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Jiahuai Han, Ph.D.

Professor Adjunct
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
jhan@scripps.edu
(858) 784-8704

Research Focus

Intracellular Signal Transduction in Innate Immunity

Work in my laboratory focuses on defining the intracellular signaling pathways in the innate immune system. One of our current projects is the mechanism of signaling transduction from Toll-like receptors to the p38 MAP kinase and from p38 MAP kinase to cytokine gene induction at the levels of transcription, mRNA stability and translation. Our major interest is to identify the molecules that bridge the known events in the signaling pathway. Another focus in the laboratory is to find the mechanism(s) that determines whether cells died with necrosis or apoptosis in response to TNF. We have developed a genetic approach to identify the genes that are required for TNF-induced necrosis and apoptosis and will try to find the difference between these genes.

Education

Ph.D. (Molecular Biology), Free University of Brussels 1990
M.S. (Protein Chemistry), Beijing University 1985
B.S. (Biochemistry), Beijing University 1982

Professional Experience

2007-2017 Professor Adjunct, Immunology and Microbial Science (IMS), The Scripps Research Institute
2004-2007 Professor, Immunology and Microbial Science (IMS), The Scripps Research Institute
1996-2004 Associate Professor, Immunology and Microbial Science (IMS), The Scripps Research Institute
1993-1996 Assistant Professor, Immunology and Microbial Science (IMS), The Scripps Research Institute
1992-1993 Research Associate, Immunology and Microbial Science (IMS), The Scripps Research Institute
1987-1992 Research Fellow, The University of Texas Southwestern Medical Center

Selected References

All Publications

Ge B., Gram H., Di Padova F., Huang B., New L., Ulevitch R. J., Luo Y. and Han J. MAP kinase kinase-independent activation of p38alpha-mediated by TAB1-dependent autophosphorylation of p38alpha. Science 295:1291-4, 2002.

Jing Q., Huang S., Guth S., Zarubin T., Motoyama A., Chen J., Di Padova F., Lin S-C., Gram H. and Han J. Involvement of MicroRNA in AU-rich Mediated mRNA Instability. Cell 120,623-634, 2005.

Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M,Dong M-Q, Frangou CG, Yates III JR, Wright PE, Han J. PRAK is Essential for ras-Induced Senescence and Tumor Suppression. Cell. 128(2):295-308, 2007.