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Xiaohua Gong, Ph.D.

Assistant Professor Adjunct
Department of Molecular Medicine
California Campus
Scripps VIVO Scientific Profile
gong@scripps.edu
(858) 784-9465

Research Focus

Cell-to-cell Communication and Intracellular Signaling



We have been mainly focusing on the studies of intercellular communication pathways via gap junction channels and intracellular signaling pathways via distinctive mitogen-activated protein (MAP) kinases in the lens. By using the ocular lens—one of the simplest in vivo system—in combined with the classical techniques from the areas of cell and developmental biology, electrophysiology, biochemistry, molecular biology, as well as cutting edge techniques such as gene-chips and proteomics, we have been able to learn some fundamental roles of gap junctions and distinctive MAP kinase pathways. With this significant amount of information on and experience from the studies of gap junctions and MAP kinases in the ocular lens, we are now studying other novel mouse mutants that develop both ocular and/or cardiovascular phenotypes.

Education

Ph.D. (Biological Sciences), The Scripps Research Institute 1997
Master of Science, Fudan University, Shanghai Medical School 1989
B.A., Fudan University, School of Pharmacy 1983

Professional Experience

2003-2017 Assistant Professor Adjunct, Cell and Molecular Biology (CMB), The Scripps Research Institute
2007-2012 Associate Professor, School of Optometry, University of California, Berkeley
2003-2006 Assistant Professor, School of Optometry, University of California, Berkeley
1999-2002 Assistant Professor, Cell and Molecular Biology (CMB), The Scripps Research Institute
1997-1998 Postdoctoral Fellow, University of California, San Diego

Selected References

All Publications

Gong, X., Wang, X., Han, J., Niesman, I., Huang, Q. and Horwitz, J. (2001) Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens. Investigative Ophthalmology and Visual Science 42:539-548.

Gong, X., Wang, X., Han, J., Niesman, I., Huang, Q. and Horwitz, J. (2001) Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens. Investigative Ophthalmology and Visual Science 42:539-548.

Rong, P., Wang, X., Niesman, I., Wu, Y., Levy, E., Dunia, I., Benedetti, L.E., Gong, X. (2002) A loss-of-function of alpha8 connexin (Cx50) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation. Development 129: 167-174.

Chang, B., Wang, X., Hawes, N.L., Davisson, M. T., Ojakian, R., Lo, W.K., Gong, X. (2002) A Gja8 (alpha8 connexin) point mutation causes an alteration of alpha3 connexin and semi-dominant cataracts in Lop10 mice. Human Molecular Genetics 11:5 507-513.