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Donald Hilvert, Ph.D.

Professor Adjunct
Department of Chemistry
California Campus
Scripps VIVO Scientific Profile
@scripps.edu
(858) 784-2400

Education

Ph.D., Columbia University 1983
B.A., Brown University 1978

Professional Experience

1993-1997 Professor, Chemistry, The Scripps Research Institute
1989-1993 Associate Professor, Chemistry, The Scripps Research Institute
1986-1989 Assistant Professor, Chemistry, The Scripps Research Institute
1983-1986 Postdoctoral Associate, The Rockefeller University

Selected References

All Publications

Gillingham, D. G., Stallforth, P., Adibekian, A., Seeberger, P. H. & Hilvert, D. Chemoenzymatic synthesis of differentially protected 3-deoxysugars. (2010). Nature Chemistry, 2(2), 102-105.

Debler, E. W., Muller, R., Hilvert, D. & Wilson, I. A. An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket. (2009). Proceedings of the National Academy of Sciences of the United States of America, 106(44), 18539-18544. PMCID: PMC2774029.

Verdino, P., Aldag, C., Hilvert, D. & Wilson, I. A. Closely related antibody receptors exploit fundamentally different strategies for steroid recognition. (2008). Proceedings of the National Academy of Sciences of the United States of America, 105(33), 11725-11730. PMCID: PMC2575270.

Debler, E. W., Muller, R., Hilvert, D. & Wilson, I. A. Conformational isomerism can limit antibody catalysis. (2008). Journal of Biological Chemistry, 283(24), 16554-16560. PMCID: PMC2423248.

Jiang, L., Althoff, E. A., Clemente, F. R., Doyle, L., Rothlisberger, D., Zanghellini, A., Gallaher, J. L., Betker, J. L., Tanaka, F., Barbas, C. F., Hilvert, D., Houk, K. N., et al. De novo computational design of retro-aldol enzymes. (2008). Science, 319(5868), 1387-1391. PMCID: PMC3431203.

Muller, R., Debler, E. W., Steinmann, M., Seebeck, F. P., Wilson, I. A. & Hilvert, D. Bifunctional catalysis of proton transfer at an antibody active site. (2007). Journal of the American Chemical Society, 129(3), 460-461.

Debler, E. W., Ito, S., Seebeck, F. P., Heine, A., Hilvert, D. & Wilson, I. A. Structural origins of efficient proton abstraction from carbon by a catalytic antibody. (2005). Proceedings of the National Academy of Sciences of the United States of America, 102(14), 4984-4989. PMCID: PMC555987.

Hotta, K., Wilson, I. A. & Hilvert, D. Probing ligand recognition in the decarboxylase antibody 21d8: Implications for the catalytic mechanism. (2002). Biochemistry, 41(3), 772-779.

Hotta, K., Lange, H., Tantillo, D. J., Houk, K. N., Hilvert, D. & Wilson, I. A. Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8. (2000). Journal of Molecular Biology, 302(5), 1213-1225.

Xu, J. A., Deng, Q. L., Chen, J. G., Houk, K. N., Bartek, J., Hilvert, D. & Wilson, I. A. Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. (1999). Science, 286(5448), 2345-2348.