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Molecular Medicine

Faculty

Katja Lamia, Ph.D.

Assistant Professor
Department of Molecular Medicine
California Campus
Laboratory Website
klamia@scripps.edu
(858) 784-7056

Scripps Research Joint Appointments

Department of Cell and Molecular Biology
Faculty, Graduate Program

Research Focus

Circadian clocks enable organisms to keep track of the time of day and to adjust their physiology to recurring, and therefore predictable, daily changes in the external environment. Our work has demonstrated that circadian clocks are critical regulators of mammalian metabolic physiology and the response to DNA damage. We are studying the molecular basis for the circadian control of metabolism, DNA damage response, and tumorigenesis to enable novel therapies to treat metabolic disease and cancer.

Education

Ph.D., Biophysics, Harvard University, 2003
B.A., Physics, University of California, Berkeley, 1996

Professional Experience

2004 – 2006 Postdoctoral Fellow with Charles Weitz (Harvard Medical School)
2007 – 2010 Postdoctoral Fellow with Ronald Evans (The Salk Institute)

Awards & Professional Activities

1995 Phi Beta Kappa
2005 Merck Fellowship from the Life Sciences Research Foundation
2012 Searle Scholars Award
2013 Sidney Kimmel Cancer Research Scholar Award

Selected References

Henriksson E and Lamia KA. Adipose clocks – burning the midnight oil. J Biol Rhythms 2015 Apr 29

Papp SJ, Huber AL, Jordan SD, Kriebs A, Nguyen M, Moresco J, Yates III J, and Lamia KA. DNA damage shifts circadian clock time via Hausp-mediated Cry1 stabilization. ELife. 2015 Mar 10; 4. doi: 10.7554/eLife.04883, PMCID: PMC4352707

Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057. PMID: 24209622, PMCID: PMC4070383

Jordan SD and Lamia KA.  AMPK at the Crossroads of Circadian Clocks and Metabolism.  Mol Cell Endocrinol. 2013 Feb 25;366(2):163-9. doi: 10.1016/j.mce.2012.06.017. Epub 2012 Jun 28. Review. PMID: 22750052, PMCID: PMC3502724

Lamia KA, Papp SJ, Yu RT, Barish GD, Uhlenhaut NH, Jonker JW, Downes M, Evans RM. Cryptochromes Mediate Rhythmic Repression of the Glucocorticoid Receptor.  Nature. 2011 Dec 14;480(7378):552-6. doi: 10.1038/nature10700. PMID: 22170608, PMCID: PMC3245818

Sadacca LA, Lamia KA, deLemos AS, Blum B, Weitz CJ. An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia. 2011 Jan;54(1):120-4. doi: 10.1007/s00125-010-1920-8. Epub 2010 Oct 3. PMID: 20890745, PMCID: PMC2995870

Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, Vasquez DS, Juguilon H, Panda S, Shaw RJ, Thompson CB and Evans RM. AMPK Regulates Circadian Clocks by Phosphorylation and Degradation of Cryptochromes. Science 2009 Oct 16; 326(5951):437-40. PMID: 19833968, PMCID: PMC2819106.

Lamia KA and Evans RM. Tick, tock, a beta cell clock. Nature 2010 Jul 29; 466(7306):571-2. PMID: 20671699, PMCID: PMC3610560

Lamia KA, Storch KF and Weitz CJ. Physiological Importance of a Peripheral Tissue Circadian Clock. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15172-7. PMID: 18779586, PMCID: PMC2532700

Yang X, Lamia KA, Evans RM. Nuclear receptors, metabolism, and the circadian clock. Cold Spring Harb Symp Quant Biol. 2007;72:387-94. doi: 10.1101/sqb.2007.72.058. Review. PMID:18419296

Shaw RJ, Lamia KA, Vasquez D, Koo S-H, Bardeesy N, DePinho RA, Montminy M, and Cantley LC. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin. Science. 2005 Dec 9;310(5754):1642-6. PMID: 16308421, PMCID: PMC3074427

Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Biol. 2004 Jun;24(11):5080-7. PMID: 15143198, PMCID: PMC416424

Links

Lamia Lab website

Molecular Medicine Seminar Series

CA Faculty

Asahara, Hiroshi
Balch, William E.
Boddy, Michael
Buxbaum, Joel
Catz, Sergio
Conti, Bruno
Cravatt, Benjamin
D'Lima, Darryl
DerMardirossian, Celine
Deryugina, Elena
Elias, Darlene
Encalada, Sandra
Felding, Brunhilde
Fowler, Velia
Friedlander, Martin
Gerace, Larry
Gottesfeld, Joel
Griffin, John
Hanneken, Anne
Heeb, Mary Jo
Henderson, Scott
Hoch, James
Joazeiro, Claudio
Johnson, Eric
Kanaji, Taisuke
Kay, Steve
Kelly, Jeffery
Koziol, James
Lamia, Katja
Lazzerini Denchi, Eros
Lipton, Stuart
Loring, Jeanne F.
Loskutoff, David
Lotz, Martin
Makarenkova, Helen P.
Mc Millan, Robert
Miles, Lindsey
Milner, Richard
Modena, Brian
Mosnier, Laurent
Paulson, James C.
Perego, Marta
Petrascheck, Michael
Pollard, Kenneth Michael
Quigley, James P.
Reed, Steven
Roberts, Edward
Rosen, Hugh
Ruggeri, Zaverio
Russell, Paul
Saez, Enrique
Smider, Vaughn
Srinivasan, Supriya
Steinhubl, Steven
Sutcliffe, J.
Tan, Eng
Topol, Eric
Vanderklish, Peter
Vogt, Peter K.
Waalen, Jill
Wiseman, Luke
Wittenberg, Curt
Wolan, Dennis W.
Wu, Peng
Wu, Xiaohua
Yang, Xiang-Lei
Yates III, John


FL Faculty

Bohn, Laura M.
Cameron, Michael
Duckett, Derek
Gill, Matt
Griffin, Patrick
Hansen, Scott
Kamenecka, Theodore
Kissil, Joseph
Luo, Junli
McDonald, Patricia
Miller, Courtney
Niedernhofer, Laura
Phinney, Donald G.
Robbins, Paul
Scampavia, Louis
Schimmel, Paul
Smith, Roy
Spicer, Timothy


Affiliated Faculty

Cline, Hollis
Kojetin, Douglas
Lairson, Luke
Paegel, Brian
Rumbaugh, Gavin
Shen, Ben
Solt, Laura A
Su, Andrew
Wu, Chunlei


Adjunct Faculty