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Faculty
Phil Baran
Professor
Department of Chemistry
TSRI - 2003
Education
B.S., New York University, 1997
Ph.D., The Scripps Research Institute, La Jolla, 2001
NIH Postdoctoral Fellowship; 2001 - 2003, Harvard University
Awards & Activities
National Fresenius Award, 2007
Pfizer Award for Creativity in Organic Chemistry, 2006
Beckman Young Investigator Award, 2006
Alfred P. Sloan Foundation Fellow, 2006-2008
BMS Unrestricted "Freedom to Discover" Grant, 2006 - 2010
NSF Career, 2006 - 2010
Eli Lilly Young Investigator Award, 2005 - 2006
AstraZeneca Excellence in Chemistry Award, 2005
DuPont Young Professor Award, 2005
Roche Excellence in Chemistry Award, 2005
Amgen Young Investigator Award, 2005
Searle Scholar Award, 2005
GlaxoSmithKline Chemistry Scholar Award, 2005-2006
Research Focus
The cycle of discovery in total synthesis is a dynamic process involving the coupling of imagination with the challenges offered by novel molecular complexity. The lessons acquired during the course of a total synthesis almost always transcend the process itself and lead to new insights and discoveries in organic chemistry. Our research program enters this cycle by identifying challenging and reoccurring structural motifs found in natural products. The hallmark of our approach is to examine problems in organic chemistry which have remained unsolved challenges for decades.
Another integral part of our research program is to develop new synthetic chemistry of broad utility. Just as total synthesis strives to gain wisdom from stimulating chemical architectures, we are developing methods using innovative and under-explored chemical entities.
The end result of such endeavors, aside from a clearer understanding of organic chemistry, is the discovery and development of new synthetic tools and access to potential pharmaceutical leads which inevitably will contribute to the fields of biology and medicine in many ways.
Selected References
Baran, P. S.; Maimone, T. J.; Richter, J. M. Total Synthesis of Marine Natural Products Without Using Protecting Groups, Nature 2007, in press.
Baran, P. S.; Shenvi, R. A. Total Synthesis of Chartelline C, J. Am. Chem. Soc. 2006, 128, 14028 - 14029.
Baran, P. S.; Hafensteiner, B. D.; Ambhaikar, N. B.; Guerrero, C. A.; Gallagher, J. D. Enantioselective Total Synthesis of Avrainvillamide and the Stephacidins. J. Am. Chem. Soc. 2006, 128, 8678 - 8693.
Baran, P. S.; Burns, N. Z. Total Synthesis of Haouamine A, J. Am. Chem. Soc. 2006, 128, 3908 - 3909.
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