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Amanda Gavin, Ph.D.

Assistant Professor of Immunology
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
agavin@scripps.edu
(858) 784-9551

Education

Ph.D., The University of Melbourne, Department of Surgery 1996
B.Sc., James Cook University 1989

Professional Experience

2014-2017 Assistant Professor of Immunology, Immunology and Microbial Science (IMS), The Scripps Research Institute
2010-2014 ARC Future Fellow, Burnet Institute
2006-2010 Assistant Professor, Immunology and Microbial Science (IMS), The Scripps Research Institute

Selected References

All Publications

Kasimsetty, S. G., Shigeoka, A. A., Scheinok, A. A., Gavin, A. L., Ulevitch, R. J. & McKay, D. B. Lack of both nucleotide-binding oligomerization domain-containing proteins 1 and 2 primes T cells for activation-induced cell death. (2017). Journal of Immunology, 199(3), 1196-1205.

Martinic, M. M., Caminschi, I., O'Keeffe, M., Thinnes, T. C., Grumont, R., Gerondakis, S., McKay, D. B., Nemazee, D. & Gavin, A. L. The bacterial peptidoglycan-sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection. (2017). Journal of Immunology, 198(7), 2649-2660. PMCID: PMC5360474.

Ota, T., Ota, M., Duong, B. H., Gavin, A. L. & Nemazee, D. Liver-expressed Igκ superantigen induces tolerance of polyclonal B cells by clonal deletion not κ to λ receptor editing. (2011). Journal of Experimental Medicine, 208(3), 617-629. PMCID: PMC3058582.

Duong, B. H., Ota, T., Aoki-Ota, M., Cooper, A. B., Ait-Azzouzene, D., Vela, J. L., Gavin, A. L. & Nemazee, D. Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape. (2011). Journal of Immunology, 187(11), 5596-5605. PMCID: PMC3227399.

Fu, G., Hu, J. F., Niederberger-Magnenat, N., Rybakin, V., Casas, J., Yachi, P. P., Feldstein, S., Ma, B., Hoerter, J. A. H., Ampudia, J., Rigaud, S., Lambolez, F., et al. Protein kinase C eta is required for T cell activation and homeostatic proliferation. (2011). Science Signaling, 4, ra84. PMCID: PMC3242502.

Ait-Azzouzene, D., Kono, D. H., Gonzalez-Quintial, R., McHeyzer-Williams, L. J., Lim, M., Wickramarachchi, D., Gerdes, T., Gavin, A. L., Skog, P., McHeyzer-Williams, M. G., Nemazee, D., Theofilopoulos, A. N. Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice. (2010). Journal of Immunology, 185(2), 1015-1027. PMCID: PMC3641794.

Duong, B. H., Ota, T., Ait-Azzouzene, D., Aoki-Ota, M., Vela, J. L., Huber, C., Walsh, K., Gavin, A. L. & Nemazee, D. Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. (2010). Journal of Immunology, 184(8), 4143-4158. PMCID: PMC2874719.

Ota, M., Duong, B. H., Torkamani, A., Doyle, C. M., Gavin, A. L., Ota, T. & Nemazee, D. Regulation of the B cell receptor repertoire and self-reactivity by BAFF. (2010). Journal of Immunology, 185(7), 4128-4136. PMCID: PMC3263398.

Huber, C., Martensson, A., Bokoch, G. M., Nemazee, D. & Gavin, A. L. FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. (2008). Journal of Biological Chemistry, 283(49), 34002-34012. PMCID: PMC2590680.

Carey, J. B., Moffatt-Blue, C. S., Watson, L. C., Gavin, A. L. & Feeney, A. J. Repertoire-based selection into the marginal zone compartment during B cell development. (2008). Journal of Experimental Medicine, 205(9), 2043-2052. PMCID: PMC2526199.