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Faculty
Chi-Huey Wong
Ernest W. Hahn Professor of Chemistry
Professor of Chemistry
Department of Chemistry
TSRI - 1989
Joint Appointments The Skaggs Institute for Chemical Biology
Education
B.S., National Taiwan University, 1970
M.S., National Taiwan University, 1977
Ph.D., Massachusetts Insititute of Technology, 1982
Postdoctoral Fellow, Harvard University, 1982–1983
Positions: Assistant Professor - Professor of Chemistry, Texas A&M University, 1983–1989
Awards & Activities
Searle Scholar Award in Biomedical Sciences, 1985
Presidential Young Investigator in Chemistry, 1986
ACS Arthur C. Cope Scholar Award, 1993
The IUPAC International Carbohydrate Award, 1994
Elected Member of Academia Sinica, Taipei 1994
Elected Member of the American Academy of Arts and Sciences, 1996
The ACS Harrison Howe Award in Chemistry, 1998
The ACS Claude S. Hudson Award in Carbohydrate Chemistry, 1999
The International Enzyme Engineering Award, 1999
Presidential Green Chemistry Award, 2000
The ACS Award for Creative Work in Synthetic Organic Chemistry, 2005
Elected Member of the National Academy of Science, 2002
Editor-in-Chief, Bioorganic & Medicinal Chemistry
Executive Board Member, Tetrahedron Publications.
Research Focus
Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting RNA and design and synthesis of inhibitors to enzymes and receptors are being performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules. Development of both synthetic and bioorganic strategies is also paramount to our research. Programmable one-pot reactions can be used for the synthesis of complex oligosaccharides and glycoarrays, and compliment development of new enzymatic catalysts for glycoprotein synthesis and other organic reactions.
Selected References
Koeller, K., Wong, C.-H. “Enzymes for chemical synthesis.” Nature (2001) 409, 232.
Ritter, T.K., Wong, C.-H. “Carbohydrate-based antibiotics: a new approach to tackle the problem of antibiotic resistance.” Angew. Chem. Int. Ed. (2001) 40, 3508.
Sears, P., Wong, C.-H. “Toward automated synthesis of oligosaccharides and glycoproteins”, Science (2001) 291, 2344.
Bryan, M.C., Fazio, F., Lee, H.-K., Huang, C.-Y., Chang, A., Best, M., Calarese, D.A., Blixt, O., Paulson, J.C., Burton, D., Wilson, I.A., Wong, C.-H. “Covalent display of oligosaccharide arrays in microtiter plates”, J. Am. Chem. Soc. (2004) 126, 8640.
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