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Molecular Medicine

Faculty

Michael Petrascheck, Ph.D.

Associate Professor
Department of Molecular Medicine
California Campus
Laboratory Website
pscheck@scripps.edu
(858) 784-7463

Scripps Research Joint Appointments

Department of Neuroscience
Assistant Professor, Dorris Neuroscience Center
Department of Molecular and Experimental Medicine
Faculty, Graduate Program

Research Focus

Old age is accompanied by a deterioration of tissues and organs, increased susceptibility to disease, and an exponential increase in mortality. The last years have seen great progress in unraveling the mechanisms underlying aging. It has become clear that aging is regulated by various genetic pathways which when properly manipulated lead to increases in lifespan. These findings raise the exciting possibility that age related diseases could be treated by targeting aging pathways instead of the disease itself.

To investigate this possibility we have screened for small molecules that extend lifespan in C.elegans. The power of the small molecule approach lies in its enormous flexibility. Small molecules can be tested in cell lines, various model organisms, different models of age related disease, in combination with each other, or in combination with mutations known to affect aging and lifespan. Using life-extending small molecules as probes we can now start to investigate the molecular connection between aging and age-related diseases.

Education

Ph.D., Molecular Biology, University of Zurich, 2001

Selected References

Petrascheck, M., Ye, X., and Buck, LB. (2009) "A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans." Ann N Y Acad Sci. 1170:698-701.

Petrascheck, M., Ye, X., and Buck, LB. (2007) "An antidepressant that extends lifespan in adult Caenorhabditis elegans." Nature 450, 553-556

Molecular Medicine Seminar Series

CA Faculty

Asahara, Hiroshi
Balch, William E.
Boddy, Michael
Buxbaum, Joel
Catz, Sergio
Conti, Bruno
Cravatt, Benjamin
D'Lima, Darryl
DerMardirossian, Celine
Deryugina, Elena
Elias, Darlene
Encalada, Sandra
Felding, Brunhilde
Fowler, Velia
Friedlander, Martin
Gerace, Larry
Gottesfeld, Joel
Griffin, John
Hanneken, Anne
Heeb, Mary Jo
Henderson, Scott
Hoch, James
Joazeiro, Claudio
Johnson, Eric
Kanaji, Taisuke
Kay, Steve
Kelly, Jeffery
Koziol, James
Lamia, Katja
Lazzerini Denchi, Eros
Lipton, Stuart
Loring, Jeanne F.
Loskutoff, David
Lotz, Martin
Makarenkova, Helen P.
Mc Millan, Robert
Miles, Lindsey
Milner, Richard
Modena, Brian
Mosnier, Laurent
Paulson, James C.
Perego, Marta
Petrascheck, Michael
Pollard, Kenneth Michael
Quigley, James P.
Reed, Steven
Roberts, Edward
Rosen, Hugh
Ruggeri, Zaverio
Russell, Paul
Saez, Enrique
Smider, Vaughn
Srinivasan, Supriya
Steinhubl, Steven
Sutcliffe, J.
Tan, Eng
Topol, Eric
Vanderklish, Peter
Vogt, Peter K.
Waalen, Jill
Wiseman, Luke
Wittenberg, Curt
Wolan, Dennis W.
Wu, Peng
Wu, Xiaohua
Yang, Xiang-Lei
Yates III, John


FL Faculty

Bohn, Laura M.
Cameron, Michael
Duckett, Derek
Gill, Matt
Griffin, Patrick
Hansen, Scott
Kamenecka, Theodore
Kissil, Joseph
Luo, Junli
McDonald, Patricia
Miller, Courtney
Niedernhofer, Laura
Phinney, Donald G.
Robbins, Paul
Scampavia, Louis
Schimmel, Paul
Smith, Roy
Spicer, Timothy


Affiliated Faculty

Cline, Hollis
Kojetin, Douglas
Lairson, Luke
Paegel, Brian
Rumbaugh, Gavin
Shen, Ben
Solt, Laura A
Su, Andrew
Wu, Chunlei


Adjunct Faculty