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Eros Lazzerini Denchi, Ph.D.

Associate Professor
Department of Molecular and Experimental Medicine
California Campus
Laboratory Website
edenchi@scripps.edu
(858) 784-7659

Scripps Research Joint Appointments

Department of Cell and Molecular Biology
Faculty, Graduate Program

Research Focus

Our lab is interested in two essential mechanisms that ensure genomic stability in mammalian cells: Protection of chromosome ends. Because of their linear organization the terminal portion of mammalian chromosomes are unstable and can be processed by the DNA damage repair machinery resulting in genomic instability. Specialized nucleoprotein complexes termed telomeres suppress these deleterious events. During the onset of several human pathologies, such as cancer and aging, cells lose the ability to efficiently protect their chromosome ends and thus accumulate high levels of genomic instability. Research in our laboratory aims to elucidate the mechanisms by which telomeres can suppress the DNA damage response in normal cells and how these mechanisms are deregulated in human pathologies. Cell type specific cell fate in response to DNA damage. A complementary approach in the lab is to understand what factors affect the cellular response to telomere deprotection. To this end we use mouse genetics to probe the cellular fate of terminally differentiated as well as multipotent stem cells to telomere deprotection.

Education

Ph.D., Cancer Biology, The Open University in London, 2004
B.S., Molecular Biology, University of Milan, 2000

Selected References

Lazzerini Denchi, E. (2009). Give me a break: How telomeres suppress the DNA damage response. DNA Repair (Amst). 2009 May 22.

Lazzerini Denchi, E. L., T. de Lange (2007). Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448(7157): 1068-71.

Lazzerini Denchi E, Celli G, de Lange T. (2006). Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes Dev. (19):2648-53.