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Oktay Kirak, M.D., Ph.D.

Assistant Professor Adjunct
Department of Immunology and Microbiology
California Campus
Laboratory Website
Scripps VIVO Scientific Profile
kirak@scripps.edu
(858) 784-9835

Research Focus

Education

M.D., Ludwig-Maximilians-Universitaet in Munich/Germany, 2003
Ph.D., Institute of Immunology at the Ludwig-Maximilians-Universitaet in Munich/Germany, 2010

Professional Experience

Awards & Professional Activities

Selected References

All Publications

Ku, M., Chang, S. E., Hernandez, J., Abadejos, J. R., Sabouri-Ghomi, M., Muenchmeier, N. J., Schwarz, A., Valencia, A. M. & Kirak, O. Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors. (2016). Proceedings of the National Academy of Sciences of the United States of America, PMCID: PMC4843484.

Ku, M., Chang, S. E., Hernandez, J., Abadejos, J. R., Sabouri-Ghomi, M., Muenchmeier, N. J., Schwarz, A., Valencia, A. M. & Kirak, O. Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors. (2016). Proceedings of the National Academy of Sciences of the United States of America, 113(16), E2316-E2325. PMCID: PMC4843484.

Kirak, O. & Riethmuller, G. A novel, nonanaphylactogenic, bispecific IgE-CD3 antibody eliminates IgE1(+) B cells. (2015). Journal of Allergy and Clinical Immunology, 136(3), 800-802.

Efeyan, A., Schweitzer, L. D., Bilate, A. M., Chang, S., Kirak, O., Lamming, D. W. & Sabatini, D. M. RagA, but not RagB, is essential for embryonic development and adult mice. (2014). Developmental Cell, 29(3), 321-329. PMCID: PMC4035553.

Sehrawat, S., Koenig, P. A., Kirak, O., Schlieker, C., Fankhauser, M. & Ploegh, H. L. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. (2013). Blood, 121(7), 1145-1156. PMCID: PMC3575758.

Avalos, A. M., Kirak, O., Oelkers, J. M., Pils, M. C., Kim, Y. M., Ottinger, M., Jaenisch, R., Ploegh, H. L. & Brinkmann, M. M. Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice. (2013). Journal of Immunology, 190(2), 695-702. PMCID: PMC3539690.

Efeyan, A., Zoncu, R., Chang, S., Gumper, I., Snitkin, H., Wolfson, R. L., Kirak, O., Sabatini, D. D. & Sabatini, D. M. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. (2013). Nature, 493(7434), 679-683. PMCID: PMC4000705.

Sehrawat, S., Kirak, O., Koenig, P. A., Isaacson, M. K., Marques, S., Bozkurt, G., Simas, J. P., Jaenisch, R. & Ploegh, H. L. CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection. (2012). Cell Reports, 1(5), 461-471. PMCID: PMC3406328.

Zheng, G. X. Y., Ravi, A., Calabrese, J. M., Medeiros, L. A., Kirak, O., Dennis, L. M., Jaenisch, R., Burge, C. B. & Sharp, P. A. A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. (2011). PLoS Genetics, 7, e1002054. PMCID: PMC3088722.

Ernst, R., Claessen, J. H. L., Mueller, B., Sanyal, S., Spooner, E., van der Veen, A. G., Kirak, O., Schlieker, C. D., Weihofen, W. A. & Ploegh, H. L. Enzymatic blockade of the ubiquitin-proteasome pathway. (2011). PLoS Biology, 9, e1000605. PMCID: PMC3066133.