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Zaverio Ruggeri, M.D.

Professor
Department of Molecular Medicine
California Campus
Laboratory Website
Scripps VIVO Scientific Profile
ruggeri@scripps.edu
(858) 784-8950

Education

University of Pavia 1981
University of Pavia 1973
M.D. (Medicine), University of Milan 1970

Professional Experience

2007-2017 Professor, Molecular and Experimental Medicine (MEM), The Scripps Research Institute
1989-2009 Head, Division of Experimental Hemostasis and Thrombosis, The Scripps Research Institute
1989-1993 Associate Professor with tenure, Department of Molecular and Experimental Medicine, The Scripps Research Institute
1985-1989 Associate Professor, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation
1982-1985 Assistant Professor, Departments of Immunology and of Basic and Clinical Research, Scripps Clinic and Research Foundation
1980-1982 Associate Director, Hemophilia and Thrombosis Centre, Policlinico Hospital, University of Milan
1978-1980 Visiting Investigator, Department of Molecular Immunology, Research Institute of Scripps Clinic
1972-1980 Assistant Clinical Professor, Policlinico Hospital, University of Milan
1976-1976 Visiting Investigator, Department of Obstetrics and Gynecology, St. Bartholomew's Hospital (London, England)
1974-1975 Visiting Investigator, Department of Hematology, St. Thomas's Hospital (London, England)
1970-1972 Research Fellow, Hemophilia Centre, University of Milan

Selected References

All Publications

Dutting, S., Gaits-Iacovoni, F., Stegner, D., Popp, M., Antkowiak, A., van Eeuwijk, J. M. M., Nurden, P., Stritt, S., Heib, T., Aurbach, K., Angay, O., Cherpokova, D., et al. A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. (2017). Nature Communications, 8.

Jackel, S., Kiouptsi, K., Lillich, M., Hendrikx, T., Khandagale, A., Kollar, B., Hormann, N., Reiss, C., Subramaniam, S., Wilms, E., Ebner, K., von Bruhl, M. L., et al. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. (2017). Blood, 130(4), 542-553.

Kossmann, S., Lagrange, J., Jackel, S., Jurk, K., Ehlken, M., Schonfelder, T., Weihert, Y., Knorr, M., Brandt, M., Xia, N., Li, H., Daiber, A., et al. Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. (2017). Science Translational Medicine, 9.

Kamikubo, Y., Mendolicchio, G. L., Zampolli, A., Marchese, P., Rothmeier, A. S., Orje, J. N., Gale, A. J., Krishnaswamy, S., Gruber, A., Ostergaard, H., Petersen, L. C., Ruf, W., et al. Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex. (2017). Blood, 130(14), 1661-1670.

Rothmeier, A. S., Marchese, P., Langer, F., Kamikubo, Y., Schaffner, F., Cantor, J., Ginsberg, M. H., Ruggeri, Z. M. & Ruf, W. Tissue factor prothrombotic activity is regulated by integrin-arf6 trafficking. (2017). Arteriosclerosis Thrombosis and Vascular Biology, 37(7), 1323-1331. PMCID: PMC5501484.

Weber, M. R., Zuka, M., Lorger, M., Tschan, M., Torbett, B. E., Zijlstra, A., Quigley, J. P., Staflin, K., Eliceiri, B. P., Krueger, J. S., Marchese, P., Ruggeri, Z. M., et al. Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream. (2016). Thrombosis Research, 140, S27.

Deguchi, H., Sinha, R. K., Marchese, P., Ruggeri, Z. M., Zilberman-Rudenko, J., McCarty, O. J. T., Cohen, M. J. & Griffin, J. H. Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va. (2016). Blood, 128(14), 1870-1878. PMCID: PMC5054698.

Estevez, B., Kim, K., Delaney, M. K., Stojanovic-Terpo, A., Shen, B., Ruan, C., Cho, J., Ruggeri, Z. M. & Du, X. Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. (2016). Blood, 127(5), 626-636. PMCID: PMC4742550.

Rothmeier, A. S., Marchese, P., Petrich, B. G., Furlan-Freguia, C., Ginsberg, M. H., Ruggeri, Z. M. & Ruf, W. Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. (2015). Journal of Clinical Investigation, 125(4), 1471-1484.

Guidotti, L. G., Inverso, D., Sironi, L., Di Lucia, P., Fioravanti, J., Ganzer, L., Fiocchi, A., Vacca, M., Aiolfi, R., Sammicheli, S., Mainetti, M., Cataudella, T., et al. Immunosurveillance of the liver by intravascular effector CD8(+) T cells. (2015). Cell, 161(3), 486-500.