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Laurent Mosnier, PhD

Associate Professor
Department of Molecular Medicine
California Campus
Scripps VIVO Scientific Profile
lmosnier@scripps.edu
(858) 784-2227

Education

Ph.D. (Thrombosis and Hemostasis), Utrecht University 2001
B.B.A. (Economics), Erasmus University 1999
M.S. (Medical Biology), Utrecht University 1997
B.S. (Medical Biology), Utrecht University 1992

Professional Experience

2005-2017 Assistant Professor, Molecular and Experimental Medicine (MEM), The Scripps Research Institute

Selected References

All Publications

Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., et al. Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis. (2018). Thrombosis and Haemostasis, 118(2), 229-250.

Sinha, R. K., Wang, Y., Zhao, Z., Xu, X., Burnier, L., Gupta, N., Fernandez, J. A., Martin, G., Kupriyanov, S., Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. (2018). Blood, 131(11), 1163-1171. PMCID: PMC5855020.

Cooke, E. J., Zhou, J. Y., Wyseure, T., Joshi, S., Bhat, V., Durden, D. L., Mosnier, L. O. & von Drygalski, A. Vascular permeability and remodelling coincide with inflammatory and reparative processes after joint bleeding in factor VIII-deficient mice. (2018). Thrombosis and Haemostasis, 118(6), 1036-1047.

Fernandez, J. A., Xu, X., Sinha, R. K., Mosnier, L. O., Sanner, M. F. & Griffin, J. H. Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S. (2017). Blood Advances, 1(18), 1423-1426. PMCID: PMC5727852.

Griffin, J. H., Mosnier, L. O., Fernandez, J. A. & Zlokovic, B. V. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis. Thrombotic stroke: neuroprotective therapy by recombinant-activated protein C. (2016). Arteriosclerosis Thrombosis and Vascular Biology, 36(11), 2143-2151. PMCID: PMC5119536.

Wyseure, T., Mosnier, L. O. & von Drygalski, A. Advances and challenges in hemophilic arthropathy. (2016). Seminars in Hematology, 53(1), 10-19. PMCID: PMC5034876.

Sinha, R. K., Yang, X. V., Fernandez, J. A., Xu, X., Mosnier, L. O. & Griffin, J. H. Apolipoprotein E receptor 2 mediates activated protein C-induced endothelial Akt activation and endothelial barrier stabilization. (2016). Arteriosclerosis Thrombosis and Vascular Biology, 36(3), 518-524. PMCID: PMC4816599.

Cramer, T. J., Anderson, K., Navaz, K., Brown, J. M., Mosnier, L. O. & von Drygalski, A. Heterozygous congenital Factor VII deficiency with the 9729de14 mutation, associated with severe spontaneous intracranial bleeding in an adolescent male. (2016). Blood Cells Molecules and Diseases, 57, 8. PMCID: PMC4874642.

Bhat, V., von Drygalski, A., Gale, A. J., Griffin, J. H. & Mosnier, L. O. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa. (2016). Thrombosis and Haemostasis, 115(3), 551-561. PMCID: PMC4775351.

Gale, A. J., Bhat, V., Pellequer, J. L., Griffin, J. H., Mosnier, L. O. & Von Drygalski, A. Safety, stability and pharmacokinetic properties of (super)Factor Va, a novel engineered coagulation Factor V for treatment of severe bleeding. (2016). Pharmaceutical Research, 33(6), 1517-1526. PMCID: PMC4854778.