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Dorian McGavern, Ph.D.

Associate Professor Adjunct
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
mcgad@scripps.edu
(858) 784-9603

Professional Experience

2009-2017 Associate Professor Adjunct, Immunology and Microbial Science (IMS), The Scripps Research Institute

Selected References

All Publications

Oldstone, M. B. A., Edelmann, K. H., McGavern, D. B., Cruite, J. T. & Welch, M. J. Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes. (2012). PLoS Pathogens, 8, e1003044. PMCID: PMC3510245.

Emonet, S. F., Garidou, L., McGavern, D. B. & de la Torre, J. C. Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest. (2009). Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3473-3478. PMCID: PMC2651270.

Brooks, D. G., Lee, A. M., Elsaesser, H., McGavern, D. B. & Oldstone, M. B. A. Il-10 blockade facilitates DNA vaccine-induced t cell responses and enhances clearance of persistent virus infection. (2008). Journal of Experimental Medicine, 205(3), 533-541. PMCID: PMC2275377.

Lauterbach, H., Zuniga, E. I., Truong, P., Oldstone, M. B. A. & McGavern, D. B. Adoptive immunotherapy induces cns dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. (2006). Journal of Experimental Medicine, 203(8), 1963-1975. PMCID: PMC2118382.

Kunz, S., Rojek, J. M., Roberts, A. J., McGavern, D. B., Oldstone, M. B. A. & de la Torre, J. C. Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus. (2006). Journal of Virology, 80(18), 9082-9092.

Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B. & Oldstone, M. B. A. Interleukin-10 determines viral clearance or persistence in vivo. (2006). Nature Medicine, 12(11), 1301-1309. PMCID: PMC2535582.

Brooks, D. G., McGavern, D. B. & Oldstone, M. B. A. Reprogramming of antiviral t cells prevents inactivation and restores t cell activity during persistent viral infection. (2006). Journal of Clinical Investigation, 116(6), 1675-1685.

Brooks, D. G., Teyton, L., Oldstone, M. B. A. & McGavern, D. B. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. (2005). Journal of Virology, 79(16), 10514-10527. PMCID: PMC1182641.

Popkov, M., Jendreyko, N., McGavern, D. B., Rader, C. & Barbas, C. F. Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody. (2005). Cancer Research, 65(3), 972-981.

Christen, U., Edelmann, K. H., McGavern, D. B., Wolfe, T., Coon, B., Teague, M. K., Miler, S. D., Oldstone, M. B. A. & von Herrath, M. G. A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes. (2004). Journal of Clinical Investigation, 114(9), 1290-1298.