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Michael B.A. Oldstone, M.D.

Professor
Department of Immunology and Microbial Science
California Campus
Laboratory Website
mbaobo@scripps.edu
(858) 784-8054

Scripps Research Joint Appointments

Faculty, Graduate Program

Other Joint Appointments

Adjunct Professor, Department of Neurosciences, UCSD School of Medicine
Resident Scholar (Professor), University of Alabama College of Arts and Sciences, Tuscaloosa, Alabama

Research Focus

Virus-Immune System Interactions and Viral Pathogenesis

The principle objectives of this laboratory are to understand how viruses cause an acute disease, how the host mounts a defense against the virus, how certain viruses escape from immune recognition and attack, and establish a persistent infection.  Our focus is on how virus affects the lymphoid and central nervous systems and causes disease.  To understand these events we use molecular, cell biologic, and genetic approaches for analysis of virus virulence and for host susceptibility.  We also study how viruses cause immunosuppression on one hand and autoimmunity on the other.

 

Education

M.D., M.D./Ph.D. Program, University of Maryland/Johns Hopkins University, Baltimore, MD, 1959
M.D., Medicine, University of Maryland, Baltimore, MD, 1961

Professional Experience

Awards & Professional Activities

National Academy of Sciences, 2008
Member, National Academy of Sciences, Institute of Medicine, 1996
Excellence in Mentoring Award, American Association of Immunologists, 2011
Pioneer in NeuroVirology Award, International Society for NeuroVirology, 2003
R.E. Dyer Lectureship and Directors Award (NIH) (contributions in viral pathogenesis), 2000
J. Allyn Taylor International Prize in Medicine (host-virus interactions), 1997
Biomedical Science Award, Karolinska Institute, Sweden (contributions virus/autoimmune diseases), 1994
Rous-Whipple Award (contributions in experimental pathology), 1993
Abraham Flexner Award (contributions in biomedical research), 1988
Cotzias Award (contributions in research of CNS), 1986
Burroughs Wellcome Professorship Award to work with J. Skehel, MRC, Mill Hill, UK
Elected Member, Scandinavian Society of Immunology
World Health Organization Committee for the Eradication of Poliomyelitis and Measles Virus
American Association of Physicians
American Clinical and Climatological Association
American Society for Clinical Investigation
Fellow, American Academy of Microbiology
Fellow, American Associaton for the Advancement of Science
Member, National Advisory Committee, The PEW Scholars Program in the Biomedical Sciences
Editor, Virology; Current Topics in Microbiology and Immunology
Editorial Board, Cell:Host Pathogen; Immunity

Selected References

Baccala, R., M. Welch, R. Gonzalez-Quintial, K.B. Walsh, J.R. Teijaro, A. Nguyen, C. Ng, B.M. Sullivan, A. Zarpellon, Z.M. Ruggeri, J.C. de la Torre, A.N. Theofilopoulos and M.B.A. Oldstone.  Type I interferon is a therapeutic target for virus-induced lethal vascular damage.  Proc. Natl. Acad. Sci. USA 111:8925-8930, 2014.  PMCID: PMC4066519

Teijaro, J.R., C. Ng, A.M. Lee, B.M. Sullivan, K.C.F. Sheehan, M. Welch, R.D. Schreiber, J.C. de la Torre and M.B.A. Oldstone.  Persistent LCMV infection is controlled by blockade of type I interferon signaling.  Science 340:207-211, 2013.  PMCID: PMC3640797

Teijaro, J.R., K.B. Walsh, S. Cahalan, D.M. Fremgen, E. Roberts, F. Scott, E. Martinborough, R. Peach, M.B.A. Oldstone and H. Rosen.  Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.  Cell 146:980-991, 2011.  PMCID: PMC3176439

Oldstone, M.B.A. and K.P. Campbell.  Decoding arenavirus pathogenesis: Essential roles for alpha-dystroglycan-virus interactions and the immune response.  Virology 411:170-179, 2011.  PMCID: PMC3071849

Brooks, D.G., M.J. Trifilo, K.H. Edelmann, L. Teyton, D.B. McGavern and M.B.A. Oldstone.  Interleukin-10 determines viral clearance or persistence in vivo.  Nature Med. 12:1301-1309, 2006.  PMCID: PMC2535582

McGavern, D., U. Christen and M.B.A. Oldstone. Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo.  Nature Immunol. 3:918-925, 2002.  PMCID: PMC2481514

Cao, W., M.D. Henry, P. Borrow, H. Yamada, J.H. Elder, E.V. Ravkov, S.T. Nichol, R.W. Compans, K.P. Campbell and M.B.A. Oldstone.  Identification of α-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus.  Science 282:2079-2081, 1998.