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Faculty
Subhash Sinha
Associate Professor of Medicinal Chemistry
Department of Molecular Biology
TSRI - 1991
Education
Ph.D., Banaras Hindu University, India, 1987
Research Focus
Antibody Catalysis, Organic Synthesis and prodrug therapy
Research activities in our laboratory include antibody catalysis, total synthesis of naturally occurring compounds and their analogs, methodology development and prodrug therapy. Antibody catalyzed reactions are performed to produce the chiral starting materials that are then converted to the natural products by chemical transformations. On the prodrug therapy topic, our main focus is on the synthesis of prodrugs, construction of catalytic antibodies and enzymes that possess both the targeting and catalytic properties, and evaluation of prodrugs and catalysts.
Selected References
Sinha, S.C., Barbas III, C.F., Lerner, R.A. The Antibody Catalysis Route to the Total Synthesis of Epothilones. Proc. Natl. Acad. Sci. USA 95:14603, 1998.
S.C. Sinha, A. Sinha, E. Keinan and S.C. Sinha. Unique Stereoselectivity in the Tandem Oxidative Cyclization Reaction with Rhenium(VII). J. Am. Chem. Soc. 120:9076, 1998.
Avedissian, H., Sinha, S.C., Yazbak, A., Sinha, A., Neogi, P., Sinha, S.C., Keinan, E. Total synthesis of asimicin and bullatacin. J. Org. Chem. 65:6035, 2000.
Sun, J., Sinha, S.C. Stereoselective Total Synthesis of Epothilones by the Metathesis Approach Involving C9-C10 Bond Formation. Angew. Chem. Int. Edn. 41:1381, 2002.
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