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Molecular Medicine

Faculty

Derek Duckett, Ph.D.

Associate Professor
Associate Scientific Director I
Department of Molecular Medicine
Florida Campus
Laboratory Website
ducketdr@scripps.edu
(561) 228-2224

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Work in our laboratory is aimed at evaluating small molecule kinase inhibitors of biologic and therapeutic interest. We are currently involved in refining a novel class of kinase inhibitors aimed at the therapeutic treatment of human diseases such as Parkinson’s Disease and Cancer. Protein kinases are important components of signal transduction pathways and deregulation of kinase activity can lead to human disease. Kinases have therefore become one of the most important target classes for drug development. Working closely with other disciplines such as chemistry, pharmacology, and drug metabolism, we aim to optimize lead compounds for potency and selectivity while minimizing toxicity to generate candidate molecules with appropriate drug like properties suitable for IND enabling and first time in human studies.

Awards & Professional Activities

Member, American Association for Cancer Research

Selected References

Therapeutic targeting of casein kinase 1δ in breast cancer. Rosenberg LH, Lafitte M, Quereda V, Grant W, Chen W, Bibian M, Noguchi Y, Fallahi M, Yang C, Chang JC, Roush WR, Cleveland JL, Duckett DR. Sci Transl Med. 2015 Dec 16;7(318):318ra202. doi: 10.1126/scitranslmed.aac8773. PMID: 26676609

Identification of an EGFRvIII-JNK2-HGF/c-Met-Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion. Saunders VC, Lafitte M, Adrados I, Quereda V, Feurstein D, Ling Y, Fallahi M, Rosenberg LH, Duckett DR. Mol Pharmacol. 2015 Dec;88(6):962-9. doi: 10.1124/mol.115.097774. Epub 2015 Oct 9. PMID: 26452771

Development of an HTS-Compatible Assay for the Discovery of Ulk1 Inhibitors. Rosenberg LH, Lafitte M, Grant W, Chen W, Cleveland JL, Duckett DR. J Biomol Screen. 2015 Aug;20(7):913-20. doi: 10.1177/1087057115579391. Epub 2015 Apr 7. PMID:25851035 

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31. PMID: 23787102

Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimer. Sturchler E, Feurstein D, Chen W, McDonald P, Duckett D. Biochim Biophys Acta. 2013 Mar;1833(3):583-92. doi: 10.1016/j.bbamcr.2012.10.023. Epub 2012 Oct 31. PMID: 23123190

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368. PMID:21857681

Molecular Medicine Seminar Series

CA Faculty

Asahara, Hiroshi
Balch, William E.
Boddy, Michael
Buxbaum, Joel
Catz, Sergio
Conti, Bruno
Cravatt, Benjamin
D'Lima, Darryl
DerMardirossian, Celine
Deryugina, Elena
Elias, Darlene
Encalada, Sandra
Felding, Brunhilde
Fowler, Velia
Friedlander, Martin
Gerace, Larry
Gottesfeld, Joel
Griffin, John
Hanneken, Anne
Heeb, Mary Jo
Henderson, Scott
Hoch, James
Joazeiro, Claudio
Johnson, Eric
Kanaji, Taisuke
Kay, Steve
Kelly, Jeffery
Koziol, James
Lamia, Katja
Lazzerini Denchi, Eros
Lipton, Stuart
Loring, Jeanne F.
Loskutoff, David
Lotz, Martin
Makarenkova, Helen P.
Mc Millan, Robert
Miles, Lindsey
Milner, Richard
Modena, Brian
Mosnier, Laurent
Paulson, James C.
Perego, Marta
Petrascheck, Michael
Pollard, Kenneth Michael
Quigley, James P.
Reed, Steven
Roberts, Edward
Rosen, Hugh
Ruggeri, Zaverio
Russell, Paul
Saez, Enrique
Smider, Vaughn
Srinivasan, Supriya
Steinhubl, Steven
Sutcliffe, J.
Tan, Eng
Topol, Eric
Vanderklish, Peter
Vogt, Peter K.
Waalen, Jill
Wiseman, Luke
Wittenberg, Curt
Wolan, Dennis W.
Wu, Peng
Wu, Xiaohua
Yang, Xiang-Lei
Yates III, John


FL Faculty

Bohn, Laura M.
Cameron, Michael
Duckett, Derek
Gill, Matt
Griffin, Patrick
Hansen, Scott
Kamenecka, Theodore
Kissil, Joseph
Luo, Junli
McDonald, Patricia
Miller, Courtney
Niedernhofer, Laura
Phinney, Donald G.
Robbins, Paul
Scampavia, Louis
Schimmel, Paul
Smith, Roy
Spicer, Timothy


Affiliated Faculty

Cline, Hollis
Kojetin, Douglas
Lairson, Luke
Paegel, Brian
Rumbaugh, Gavin
Shen, Ben
Solt, Laura A
Su, Andrew
Wu, Chunlei


Adjunct Faculty