Scripps Research Logo

Andrew Saphire, Ph.D.

Assistant Professor of Immunology
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
saphire@scripps.edu
(858) 784-8129

Education

Ph.D. (Macromolecular and Cellular Structure and Chemistry), The Scripps Research Institute 1998

Professional Experience

2004-2017 Assistant Professor of Immunology, Immunology and Microbial Science (IMS), The Scripps Research Institute

Selected References

All Publications

Fink, E., Fuller, K., Agan, B., Berger, E. A., Saphire, A., Quinnan, G. V. & Elder, J. H. Humoral antibody responses to HIV viral proteins and to CD4 among HIV controllers, rapid and typical progressors in an HIV-positive patient cohort. (2016). AIDS Research and Human Retroviruses, 32(12), 1187-1197.

Edgcomb, S. P., Carmel, A. B., Naji, S., Ambrus-Aikelin, G., Reyes, J. R., Saphire, A. C. S., Gerace, L. & Williamson, J. R. DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication. (2012). Journal of Molecular Biology, 415(1), 61-74. PMCID: PMC3249508.

Naji, S., Ambrus, G., Cimermancic, P., Reyes, J. R., Filbrandt, R., Huber, M. D., Vesely, P., Krogan, N. J., Yates, J. R., Saphire, A. C., Gerace, L., Johnson, J. R. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. (2012). Molecular & Cellular Proteomics, 11, M111.015313. PMCID: PMC3322577.

Saphire, A. C. S., Gallay, P. A. & Bark, S. J. Proteomic analysis of human immunodeficency virus using liquid chromatography/tandem mass spectrometry effectively distinguishes specific incorporated host proteins. (2006). Journal of Proteome Research, 5(3), 530-538.

Bobardt, M. D., Saphire, A. C. S., Hung, H. C., Yu, X. C., Van der Schueren, B., Zhang, Z., David, G. & Gallay, P. A. Syndecan captures, protects, and transmits HIV to T lymphocytes. (2003). Immunity, 18(1), 27-39.

Saphire, A. C. S., Bobardt, M. D. & Gallay, P. A. Cyclophilin A plays distinct roles in human immunodeficiency virus type 1 entry and postentry events, as revealed by spinoculation. (2002). Journal of Virology, 76(9), 4671-4677.

Saphire, A. C. S., Bobardt, M. D. & Gallay, P. A. Trans-complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity. (2002). Journal of Virology, 76(5), 2255-2262.

Saphire, A. C. S., Bobardt, M. D., Zhang, Z., David, G. & Gallay, P. A. Syndecans serve as attachment receptors for human immunodeficiency virus type 1 on macrophages. (2001). Journal of Virology, 75(19), 9187-9200.

Saphire, A. C. S., Bobardt, M. D. & Gallay, P. A. Human immunodeficiency virus type 1 hijacks host cyclophilin A for its attachment to target cells. (2000). Immunologic Research, 21(2-3), 211-217.

Saphire, A. C. S., Guan, T. L., Schirmer, E. C., Nemerow, G. R. & Gerace, L. Nuclear import adenovirus DNA in vitro involves the nuclear protein import pathway and hsc70. (2000). Journal of Biological Chemistry, 275(6), 4298-4304.