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Metabolism and Aging

Publications

Roy Smith
Andrew Butler
Shuji Kishi
Courtney Miller
William Ja

Roy Smith

Albarran-Zeckler RG, Brantley AF, Smith RG.  Growth hormone secretagogue receptor (GHS-R1a) knockout mice exhibit improved spatial memory and deficits in contextual memory. Behav Brain Res 2012 Mar 31: 232(1):13-19.  NIHMS37006.  [Epub ahead of print].

Kern A, Albarran-Zeckler R, Walsh HE, Smith RG.  Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism.  Neuron 2012 Jan 26: 73(2):317-32.  NIHMS345796  [PubMed – in process]. PMCID: PMC3269786 [Available on 2013/1/26]

Albarran-Zeckler RG, Sun Y, Smith RG.  Physiological roles revealed by ghrelin and ghrelin receptor deficient mice.  Peptides. 2011 Nov;32(11):2229-35. PMCID: PMC3221867.

Clifford S, Zeckler RA, Buckman S, Thompson J, Hart N, Wellman PJ, Smith RG. Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice.  Addict Biol. 2011 Jul;16(3):386-92. doi: 10.1111/j.1369-1600.2010.00253.x. Epub 2010 Nov 4.

Smith, R.G. (2005).  Development of growth hormone secretagogues.  Endocrine Reviews 26(3):346-360.

Jiang, H., Betancourt, L., Smith, R.G. (2006) Ghrelin amplifies dopamine signaling by crosstalk involving Formation of GHS-R/D1R Heterodimers.  Molecular Endocrinology 20:1772-1785.

Cowley, M., Smith, R.G., Diano, S., Tschop, M., Pronchuk, N., Grove, K., Strasburger, C., Bidlingmaier, M., Esterman, M., Heiman, M., Garcia-Segura, L., Nillni, E., Mendez, P., Low, M., Sotonyi, P., Friedman, J., Liu, H., Pinto, S., Colmers, WS., Cone, R., Horvath, T. (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.  Neuron 37(4)649-661.

Sun, Y., Wang, P., Zheng, H., Smith, R.G. (2004) Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc. Natl. Acad. Sciences, USA 101:4679-4684.

Sun, Y., Asnicar, M., Saha, P.K., Chan, L., Smith, R.G. (2006) Ablation of ghrelin gene improves the diabetic but not obese phenotype of ob/ob mice. Cell Metabolism 3:379-386.

Wang G-L, Shi X, Salisbury E, Sun Y, Albrecht JH, Smith RG and Timchenko NA. (2006) Cyclin D3 maintains growth inhibitory activity of C/EBPα by stabiliziang C/EBPα-cdk2 and C/EBPα-Brm complexes.  Molecular and Cellular Biology 26: 2570-2582.

Wang G-L, Shi X, Salisbury E, Sun Y, Albrecht JH, Smith RG and Timchenko NA. (2007) Growth Hormone Corrects Proliferation and Transcription of Phosphoenolpyruvate Carboxykinase in Livers of Old Mice via Elimination of CCAAT/Enhancer-binding Protein-Brm Complex. J. Biol. Chem. 282:1468 – 1478

Dixit V. D., Yang H, Sun Y, Weeraratna AT, Youm Y-H, Smith R. G. and Taub DD. (2007) Ghrelin promotes thymopoiesis during aging. Journal of Clinical Investigation 117:2778-2790.

Sun Y, Asnicar M, Smith R. G. (2007) Central and Peripheral Roles of Ghrelin on Glucose Homeostasis. Neuroendocrinology 86(3):215-228.

Garcia J. M, Cata J. P., Dougherty P. M., and Smith R. G. (2008) Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia. Endocrinology 149(2):455-460.  PMCID: PMC2219295.

Smith R.G, Sun Y, Jiang H, Albarran-Zeckler R, and Timchenko N (2007) Ghrelin receptor agonists show potential as interventive gents during aging. Ann N Y Acad Sci 1119:147-164.

Yang H, Dixit V. D., Patel K, Vandanmagsar B., Collins G., Sun Y., Smith R. G., and Taub D.D. (2008) Reduction in hypophyseal growth hormone and prolactin expression due to deficiency in ghrelin receptor signaling is associated with Pit-1 suppression: Relevance to the immune system.  Brain Behav Immun. (2008) 22:1138-1145. PMCID: PMC2783985.

Hill J. T., Mastracci T. L., Vinton C., Doyle M. L. Anderson K. R,, Loomis Z. L,, Schrunk J. M., Minic A. D., Pugliese A., Sun Y., Smith R. G., and Sussel L. (2009) Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regulatory Peptides 157:51-56 PMID: 19268691.

Szentirmai, E., Kapas, L., Sun, Y., Smith, R.G., and Krueger, J.M. (2009)  The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice.  Proc Natl Acad Sci USA 106(33):14069-74.  PMCID: PMC272902.

Smith, RG (2009) From GH to Billy Ghrelin (Preview).  Cell Metab 10(2):82-83.

Szentirmai, E., Kapás, Sun, Y., Smith, RG, Krueger, JM (2010) Restricted feeding-induced sleep, activity, and body temperature changes in normal and preproghrelin-deficient mice.  Am J Physiol Regul Integr Comp Physiol 298 R467-R477.  PMCID: PMC2828180

 

Andrew Butler

 Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, Shin Y, Liu J, Cameron MD, Noel R, Yoo SH, Takahashi JS, Butler AA, Kamenecka TM, Burris TP. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.  Nature. 2012 (May 3) 485:62-68

Begriche K, Marston OJ, Rossi J, Burke LK, McDonald P, Heisler LK, Butler AA. Melanocortin-3 receptors are involved in adaptation to restricted feeding. Genes Brain Behav. 2012 Apr;11(3):291-302.

Ganesh Kumar K, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, Culler MD, Mynatt RL, Butler AA. Adropin Deficiency Is Associated With Increased Adiposity and Insulin Resistance. Obesity (Silver Spring). 2012 Feb 9. doi: 10.1038/oby.2012.31. [Epub ahead of print]

Begriche K, Levasseur PR, Zhang J, Rossi J, Skorupa D, Solt LA, Young B, Burris TP, Marks DL, Mynatt RL, Butler AA. Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis. J Biol Chem. 2011 Nov 25;286(47):40771-81.

Begriche K, Sutton GM, Butler AA. Homeostastic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism. Physiol Behav. 2011 Sep 26;104(4):546-54

Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP. Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.  ACS Chem Biol. 2011 Mar 18;6(3):218-22.

Smith BJ, Sutton GM, Wu X, Yu G, Goh BC, Hebert T, Pelled G, Gazit Z, Gazit D, Butler AA, Gimble JM. Ovariectomy and genes encoding core circadian regulatory proteins in murine bone. Osteoporos Int. 2011 May;22(5):1633-9.

Butler AA. More news about NUCB2/Nesfatin-1 – a new factor in the hypothalamic control of glucose homeostasis? (Commentary) Diabetes (accepted subject to minor revision).

Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, Kousoulas KG, Rogers PM, Kesterson RA, Thearle M, Ferrante AW Jr, Mynatt RL, Burris TP, Dong JZ, Halem HA, Culler MD, Heisler LK, Stephens JM, Butler AA. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 2008 Dec;8(6):468-81.

Faculty of 1000 selection - recommended.

Sutton GM, Perez-Tilve D, Nogueiras R, Fang J, Kim JK, Cone RD, Gimble JM, Tschöp MH, Butler AA. The melanocortin-3 receptor is required for entrainment to meal intake. J Neurosci. 2008 Nov 26;28(48):12946-55.

Zhou L, Sutton GM, Rochford JJ, Semple RK, Lam DD, Oksanen LJ, Thornton-Jones ZD, Clifton PG, Yueh CY, Evans ML, McCrimmon RJ, Elmquist JK, Butler AA, Heisler LK. Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways. Cell Metab. 2007 Nov;6(5):398-405.

Discussed by Pissios P and Maratos-Flier E - More Then Satiety: Central Serotonin Signaling And Glucose Homeostasis (News and Views). Cell Metabolism 2007 Nov; 6(5):345-347; Miller KJ and Azzara AV - An Old Dog Leans A New Trick: Regulation Of Peripheral Glucose Homeostasis By The Serotonin (5-HT)2C receptor. Molecular Interventions 2008 8:73-77, and in Crunkhorn S - Metabolic Disease: New Opportunity for Serotonin Receptor Agonists. Nature Reviews Drug Discovery 2008 7:17.

Faculty of 1000 selection - must read

Perez-Tilve D, Hofmann SM, Basford J, Nogueiras R, Pfluger PT, Patterson JT, Grant E, Wilson-Perez HE, Granholm NA, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, Sleeman MW, DiMarchi RD, Hui DY, Tschöp MH. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat Neurosci. 2010 Jul;13(7):877-82

Discussed by Yi-Chun Loraine Tung and Giles SH Yeo. Central melanocortin signaling regulates cholesterol  (News and Views). Nature Neuroscience 2010 Jul; 13(7), 779-780.

Faculty of 1000 selection - must read

Sutton GM, Centanni AV, Butler AA. Protein malnutrition during pregnancy in C57BL/6J mice results in offspring with altered circadian physiology before obesity. Endocrinology. 2010 Apr;151(4):1570-80.

Discussed by Reyes TM and Simmons RA - Setting the “Clock”: Importance of Maternal Diet (Editorial). Endocrinology 2010 151(4), 1385-1386.

Sutton GM, Begriche K, Kumar KG, Gimble JM, Perez-Tilve D, Nogueiras R, McMillan RP, Hulver MW, Tschöp MH, Butler AA. Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. FASEB J. 2010 Mar;24(3):862-72.

Yang H, Youm YH, Vandanmagsar B, Rood J, Kumar KG, Butler AA, Dixit VD. Obesity accelerates thymic aging. Blood. 2009 Oct 29;114(18):3803-12.

Butler AA, Kozak LP. A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes.  Diabetes. 2010 Feb;59(2):323-9.

Shuji Kishi

Koshimizu E, Imamura S, Qi J, Toure J, Valdez DM Jr, Carr CE, Hanai J, Kishi S. Embryonic senescence and laminopathies in a progeroid zebrafish model.  PLoS One 2011 Mar 30: 6(3):e17688. 

Xu X, Shi Y, Zhang HM, Swindell EC, Marshall AG, Guo M, Kishi S, Yang XL. Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.  Nat Commun. 2012 Feb 21;3:681. doi: 10.1038/ncomms1686. PMID: 22353712  [PubMed - in process].

Kishi S. The search for evolutionary developmental origins of aging in zebrafish: a novel intersection of developmental and senescence biology in the zebrafish model system.  Birth Defects Res C Embryo Today. 2011 Sep;93(3):229-48. doi: 10.1002/bdrc.20217. Review.

Sajish M, Zhou Q, Kishi S, Valdez DM Jr, Kapoor M, Guo M, Lee S, Kim S, Yang XL, Schimmel P.  Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.  Nat Chem Biol. 2012 Apr 15. doi: 10.1038/nchembio.937. [Epub ahead of print].

Imamura, S., Uchiyama, J., Koshimizu, E., Hanai, J., Raftopoulou, C., Murphey, R. D., Bayliss, P. E., Imai, Y., Burns, C. E., Masutomi, K., Gagos, S., Zon, L. I. Roberts, T. M., Kishi, S. (2008). A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS ONE 3, e3364.

Kishi, S., Bayliss, P. E., Uchiyama, J., Koshimizu, E., Qi, J., Nanjappa, P., Imamura, S., Islam, A., Neuberg, D., Amsterdam, A., and Roberts, T. M. (2008). The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet 4, e1000152. (Featured by RESEARCH HIGHLIGHTS (2008). Stress response and aging: zebrafish screens identify genes involved in aging. Dis Model Mech 1, 70-71.)

Sidi, S., Sanda, T., Kennedy, R. D., Hagen, A. T., Jette, C. A., Hoffmans, R., Pascual, J., Imamura, S., Kishi, S., Amatruda, J. F., Kanki, J. P., Green, D. R., D'Andrea, A. A., Look, A. T. (2008). Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133, 864-877.

Hanai, J., Cao, P., Tanksale, P., Imamura, S., Koshimizu, E., Zhao, J., Kishi, S., Yamashita, M., Phillips, P. S., Sukhatme, V. P., and Lecker, S. H. (2007). The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J Clin Invest 117, 3940-3951.


Courtney Miller

Gavin CF, Rubio MD, Young E, Miller C, Rumbaugh G.  Myosin II motor activity in the lateral amygdala is required for fear memory consolidation.  Learn Mem. 2011 Dec 14;19(1):9-14. doi: 10.1101/lm.024042.111. Print 2012 Jan.

Rex C, Gavin CF, Rubio MD, Kramar EA, Jia Y, Huganir RL, Muzyczka N, Gall CM, Miller CA, Lynch G and Rumbaugh G (2010) Myosin IIB regulates actin dynamics during synaptic plasticity and memory formation. Neuron 67:603-17.

Miller CA, Gavin CF, White JA, Parrish RR, Honasoge A, Yancey CR, Rivera IM, Rubio MD, Rumbaugh G and Sweatt JD (2010) Cortical DNA methylation maintains remote memory. Nature Neuroscience 13: 664-6.

Kilgore M*, Miller CA*, Fass DM, Hennig KM, Haggerty S, Sweatt JD and Rumbaugh G (2010) Inhibitors of Class I histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer’s Disease. Neuropsychopharmacology 35: 870-80.

Cahill ME, Xie Z, Day M, Barbolina MV, Miller CA, Weiss C, Radulovic J, Sweatt JD, Disterhoft JF, Surmeier DJ and Penzes P. (2009) Kalarin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proceedings of the National Academy of Sciences 106: 13058-63.

Guo X, Hamilton PJ, Reish N, Sweatt JD, Miller CA, and Rumbaugh G (2008) Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia. Neuropsychopharmacology 34: 1659-72.

Miller CA, Campbell SL and Sweatt JD (2008) DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity.  Neurobiology Learning and Memory 89: 599-603.

Miller CA and Sweatt JD (2007) Covalent modification of DNA regulates memory formation.  Neuron 53: 857-69.

Levenson MJ, Roth TL, Lubin FD, Miller CA, Huang IC, Desai P, Malone L, Sweatt JD (2006)  Evidence that DNA (Cytosine-5) methyltransferases regulate synaptic plasticity in the hippocampus.  Journal of Biological Chemistry 281: 15763-73.

Miller CA and Marshall JF (2005) Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory.  Neuron 47: 873-84.

Miller CA and Marshall JF (2005). Altered Fos expression in neural pathways involved in cue-elicited drug seeking. European Journal of Neuroscience 21, 1385-93.

Miller CA and Marshall JF (2004). Altered prelimbic cortex output during cue-elicited drug seeking. Journal of Neuroscience 24, 6889-97.

William Ja


Ja WW, Carvalho GB, Zid BM, Mak EM, Benzer S (2009) Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan. Proc. Natl. Acad. Sci. USA 106, 18633-18637.

Ja WW, Carvalho GB, Madrigal M, Roberts RW, Benzer S (2009) The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides. Protein Sci. 18, 2203-2208.

Ja WW, West AP Jr., Delker S., Bjorkman PJ, Benzer S, Roberts RW (2007) Extension of Drosophila melanogaster life span using a GPCR peptide inhibitor. Nature Chem. Biol. 3, 415-419.

Ja WW, Carvalho GB, Mak EM, de la Rosa NN, Fang AY, Liong JC, Brummel T, Benzer S (2007) Prandiology of Drosophila and the CAFÉ assay. Proc. Natl. Acad. Sci. USA 104, 8253-8256.