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Toshihide Kurihara, MD, PhD

Assistant Professor Adjunct
Department of Molecular Medicine
California Campus
Scripps VIVO Scientific Profile
(858) 784-2930

Professional Experience

2013-2017 Assistant Professor Adjunct, Cell and Molecular Biology (CMB), The Scripps Research Institute
2012-2013 Assistant Professor, Cell and Molecular Biology (CMB), The Scripps Research Institute
2009-2012 Research Associate, Cell and Molecular Biology (CMB), The Scripps Research Institute

Selected References

All Publications

Usui, V., Westenskow, P. D., Kurihara, T., Aguilar, E., Sakimoto, S., Paris, L. P., Wittgrove, C., Feitelberg, D., Friedlander, M. S. H., Moreno, S. K., Dorrell, M. I., Friedlander, M. Neurovascular crosstalk between interneurons and capillaries is required for vision. (2015). Journal of Clinical Investigation, 125(6), 2335-2346.

Westenskow, P. D., Kurihara, T., Bravo, S., Feitelberg, D., Sedillo, Z. A., Aguilar, E. & Friedlander, M. Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension. (2015). Journal of Visualized Experiments : JoVE, e52247. PMCID: PMC4354541.

Kurihara, T., Westenskow, P. D. & Friedlander, M. Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina. (2014). Advances in Experimental Medicine and Biology, 801, 275.

Michael, I. P., Westenskow, P. D., Hacibekiroglu, S., Greenwald, A. C., Ballios, B. G., Kurihara, T., Li, Z., Warren, C. M., Zhang, P., Aguilar, E., Donaldson, L., Marchetti, V., et al. Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. (2014). EMBO Molecular Medicine, 6(5), 604-623. PMCID: PMC4023884.

Westenskow, P. D., Kurihara, T. & Friedlander, M. Utilizing stem cell-derived RPE cells as a therapeutic intervention for age-related macular degeneration. (2014). Advances in Experimental Medicine and Biology, 801, 323.

Westenskow, P. D., Kurihara, T., Aguilar, E., Scheppke, E. L., Moreno, S. K., Wittgrove, C., Marchetti, V., Michael, I. R., Anand, S., Nagy, A., Cheresh, D., Friedlander, M. Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting. (2013). Journal of Clinical Investigation, 123(11), 4900-4908. PMCID: PMC3809796.

Krohne, T. U., Westenskow, P. D., Kurihara, T., Friedlander, D. F., Lehmann, M., Dorsey, A. L., Li, W. L., Zhu, S. Y., Schultz, A., Wang, J. H., Siuzdak, G., Ding, S., et al. Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells. (2012). Stem Cells Translational Medicine, 1(2), 96-109. PMCID: PMC3328503.

Kurihara, T., Westenskow, P. D., Bravo, S., Aguilar, E. & Friedlander, M. Targeted deletion of Vegfa in adult mice induces vision loss. (2012). Journal of Clinical Investigation, 122(11), 4213-4217. PMCID: PMC3484459.

Westenskow, P. D., Moreno, S. K., Krohne, T. U., Kurihara, T., Zhu, S. Y., Zhang, Z. N., Zhao, T. B., Xu, Y., Ding, S. & Friedlander, M. Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPs-derived RPE cells. (2012). Investigative Ophthalmology and Visual Science, 53(10), 6282-6290. PMCID: PMC3444211.

Kurihara, T., Westenskow, P. D., Krohne, T. U., Aguilar, E., Johnson, R. S. & Friedlander, M. Astrocyte pVHL and HIF-alpha isoforms are required for embryonic-to-adult vascular transition in the eye. (2011). Journal of Cell Biology, 195(4), 689-701. PMCID: PMC3257537.