Directory | Contact | Careers | Intranet | Home

Scripps Research Joint Appointments

Department of Integrative Structural and Computational Biology
Faculty, Kellogg School of Science and Technology

Other Joint Appointments

Director of Research, Scripps Health, Scripps Genomic Medicine
Professor of Psychiatry and Biostatistics (adjunct), UCSD

Research Focus

Genetic Analysis of Complex Human Phenotypes

Dr. Schork and his laboratory focus on the development and implementation of analysis methods for understanding the genetic determinants of complex human traits and diseases such as cancer, neuropsychiatric disease, and cardiovascular disease. These methods focus on both the design of studies making use of contemporary high-throughput, high-dimensional genomic technologies such as DNA sequencing technologies, multilocus genotyping technologies, and DNA microarrays, as well the interpretation of the results obtained from studies making use of these technologies. Dr. Schork and his laboratory also consider the integration of studies making use of different technologies. In addition, Dr. Schork has a long history of collaborative research in which he has contributed data analysis methodology and data analysis expertise. For example, Dr. Schork is the Director of the Bioinformatics and Biostatistics Core of the NIA-sponsored Longevity Consortium (http://www.longevityconsortium.org/), the Director of statistical genetics for the NIMH-sponsored Consortium on the Genetics of Schizophrenia (http://www.npistat.com/cogs/), the Director of Data Analysis for the GAIN funded Bipolar Consortium and a statistical geneticist for the NHLBI-sponsored Family Blood Pressure Program (http://www.sph.uth.tmc.edu/hgc/fbpp/).

Education

M.A., Applied Statistics, University of Michigan, 1991
Ph.D., Epidemiology, University of Michigan, 1994
B.A., Philosophy, University of Michigan, 1985
M.A., Philosophy, University of Michigan, 1992

Awards & Professional Activities

Singapore 2007-Present: Member, NUS-GIS Center for Molecular Epidemiology, International Advisory Panel 2007-Present: Member, The Singapore Consortium of Cohort Studies, International Advisory Panel National 2003-2007: Member, National Academy of Sciences Food and Nutrition Board 2002-2006: Member, National Academy of Sciences Twin Analysis Subcommittee Editorial Boards 2007-Present: Associate Editor, Public Library of Science (PLoS): Genetics 2000-Present: Associate Editor, American Journal of Pharmacogenetics 2002-Present: Associate Editor, (Statistical Genetics), American Journal of Psychiatry 2000-2003: Scientific Advisor, Encyclopedia of Human Genetics 2002-Present: Scientific Advisor, Encyclopedia of Diagnostic Genomics and Proteomics 2000-2003: Associate Editor, Physiological Genomics 1999-2001: Associate Editor, American Journal of Human Genetics 1998-2002: Section Editor, Current Hypertension Reports 1995-1999: Associate Editor, Gene-COMBIS

Selected References

Nievergelt CM, Libiger O, Schork NJ. Generalized analysis of molecular variance. PLoS Genet. 2007 Apr 6;3(4):e51. Epub 2007 Feb 22.

Torkamani A, Schork NJ. Accurate prediction of deleterious protein kinase polymorphisms. Bioinformatics. 2007 Nov 1;23(21):2918-25. Epub 2007 Sep 12.

Wessel J, Schork NJ. Generalized genomic distance-based regression methodology for multilocus association analysis. Am J Hum Genet. 2006 Nov;79(5):792-806. Epub 2006 Sep 21.

Zapala MA, Schork NJ. Multivariate regression analysis of distance matrices for testing associations between gene expression patterns and related variables. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19430-5. Epub 2006 Dec 4.

Links

Longevity Consortium

Family Blood Pressure Program

Consortium on the Genetics of Schizophrenia