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John Elder, Ph.D.

Professor
Department of Immunology and Microbial Science
California Campus
Laboratory Website
jelder@scripps.edu
(858) 784-8270

Scripps Research Joint Appointments

Department of Cell and Molecular Biology
Faculty, Graduate Program

Research Focus

Feline Immunodeficiency Virus

Our research centers around the molecular and biological characterization of feline immunodeficiency virus, FIV. This virus is a lentivirus similar to human immunodeficiency virus (HIV), the virus that causes AIDS in humans. FIV causes an AIDS-like disease in the domestic cat and thus provides a valuable small animal model for developing intervention therapies that may be employed to treat virus infections in both man and cat. Potential approaches include development of drug treatments through structure-based rational drug design as well as vaccine development using defined recombinant target antigens. Both approaches demand that we first understand the molecular structure of the virus as well as the virus life cycle. To this end, we have embarked on a series of projects to determine the molecular structure of certain viral enzymes as well as to define regulatory mechanisms that control FIV expression.

Education

B.S., Biological Education, Purdue University, 1971
M.S., Cell Physiology, Purdue University, 1973
Ph.D., Biochemistry, Purdue University, 1975

Professional Experience

Undergraduate Assistant, Dept. of Biology, Purdue University, Lafayette, Indiana, 1970
Graduate Assistant, Dept. of Biology, Purdue University, Lafayette, Indiana, 1971-1975
Research Fellow, Dept. of Immunopathology, The Scripps Research Institute, La Jolla, California, 1975-1977
Research Associate, Dept. of Cellular and Developmental Immunology, TSRI, 1977
Assistant Professor I, Dept. of Cellular and Developmental Immunology, TSRI, 1977-1978
Assistant Professor II, Dept. of Cellular and Developmental Immunology, TSRI, 1978-1982
Associate Professor, Tenured, Dept. of Molecular Biology,TSRI, 1982-1993
Professor, Dept. of Molecular Biology, TSRI, 1993-Present

Awards & Professional Activities

Reviewing Member, AIDS and Related Research Review Group 2, National Institutes of Health; Editorial Boards, Journal of Virology, Virology. Clinical and Celular Immunology


Selected References

172) Hu QY, E. Fink, Y. Hong, C. Wang, CK Grant, JH Elder (2010) Fine definition of the CXCR4-binding region on the V3 loop of feline immunlodeficiency virus surface glycoprotein. PLoSONE 18,5(5):e10689. PMCID: PMC2872658

173) Chang MW, M.J. Giffin, R. Muller, J. Savage, Y.C. Lin, S. Hong, W. Jin, L.R. Whitby, J.H. Elder, D.L. Boger, B.E. Torbett (2010) Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. Biochem J. 1;429(3):527-32. PMCID: PMC3084599

 174) Hu QY, E. Fink, M. Happer, J.H. Elder (2011) Identification of Amino Acid Residues Important for Heparan Sulfate Proteoglycan (HSPG) Interaction within Variable Region 3 of the Feline Immunodeficiency Virus Surface Glycoprotein J. Virol. 84(14):7108-17. PMCID: PMC3126603

175) Lin YC, A.L. Perryman, A.J. Olson, B.E. Torbett, J.H. Elder, C.D. Stout. (2011) Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease Acta Cryst. D67, part 6, 540-548  PMCID: PMC3107052

176) Miller C., H. Bielefeldt-Ohmann, M. Macmillan, S. Huitron-Resendiz, S. Henriksen, J.H.  Elder , S. Vandewoude (2011) Strain-specific viral distribution and neuropathology of feline immunodeficiency virus Vet  Immunol Immunopathol. PMCID:PMC3167954

177) Bucy D.S., M. S Brown, H. Bielefeldt-Ohmann, J. Thompson, A.M. Bachand, M. Morges, J.H. Elder, S. VandeWoude (2011) Early detection of neuropathophysiology using diffusion-weighted magnetic resonance imaging in asymptomatic cats with feline immunodeficiency viral infection J. Neurovirol. 17(4) 341-52 PMID 21786078 In press

178) Thompson J. MacMillan M, Boegler K, Wood C, Elder JH, VandeWoude S (2011) Pathogenicity and rapid growth kinetics of feline immunodeficiency virus are linked to 3' elements PLoS One 6(8)e24020 PMID 21887365 in process 

179) Hu Q.-Y., Fink, E., Elder, (2012) J. Mapping of Receptor Binding Interactions with the FIV Surface Glycoprotein (SU); Implications Regarding Immune Surveillance and Cellular Targets of Infection, Retrovirology (4): 1-11 PMCID:PMC3523734

180) Tiefenbrunn, T., Forli, S., Baksh, M.M., Chang, M.W., Happer, M., Perryman, A.L., Torbett, B.E., Olson, A.J., Elder, J.H., and Stout, C.D. (2012) Small Molecule Regulation of Protein Conformation by Binding inthe Flap of HIV Protease ACS Chemical Biology (8): 1223- 1231 PMCID:PMC3769432

181)  Lin, Y.-C., Happer, M., Elder, J.H. (2013)  Selection of Drug-resistant Feline Immunodeficiency Virus (FIV) Encoding FIV/HIV Chimeric Protease in The Presence of HIV-specific Protease Inhibitors, J. Virology. 87(15):8524-34. PMICD: PMC3719837

182)  Troyer, R.M., Thompson, J., Elder, J.H., VandeWoude, S. (2013) Accessory Genes Confer a High Replication Rate to Virulent Feline Immunodeficiency Virus, J. Virology, 87(14):7940-51. PMCID: PMC3700203

183) Wood, B.A., Carver, S., Troyer, R.M., J., Elder, VandeWoude, S. (2013) Domestic cat microsphere immunoassays: detection of antibodies during feline immunodeficiency virus infection, J. of Imm. Methods, 396(1-2):74-86 yet PMCID: PMC3823060

Links

Elder Website