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Paul Russell, Ph.D.

Professor
Department of Molecular Medicine
California Campus
Laboratory Website
Scripps VIVO Scientific Profile
prussell@scripps.edu
(858) 784-8273

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Preservation of Genome Integrity; Cellular Responses to Environmental Toxins
Understanding how cells respond to genotoxic and cytotoxic stress is essential for developing new strategies to prevent and treat cancer and many other diseases. We investigate these mechanisms in fission yeast, an experimental organism ideally suited for high throughput genetic screens, proteomic analysis of protein complexes, whole genome expression analysis by microarray, chromatin immunoprecipitation, and live cell imaging of signaling proteins by deconvolution microscopy.

Education

B.S., Biology, University of California, Irvine, 1978
Ph.D., Genetics, University of Washington, 1982

Professional Experience

Postdoctoral
ZymoGenetics, Inc. Seattle, Washington, 1982-1983
University of Sussex, England, 1983-1984, with Sir Paul Nurse
Imperial Cancer Research Fund (ICRF) Laboratories, Lincoln’s Inn Fields, London, England, 1984-1987, with Sir Paul Nurse

Selected References

All Publications

For a complete list of publications: http://www.scripps.edu/russell/publications.html

Jensen, K.L., Russell, P. (2016) Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable. Nucleic Acids Res. 44,8241-8249.

Guo, L., Ganguly, A., Sun, L., Suo, F., Du, L.L., Russell. P. (2016) Global fitness profiling identifies arsenic and cadmium tolerance mechanisms in fission yeast. G3, 6, 3317-3333.

Mejia-Ramirez, E., Limbo, O., Langerak, P., Russell, P. Critical function of γH2A in S-phase. PLoS Genet. 11:e1005517, 2015.

Caetano, C., Limbo, O., Farmer, S., Klier, S., Dovey, C., Russell, P., de Bruin, R.A. Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability. Cell Reports 9:2279, 2014.

Limbo, O., Moiani, D., Kertokalio, A., Wyman, C., Tainer, J.A., Russell, P.  Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.  Nucl. Acids Res. 40:11435-11449, 2012.

Langerak, P., Mejia-Ramirez, E., Limbo, O., Russell, P. Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Genet. 7:e1002271, 2011.

Williams, J.S., Williams, R.S., Dovey, C.L., Guenther, G., Tainer, J.A., Russell, P. γH2A binds Brc1 to maintain genome integrity during S-phase. EMBO J. 29:1136-1148, 2010.

Mendoza-Cozatl, D., Zhai, Z., Jobe, T., G.Z., A., Song, W. Y., Limbo, O., Russell, M., Kozlovskyy, V., Martinoia, E., Vatamaniuk, O. K., Russell, P., Schroeder, J. I. Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance.  J. Biol. Chem. 285:40416-40426, 2010.

Williams, R.S., Dodson, G.E., Limbo, O.L., Yamada, Y., Williams, J.S., Grant, G., Classen, S., Glover, J.N. M., Iwasaki, H., Russell, P., Tainer, J.A.T. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate double-strand break processing and repair. Cell 139:87-99, 2009.

Williams, R.S., Moncalian, G., Williams, J.S., Yamada, Y., Limbo, O., Shin, D.S., Groocock, L.M., Cahill, D., Hitomi, C., Guenther, G., Moiani, D., Carney, J.P., Russell, P., Tainer, J.A. Mre11 dimers coordinate DNA end bridging and nuclease processing in double strand break repair.  Cell 135:97-109, 2008.

Limbo, O., Chahwan, C., Yamada, Y., de Bruin, R.A.M., Wittenberg, C., Russell, P. Ctp1 is a cell cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol. Cell 28:134-146, 2007.

Gaillard, P.-H., Noguchi, E., Shanahan, P., Russell, P. The endogenous Mus81-Eme1 complex resolves Holliday Junctions by a nick and counternick mechanism.  Mol. Cell 12:747-759, 2003.

Saitoh, S., Chabes, A., McDonald, W. H., Thelander, L., Yates, J. Y. 3rd, Russell, P. Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.  Cell 109:563-573, 2002.

Boddy, M. N., Gaillard, P.-H. L., McDonald, W. H., Shanahan, P., Yates, J. R., Russell, P. Mus81-Eme1 are essential components of a Holliday junction resolvase. Cell 107:537-548, 2001.

Lopez-Girona, A., Furnari, B., Mondesert, O., Russell, P. Nuclear localization of Cdc25 regulated by DNA damage and 14-3-3 protein.  Nature 397:172-175, 1999.

Boddy, M., Furnari, B., Mondesert, O., Russell, P. Replication checkpoint enforced by kinases Cds1 and Chk1.  Science 280:909-912, 1998.

Furnari, B., Rhind, N., Russell, P. Cdc25 phosphatase targeted by Chk1 checkpoint kinase.  Science 277:1495-1497, 1997.

Shiozaki, K., Russell, P. Cell-cycle control linked to the extracellular environment by MAP kinase pathway in fission yeast.  Nature 378:739-743, 1995.