Scripps Research Joint Appointments

Center for Integrative Molecular Biosciences
Faculty, Kellogg School of Science and Technology

Research Focus

Automated Molecular Microscopy

The focus of our group is the development of automated imaging techniques for solving the three-dimensional structure of macromolecular complexes using cryoTEM. Our current goal is to develop new methods to improve the throughput of the entire process, from specimen preparation to the generation of the final three-dimensional map.

Awards & Professional Activities

Member, American Society of Cell Biology
Editorial Board, Journal of Structural Biology

Selected References

Mouche, Fabrice, Yuanxin Zhu, James Pulokas, Clinton S. Potter, and Bridget Carragher "Automated three-dimensional reconstruction of keyhole limpet hemocyanin type 1". JSB, 144, 301-312. 2003

Zhu, Yuanxin, Bridget Carragher, Robert M. Glaeser, Denis Fellmann, Chandrajit Bajaj, Marshall Bern, Fabrice Mouche, Felix de Haas, Richard J. Hall, Steven C. Ludtke, Pawel A. Penczek, Alan M. Roseman, Fred J. Sigworth, Niels Volkmann, and Clinton S. Potter, "Automatic Particle Selection: Results of A "Bakeoff"", JSB, 145, 3-14. 2003

Ward, Andrew, Michael F. Moody, Brian Sheehan, Ronald A. Milligan and Bridget Carragher, "Windex: a toolset for indexing helices", JSB, 144, 172-183. 2003

Potter, Clinton S., James Pulokas, Paul Smith, Christian Suloway and Bridget Carragher. "Robotic Grid Loading System for a Transmission Electron Microscope", JSB, 146, 431-440. 2004

Links

AMI group website