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Duncan McRee, PhD

Associate Professor Adjunct
Department of Integrative Structural and Computational Biology
California Campus
Scripps VIVO Scientific Profile
(858) 784-9235


Ph.D. (Biochemistry), Duke University 1985

Selected References

All Publications

Perryman, A. L., Zhang, Q., Soutter, H. H., Rosenfeld, R., McRee, D. E., Olson, A. J., Elder, J. E. & Stout, C. D. Fragment-based screen against HIV protease. (2010). Chemical Biology & Drug Design, 75(3), 257-268. PMCID: PMC2911974.

Giffin, M. J., Heaslet, H., Brik, A., Lin, Y. C., Cauvi, G., Wong, C. H., McRee, D. E., Elder, J. H., Stout, C. D. & Torbett, B. E. A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant. (2008). Journal of Medicinal Chemistry, 51(20), 6263-6270. PMCID: PMC2744648.

Heaslet, H., Rosenfeld, R., Giffin, M., Lin, Y. C., Tam, K., Torbett, B. E., Elder, J. H., McRee, D. E. & Stout, C. D. Conformational flexibility in the flap domains of ligand-free HIV protease. (2007). Acta Crystallographica Section D-Biological Crystallography, 63(Pt 8), 866-875.

Yang, X. L., Guo, M., Kapoor, M., Ewalt, K. L., Otero, F. J., Skene, R. J., McRee, D. E. & Schimmel, P. Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase. (2007). Structure, 15(7), 793-805. PMCID: PMC2104486.

Yang, X. L., Otero, F. J., Ewalt, K. L., Liu, J. M., Swairjo, M. A., Kohrer, C., RajBhandary, U. L., Skene, R. J., McRee, D. E. & Schimmel, P. Two conformations of a crystalline human tRNA synthetase–tRNA complex: implications for protein synthesis. (2006). EMBO Journal, 25(12), 2919-2929. PMCID: PMC1500858.

Carter, D. C., Rhodes, P., McRee, D. E., Tari, L. W., Dougan, D. R., Snell, G., Abola, E. & Stevens, R. C. Reduction in diffuso-convective disturbances in nanovolume protein crystallization experiments. (2005). Journal of Applied Crystallography, 38, 87.

Swairjo, M. A., Otero, F. J., Yang, X. L., Lovato, M. A., Skene, R. J., McRee, D. E., Ribas de Pouplana, L. & Schimmel, P. Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition. (2004). Molecular Cell, 13(6), 829-841.

Hosfield, D., Palan, J., Hilgers, M., Scheibe, D., McRee, D. E. & Stevens, R. C. A fully integrated protein crystallization platform for small-molecule drug discovery. (2003). Journal of Structural Biology, 142(1), 207-217.

Yang, X. L., Liu, F. M., Skene, R. J., McRee, D. E. & Schimmel, P. Crystal structure of an EMAP-II-like cytokine released from a human tRNA synthetase. (2003). Helvetica Chimica Acta, 86(4), 1246-1257.

Yang, X. L., Otero, F. J., Skene, R. J., McRee, D. E., Schimmel, P. & Ribas de Pouplana, L. Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains. (2003). Proceedings of the National Academy of Sciences of the United States of America, 100(26), 15376-15380. PMCID: PMC307575.