Scripps Research Joint Appointments

Department of Chemistry
Department of Cell and Molecular Biology
Professor, Department of Integrative Structural and Computational Biology

Research Focus

Metabolomics and Mass Spectrometry

Our lab is developing mass spectrometry-based technology for unbiased comparative analysis as well as the structural and biological characterization of metabolites. These developments include nanostructure-based mass imaging, novel data analysis software, as well as a unique database to facilitate metabolite identification. Our XCMS software, a metabolomics LC/MS data analysis approach, has been widely applied (with over 20,000 downloads) for alignment and statistical data LC/MS analysis. XCMS is also coupled with Metlin, a database of metabolites and MS/MS data used to facilitate metabolite identification and classification. Our nanostructure-based mass spectrometry platform, a novel matrix-free surface analysis technology, is being developed for metabolite tissue imaging, activity screening and analyzing nano-arrays.

Education

Ph.D., Physical Chemistry, Dartmouth, 1990

Awards & Professional Activities

Rhode Island College Gehrenbeck lecturer Society of Analytical Chemists Distinguished Lecturer Environmental Protection Agency Distinguished Lecturer Ronald J. Boruch Award in Physical Sciences

Selected References

Tautenhahn R., Cho K.Y., Uritboonthai W., Zhu Z., Patti G.J., Siuzdak G.
An accelerated workflow for untargeted metabolomics using the METLIN database
Nature Biotechnology, 2012, 30(9), 826-828

Patti G.J., Yanes O., Siuzdak G.
Metabolomics:  The Apogee of the Omic Trilogy
Nature Reviews, 2012, 13, 263-269

Patti G.J., Tautenhahn R., Siuzdak G.
Meta-Analysis of untargeted metabolomic data from multiple profiling experiments
Nature Protocols, 2012, 7(3), 508-516

Patti G.J., Yanes O., Shriver L., Courade J-P., Tautenhahn R., Manchester M., Siuzdak G.
Metabolomics Implicates Altered Sphingolipid Metabolites in Chronic Pain of Neuropathic Origin
Nature Chemical Biology, 2012, 8, 232-234

Patti G.J., Yanes O., Shriver L., Courade J-P., Tautenhahn R., Manchester M., Siuzdak G.
Metabolomics Implicates Altered Sphingolipid Metabolites in Chronic Pain of Neuropathic Origin
Nature Chemical Biology, 2012, 8, 232-234. 

Yanes O., Hsu J., Wong D.M., Sanchez-Ruiz A., Benton H.P., Trauger S.A., Despont C., Ding S., Siuzdak G.
Metabolic oxidation regulates embryonic stem cell differentiation
Nature Chemical Biology, 2010, 6, 411-417.

Cvetkovic A., Menon A.L., Thorgersen M.P., Scott J.W., Poole F.L. II, Jenney F.E. Jr., Lancaster W.A., Praissman J.L., Shanmukh S., Vaccaro B.J., Trauger S.A., Kalisiak E., Apon J.V., Siuzdak G., Yannone S.M., Tainer J.A., Adams M.W.W.
Microbial metalloproteomes are largely uncharacterized
Nature, 2010, 466, 779-784

Woo H.K., Northen T.R., Yanes O., Siuzdak G.
Nanostructure-initiator mass spectrometry: a protocol for preparing and applying NIMS surfaces for high-sensitivity mass analysis
Nature Protocols, 2008, 3(8), 1341-1349

Northen T.R., Yanes O., Northen M.T., Marrinucci D., Uritboonthai W., Apon J., Golledge S.L., Nordstrom A., Siuzdak G.
Clathrate nanostructures for mass spectrometry
Nature, 2007, 449(7165), 1033-U3

Talkington M.T., Siuzdak G., Williamson J.R.
An assembly landscape for the 30S ribosomal subunit
Nature, 2005, 438, 628-632

Links

Center for Metabolomics and Mass Spectrometry