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Michael Farzan, Ph.D.

Professor
Department of Infectious Diseases
Florida Campus
mfarzan@scripps.edu
(561) 228-2300

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Our laboratory focuses on entry processes of enveloped viruses and the various ways that the innate and adaptive immune responses inhibit these processes. We also apply our insights toward developing therapeutic strategies that enhance or supplement these immune responses. Our work can be divided into three categories: (1) biochemical studies of the HIV-1 entry process and its inhibition, (2) identification and characterization of obligate factors, including receptors, necessary for the entry of other enveloped viruses, and (3) identification and characterization of host restriction factors that inhibit early steps in the viral life cycle, in particular those of the IFITM family.

Education

A.B., Government, Harvard College, 1984
Ph.D., Immunology, Harvard Medical School, 1997

Professional Experience

1993-1997  Graduate Student, Harvard Medical School (HMS)
1997-1999  Post-Doctoral Fellow, Department of Pathology, HMS
1999-2002  Instructor, Department of Pathology, HMS
2002-2004  Assistant Professor, Department of Medicine, HMS
2005-2007  Assistant Professor, Department of Microbiology and Molecular Genetics, HMS
2007-2012  Associate Professor, Department of Microbiology and Immunobiology, HMS
2012   Professor, Department of Microbiology and Immunobiology, HMS
2012-  Professor, Department of Infectious Diseases, TSRI-Florida

Awards & Professional Activities

Awards
Dana-Farber Cancer Institute Richard A. Smith Prize 2000
GlaxoSmithKline Drug Discovery and Developmental Research Award 2004
Burroughs Wellcome Fund Investigators in Pathogenesis Award 2007-2012
The Kavli Foundation and the National Academy of Sciences Kavli Fellowship 2008

Activities

Section Editor for Viral Pathogenesis, PLoS Pathogens
Member, NIH AIDS Molecular and Cellular Biology (AMCB) Study Section
Member, NIH Systems Biology Working Group (SBWG)
Steering Committee, Infectious Disease Initiative, Broad Institute
Editorial Board, Journal of Virology

Selected References

Primary Publications (from >100)

Farzan M, Mirzabekov T, Kolchinsky P, Wyatt R, Cayabyab M, Gerard NP, Gerard C, Sodroski J, Choe H.  Tyrosine sulfation of the amino-terminus of CCR5 facilitates HIV-1 entry.  Cell. 1999; 96:667-76.

Choe H, Li W, Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman T, Zwick MB, Wang L, Rosenberg ES, Kwong PD, Burton DR, Robinson JE, Sodroski JG, Farzan M.  Tyrosine sulfation of human antibodies contributes to recognition of the CCR5-binding region of HIV-1 gp120.  Cell. 2003; 114:161-70.

Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M.  Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.  Nature 2003; 426:450-4.

Li W, Zhang C, Sui J, Kuhn JH, Moore MJ, Luo S, Wong SK, Huang IC, Xu K, Vasilieva N, Murakami A, He Y, Marasco WA, Guan Y, Choe H, Farzan M.  Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2.  EMBO J. 2005; 24:1634-43.

Li F, Li W, Farzan M, and Harrison SC.  Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.  Science. 2005; 30:1864-8.

Radoshitzky SR, Abraham J, Spiropoulou CF, Kuhn JH, Nguyen D, Li W, Nagel J, Schmidt PJ, Nunberg JH, Andrews NC, Farzan M, Choe H. Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. Nature. 2007; 446:92-6.

Radoshitzky SR, Kuhn JH, Spiropoulou CF, Albariño CG, Nguyen DP, Salazar-Bravo J, Dorfman T, Lee AS, Wang E, Ross SR, Choe H, Farzan M. Receptor Determinants of Zoonotic Transmission of New World Hemorrhagic Fever Arenaviruses. Proc Natl Acad Sci U S A. 2008; 105:2664-9.

Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan B, JL. Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M*, Elledge SJ. IFITM Proteins Mediate the Innate Immune Response to Influenza A H1N1 Virus, West Nile Virus and Dengue Virus. Cell. 2009; 139:1243-54.   *co-corresponding

Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011; 7:e1001258

Bailey CC, Huang IC, Kam C, Farzan M. Ifitm3 limit the severity of acute influenza in mice. PLoS Pathog 2012; 8:e1002809.

Reviews summarizing our work

Li W, Wong SK, Li F, Kuhn JH, Huang IC, Choe H, Farzan M.  Animal Origins of SARS Coronavirus: Insight from ACE2/S-protein Interactions. J Virol. 2006; 80:4211-9.

Choe H and Farzan M.  Tyrosine sulfation of HIV-1 coreceptors and other chemokine receptors. Methods Enzymol. 2009;461:147-70

Choe H, Jemielity S, Abraham J, Radoshitzky SR, Farzan M. Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses. Curr Opin Microbiol. 2011; 14:476-82.

Diamond MS and Farzan M. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Nat Rev Immunol. 2013; in press.