Directory | Contact | Careers | Intranet | Home

Scripps Research Joint Appointments

Associate Professor, Department of Molecular Therapeutics

Research Focus

Progress in drug discovery is often coupled to parallel advancements in instrument technology. In our department, High Throughput Screening (HTS) robotics is employed to accelerate the drug discovery process thorough full automation of large scale screening experiments. HTS technology can be used to execute and analyze hundreds of thousand of experiments against large compound libraries to identify a few select compounds of therapeutic value. These "therapeutic leads" provide important insight and basis for the medicinal development of novel drugs for clinical application.

 Research efforts are currently focused on:

• Working with collaborators to develop biological assays for HTS compatibility.
• Performing exploratory HTS campaigns for drug lead discovery.
• Research and development of novel instruments and technologies for the advancement of HTS robotics.

Collaborative efforts are coordinated with a large community of scientists and include TSRI faculty, Florida researchers, and scientists funded through the National Institutes of Health sponsored Molecular Library Screening Center Network program (http://nihroadmap.nih.gov/).

Selected References

Mesiwala AH, Scampavia LD, Rabinovitch PS, Ruzicka J, Rostomily RC. On-line flow cytometry for real-time surgical guidance. Neurosurgery. 2004 Sep; 55(3):551-60; discussion 560-1.

Ogata Y, Scampavia L, Carter TL, Fan E, Turecek F. Automated affinity chromatography measurements of compound mixtures using a lab-on-valve apparatus coupled to electrospray ionization mass spectrometry. Anal Biochem. 2004 Aug 1; 331(1):161-8.

Carroll AD, Scampavia L, Luo D, Lernmark A, Ruzicka J. Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus. Analyst. 2003 Sep; 128(9):1157-62.

Wu CH, Scampavia L, Ruzicka J. Related Articles, Links Micro sequential injection: automated insulin derivatization and separation using a lab-on-valve capillary electrophoresis system. Analyst. 2003 Sep; 128(9):1123-30.