Faculty, Graduate Program
Human adenoviruses are a major cause of acute respiratory, intestinal and ocular infections. However, these viruses have also served as valuable tools with which to investigate fundamental cell and molecular biological processes. Research in the Nemerow lab is focused on gaining a better understanding of adenovirus interactions with host cells. We investigate basic mechanisms involved in virus attachment, internalization, membrane penetration and nuclear localization. A major focus of these studies is the signaling events initiated by cell integrins that promote adenovirus endocytosis. Collaborations with structural, cell biologists, protein chemists at TSRI and Vanderbilt University play a significant role in these investigations. Fundamental knowledge gained from virus-host cell interaction studies is exploited for the design of novel viral vectors with increased capacity to deliver therapeutic genes to specific cell types including endothelial, vascular smooth muscle cells and photoreceptors.
B.S., Biology, Syracuse University, Syracuse, New York, 1973
Ph.D., Microbiology and Immunology, University of Illinois, Chicago, Illinois, 1979
Postdoctoral Training, Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA
Leukemia Society of America Fellowship, 1981-1983
Leukemia Society of America Special Fellowship, 1983-1985
Pew Scholars Award in the Biomedical Sciences, 1986-1990
Nguyen, E.K., Nemerow, G.R., Smith, J.G. Direct evidence from single-cell analysis that human alpha-defensins block adenovirus uncoating to neutralize infection. J. Virol. 84(8):4041-9, 2010.
PubMed Central Free Access - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849482
Reddy V.S., Natchiar S.K., Gritton L., Mullen T.M., Stewart P.L., Nemerow G.R. Crystallization and preliminary X-ray diffraction analysis of human adenovirus. Virology 402(1), 209-14, 2010.
PubMed Central Free Access - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871957/?tool=pubmed
Smith J.G., Silvestry M., Lindert S., Lu W., Nemerow G.R., Stewart P.L. Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization. PLoS Pathog. 6(6):e1000959, 2010.
PubMed Central Free Access - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891831
Reddy V.S., Natchiar S.K., Stewart P.L., Nemerow G.R. Crystal structure of human adenovirus at 3.5 Å resolution. Science 329(5995):1071-5, 2010.
PubMed Central Free Access - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929978/?tool=pubmed
Smith J.G., Wiethoff, C.M., Stewart, P.L. and Nemerow, G.R. Adenovirus: In Current Topics in Microbiology and Immunology. (Johnson, J.E., Ed.) Springer Verlag Kg. Volume 2100, 195-224, 2010.
PubMed Central Free Access - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093298/?tool=pubmed
Moyer C.L, Wiethoff C.M., Maier O., Smith J.G., Nemerow G.R. Functional Genetic and Biophysical Analyses of Membrane Disruption by Human Adenovirus. J. Virol. Mar;85(6):2631-41, 2011.
PubMed - http://www.ncbi.nlm.nih.gov/pubmed/21209115