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Immunology and Microbial Science

Donald Mosier, M.D., Ph.D.

Professor Emeritus
Department of Immunology and Microbiology
California Campus
Laboratory Website
dmosier@scripps.edu
(858) 784-9121

Research Focus

Human immunodeficiency virus type 1 (HIV-1) is responsible for the AIDS pandemic. HIV-1 has entered the human population in the last century, and both the virus and the host are evolving, rapidly in the case of the virus, and slowly in the case of the human host. HIV-1 is a diverse swarm of related viruses both in individuals and in the global infected population. The most diverse region of the virus is the envelope gene that encodes the virus spike. The spike mediates virus binding to human cells and subsequent entry, and is also the target for host immune responses. Primary infection with HIV-1 almost always involves viral spikes (trimers of the envelope proteins) that bind host cell surface molecules CD4 and CCR5, but the virus can evolve to use other molecules for infection during the course of chronic infection. We are studying this virus evolution and its impact on sensitivity of the virus to entry inhibitors and the use of alternative coreceptors. In addition, we are developing CCR5 inhibitors as potential microbicides to prevent sexual transmission of HIV-1.

Education

M.D., Medicine, The University of Chicago, 1971
Ph.D., The University of Chicago, 1969

Professional Experience

B.S., Indiana Univ., Bloomington, IN, 1965Ph.D., University of Chicago, Chicago, IL, 1969

M.D. (honors), University of Chicago, 1971

Post-doctoral Fellow, Damon Runyon Foundation, National Institute for Medical Research, Mill Hill, London, UK, 1971

Post-doctoral Fellow, NIH, Harvard Medical School, Boston, MA, 1971-2

Awards & Professional Activities

Elected Fellow, American Association for the Advancement of Science, 1998.CFAR External Review Committee, U. Washington, Seattle, WA, 1989-present

CFAR External Review Committee, Dana-Farber Cancer Institute, Boston, MA, 1990-96

Member, Transplantation Immunology Review Committee, NIAID, NIH, 1983-1986.

Member, Special Review Committee on Human Retroviruses, NCI, NIH, 1986.

Chair, AIDS Research Review Committee, NIAID, NIH, 1987-1991.

Member, University of California AIDS Task Force, 1992-1998; Chair, 1997-98

Selected References

Pastore, C., R. Nedellec, A. Ramos, S. Pontow, L. Ratner, and D.E. Mosier. 2006. Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations. J Virol 80:750-758.

Pastore, C., R. Nedellec, A. Ramos, O. Hartley, J.L. Miamidian, J.D. Reeves, and D.E. Mosier. 2007. Conserved changes in envelope function during human immunodeficiency virus type 1 coreceptor switching. J Virol 81:8165-8179.

Coetzer, M., R. Nedellec, J.R. Salkowitz, S. McLaughlin, Y. Liu, L. Heath, J.I. Mullins, and D.E. Mosier. 2008. Evolution of CCR5 use before and during coreceptor switching. J Virol 82:11758-11766.

Gaertner, H., F. Cerini, J.M. Escola, G. Kuenzi, A. Melotti, R. Offord, I. Rossitto-Borlat, R. Nedellec, J. Salkowitz, G. Gorochov, D. Mosier, and O. Hartley. 2008. Highly potent, fully recombinant anti-HIV chemokines: reengineering a low-cost microbicide. Proc Natl Acad Sci U S A 105:17706-17711.