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Max Crispin, PhD

Professor Adjunct
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
crispin@scripps.edu
(858) 784-8157

Education

D.Phil. (Glycobiology), University of Oxford 2005
M.S. (Molecular and Cellular Biochemistry), University of Oxford 2001

Professional Experience

2014-2020 Against Breast Cancer Senior Research Fellow, Oriel College, University of Oxford
2014-2018 Stipendiary Lectureship in Biochemistry, Director of Studies (Biochemistry), Corpus Christi College, University of Oxford
2016-2017 Professor Adjunct, Immunology and Microbial Science (IMS), The Scripps Research Institute
2013-2016 Founder & CEO, Immago Biosystems
2008-2014 Fellow and Tutor in Biochemistry, Oriel College, University of Oxford
2009-2013 Senior Research Associate, Oxford Glycobiology Institute, University of Oxford
2006-2009 Postdoctoral Associate, Division of Structural Biology, University of Oxford
2007-2008 Lecturer in Biochemistry, Director of Studies (Biochemistry), Oriel College, University of Oxford

Selected References

All Publications

Bale, S., Martine, A., Wilson, R., Behrens, A. J., Le Fourn, V., de Val, N., Sharma, S. K., Tran, K., Torres, J. L., Girod, P. A., Ward, A. B., Crispin, M., et al. Cleavage -Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies. (2018). Frontiers in Immunology, 9. PMCID: PMC5976746.

Maurer, M. A., Meyer, L., Bianchi, M., Turner, H. L., Le, N. P. L., Steck, M., Wyrzucki, A., Orlowski, V., Ward, A. B., Crispin, M. & Hangartner, L. Glycosylation of human IgA directly inhibits influenza A and other sialic-acid-binding viruses. (2018). Cell Reports, 23(1), 90-99.

Behrens, A. J., Kumar, A., Medina-Ramirez, M., Cupo, A., Marshall, K., Portillo, V. M. C., Harvey, D. J., Ozorowski, G., Zitzmann, N., Wilson, I. A., Ward, A. B., Struwe, W. B., et al. Integrity of glycosylation processing of a glycan-depleted trimeric HIV-1 immunogen targeting key B-cell lineages. (2018). Journal of Proteome Research, 17(3), 987-999. PMCID: PMC5846105.

Crispin, M., Ward, A. B. & Wilson, I. A. Structure and immune recognition of the HIV glycan shield. (2018). Annual Review of Biophysics, 47, 499.

Sarkar, A., Bale, S., Behrens, A. J., Kumar, S., Sharma, S. K., de Val, N., Pallesen, J., Irimia, A., Diwanji, D. C., Stanfield, R. L., Ward, A. B., Crispin, M., et al. Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer. (2018). Nature Communications, 9. PMCID: PMC5955915.

Dey, A. K., Cupo, A., Ozorowski, G., Sharma, V. K., Behrens, A. J., Go, E. P., Ketas, T. J., Yasmeen, A., Klasse, P. J., Sayeed, E., Desaire, H., Crispin, M., et al. cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate. (2018). Biotechnology and Bioengineering, 115(4), 885-899. PMCID: PMC5852640.

Medina-Ramirez, M., Garces, F., Escolano, A., Skog, P., de Taeye, S. W., Del Moral-Sanchez, I., McGuire, A. T., Yasmeen, A., Behrens, A. J., Ozorowski, G., van den Kerkhof, Tlgm, Freund, N. T., et al. Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo. (2017). Journal of Experimental Medicine, 214(9), 2573-2590. PMCID: PMC5584115.

Voss, J. E., Andrabi, R., McCoy, L. E., de Val, N., Fuller, R. P., Messmer, T., Su, C. Y., Sok, D., Khan, S. N., Garces, F., Pritchard, L. K., Wyatt, R. T., et al. Elicitation of neutralizing antibodies targeting the V2 apex of the HIV Envelope trimer in a wild-type animal model. (2017). Cell Reports, 21(1), 222-235. PMCID: PMC5640805.

Struwe, W. B., Stuckmann, A., Behrens, A. J., Pagel, K. & Crispin, M. Global N-glycan site occupancy of HIV-1 gp120 by metabolic engineering and high-resolution intact mass spectrometry. (2017). ACS Chemical Biology, 12(2), 357-361.

Behrens, A. J., Struwe, W. B. & Crispin, M. Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1. (2017). Expert Review of Proteomics, 14(10), 881-890.