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Brian Paegel, Ph.D.

Associate Professor
Department of Chemistry
Florida Campus
Laboratory Website
Scripps VIVO Scientific Profile
briandna@scripps.edu
(561) 228-2754

Scripps Research Joint Appointments

Associate Professor, Department of Molecular Medicine
Faculty, Graduate Program

Research Focus

All of contemporary biology and most chemistry is compartmentalized. For example, beakers, flasks or microplate wells spatially segregate individual chemical reactions. Likewise, membranes compartmentalize individual cells and subcellular organelles, tissues and organs organize the metabolism of multi-cellular organisms, and even organisms themselves are merely the vehicles for selfishly replicating genes in a population. Reaction vessels, seemingly innocuous entities, actually play starring roles in activities ranging from drug discovery laboratory automation and technology development to natural selection and the origins of life on Earth. We are broadly interested in the rational construction of microscopic reaction vessels and the interesting chemical and biological operations that we can conduct within their confines.

Education

B.S., Chemistry, Duke University, 1998
Ph.D., Chemistry, University of California, Berkeley, 2003

Professional Experience

2015-2017 Associate Professor, Molecular Therapeutics, The Scripps Research Institute
2009-2015 Assistant Professor, Chemistry, The Scripps Research Institute
2009-2015 Assistant Professor (Joint Appointment), Molecular Therapeutics, The Scripps Research Institute
2004-2008 Postdoctoral Fellow with Dr. Gerald Joyce, Molecular Biology, The Scripps Research Institute

Awards & Professional Activities

NSF CAREER Award (2013)
NIH Director's New Innovator Award (2011)
NIH Pathway to Independence Award (2007)
NIH NRSA Postdoctoral Fellow (2004)

Selected References

All Publications

MacConnell, A. B., Price, A. K. & Paegel, B. M. An integrated microfluidic processor for DNA-encoded combinatorial library functional screening. (2017). ACS Combinatorial Science, 19(3), 181-192. PMCID: PMC5350604.

Malone, M. L., Cavett, V. J. & Paegel, B. M. Chemoselective coupling preserves the substrate integrity of surface-immobilized oligonucleotides for emulsion PCR-based gene library construction. (2017). ACS Combinatorial Science, 19(1), 9-14. PMCID: PMC5243130.

Mendes, K. R., Malone, M. L., Ndungu, J. M., Suponitsky-Kroyter, I., Cavett, V. J., McEnaney, P. J., MacConnell, A. B., Doran, T. M., Ronacher, K., Stanley, K., Utset, O., Walzl, G., et al. High-throughput identification of DNA-encoded IgG ligands that distinguish active and latent Mycobacterium tuberculosis infections. (2017). ACS Chemical Biology, 12(1), 234-243. PMCID: PMC5250564.

MacConnell, A. B. & Paegel, B. M. Poisson statistics of combinatorial library sampling predict false discovery rates of screening. (2017). ACS Combinatorial Science, 19(8), 524-532. PMCID: PMC5558193.

Price, A. K. & Paegel, B. M. Discovery in droplets. (2016). Analytical Chemistry, 88, 339. PMCID: PMC4865373.

Tran, D. T., Cavett, V. J., Dang, V. Q., Torres, H. L. & Paegel, B. M. Evolution of a mass spectrometry-grade protease with PTM-directed specificity. (2016). Proceedings of the National Academy of Sciences of the United States of America, 113(51), 14686-14691. PMCID: PMC5187733.

Malone, M. L. & Paegel, B. M. What is a "DNA-compatible" reaction?. (2016). ACS Combinatorial Science, 18(4), 182-187. PMCID: PMC4946796.

Price, A. K., MacConnell, A. B. & Paegel, B. M. hvSABR: photochemical dose-response bead screening in droplets. (2016). Analytical Chemistry, 88(5), 2904-2911. PMCID: PMC4776284.

MacConnell, A. B., McEnaney, P. J., Cavett, V. J. & Paegel, B. M. DNA-encoded solid-phase synthesis: encoding language design and complex oligomer library synthesis. (2015). ACS Combinatorial Science, 17(9), 518-534. PMCID: PMC4571006.

Price, A. K., MacConnell, A. B. & Paegel, B. M. Microfluidic bead suspension hopper. (2014). Analytical Chemistry, 86(10), 5039-5044. PMCID: PMC4029372.

Links

Pubmed Publication List