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Molecular Medicine

Faculty

Gavin Rumbaugh, Ph.D.

Associate Professor
Department of Neuroscience
Florida Campus
Laboratory Website
grumbaug@scripps.edu
(561) 228-3461

Scripps Research Joint Appointments

Department of Molecular Medicine
Faculty, Graduate Program

Other Joint Appointments

Adjunct Assistant Professor, Department of Neurobiology, University of Alabama at Birmingham

Research Focus

The goal of my lab is to understand how synaptic connections contribute to development and function of neural circuits that underlie memory and cognition. Presently, we are focused on two major research areas:

1) We have identified several genes that are critical regulators of synaptic function. These genes also increase the risk for developing neurodevelopmental disorders of cognition and sociability, such as intellectual disability and autism spectrum disorders. These genes encode proteins that regulate synaptic properties during critical periods of neurodevelopment. Current studies in the lab are aimed at understanding how disruptions in synaptic properties during these developmentally sensitive periods lead to alterations in cognition, memory and sociability. Based on these studies, we hope to develop novel therapeutic strategies to improve brain function in patents with autism spectrum disorders and intellectual disability.

2) Alterations in synaptic connections are implicated in nearly all brain disorders. In particular, synapse loss is a particularly profound problem in brain disorders that attack cognitive function, such as schizophrenia and Alzheimer’s disease. Our lab has initiated a research program aimed at discovering novel mechanisms that trigger increases in neural connectivity as a strategy to combat these illnesses. We believe that increasing connectivity among neurons in networks that mediate critical cognitive processes, such as memory and executive function, will lead to significant improvements in patients with these types of mental disorders. Our approach is to combine the vast chemical resources at TSRI with a novel neuron-based screening platform that was created in the Department of Neuroscience at Scripps Florida. We expect that this combined technology will facilitate the discovery novel chemical probes that trigger increases in synaptic connectivity. These probes will then serve as developmental platforms for future generations of drugs that treat a wide range of brain disorders.

Awards & Professional Activities

1996 NCAA/NAIA Academic All-America (Westminster College)
2002 National Research Scholar Award 2006
Alabama Health Sciences Foundation Scholar 2009 
NARSAD Young Investigator Award 2009
Faculty Research Award, American College of Neuropsychopharmacology (ACNP)

Selected References


Rumbaugh G., Adams JP, Kim JH, Huganir RL. (2006) SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. PNAS 21;103(12):4344-51

Shepherd JS*, Rumbaugh G.*, Chowdhury A, Huganir RL, Worley P. (2006) Arc regulates homeostatic synaptic scaling of AMPA receptors in cultured neurons. Neuron. 52(3):475-484. 

Heine M, Groc L, Frischknecht R, Béïque JC, Lounis B, Rumbaugh G., Huganir RL, Cognet L, Choquet D (2008) Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission. Science. 320 (1): 201 – 205. (Faculty of 1000 selection)

Guo X, Hamilton PJ, Reish NJ, Sweatt JD, Miller CA, Rumbaugh G. (2009) Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia. Neuropsychopharmacology. 34: 1659-1672.

Funk AJ, Rumbaugh G., Harotunian V, McCullumsmith RE, Meador-Woodruff JH (2009) Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia. Neuroreport. Jul 15;20(11):1019-22.

Kilgore M, Miller CA, Haggarty SJ, Sweatt JD, Rumbaugh G. (2010) Class 1 histone deacetylase inhibitors reverse contextual memory deficits in a mouse model of Alzheimer’s disease. Neuropsychopharmacology. 35: 870-880.

Miller CA, Gavin CF, White JA, Parrish RR, Honasoge A, Yancey CR, Rivera IM, Rubio MD, Rumbaugh G., Sweatt JD ( 2010) Cortical DNA methylation maintains remote memory. Nat Neurosci. 13(6):664-6. (Faculty of 1000 selection)

Rex CS, Gavin CF, Rubio MD, Kramar EA, Chen LY, Jia Y, Huganir RL, Muzyczka N, Gall CM, Miller CA, Lynch G, Rumbaugh G. (2010) Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation. Neuron. 67(4):603-617  

Rubio MD, Johnson RC, Miller CA, Huganir RL, Rumbaugh G. (2011) Regulation of synapse structure and function by distinct Myosin II motors. J Neurosci. 31(4): 1448-60.

Gavin CF, Rubio MD, Young E, Miller C, Rumbaugh G. (2012) Myosin II motor activity in the lateral amygdala is required for fear memory consolidation. Learn Mem. Dec 14;19(1):9-14. Print 2012 Jan

Kramár EA, Babayan AH, Gavin CF, Cox CD, Jafari M, Gall CM, Rumbaugh G*, Lynch G* (2012) Synaptic Evidence for the Efficacy of Spaced Learning. Proc Natl Acad Sci. 109(13):5121-6.  *co-corresponding author

Clement JP, Aceti M, Creson TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller BH, Wiltgen BJ, Miller CA, Xu X, Rumbaugh G.(2012) Pathogenic SYNGAP1 mutations impair cognitive development by disrupting the maturation of dendritic spine synapses. Cell.151(4):709-23 

Links

Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors

Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.

Molecular Medicine Seminar Series

CA Faculty

Asahara, Hiroshi
Balch, William E.
Boddy, Michael
Buxbaum, Joel
Catz, Sergio
Conti, Bruno
Cravatt, Benjamin
D'Lima, Darryl
DerMardirossian, Celine
Deryugina, Elena
Elias, Darlene
Encalada, Sandra
Felding, Brunhilde
Fowler, Velia
Friedlander, Martin
Gerace, Larry
Gottesfeld, Joel
Griffin, John
Hanneken, Anne
Heeb, Mary Jo
Henderson, Scott
Hoch, James
Joazeiro, Claudio
Johnson, Eric
Kanaji, Taisuke
Kay, Steve
Kelly, Jeffery
Koziol, James
Lamia, Katja
Lazzerini Denchi, Eros
Lipton, Stuart
Loring, Jeanne F.
Loskutoff, David
Lotz, Martin
Makarenkova, Helen P.
Mc Millan, Robert
Miles, Lindsey
Milner, Richard
Modena, Brian
Mosnier, Laurent
Paulson, James C.
Perego, Marta
Petrascheck, Michael
Pollard, Kenneth Michael
Quigley, James P.
Reed, Steven
Roberts, Edward
Rosen, Hugh
Ruggeri, Zaverio
Russell, Paul
Saez, Enrique
Smider, Vaughn
Srinivasan, Supriya
Steinhubl, Steven
Sutcliffe, J.
Tan, Eng
Topol, Eric
Vanderklish, Peter
Vogt, Peter K.
Waalen, Jill
Wiseman, Luke
Wittenberg, Curt
Wolan, Dennis W.
Wu, Peng
Wu, Xiaohua
Yang, Xiang-Lei
Yates III, John


FL Faculty

Bohn, Laura M.
Cameron, Michael
Duckett, Derek
Gill, Matt
Griffin, Patrick
Hansen, Scott
Kamenecka, Theodore
Kissil, Joseph
Luo, Junli
McDonald, Patricia
Miller, Courtney
Niedernhofer, Laura
Phinney, Donald G.
Robbins, Paul
Scampavia, Louis
Schimmel, Paul
Smith, Roy
Spicer, Timothy


Affiliated Faculty

Cline, Hollis
Kojetin, Douglas
Lairson, Luke
Paegel, Brian
Rumbaugh, Gavin
Shen, Ben
Solt, Laura A
Su, Andrew
Wu, Chunlei


Adjunct Faculty