Member, Pearson Center for Alcohol and Addiction Research
Faculty, Graduate Program
Associate Adjunct Professor, Department of Neurosciences, UCSD
Member, Neurosciences Graduate Program, UCSD
The Zorrilla laboratory seeks to understand the neural substrates of motivated behavior and of the regulatory control of energy balance using interdisciplinary molecular, biochemical, neuroanatomical, pharmacological, physiological, behavioral and statistical techniques. We are particularly interested in genetic, epigenetic and neuroadaptive differences in the neurobiology of reward and stress circuits that subserve the control of food intake as well as of other appetitive (reward-driven) and stress-related behaviors. Our work aims to be therapeutically relevant to the increased incidence of obesity, binge eating disorders, alcoholism and drug addiction, and stress-related psychiatric disorders of anxiety and depression in industrialized societies.
Ph.D., Psychology, University of Pennsylvania, 1996
M.A., Psychology, University of Pennsylvania, 1992
B.S., Psychology/Economics/Political Science (triple major), Duke University, 1991
2003-2017 Associate Professor, Committee on the Neurobiology of Addictive Disorders (CNAD), The Scripps Research Institute
2001-2003 Senior Research Associate, The Scripps Research Institute
1997-2001 Research Associate, The Scripps Research Institute
1996-1997 Postdoctoral Fellow, Neurocrine Biosciences
Frihauf, J. B., Fekete, E. M., Nagy, T. R., Levin, B. E. & Zorrilla, E. P. Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers. (2016). American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 311(6), R1045-R1059.
Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E. & Smith, S. B. Progesterone receptor membrane component 1 (PGRMC1) expression in murine retina. (2016). Current Eye Research, 41(8), 1105-1112. PMCID: PMC4896862.
Francesconi, W., Sanchez-Alavez, M., Berton, F., Alboni, S., Benatti, C., Mori, S., Nguyen, W., Zorrilla, E., Moroncini, G., Tascedda, F. & Conti, B. The proinflammatory cytokine interleukin 18 regulates feeding by acting on the bed nucleus of the stria terminalis. (2016). Journal of Neuroscience, 36(18), 5170-5180.
Wang, J., Shanmugam, A., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B. Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger. (2015). Free Radical Biology and Medicine, 86, 25. PMCID: PMC4554890.
Shanmugam, A., Wang, J., Markand, S., Perry, R. L., Tawfik, A., Zorrilla, E., Ganapathy, V. & Smith, S. B. Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1 gamma, MIP2, MIP3 alpha, and IL12 (p40/p70) by retinal Muller glial cells. (2015). Journal of Neurochemistry, 132(5), 546-558. PMCID: PMC4451448.
Zorrilla, E. P., Logrip, M. L. & Koob, G. F. Corticotropin releasing factor: a key role in the neurobiology of addiction. (2014). Frontiers in Neuroendocrinology, 35(2), 234-244. PMCID: PMC4213066.
Zorrilla, E. P. & Conti, B. Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice. (2014). Brain Behavior and Immunity, 37, 45. PMCID: PMC4219830.
Logrip, M. L., Vendruscolo, L. F., Schlosburg, J. E., Koob, G. F. & Zorrilla, E. P. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. (2014). Neuropsychopharmacology, 39(7), 1722-1731. PMCID: PMC4023146.
Ha, Y. J., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. (2014). Cell and Tissue Research, 356(1), 15-27. PMCID: PMC3976706.
Zorrilla, E. P. & Koob, G. F. Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley. (2013). Neuroscience and Biobehavioral Reviews, 37(9), 1932-1945. PMCID: PMC3838492.