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Max Crispin, Ph.D.

Professor Adjunct
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
crispin@scripps.edu
(858) 784-8157

Education

D.Phil. (Glycobiology), University of Oxford 2005
M.S. (Molecular and Cellular Biochemistry), University of Oxford 2001

Professional Experience

2014-2020 Against Breast Cancer Senior Research Fellow, Oriel College, University of Oxford
2014-2018 Stipendiary Lectureship in Biochemistry, Director of Studies (Biochemistry), Corpus Christi College, University of Oxford
2016-2017 Professor Adjunct, Immunology and Microbial Science (IMS), The Scripps Research Institute
2013-2016 Founder & CEO, Immago Biosystems
2008-2014 Fellow and Tutor in Biochemistry, Oriel College, University of Oxford
2009-2013 Senior Research Associate, Oxford Glycobiology Institute, University of Oxford
2006-2009 Postdoctoral Associate, Division of Structural Biology, University of Oxford
2007-2008 Lecturer in Biochemistry, Director of Studies (Biochemistry), Oriel College, University of Oxford

Selected References

All Publications

Struwe, W. B., Stuckmann, A., Behrens, A. J., Pagel, K. & Crispin, M. Global N-glycan site occupancy of HIV-1 gp120 by metabolic engineering and high-resolution intact mass spectrometry. (2017). ACS Chemical Biology, 12(2), 357-361.

Yu, X., Marshall, M. J. E., Cragg, M. S. & Crispin, M. Improving antibody-based cancer therapeutics through glycan engineering. (2017). Biodrugs, 31(3), 151-166.

Torrents de la Pena, A., Julien, J. P., de Taeye, S. W., Garces, F., Guttman, M., Ozorowski, G., Pritchard, L. K., Behrens, A. J., Go, E. P., Burger, J. A., Schermer, E. E., Sliepen, K., et al. Improving the immunogenicity of native-like HIV-1 envelope trimers by hyperstabilization. (2017). Cell Reports, 20(8), 1805-1817.

Ringe, R. P., Ozorowski, G., Rantalainen, K., Struwe, W. B., Matthews, K., Torres, J. L., Yasmeen, A., Cottrell, C. A., Ketas, T. J., LaBranche, C. C., Montefiori, D. C., Cupo, A., et al. Reducing V3 antigenicity and immunogenicity on soluble, native-like HIV-1 Env SOSIP trimers. (2017). Journal of Virology, 91(15), e00677-17. PMCID: PMC5512241.

Behrens, A. J. & Crispin, M. Structural principles controlling HIV envelope glycosylation. (2017). Current Opinion in Structural Biology, 44, 125. PMCID: PMC5513759.

van Gils, M. J., van den Kerkhof, T. L., Ozorowski, G., Cottrell, C. A., Sok, D., Pauthner, M., Pallesen, J., de Val, N., Yasmeen, A., de Taeye, S. W., Schorcht, A., Gumbs, S., et al. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability. (2016). Nature Microbiology, 2. PMCID: PMC5372380.

Calow, J., Behrens, A. J., Mader, S., Bockau, U., Struwe, W. B., Harvey, D. J., Cormann, K. U., Nowaczyk, M. M., Loser, K., Schinor, D., Hartmann, M. W., Crispin, M. Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity. (2016). MAbs, 8(8), 1498-1511.

Behrens, A. J., Vasiljevic, S., Pritchard, L. K., Harvey, D. J., Andev, R. S., Krumm, S. A., Struwe, W. B., Cupo, A., Kumar, A., Zitzmann, N., Seabright, G. E., Kramer, H. B., et al. Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein. (2016). Cell Reports, 14(11), 2695-2706. PMCID: PMC4805854.

Coss, K. P., Vasiljevic, S., Pritchard, L. K., Krumm, S. A., Glaze, M., Madzorera, S., Moore, P. L., Crispin, M. & Doores, K. J. HIV-1 glycan density drives the persistence of the mannose patch within an infected individual. (2016). Journal of Virology, 11132-11144.

Le, N. P. L., Bowden, T. A., Struwe, W. B. & Crispin, M. Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies. (2016). Biochimica Et Biophysica Acta-General Subjects, 1860(8), 1655-1668. PMCID: PMC4922387.