Source: Interfolio F180


Robyn Stanfield

Institute Investigator
Department of Integrative Structural and Computational Biology


 Email

Research Focus

X-ray crystallographic studies of antibody-antigen complexes

My research is focused on x-ray crystallographic studies of antibody-antigen complexes, with an emphasis on antibodies that neutralize the HIV-1 virus. By studying the detailed structures of these complexes we can better understand how antibodies recognize their antigens, and how to design antigens to elicit an effective anti-viral response.


Education

B.S. (Chemistry), North Carolina State University, 1980
Ph.D. (Chemistry), The University of Texas at Austin, 1986

Selected Publications

Stanfield, R. L.; Dooley, H.; Flajnik, M. F.; Wilson, I. A. Crystal structure of a shark single-domain antibody V region in complex with lysozyme. 2004, 305, 1770-3.

Stanfield, R. L.; Gorny, M. K.; Williams, C.; Zolla-Pazner, S.; Wilson, I. A. Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D. 2004, 12, 193-204.

Stanfield, R.; Cabezas, E.; Satterthwait, A.; Stura, E.; Profy, A.; Wilson, I. Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs. 1999, 7, 131-42.