does it produce long lasting electrophysiological effects? Alcohol, 44(1):27-37, 2010. PMID: 20113872; PMC:2818286

Ehlers CL, Gizer IR, Vieten C, Wilhelmsen KC. Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco Family Study. Am J. Med Genet B. Neuropsychiatric Genet, April 5; 153B(3): 802-811, 2010. PMID: 19937978; PMC 2940710