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Scripps Research Joint Appointments

Faculty, Kellogg School of Science and Technology

Research Focus

Molecular Mechanisms of Cell Cycle Control
in Yeast and Animal Cells.

Research in our laboratory focuses on the molecular basis for regulation of cell cycle progression. Our investigations center around a family of conserved enzymes known as cyclin-dependent kinases (and related proteins), which have been shown to be central to control of cell division in all eukaryotic organisms. For these studies we use model systems ranging from yeast, to mice to human cells in culture and methodologies ranging from genetic analysis, to cytological analysis and biochemistry. Much of our recent work has focused on the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis and neurodegenerative diseases.

Education

B.S., Biology , Yale University, 1970
Ph.D., Biology, Stanford University, 1976

Professional Experience

1970 - 1976: Graduate School, Stanford University, RA and TA positions. Research supervised by Dr. George Stark
1976 - 1979: Postdoctoral Fellow, University of Washington - American Cancer Society Fellow. Laboratory of Dr. Leland Hartwell
1979 - 1986: Associate Professor, Department of Biological Sciences, University of California Santa Barbara
1986 - 1991: Associate Member, Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA
7/91- present: Professor, Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA
7/05 - present: Joint-Appointment, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA

Awards & Professional Activities

AWARDS:
NIH Merit Award, 2000
American Cancer Society Faculty Research Award, April 1983 - March 1988
NIH Research Career Development Award, (Declined) September, 1983 - August, 1988
American Cancer Society Postdoctoral Fellowship, September, 1976 - August, 1978
Yale, Magna Cum Laude, 1970

ACTIVITIES:
Member of American Association for Cancer Research (AACR)
Editorial Board, Cell Cycle
Ad hoc reviewer for journals: Genetics, Cell, Proc. Natl. Acad. Sci., Exp. Cell Res., J. Biol. Chem., Nature, Science, Genes and Dev., Current Biol.

Selected References

Spruck CH, de Miguel MP, Smith AP, Ryan A, Stein P, Schultz RM, Lincoln AJ, Donovan PJ, Reed SI. Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis.Science. 300:647-50. 2003

Morris MC, Kaiser P, Rudyak S, Baskerville C, Watson MH, Reed SI. Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast. Nature. 423:1009-13. 2003

Ekholm-Reed S, Mendez J, Tedesco D, Zetterberg A, Stillman B, Reed SI.Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J Cell Biol. 165:789-800. 2004

Strohmaier, H., C. H. Spruck, P. Kaiser, K. A. Won, O. Sangfelt and S. I. Reed (2001).Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line, Nature, 413:316-322.