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Faculty
Michael Taffe
Associate Professor
Committee On The Neurobiology Of Addictive Disorders
TSRI - 1996
Education
Ph.D., University of California, San Diego, 1995
Research Focus
Neuropharmacology of Primate Cognition
Research in the Primate Neurobehavioral Laboratory centers on brain mechanisms which contribute to cognitive function and complex behavior. We have developed a model in which rhesus monkeys are trained to perform multiple behavioral tasks which can concurrently evaluate a number of cognitive domains, including learning, memory, attention and motor performance. Our work consists of two main themes. The first line of investigation is an effort to determine the unique or overlapping contributions made by specific brain neurotransmitter system components to particular cognitive and behavioral functions. The second experimental theme in the laboratory comprises study of the etiology of cognitive dysfunction associated with a number of brain insults, including exposure to recreationally abused drugs, infection with neurotropic viruses and the aging process.
Selected References
Taffe, M.A., Weed, M.R., Gutierrez, T., Davis, S.A., and Gold, L.H. Differential muscarinic and NMDA contributions to visuo-spatial paired-associate learning in rhesus monkeys, Psychopharmacology, 2002, 160:253-262.
Taffe, M.A., Davis, S.A., Yuan, J., Schroeder, R., Hatzidimitriou, G., Parsons, L.H., Ricaurte, G.A., and Gold, L.H. Cognitive performance of MDMA-treated rhesus monkeys: Sensitivity to serotonergic challenge, Neuropsychopharmacology, 2002 27(6):993-1005.
Weed, M.R., Gold, L.H., Polis, I., Koob, G.F., Fox, H.S. and Taffe M.A. Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection, AIDS Res Hum Ret, 2004, 20(1):77-89.
Katner, S.N., Flynn, C.T., Von Huben, S.N., Kirsten, A.J., Davis, S.A., Lay, C.C., Cole, M., Roberts, A.J., Fox, H.S. and Taffe M.A. Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure, Alcohol Clin Exp Res, 2004 Jun;28(6):873-83.
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