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Edward Dennis, Ph.D.

Professor Adjunct
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
edennis@scripps.edu
(858) 784-8557

Education

University of Lyon, INSA-Lyon (France) 2014
Goethe University of Frankfurt (Germany) 2008
Ph.D. (Chemistry), Harvard University 1968
M.A. (Chemistry), Harvard University 1965
B.A. (Chemistry), Yale University 1963
Harvard University, Medical School 1969

Professional Experience

1999-2017 Professor Adjunct, Immunology and Microbial Science (IMS), The Scripps Research Institute
2012-2012 Foreign Visiting Professor, College de France
2002-2011 Vice Chairman, Health Sciences Biochemistry, Department of Chemistry and Biochemistry, University of California, San Diego
2003-2004 Professor, Department of Pharmacology, University of California, San Diego
1981-2004 Professor, Department of Chemistry and Biochemistry, University of California, San Diego
1999-2002 Chairman, Department of Chemistry and Biochemistry, University of California, San Diego
1996-1999 Head, Division of Biochemistry, Department Chemistry and Biochemistry, University of California, San Diego
1992-1997 Vice Chairman, Medical Biochemistry, Department of Chemistry and Biochemistry, University of California, San Diego
1987-1988 Chairman, Academic Senate, University of California, San Diego
1984-1987 Vice Chairman, Department of Chemistry, University of California, San Diego
1984-1984 Visiting Scientist, Department of Biochemistry, Brandeis University
1983-1984 Visiting Professor, Department of Biological Chemistry, Harvard Medical School, Harvard University
1975-1981 Associate Professor, Department of Chemistry, University of California, San Diego
1970-1975 Assistant Professor, Department of Chemistry, University of California, San Diego
1967-1969 NIH Postdoctoral Fellow, Department of Biological Chemistry, Harvard Medical School, Harvard University
1966-1967 Teaching Fellow, Department of Biological Chemistry, Harvard University
1963-1967 NIH Predoctoral Fellow, Department of Chemistry, Harvard University

Selected References

All Publications

Grover, R., Cheng, J. L., Peng, Y. J., Jones, T. M., Ruiz, D. I., Ulevitch, R. J., Glass, J. I., Dennis, E. A., Salomon, D. R. & Lerner, R. A. The costimulatory immunogen LPS induces the B-cell clones that infiltrate transplanted human kidneys. (2012). Proceedings of the National Academy of Sciences of the United States of America, 109(16), 6036-6041. PMCID: PMC3341022.

Raetz, C. R. H., Garrett, T. A., Reynolds, C. M., Shaw, W. A., Moore, J. D., Smith, D. C., Ribeiro, A. A., Murphy, R. C., Ulevitch, R. J., Fearns, C., Reichart, D., Glass, C. K., et al. Kdo(2)-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. (2006). Journal of Lipid Research, 47(5), 1097-1111.

Horkko, S., Bird, D. A., Miller, E., Itabe, H., Leitinger, N., Subbanagounder, G., Berliner, J. A., Friedman, P., Dennis, E. A., Curtiss, L. K., Palinski, W., Witztum, J. L. Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. (1999). Journal of Clinical Investigation, 103(1), 117-128.

Fremont, D. H., Anderson, D. H., Wilson, I. A., Dennis, E. A. & Xuong, N. H. Crystal-structure of phospholipase-a(2) from indian cobra reveals a trimeric association. (1993). Proceedings of the National Academy of Sciences of the United States of America, 90(1), 342-346.

Lister, M. D., Glaser, K. B., Ulevitch, R. J. & Dennis, E. A. Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. (1989). Journal of Biological Chemistry, 264(15), 8520-8528.

Lister, M. D., Deems, R. A., Watanabe, Y., Ulevitch, R. J. & Dennis, E. A. Kinetic-analysis of the ca-2+-dependent, membrane-bound, macrophage phospholipase-a2 and the effects of arachidonic-acid. (1988). Journal of Biological Chemistry, 263(16), 7506-7513.

Ulevitch, R. J., Watanabe, Y., Sano, M., Lister, M. D., Deems, R. A. & Dennis, E. A. Solubilization, purification, and characterization of a membrane-bound phospholipase-a2 from the p388d1 macrophage-like cell-line. (1988). Journal of Biological Chemistry, 263(7), 3079-3085.

Ross, M. I., Deems, R. A., Jesaitis, A. J., Dennis, E. A. & Ulevitch, R. J. Phospholipase activities of the p388d1 macrophage-like cell-line. (1985). Archives of Biochemistry and Biophysics, 238(1), 247-258.

Shaw, J. O., Roberts, M. F., Ulevitch, R. J., Henson, P. & Dennis, E. A. Phospholipase a2 contamination of cobra venom factor preparations. Biologic role in complement-dependent in vivo reactions and inactivation with p-bromophenacyl bromide. (1978). American Journal of Pathology, 91(3), 517-530. PMCID: PMC2018306.